in vitro drug metabolism studies during development of new drugs

... by each of the viruses included in this study These pathways are of particular interest in the context of explaining our findings with respect to PXR and RXR expression Ding and Staudinger described ... Carman CV, Springer TA: Structural basis of integrin regulation and signaling Annu Rev Immunol 2007, 25:619-647 Ding X, Staudinger JL: Induction of drug metabolism by forskolin: the role of the pregnane ... (CAR), facilitates interactions between penton base proteins and cell surface integrins promoting virus internalization [33] Engagement of integrin receptors during this process initiates several...

Ngày tải lên: 20/06/2014, 01:20

... Mozambicoffea (E Africa) Mozambicoffea (E Africa) Mozambicoffea (C Africa) Melanocoffea (W Africa) Paracoffea (India) Paracoffea (India) Development of new SSR markers In coffee, to the best of our ... CS, Singh L: Fingerprinting of Indian coffee selections and development of reference DNA polymorphism panels for creating molecular IDs for variety identification In Proceedings of 20th international ... non-targeted MNRs of minimum 12-mer length (a) Number of targeted DNRs having a minimum of repeats (b) Number of non-targeted DNRs having a minimum of repeats (c) Total number of DNRs (b+c) Number of targeted...

Ngày tải lên: 12/08/2014, 05:20

... pre-existing increased insulin resistance and dysfunction of beta cells Insulin resistance is present in the acutely ill [13,15,18,28] in different intensity, but the factors determining the extent of ... Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings Curr Opin Clin Nutr Metab Care 2002, 5:377-383 15 Marik PE, Raghavan M: Stress-hyperglycemia, insulin and immunomodulation ... associated with increased risk of developing diabetes in the five-year period after the discharge Stress and inflammation during acute illness seem to reveal an inherent disorder of glucose metabolism...

Ngày tải lên: 25/10/2012, 10:02

... components: Bac Linh Dam (North of Linh Dam), Linh Dam peninsula in the middle and Linh Dam expansion (South of Linh Dam) The success of the project has set the stage for a series of New Towns that ... Changing types of architecture through main axis (Nguyen Duy Trinh street) in Linh Dam (Mapping - Quyen Phuong, 2011) 669 Linh Dam new town - Solution for the High-density development of New settlements ... De Klerk (2007) New Towns in development policy: an introduction”, In: D.H Frieling, ed., Research on New Towns First International Seminar 2006, Almere, International New Town Institute, Almere,...

Ngày tải lên: 29/08/2013, 08:15

... vật chất, tinh thần lao động nghèo nàn Họ thường tiêu tiết kiệm cho khoản chi phí sinh hoạt thiết yếu Có 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt thiếu thốn, vệ sinh Họ thường ... 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt không đảm bảo, vệ sinh; 40,95% không sử dụng nước có không ổn định; 11,43% cho chỗ họ an ninh không đảm bảo Có thể nói, nơi nữ lao động ... theo điều kiện sống mức tối thiểu, tạm bợ khu nhà trọ rẻ tiền với điều kiện sinh hoạt an ninh không đảm bảo Đời sống tinh thần lao động hạn chế Họ thấy cô đơn, nhớ gia đình Các hoạt động giao lưu,...

Ngày tải lên: 29/08/2013, 08:15

... have a beginning and an ending, and project management has corresponding initiating and closing processes The middle, or work of the project, is managed by planning, executing, and monitoring and ... equalizing income disparity among workers SMEs are increasingly internationalizing their business activities (Beck et al., 2005) According to Ale Ebrahim, there are many accepted definitions of SMEs ... According to these definitions and the importance of SMEs in manufacturing industries in this research, the author chose these types of companies Strengths and weakness characteristics of SMEs in...

Ngày tải lên: 07/03/2014, 00:20

... Petri dish was used in the analysis to maintain independence of the data points The proportion of pollen grains germinating was angularly transformed prior to analysis None of the residuals deviated ... rehydrated pollen Increasing sucrose and PEG concentrations caused a decline in the proportion of germinating pollen grains (t -4.0 and -4.2, both P < 0.001).The non-linearities in these respectively; ... (proportion germinating, length of all pollen grains after days on elongation media and length of germinated pollen grains) were analyzed by multiple regression using the lm() function of S-Plus The...

Ngày tải lên: 08/08/2014, 14:21

... Discussion In this study, PVM was detected in several potato samples from an experimental farm in the province of Page of Figure Sensitivity of RT-PCR using primer set PVM3/PVM4 for detecting PVM in ... amplified in RT-PCR using primer set PVM1/PVM2 flanking the entire CP gene of PVM resulting in PCR amplicons of 917 bp (CP gene: 915 bases) that were then sequenced from both directions using primers ... isolates were maintained in infected potato plants that were grown under greenhouse conditions and progeny tubers were harvested and stored at 4°C Dormancy breaking was done by maintaining tubers...

Ngày tải lên: 12/08/2014, 04:21

... finished follow-up 66 died 93 discontinued follow-up started steroid treatment 193 47 IGF / IFG 33 DM 113 normoglycaemic Figure Flow diagram showing the loss of patients from initial screening ... http://ccforum.com/content/14/5/444 Page of 2207 patients admitted to medical ICU 385 with a history of DM, IFG or IGT 1822 274 died in hospital 1548 screened 443 excluded - 211 refused participation - 203 terminally ill ... terminally ill - 29 receiving corticosteroids 669 436 NORMOGLYCAEMIA HYPERGLYCAEMIA 76 excluded: - newly diagnosed DM, IGT or IFG 669 360 started follow-up 102 died 154 discontinued follow-up 15 started...

Ngày tải lên: 13/08/2014, 21:21

... Sustainable Development (SATREPS) MULTI-BENEFICIAL FOR MITIGATION OF CLIMATE CHANGE IN VIETNAM AND INDOCHINA COUNTRIES BY DEVELOPMENT OF BIOMASS ENERGY PROJECT The 1st Joint Coordinating Com m ... of oil plants i JOINT COORDINATING COMMITTEE (JCC) MEETING Hanoi, January 7, 2013 Study of Jatropha curcas micropropagation Nguyen Thi Quynh Institute of Tropical Biology, VAST Table Effect of ... ig h t and root length of Jatropha plant cultured in vitro at day 42 Table Effect of supporting material on leaf area and increase dry weight of Jatropha plant culture in vitro on day 42 Treatment...

Ngày tải lên: 18/03/2015, 13:20

Ngày tải lên: 26/03/2015, 08:58

... embryonic development and organogenesis in all metazoans In addition to the growing body of recent findings about roles of Tbx2 during cancer progression, study of the gene function during embryonic development ... incubated overnight at 68°C in a circulating water bath The following morning, the embryos were incubated in four changes of washing solution containing a decreasing percentage of formamide in ... deficiency in vitamin A which results in the inactivation of retinoic acid signalling can cause malformed pharyngeal pouches in chick (Quinlan et al., 2002) Independent from retinoic acid signalling,...

Ngày tải lên: 14/09/2015, 14:08

... intraduodenal administration of cinnarizine loaded into performed cubic phase comprising a monolaurin / lauric acid mixture, resulted in a slow release in the concentration of cinnarizine in plasma ... by drugs (Müller-Goymann, 2004) Drug Arsphenamine Disodium cromoglicinate Nafoxidin-HCl Diethylammonium flufenamate NSAID salts Fenoprofen Ketoprofen Ibuprofen Flurbiprofen Pirprofen Diclofenac ... model drugs without loss of the smectic state structure Drugs of lower melting points such as ibuprofen, etomidate and miconazole were incorporated in the dispersions at a concentration of 10...

Ngày tải lên: 09/10/2015, 11:18

... PROTEIN BINDING STUDY 5.1.1 Introduction The binding of drugs to plasma and tissue proteins is a major determinant of drug distribution throughout the body Protein binding displacement interactions ... has gained prominence as a possible mechanism of drug- drug interaction In the case of plasma protein binding, most displacement of drugs from plasma binding sites is via a direct competition of ... analysis Much of the drug interaction in vitro in the past has been interactions between drug and drug, and drug and fluid in intravenous infusions Newer work has concentrated on interactions...

Ngày tải lên: 09/10/2015, 11:24

... prevalent in Southern China, particularly in Guangdong province and in the northern parts of Africa and Inuits of Alaska[1] Till date radiotherapy remains the mainstay treatment of NPC[2] A definitive ... total dose of 70Gy[53] By stringently limiting doses to the temporal lobes, using conventional fraction size, adoption of IMRT and replanning during IMRT, occurrence of TLN can be prevented in most ... mutifactorial etiologies of TLN including dose fraction size should always be kept in mind when treating NPC patients In cases where a definite diagnosis of TLN is difficult to make according to conventional...

Ngày tải lên: 09/08/2014, 09:21

... factor; p/CIP: p300/CBP interacting protein; PRMT: Protein arginine methyltransferase; RBP-2: retinol-binding protein 2; RIZ1: retinoblastoma protein-interacting zinc-finger 1; SAS2: serum antigenic ... be achieved by inducing HIV-1 replication in latently-infected cells, while maintaining or intensifying HAART in order to prevent new spreading infection Once reactivated, latentlyinfected cells ... HS7 located in the pol gene is indicated (B) Schematic representation of the main transcription factor binding sites located in the 5'LTR and in the beginning of the leader region of HIV1 The...

Ngày tải lên: 12/08/2014, 23:22

... mutate in key residues, hindering RITA binding but not altering its physiological role; d) as pointed by Van Regenmortel, the binding site should not be visualized without considering the binding ... was employed for performing "fine docking" on the most populated binding site found during the "blind docking" stage In both cases, docking simulations were carried out using the Lamarckian Genetic ... domain-binding cleft By using the "blind docking" approach, it was found that RITA preferentially binds to the hydrophobic MDM2 p53 transactivation domain-binding cleft RITA could also bind to...

Ngày tải lên: 13/08/2014, 23:20

... attracting customers, especially in markets where income of the population is low In developing new products businesses have pricing appropriate to make products stand firmly seats on the market In ... satisfaction of customers for services provided The importance of marketing mix Markeing-Mix is a strategic combination of elements mainly Marketing of a reasonably effective to achieve high business ... wholesale intermediaries selling some or all product lines of business in the territories before An agent's production is very useful in three situations below: • A small business with some type of...

Ngày tải lên: 21/06/2015, 18:48

... Using baculoviral vectors containing eGFP at an MOI of 100 PFU, up to 80% of the cells in the infected hESC clumps were eGFP-positive at day 2, as determined using flow cytometry In a following ... effects of intravenous injection The systemic intravenous administration of NSCs is an attractive option, given that intravenous injection is a minimally invasive procedure, and the injected ... CD40L-blocking antibody LL48 abolished these antitumor effects in vitro and in vivo, indicating the dependence on CD40 in these treatments In contrast, - CD40L is ineffective in altering the growth...

Ngày tải lên: 09/09/2015, 10:06