... Edinburgh corpus. For boththe deletion and letter transformation lookup tables,we generate a ranked list of candidate words for eachnonstandard token, by sorting the combined scorep(Ti|Si) ... ShankarKumar, Mari Ostendorf, and Christopher Richards.2001. Normalization of non-standard words. Com-puter Speech and Language, 15(3):287–333.Kristina Toutanova and Robert C. Moore. 2002. Pronun-ciation ... significant mean-ings with the context-appropriate standard Englishwords. This is a very challenging task due to thevast amount and wide variety of existing nonstan-dard tokens. We found more than...
... and Parkinson disease, and in other neuropsychiatric disorders such asschizophrenia [27]. Cannabinoid receptors therefore areimportant modulators of brain function and loss of thesereceptors ... in an over-exposure of an RPA analysis of 25 lgwild-type cortical (lane 5), wild-type striatal (lane 6), R6/2 striatal (lane 7) and R6/2 cortical (lane 8) RNA. T he arrow to the right o f l ane ... deeply anaesthetized usingsodium pentobarbital (65 mgÆkg)1i.p.), decapitated, andcortical and striatal tissue was dissected. The tissue wasimmersed in liquid nitrogen and stored at )70 °CpriortoRNA...
... 4261MINIREVIEWHuntington’s disease: revisiting the aggregationhypothesis in polyglutamine neurodegenerative diseasesRay Truant, Randy Singh Atwal, Carly Desmond, Lise Munsie and Thu TranDepartment of Biochemistry and ... mutant, and not wild-type, protein.AcknowledgementsThe Truant laboratory is supported by current andpast grants from the Hereditary Disease Foundation,(HDF) USA, the Cure Huntington’s Disease ... diseases, includingtransmitted spongiform encephalopathies, Parkinson’s disease, and Alzheimer’s disease [15]. Polyglutaminediseases have often been historically considered asamyloid diseases.New...
... many months. mTOR isan importantsignaling molecule that regulates diverse cellular func-tions, such as initiation of mRNA translation, ribo-some biogenesis, transcription, cell growth, andcytoskeletal ... rational mechanism for com-bination treatment of Huntington’s disease using lith-ium and rapamycin. Hum Mol Genet 17, 170–178.50 Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y,Zhang X, Yang Q, Bennett ... half-livesand can include protein complexes or damaged cellularorganelles. This process involves the formation ofsmall double-membrane structures of unknown ori-gin(s) called phagophores, which...
... MINIREVIEWHuntington’s disease: roles of huntingtin-interactingprotein 1 (HIP-1) and its molecular partner HIPPI in theregulation of apoptosis and transcriptionNitai P. Bhattacharyya, Manisha Banerjee and Pritha ... models, brainsof transgenic animals, and post-mortem brains of HDpatients [2]. Aggregate formation is enhanced with theincrease in the number of glutamines in vitro andin vivo, and is believed to ... Onset and pre-onsetstudies to define the Huntington’s disease naturalhistory. Brain Res Bull 56, 233–238.2 Young AB (2003) Huntingtin in health and disease. J Clin Invest 111, 299–302.3 Cowan...
... FEBSHuntington’s disease (HD) is a progressive neurode-generative disorder, which is inherited in an autosomaldominant fashion [1]. It affects approximately one in10 000 individuals. The diseaseis characterized ... trinucleotiderepeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72, 971–983.5 Perez-De La Cruz V & Santamaria A (2006) Integrativehypothesis for Huntington’s disease: a brief ... experiments were carried out in accordance withthe European Union Guide for the Care and Use of Labo-ratory Animals and were approved by the local animal carecommittee. For ethical reasons, the number...
... Bilney B, Morris ME, Churchyard A, Chiu E, Georgiou-Karistianis N:Evidence for a disorder of locomotor timing in Huntington's disease. Mov Disord 2005, 20:51-57.8. Tian J, Herdman SJ, Zee ... Salarian A, Russmann H, Vingerhoets FJ, Dehollain C, Blanc Y, Bur-khard PR, Aminian K: Gait assessment in Parkinson's disease: toward an ambulatory system for long-term monitoring.IEEE Trans ... cycle timing in Parkinson's disease and Hunting-ton's disease. Mov Disord 1998, 13:428-437.10. Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gaitin Parkinson patients:...
... published methods. Ratios higher than 0.022 wereconsidered abnormal (12).Statistical AnalysisQuantitative variables are described as medians with rangesin parentheses. The significance of changes ... of 14.5 years (range, 10–18). Two patientshad ileocolonic disease and two others had gastrocolonic disease. None had a fistula. Median duration of Crohn’s disease was 3 years (range, 1–5). All ... sup-ports the role of mucosal barrier defect in initiation ofCrohn’s disease (15).The normal intestinal microflora may offer resistanceto colonization by pathogens and thus functions as an important...
... Sharp and Dohme. We thank DrsS. Lichtenthaler, G. Muscat, H. Clarris, C. Bergmann, T. Hartmann,F. Reinhard and A. Weidemann for providing DNA-constructs andadvice, and Ms. F. Katsis for protein ... fluorescenceand Ab-secretionPresenilin is required for 40–42 cleavage, or c cleavage (forthe release of Ab40)42), and 49 cleavage, or e cleavage, ofAPP. The precise cleavage mechanism is ... stably transfected with empty vector(–, lanes 1, 5 and 6), SP-A4DCT-GV (A, lanes 2–4) or SP-NOTL-GV(N, lane 7) constructs were pulsed for 30 min and chased for 1 h. Celllysates were analyzed...
... the Taylor & Francis e-Library, 2005.“To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go towww.eBookstore.tandf.co.uk.”Published ... for the condition is often disappointing, although anticholinergictherapy, in large doses, is sometimes beneficial. An occasional response is seen to dopaminergic agonistsand antagonists, and ... age. Dementia is not a feature ofmultiple system atrophy, nor is there an ophthalmoplegia (although this is recorded in both sporadic andfamilial forms of OPCA). Although poor or absent dopa...
... these isoforms may differ, we exam-ined the expression of the isoforms known to be tran-scribed in brain tissue, isoforms RCAN1-1 andRCAN1-4. To determine which, if any, protein iso-forms ... arethree RCAN1 protein isoforms expressed in human brain: RCAN1-1L,RCAN1-1S, and RCAN1-4. We have determined that RCAN1-1L is expressed at twice the level of RCAN1-4, and that there is very minorexpression ... As this antibody is generated against a pep-tide present in both RCAN1-1 isoforms, it recognizesboth bands. RCAN1-1S was the minor band, whichwas very weak and difficult to detect and quantify.The...
... translated into many languages allover the world and extensively used for PD research bymany authors [10-13]. Translation and validation of an instrument is a prerequisite for its use in a new ... frequently reported concomitant diseases werehigh blood pressure (24%), coronary heart disease (24%),and joint disease (14%). There were two cases of strokeand one of malignancy among the ... score 35.8, for patients ina moderate stage of disease it was 46.1 and for patients in an advanced stage of the disease it was 59.1 (Figure 1).There was a statistically significant difference...