injectable polymeric scaffolds for bone tissue engineering

... FUNCTIONAL PERFORMANCE OF EXTRUSION-BASED ADDITIVE MANUFACTURED SCAFFOLDS FOR BONE TISSUE ENGINEERING MUHAMMAD TARIK ARAFAT (B.Sc in Mechanical Engineering, BUET) A THESIS SUBMITTED FOR THE DEGREE ... suitable surface chemistry In this context high performance extrusion based additive manufactured scaffolds were developed for bone tissue engineering by improving their mechanical, biochemical ... (Empty), on host calvarial bone (Bone) , implant struts (Strut), and non-bony tissue as controls (Tissue) Additionally, push-out tests were performed on host calvarial bone as controls 134 Micro-compression...

Ngày tải lên: 10/09/2015, 15:51

... coined as bone tissue engineering A key component in tissue engineering for bone regeneration is the scaffold that serves as a 3D template for initial cell interactions and the formation of boneextracellular ... 1.1.1 Bone tissue engineering Loss of human tissues or organs is a devastating problem that can affect individuals of all ages Bone, a complex living tissue that provides internal support for all ... gradually replaced by cells to form functional tissues [Pollok, 1996] A well-designed scaffold for bone tissue engineering then plays an important role in facilitating bone healing To so effectively,...

Ngày tải lên: 09/10/2015, 11:18

... biomaterial for bone tissue engineering, intended as a single-step cell expansion and in-situ osteogenic differentiation platform to be implemented as a non-invasive, injectable bone graft substitute for ... for bone tissue engineering Key Engineering Materials 529530 2013 Conferences (Oral): 1) Feng J, Chong M, Chan J, Zhang ZY, Teoh SH, Thian ES Cell-loaded ceramic based microbeads for direct bone ... Literature Review 2.1 Bone biology In order to develop engineering considerations for the bone tissue engineered construct, it is necessary to understand the biology of bone The bone is the major...

Ngày tải lên: 22/09/2015, 15:18

... oLimitations to current bone grafts as discussed propel researchers to look into the field of bone tissue engineering for an ideal bone substitute 1.1.3 Strategies in BTE Tissue engineering is the ... treatments for bone defects For surgical procedures involving bone grafts, patients usually suffer from trauma-related injuries or bone fractures Currently, the gold standard for bone grafts ... century ago that bone has excellent regenerative capabilities Ectopic bone formation was induced using decalcified bone or injected bone extracts in one of the earliest study on bone regeneration...

Ngày tải lên: 09/10/2015, 11:18

... Scaffolds for Vascularised Bone Tissue Engineering Tissue Engineering Part (A) 2012 Oct 26 doi:10.1089/ten.TEA.2012.0187 Yuchun Liu, Jerry KY Chan, Swee-Hin Teoh Review on Vascularised Bone Tissue ... 1.4 Bone Tissue Engineering 1.4.1 Limitations in Bone Tissue Engineering 1.5 Importance of Vascularisation 1.5.1 Vascularisation in Bone Tissue Engineering ... Haematoma formation linking bone fragments • Recruitment of fibroblasts, MSC • Granulation tissue formation Soft callus formation • • • • Hard callus formation • • • Bone remodelling • • • Cartilage formation...

Ngày tải lên: 09/09/2015, 10:16

... selection for liver tissue engineering 2-11 Scaffold fabrication for liver tissue engineering 2-16 Scaffold surface modification 2-20 Tissue culture for liver tissue engineering ... failure 2-8 2.2 TISSUE ENGINEERING AND APPLICABILITY IN LIVER FAILURE 2-10 2.2.1 Overview of tissue engineering 2-10 2.2.2 Liver tissue engineering 2-11 ... CONCLUSIONS 7-1 7.2 RECOMMENDATIONS FOR FUTURE WORK 7-5 7.2.1 Liver tissue engineering 7-5 7.2.2 Bone tissue engineering 7-9 Bibliography ...

Ngày tải lên: 12/09/2015, 10:22

... neointimal hyperplasia [84, 106] 2.3 Vascular Tissue Engineering (VTE) Vascular tissue engineering (VTE) is an interdisciplinary field involving the principles of engineering and life sciences to develop ... TCP Tissue Culture Plate TEBV Tissue Engineered Blood Vessel TGF-β1 Transforming Growth Factor Beta UV Ultraviolet UV-Vis Ultraviolet-Visible vSMC Vascular Smooth Muscle Cell VTE Vascular Tissue ... RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...

Ngày tải lên: 10/09/2015, 09:08

... differentiation………………… 21 2.3.4.1 Cartilage tissue engineering using hydrogels……………………… 21 2.3.4.2 Cartilage tissue engineering using polymeric scaffolds ………… 23 2.4 Cartilage formation and regeneration using ... cartilaginous tissue constructs with no collagen I (Koay et al., 2007) 2.3.4.2 Cartilage tissue engineering using polymeric scaffolds In addition to hydrogels, porous biodegradable polymer scaffolds ... microenvironments for the culture and differentiation of ESCs in vitro In this context, natural and synthetic biomaterials in the form of hydrogels, polymeric scaffolds and sponges have been widely used for...

Ngày tải lên: 11/09/2015, 09:57

... potential donor cell for our engineered ligament Generally, bone marrow and specific organs are the optimal cell sources for tissue engineering BMSCs have been extensively studied for bone, cartilage ... vortex flow and turbulent Taylor flow for cell cultivation Such flow pattern is not suitable for suspension of the film-like polymeric scaffolds for ligament tissue reconstruction 2.2.2.3 The Flow ... to the patient at the desired site of the functioning tissue to restore lost tissue function The appropriate cell type for ligamental tissue engineering must show enhanced proliferation and production...

Ngày tải lên: 04/10/2015, 10:25

... Fib/Coll(1:4)-CL and Fib-CL scaffolds IX LIST OF ABBREVIATIONS ECM Extracellular matrix MI Myocardial Infarction LV Left Ventricle TE Tissue Engineering CTE Cardiac Tissue Engineering VEGF Vascular ... other therapies are experimented for the treatment of the infarcted myocardium, of which the tissue engineering approach is gaining much attention Cardiac tissue engineering promises to bring about ... fibrinogen in the natural composite for cardiac tissue engineering application is identified To improve the mechanical integrity of the natural polymeric scaffolds they were cross-linked and...

Ngày tải lên: 05/10/2015, 19:04

... for cardiac tissue replacement, further confirming its huge promise for cardiovascular tissue engineering application This thesis reports on a novel hybrid nanofibrous PCL membrane scaffold for ... dimensional system for tissue engineering application - 20 - Chapter 2: LITERATURE REVIEW - 21 - 2.1 Cardiovascular Tissue Engineering The limitation of existing therapies necessitates the need for alternative ... to promote in vivo tissue regeneration; and scaffold-based tissue engineering approaches, the formation of functional tissue in vitro, followed by implantation and in vivo tissue regeneration...

Ngày tải lên: 26/11/2015, 22:40

... environment optimal for the in vivo tissue engineering can be produced only with great difficulty 349 350 14 Biodegradable Polymers as Scaffolds for Tissue Engineering 14.3.3 Need for Scaffolds It should ... efforts are required to enhance the beneficial effects of growth factors on tissue engineering 14.3.2 Favorable Environments for Tissue Regeneration There are two modes of tissue engineering for ... as Scaffolds for Tissue Engineering medical revolution However, the regeneration of human tissues is currently almost impossible except for a few tissues including blood cells, epithelia, and bones...

Ngày tải lên: 25/10/2013, 08:20

... current treatment options for bone defects has digressed our attention to bone tissue engineering as a potential substitute method 1.1.2 Bone Tissue Engineering strategies Tissue engineering has been ... treatments for the repair of bone defects and their corresponding drawbacks that lead the author to pursue a bone tissue engineering strategy 1.1.1 Current treatments for bone defects Bone tissue, ... polycaprolactone scaffolds can serve as effective protein delivery systems for the repair 28 of bone tissue The merit of the work was that the PCL-based scaffolds could serve not only as a template for bone...

Ngày tải lên: 15/09/2015, 17:10

... Cells for Tissue Engineering is a new volume in the John Wiley series Culture of Specialized Cells, with focus on procedures for obtaining, manipulating, and using cell sources for tissue engineering ... effort to provide a user-friendly reference for sourcing, characterization, and use of cells for tissue engineering, for researchers with a variety of backgrounds (including basic science, engineering, ... 61 Cell Sources for Cartilage Tissue Engineering Brian Johnstone, Jung Yoo, and Matthew Stewart 83 Lipid-Mediated Gene Transfer for Cartilage Tissue Engineering Henning...

Ngày tải lên: 22/03/2014, 15:20

... and Bunge [31] for review) The core approach of tissue engineering consists of provision of an interactive environment between cells, scaffolds and bioactive molecules to promote tissue repair ... poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering Biomaterials 2004, 25:5821-5830 169 Gautier SE, Oudega M, Fragoso M, Chapon P, Plant GW, Bunge MB, Parel JM: Poly(alpha-hydroxyacids) for application ... field very slow for many years But, in the last decade, the rapid progress that has been made in the field of tissue engineering as the result of Page 10 of 16 (page number not for citation purposes)...

Ngày tải lên: 19/06/2014, 10:20

... production of scaffolds, which are used for framework and initial support for the cells to attach, proliferate and differentiate, and form an extracellular matrix, is one area of tissue engineering ... β-tricalcium phosphate scaffolds under vacuum The mechanical and biological properties of the fabricated scaffolds were evaluated and compared to the uniformly sized porous scaffolds and scaffolds that ... composition to the human bone, a high biocompatibility with the surrounding living tissue, and high osteoconduction characteristics [4] With the current tissue engineering, the scaffolds have suffered...

Ngày tải lên: 21/06/2014, 17:20

... bone defects in the rat [81] Significant bridging of the alveolar defect was seen in conjunction with new cementum formation and fibrous connective tissue attachment Interestingly, new bone formation ... Methods: a comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering Tissue Eng 2005, 11:1356-1367 Weinberg MA, Brai M: Laboratory animal models in periodontology ... 15:99-104 Jin QM, Anusaksathien O, Webb SA, Rutherford RB, Giannobile WV: Gene therapy of bone morphogenetic protein for periodontal tissue engineering J Periodontol 2003, 74:202-213 Jin QM,...

Ngày tải lên: 11/08/2014, 23:22

... 11, 20-22] For the purpose of tissue engineering ligament tissues, the goal will be to generate neotissue from autologous cells grown on biocompatible and biodegradable scaffolds Scaffolds of ... used for tendon tissue engineering [35] From a biomimetic perspective, ligament anatomy suggests fibrous structures apposite templates as an important consideration for ligament tissue engineering ... and (B,D,F,H) AL hybrid scaffolds after culturing statically for (A,B,C,D) days and (E,F,G,H) 14 days ECM deposition was initiated at day for the AL scaffolds with uniform cellular elongation...

Ngày tải lên: 10/09/2015, 15:52

... new tissue formation Therefore, the properties of such biomaterials are crucial in determining the success of many tissue engineering applications Tissue engineering scaffolds act as templates for ... produce large, vascularised tissues that can integrate with the host native tissues 2.2 Biomaterials for Tissue Engineering Biomaterials is one important component in tissue engineering and regenerative ... of tissue engineering and regenerative medicine Since the development of tissue engineering scaffolds, there is a need for these constructs to function more than just a mechanical support for...

Ngày tải lên: 11/09/2015, 09:10