is routine activity theory scientific

Ngày tải lên: 13/08/2014, 20:22

Ngày tải lên: 13/08/2014, 21:21

... Netherlands 4 Clinical Epidemiologist, Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 5 Internist-intensivist, Department of ... m.j.schultz@amc.uva.nl Received: 3 Oct 2005 Revisions received: 24 Nov 2005 Accepted: 28 Nov 2005 Published: 30 Dec 2005 Critical Care 2006, 10:R11 (doi:10.1186/cc3955) This article is online at: http://ccforum.com/content/10/1/R11 â ... Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution,...

Ngày tải lên: 25/10/2012, 10:39

... the ERK pathway is sufficient to induce apoptosis. It is unclear why the mutant is defec- tive at causing pyroptosis, but it is presumably because LF-K518E ⁄ E682G has a diminished capacity to ... cells. These data are consistent with the notion that induction of pyroptosis and apop- tosis by LF occurs through the cleavage of distinct substrates. Results and Discussion We screened a collection ... of mice are rapidly killed by pyroptosis. Pyroptosis differs from apoptosis in that it is a proinflammatory form of cell death that depends on caspase-1 activity. A highly polymorphic gene, Nlrp1b...

Ngày tải lên: 16/02/2014, 09:20

... framework; the latter is described below. The family of distributions used for the forecast error is the normal family with precision τ. 12 In this case the likelihood for an observation is L(y it |θ, ... squared differences between the cash distribution and the stationary distribution). The second block is a random walk Metropolis-Hastings step to draw a realization 12 T he precision is just the inverse of ... This suggests that banks with higher liquidity holdings delay less, however this is not quite significant at the 10% confidence level (The p-value of the slope of the trend line is .1009). 14 This...

Ngày tải lên: 16/02/2014, 12:20

... autolysis. Therefore, it is premature to draw conclusions regarding the mechanism of the enhancing effects of IST1 on mGFP–calpain 7–Strep autolysis in vitro. Both mGFP–calpain 7 and IST1 have ... pathway are not evident, IST1 is required for efficient cytokinesis in HeLa cells [32,33]. IST1 and Ist1 associate with CHMP1 ⁄ Did2 to regulate the local- ization and ATPase activity of VPS4 ⁄ Vps4 ... the punctate distribution of mGFP–calpain 7 between cells coex- pressing FLAG–IST1 and and those coexpressing FLAG-IST1 DMIM1,2 (data not shown). Thus, it is not clear why FLAG–IST1 had no enhancing...

Ngày tải lên: 18/02/2014, 04:20

... ATP hydrolysis is important for a mechanistic step after the formation of an ID complex. This is supported by studies performed with N-ethylmaleimide-treated 40 kDa ChlI subunit of Synechocystis [19]. ... to exist. Acknowledgements Dr Salam Al-Karadaghi is acknowledged for fruitful discussions. This work was made possible thanks to generous support from the Swedish Research Council, the Swedish ... it is well-known that Mg 2+ is required to perform the ATP hydrolysis. In addition, kinetic analysis had shown binding of Mg 2+ to this subunit [21]. An integrin I domain, suggested to exist...

Ngày tải lên: 19/02/2014, 12:20

... Sinclair, unpublished data). However, KIPase is also resistant to inhibition by the broad specificity caspase inhibitor, z-VAD-fmk. This raises the question of whether KIPase is a member of the ... demonstrated that KIPase is distinct from human caspases 1–10. The evidence supporting this is three fold: (a) KIPase is not inhibited by z-VAD-fmk whereas Fig. 7. DPSD-CHO inhibits KIPase activity. Extracts ... derivative of the DPSD tetra peptide is unable to inhibit caspases, but is a good inhibitor of KIPase activity. This supports a hypo- thesis whereby KIPase is a currently unidentified caspase- like...

Ngày tải lên: 19/02/2014, 13:20

... of this protease effectively inhibit this proteolytic process. This result refutes the long-standing idea that antizyme is a stable protein [2,13,21]. The rapid degradation of antizyme is compatible ... this proteolytic process is unclear. The prominent notion which is based predominantly on studies performed in vitro in degradation extracts assumes that a ntizyme is a stable protein that is ... heterodimer [20]. While it is clear that interaction with antizyme is absolutely required for marking ODC for rapid degrada- tion, it is not clear what happens to antizyme during this proteolytic process....

Ngày tải lên: 22/02/2014, 04:20

... 1 80 85 90 95 100 105 110 average central bank loss STR p Warsaw, November 2008 The Relativity Theory Revisited: Is Publishing Interest Rate Forecasts Really so Valuable? 0LFKDï%U]R]D%U]H]LQD Adam Kot NATIONAL ... K( central bank knows: IS equation Philips curve policy rule IS equation Philips curve policy rule IS equation Philips curve policy rule public knows: – )UDFWLRQŘe): IS equation, Philips curve Fraction ... Ř 5HVXOWVRIVLPXODWLRQV  DUHGHSLFWHGLQ)LJXUHVDQG$VWKHVDPSOHOHQJWKhbea used by agents rises the central bank loss tends to be lower. This is in line with the intuition WKDWXVLQJODUJHUGDWDVHWVE\DJHQWVHQDEOHVWKHPWREHWWHUDSSUR[LPDWHWKHWUXHODZRI PRWLRQRIWKHHFRQRP\DQGWKXVORZHUFHQWUDOEDQNORVV$VUHJDUGVWKHIUDFWLRQeWKH PRUHDJHQWVKDYHWRUHVRUWWRWKHPDFURHFRQRPLFSURMHFWLRQVSXEOLVKHGE\WKHFHQWUDO EDQNWKHKLJKHUWKHYDOXHVRIFHQWUDOEDQNORVVDQGWKHKLJKHUWKHJDLQIURPGLVFORVLQJWKH LQWHUHVWUDWHSDWK2QWKHRWKHUKDQGLWLVZRUWKQRWLQJWKDWVKRZLQJWKH,6DQG3&FXUYHV WRDOODJHQWVe...

Ngày tải lên: 06/03/2014, 02:21

... water molecules, a two-metal ion catalysis mechanism has been proposed for RNase H [14,16,17]. According to this mechanism, one metal ion is required for sub- strate-assisted nucleophile formation and ... stability of Tma-W22A is not significantly changed even when the HBD is completely removed, and therefore it is highly likely that Tma-W22A is as stable as Tma-RNase HI. Discussion Importance of ... Mg 2+ -dependent activity is higher than its maximal Mn 2+ -dependent activity by 16-fold. By contrast, Tma-CD prefers Mn 2+ to Mg 2+ because its maximal Mn 2+ -dependent activity is higher than...

Ngày tải lên: 06/03/2014, 22:21

... A, Lang A, Horler D, Kissling R & Merlin C (1995) Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage. Ann Rheum Dis 54 , 289–297. 7 Coulombe ... B, although it was not clear whether this activity belonged to the zymogen [14]. To address this question, the possible activity of procat- hepsin B on this substrate was investigated by zymog- raphy. ... [15–17]. The major outcome of the mutagenesis studies was that cathepsin B is not a very specific enzyme and is capable of cleaving procathepsin B at different sites, which is in agreement with the general...

Ngày tải lên: 07/03/2014, 03:20

... individ- ually defective in ATP hydrolysis, the ATPase activity that is stimulated upon mixing the two proteins sug- gests assembly of a hybrid oligomer in vitro. This is consistent with previous studies ... Vps20p–Vps4p interaction is stabilized in vivo by mutation of the C-terminal helix. This is consistent with an essential role of the C-terminal helix in Vps4p ATPase activity in vivo. Loss of ATPase activity ... domain, is dispensable for recruitment to endosomes but is essential for Vps4p oligomerization and ATPase activity in vitro. In contrast to the b domain, however, the C-terminal helix is dispensable...

Ngày tải lên: 07/03/2014, 05:20

... product dissociation, this internal proton relay system can be reloaded, leading to protonation of His106, such that the enzyme is ready for the next sub- strate turnover. In this mechanism, His106 ... site of chorismate synthase, which form a pro- ton relay system among the isoalloxazine ring of FMN, His106 and substrate. This proton relay system is essential for catalysis and is probably ... double-mutant protein is devoid of any detectable catalytic activity, indicating that replacement of both serine residues produces a syner- gistic effect. This result is consistent with the inability of...

Ngày tải lên: 07/03/2014, 05:20

... his3:hisG/his3::hisG trp1::hisG/trp1::hisG This study MR211 S1278b; MATa ura3–52 his3:hisG leu2::hisG ras2::kanMX MR298 S1278b; MATa/a ras2::kanMX/ras2::kanMX ura3–52/ura3–52 his3:hisG/his3:hisG leu2::hisG ... his3:hisG/his3:hisG leu2::hisG leu)2::hisG This study AR2 S1278b; MATa/a sut2::S.pombe his5 + /sut2::S.pombe his5 + ura3–52/ura3–52 his3:hisG/his3:hisG leu2::hisG/LEU2 TRP1/trp1::hisG This study MR287 S1278b; ... ura3–52 his3:hisG leu2::hisG FLO11::lacZ This study AR3 S1278b; MATa ura3–52 his3:hisG leu2::hisG ras2::kanMX FLO11::lacZ This study AR4 S1278b; MATa ura3–52 his3:hisG leu2::hisG sut2::S.pombe his5 + FLO11::lacZ...

Ngày tải lên: 07/03/2014, 15:20

... beats tied is calculated by basic addition. This is a real popular beat! The “and” of beat two is tied to beat three, then the “and” of three is struck leading into beat four. This is called “Syncopation”. ... Guitarist Can Ambitious Guitarists Even Dream? Cheap Tricks for the Lazy Guitarist Interval Graphics 3 A Complimentary Music Theory Overview for the Guitarist, by Steve Ono Visit the Onomuse Web Site ... second chord (II), is a minor chord: “Dm”. If you see a “D7” we are not in “C” anymore. D7 is the V7 of “G”; G7 is the V7 of “C”. D7 is the “V of V” AKA Secondary Dominant. This a Key Center Change...

Ngày tải lên: 15/03/2014, 13:03

... elucidated. This study shows that EmbR is a substrate for multiple STPKs, as well as a substrate for Mstp. In addition, we show, for the first time, that a phosphory- lation-dependent ATPase activity is ... radioactivity after incubation for the indicated time periods and under the experimental conditions described. Shown is the residual PknH- and EmbR-associated radioactivity. Each value is the ... demonstrate the modulation of ATPase activity and DNA-binding activity of EmbR as a possible physical mechanism to modulate its regulatory effect on emb genes. On the basis of the results obtained so far,...

Ngày tải lên: 16/03/2014, 14:20

Ngày tải lên: 16/03/2014, 23:20

Ngày tải lên: 17/03/2014, 10:20