interaction of tumour with host stroma in hepatocellular carcinoma

... tumor initiating potential of cancer cells in driving cancer pluripotent stem cells establishment, stem cell maintenance, and lineage fate determinant in various types of cancers [15–20] In the present ... monitor the extent of tumor dedifferentiation and predict patient prognosis in HCC Further incorporation of the gene signature into clinical RNA-seq profiling might help identify groups of highrisk ... defined with a sox signature score greater than 2, and the “Low SOX signature group” was defined with a sox signature score less than and including The association of the SOX signature with clinical

Ngày tải lên: 17/06/2020, 17:36

... including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis The arginine-lowering ... Keywords: Arginine, Argininosuccinate synthetase, Arginine deiminase, Cisplatin, Hepatocellular carcinoma, Combination therapy * Correspondence: jmcalpine@polarispharma.com Department of Biology, ... combination of ADI-PEG 20 and cisplatin can increase apoptosis in melanoma cell lines [34] In addition, combined treatment of oxaliplatin and human arginase in HCC exhibited synergistic inhibiting

Ngày tải lên: 14/10/2020, 15:01

... HCV infection causes hepato cellular carcinoma mainly by direct way Oppositely, patients of chronic hepatitis C often develop into hepato cellular carcinoma (HCC) on cirrhosis In addition, indirect ... GENOTYPES IN HEPATOCELLULAR CARCINOMA PATIENTS Speciality: Gastroenterology Code: 62.72.01.43 SUMMARY THESIS’ DOCTOR OF MEDICINE HANOI – 2018 THE THESIS WAS DONE IN: 108 INSTITUTE OF CLINICAL MEDICAL ... Library of Vietnam Library of 108 Institute of Clinical Medical and Pharmaceutical Sciences Central Institute for Medical Science Infomation and Tecnology 1 Introduction Hepato cellular carcinoma

Ngày tải lên: 08/01/2020, 16:39

... diaminobenzidine staining and Meyer’s haematoxylin counterstaining Two investigators who did not have any clinical or pathological information regarding the origin of the samples scored the IHC staining ... function of hornerin (HRNR), a member of the S100 protein family, is poorly clarified in the development of human tumors The role of HRNR in hepatocellular carcinoma (HCC) progression is investigated ... Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration Biochim Biophys Acta 1812;2011:703–10 10 Edmondson HA, Steiner PE Primary carcinoma

Ngày tải lên: 03/07/2020, 01:38

... protein–protein interaction and gene expression interaction [20] We downloaded the data of protein interactions from MIPS database (http://mips.helmholtz-muenchen.de/ proj/ppi/) [21] For the interaction ... vascular invasion b Forest plot showing SMD of miR-34a expression in HCC tissues with or without cirrhosis c Forest plot showing SMD of miR-34a expression in HCC tissues with or without metastasis Integrative ... Fig Flow chart of the natural language processing (NLP) analysis of hepatocellular carcinoma Fourteen eligible datasets were involved in this study, which included datasets containing HCC tissues

Ngày tải lên: 24/07/2020, 00:03

... lumen and intracellular organelle lumen in the CC cat-egory; and DNA binding, transcription regulator activity, transcription factor binding, RNA binding and sequence-specific DNA binding in the ... ribonucleotide binding, ATP binding, purine nucleoside binding and nucleoside binding in the MF category.KEGG pathway enrichment analysisTo further analyze the enriched pathways of these tar-get ... pathways in cancer, focal adhesion, MAPK signaling pathway, neurotrophin signaling pathway and chemokine signaling pathway Interestingly, both tar-get genes of upregulated miRNAs and tartar-gets of

Ngày tải lên: 29/04/2024, 22:44

... Zhang4, Pengbo Ning5 and Qingan Jia4* Abstract Background: Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they ... play a critical role in HCC progression However, the precise role of HSCs trending, infiltration and paracrine in orchestrating the stroma- derived oxaliplatin-resistance in HCC is still vague ... RESEARCH ARTICLE Open Access Remodeling of hepatic stellate cells orchestrated the stroma- derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma Xia Liao1†, Yang Bu2†, Fan

Ngày tải lên: 17/06/2020, 19:36

... ­  The study showed that A allele, genotype containing allele A? ?of? ? TNF­α  ­308  increased the risk? ?of? ?HCC compared? ?with? ?G allele and  genotype containing allele G. Alen T, genotype containing allele T? ?of? ? TGF­β1­509 increased the risk? ?of? ?HCC compared? ?with? ?C allele and  ... MINISTRY? ?OF? ?EDUCATION  MINISTRY? ?OF? ?DEFENCE AND TRAINING VIETNAM MILITARY MEDICAL UNIVERSITY PHAN THI HIEN LUONG STUDYING POLYMORPHISM? ?OF? ?TNF­α ­308 G>A AND  TGF­β 1­509C>T? ?IN? ?HEPATOCELLULAR? ?CARCINOMA? ? ... IFN­γ, IL­1β, IL­6 and IL10 genes? ?with? ?risk? ?of? ?HCC? ?in? ?China? ?in? ?720   HCC patients and 784 healthy people, had concluded that although  not a single SNP increased the risk? ?of? ?HCC, but   combination? ?of? ?6  SNP had increased HCC risk? ?with? ?OR = 1,821; 95%CI = 1,078 ­ 

Ngày tải lên: 17/07/2020, 23:31

... Cytomation, Carpinteria, USA) was used to detect antibodies of tissues sections We graded the samples according to the staining intensity and percentage of cells stained with a score of 0–3 According to ... Down-regulation of KOR protein in HCC a Representative immunohistochemical staining of KOR protein expression in 174 HCC tissue samples (magnification ×200) Absent or weak staining was defined as negative ... patients into three groups according to the intensity of IHC staining in tumour tissues and adjacent non -tumour tissue, i.e the KOR loss group (KORT < N), KOR gain group (KORT > N), and KOR retain

Ngày tải lên: 06/08/2020, 06:48

... resection of 386 consecutive patients with hepatocellular carcinoma J Am Coll Surg 2000, 191:381–388 Lin XD, Lin LW: Local injection therapy for hepatocellular carcinoma Hepatobiliary Pancreat Dis Int ... showed that transfection of Beclin-1 into a transformed breast carcinoma cell line decreased its tumorigenic potential in nude mice [27] These findings suggested that these carcinomas might possess ... observed in Beclin-1 expression between HCC and ANT samples (χ2 = 6.085, P = 0.015) Association of Beclin-1 expression with clinicopathologic features of HCC The correlation of Beclin-1 expression with

Ngày tải lên: 05/11/2020, 00:22

... data explaining the interaction mechanism(s) are lacking Our objective is to investigate the anticancer efficacy and mechanism of combined sorafenib and 5-FU therapy in vitro in HCC cell lines MHCC97H ... associated with acquired and intrinsic resistance Sorafenib (BAY 43-9006, Nexavar) is an oral multikinase inhibitor that inhibits the serine-threonine kinases C-Raf and B-Raf, the receptor tyrosine kinase ... combined administration of the two agents Manov and colleagues [18] found that sorafenib, when combined with doxorubicin, increased survival and reduced doxorubicin-induced autophagy by inhibiting

Ngày tải lên: 05/11/2020, 05:54

... using in situ hybridization and immunostaining of TNRC6B Positive in situ hybridization staining and immunostaining were interpreted semi-quantitatively by assessing the intensity and extent of ... prognosis Table S3 Inserter sequence of the miR-18b binding sequence of the TNRC6B 3′UTR for reporter vector Abbreviations HCC: Hepatocellular carcinoma; TNRC6B: Trinucleotide repeat containing 6B; CHC: ... transfected with lipofectamine RNAiMAX (Invitrogen) ug of plasmids containing the TNRC6B (Addgene), or empty vector pcDNA3 (Invitrogen) was transfected with FuGENE (Roche) After 24 or 72 hr of transfection,

Ngày tải lên: 05/11/2020, 07:17

... study [1] with the study of Auvinen et al of leukaemia i n Finland in those drinking well water high levels of Uranium [46]. The mean level of Uranium water in the leukaemia cases in Finland was ... reported rates of congenital malforma- tions in a group of 13,191 offspring of male and 360 off- spring of female UK Gulf war veterans, finding relative risks of 1.5 (95% CI 1.3-1.7) for all CA’s. Araneta ... showed levels of infant mortality of around 80 per 1000 live births in children, which can be compared with a figure of 17 in Jordan and 9 in Kuwait. However, it seems that the findings in Fallujah

Ngày tải lên: 13/08/2014, 15:21

... domains in the pancreas The in situ hybridization staining profiles of 605 genes with informative stain in TS22 pancreas tissue were classified into the groups shown using the ... restriction of the stain- ing seen in the TS22 whole embryo sections. Genes with high S values showed staining specifically in the pancreas, genes with medium S values showed staining in the pancreas ... TS22 pancreas staining patterns of 601 genes in the GenePaint database [27,28], providing insight into the expression profiles of hundreds of transcripts previ- ously not described in the pancreas.

Ngày tải lên: 14/08/2014, 20:22

... whereas fibronectin and a 30-kDa fibronectin fragment having heparin-binding ability showed interaction with tendon decorin (Fig 4) Fibronectin is known to interact with decorin protein core [45] ... relevance of Lys/Hyl residues both in collagens and peptides for interaction with decorin is in contrast with the findings that the binding site for decorin is located in a sequence within the peptide ... helical domain) On the contrary, CB7 and CB6 lie in the C-terminal half of the chain Binding specificity is demonstrated by the following (a) The absence of interaction with decorin(s) of some peptides...

Ngày tải lên: 21/02/2014, 15:20

... differences were observed in the detected proteins Determination of partial amino acid sequences of binding proteins of dicalcin Purified binding proteins of dicalcin were digested with lysyl endopeptidase ... the interaction of frog annexin A1 and annexin A2 with dicalcin Consistently, we observed that the 35 kDa forms of annexin A1 and annexin A2 found in the fraction of the binding proteins of dicalcin ... proteins Fig Ca2+-dependent binding of recombinant annexins to dicalcin The cell lysate of E coli (lysate) expressing recombinant annexin A1, annexin A2 or annexin A5 was mixed with dicalcin-Sepharose...

Ngày tải lên: 07/03/2014, 05:20

... microscopy [15] In this study, we measured the interaction of stefin B with various combinations of phospholipid monolayers and bilayers Interaction of stefin B in the prefibrillar aggregated state with model ... membranes Fig Insertion of stefins into DOPC and DOPG monolayers (A) Kinetic traces of the insertion into DOPG lipid monolayers at initial pressure of mNÆm)1 The proteins were injected into the subphase ... FEBS Fig Insertion of stefin B in prefibrillar form into an air–water interfaceInsertion into the air–water interface was measured in 10 mM Hepes, 200 mM NaCl, pH 7.5 with constant stirring at room...

Ngày tải lên: 07/03/2014, 17:20

... immunoprecipitate, indicating that the interactions of these different proteins are likely to be indirect, depending on the presence of intact RNA as integral component of the RNP Association of 42Sp50 with ... [31–33] Together with the findings obtained in the present study, interaction of VICKZ and poly(A) binding proteins thus appears to define a conserved feature of mRNPs forming in different biological ... presence of 42Sp50 in nucleus and cytoplasm indicates that it might be a shuttling protein with a function in the nuclear export of localizing mRNAs To determine whether 42Sp50 is capable of shuttling,...

Ngày tải lên: 23/03/2014, 03:20

... Annotation of grapevine Gene Index Annotation of grapevine Gene Index (VvGI version 5) using the MapMan ontology was performed by including information on grapevine genome and plant protein domains, ... relatively weak This is in line with the hypothesis that defence compounds are induced in resistant as well in susceptible interaction, the main difference being the speed and intensity of response Also, ... expression analyses in individual grape (Vitis vinifera L.) berries during ripening initiation reveal that pigmentation intensity is a valid indicator of developmental staging within the cluster Plant...

Ngày tải lên: 12/08/2014, 03:21

... Annals of Mathematics, 168 (2008), 367–433 The distribution of integers with a divisor in a given interval By Kevin Ford Abstract We determine the order of magnitude of H(x, y, z), the number of integers ... a satisfying (i), L (a; η) consists of a disjoint union of intervals, each with length ≥ η Breaking long intervals into shorter ones, we may 1 partition L (a; η) into intervals each with length ... For fixed σ, θ(σ, t) is decreasing, ν(σ, t) is increasing and G(θ)/θ is increasing, as functions of t Thus, we have the following 389 INTEGERS WITH A DIVISOR IN AN INTERVAL Lemma 3.9 Suppose y...

Ngày tải lên: 06/03/2014, 08:21