in the initiation of breast and other human cancers
HUMAN CARBOXYLESTERASE 2 SPLICE VARIANTS: EXPRESSION, ACTIVITY, AND ROLE IN THE METABOLISM OF IRINOTECAN AND CAPECITABINE
Ngày tải lên :
24/08/2014, 12:18
... benzamidine and 10% ethylene glycol The amount of protein was quantified using the Protein the BioRad Protein Assay with bovine serum albumin used for a standard curve The purity of the protein, ... Bob and Linda Reiff and John and Cheryl Jugovic; and my cousins Erin Dunivan and Kristin and Scott Petherick Your love and support throughout my life and education has been and continues to be incredible ... further elucidate the pharmacogenomic profiles of each enzyme or drug transporter involved in the metabolism of these drugs The data should then be used together to tailor chemotherapy for the...
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the role of ikkalpha, ikkbeta and nf-kappab in the progression of breast cancer
Ngày tải lên :
22/12/2014, 21:49
... phosphorylated and processed into p52 The processing of p100 to p52 results in the loss of the ankyrin repeats in the C-terminus and allows translocation of the RelB/p52 dimers into the nucleus ... been added with the division of the luminal subtype into luminal A and B, and the inclusion of the claudin-low subtype [50-51] Both the luminal A and B subtypes show expression of ER, PgR or ER ... (OPTIMA) trial began in the UK in 2012 with the aim of testing whether standard therapy (chemotherapy and endocrine therapy for all patients) or test-directed therapy (chemotherapy given only to...
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The meaning of tingo and other extraordinary words from around the world
Ngày tải lên :
15/01/2014, 10:51
... Northern Chin of Burma, the banging on the roots of trees practised by the Melanesians, the yodelling of the Swiss, the humming of the Chekiang Chinese and the smoke signals of the American Indians ... of the right kind, as in kontal-kontil, the swinging of long earrings or the swishing of a dress as one walks’, and the wrong, as in jerangkang, ‘to fall over with your legs in the air’ Others ... corners of the world, from the Fuegian of southernmost Chile to the Inuit of northernmost Alaska, and from the Maori of the remote Cook Islands to Siberian Yakut Some of them describe, of course,...
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Tài liệu Seasonal variation in the incidence of preeclampsia and eclampsia in tropical climatic conditions ppt
Ngày tải lên :
13/02/2014, 06:20
... et al, in their study, have evaluated the link between the timing of conception with risk of preeclampsia [13] They found the highest risk of preeclampsia in conceptions occurring in the summer ... during the study period Figure barometric pressure during in study period Graph showing the variationthethe monthly average morning Graph showing the variation in the monthly average morning ... whereas there was no significant variation in the incidence of preeclampsia based on the timing of delivery In our study, we intend to establish if any such association exists in the distinct climate...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
Ngày tải lên :
14/02/2014, 19:20
... solid line), in the presence of 100 lM neurotoxin ( , dotted line), in the presence of 200 lM neurotoxin ( , dotted line) and in the presence of neurotoxin and 50 lM dopamine (h, dashed line) • 1692 ... (C), in the presence of 100 lM MPP+ (D), in the presence of 200 lM MPP+ (E), in the presence of 100 lM MPTP and 50 lM dopamine (F), in the presence of 200 lM MPTP and 50 lM dopamine (G), in the ... shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 lm dopamine on the aggregation process Dopamine delayed the lag phase of aggregation marginally...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an ... apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish It ... cis-acting sequence serves to maintain a level of AP-2a expression that limits the size of the hand plate and the associated number of digit primordia [72] AP-2 function was also analyzed in other...
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Tài liệu ISSUES IN THE INTEGRATION OF RESEARCH AND OPERATIONAL SATELLITE SYSTEMS FOR CLIMATE RESEARCH pdf
Ngày tải lên :
17/02/2014, 07:20
... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their ... services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the National ... agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities The Council...
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Tài liệu Guide to Using International Standards on Auditing in the Audits of Small- and Medium- sized Entities pptx
Ngày tải lên :
18/02/2014, 05:20
... Events 570 Going Concern 580 Management Representations 600 Using the Work of Another Auditor 610 Considering the Work of Internal Auditing 620 Using the Work of an Expert 700 The Independent ... Internet site The internal system is mainly used for email, order taking and accounting The son of one of Jawad’s friends, Remal, helped with the basic set-up of the system and installation of the programs ... USING INTERNATIONAL STANDARDS ON AUDITING IN THE AUDITS OF SMALL- AND MEDIUM-SIZED ENTITIES 1.1.6 Reporting Exhibit 1.1-7 The final phase of the audit is to assess the audit evidence obtained and...
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Tài liệu Essays in the Economics of Crime and Punishment doc
Ngày tải lên :
20/02/2014, 19:20
... of p andf On the other hand, an increase in the other component of the cost of apprehension and conviction, has no direct effect on the marginal cost of changing offenses with f and reduces the ... in the elasticity of offenses with respect to f increases the marginal revenue of changing offenses by changing f (see Figure 4a) The result is an increase in the optimal number of offenses and ... increases the marginal revenue from changing the number of offenses by changing p orf and thereby increases the optimal number of offenses, reduces the optimal value off, and increases the optimal...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
Ngày tải lên :
20/02/2014, 23:20
... Although succinylacetone and CoCl2 are known inhibitors of heme biosynthesis, these agents also elicit nonspecific and toxic effects in animals To ascertain that the effects of these agents, on the catalytic ... 0.1% Chaps and 150 mM NaCl and protease inhibitors [5 lgÆmL)1 pepstatin A, lgÆmL)1 aprotinin, and mM phenylmethanesulfonyl fluoride]) and lysed by three cycles of freezing and thawing in liquid ... assayed in membrane fragments (SMP) by the method of Smith [20], wherein the rate of oxidation of ferrocytochrome c was measured by following the decrease in absorbency of its a band at 550 nm The...
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Tài liệu Báo cáo khoa học: "Some Pragmatic Issues in the Planning of Definite and Indefinite Noun Phrases" potx
Ngày tải lên :
21/02/2014, 20:20
... degenerate case of the NSI action In the case of the NSI action, the speaker and hearer mutually know of a plan that will result in identification of the intended referent, and in the case of the S[ action, ... along the horizontal axis of Figure There are really' two kinds of definite referring actions: one is that in which the precondition is mutual knowledge of a description and the other in which there ... possible There are several ways to measure the complexity of a description, including the number of descriptors involved and the ease with which these descriptors can be incorporated into the utterance...
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INTERNET ADDRESS SPACE: ECONOMIC CONSIDERATIONS IN THE MANAGEMENT OF IPv4 AND IN THE DEPLOYMENT OF IPv6 pptx
Ngày tải lên :
06/03/2014, 21:20
... addresses in a hierarchical manner, to permit the grouping of routing information and limit the number of routing entries advertised in the Internet Aggregation is one of the main goals of Internet ... IPv6 In other words, once the cost of deploying IPv4 infrastructure – determined by the cost of obtaining the addresses themselves and the cost of designing and operating networks that use fewer ... experiences of businesses, governments and others that have implemented IPv6 A parallel priority is to increase IPv6 training and expertise, including in the area of security, since IPv6 networks introduce...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... actin is associated with rDNA genes, and microinjection of anti-actin Ig into the nuclei of HeLa cells inhibits pre-rRNA synthesis in vivo [25,34] The interaction of NM1 with actin in the initiation ... that the RPEL domain of MRTF-A binds actin more strongly than the RPEL domain of myocardin, and that the RPEL motif itself is an actin-binding element RPEL1 and RPEL2 of myocardin bind actin weakly ... and perinuclear areas of the cell via its N-terminal ABD In the absence of ligand, AR is localized predominantly in the cytoplasm, and its hinge domain and the LBD are tethered to the C-terminal...
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Making the Poor Pay for Public Goods via Microfinance Economic and Political Pitfalls in the Case of Water and Sanitation docx
Ngày tải lên :
16/03/2014, 09:20
... explaining the concept of microfinance in the context of neoliberal restructuring and the rise of the vision of fragmented entrepreneurial development Section discusses the characteristics of the ... been growing in popularity approximately since the beginning of the millennium As one recent online microfinance publication observed, The latest craze in the creative use of microfinance as ... disbursement of the 50 percent subsidy; the household must complete a certain part of the construction before one half of the subsidy is disbursed and finish the sanitary works and the roof before the other...
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Báo cáo "Developing a bilateral input-output table in the case of Thailand and Vietnam: Methodology and applications " doc
Ngày tải lên :
22/03/2014, 13:20
... products of the manufacturing industry in Thailand This will result in an increase in the output of the manufacturing industry in Thailand, which could result in an increase in demand for relevant inputs ... Only half of the 14 industries in Thailand and industries in Vietnam had values for backward linkages greater than one in 2000 In the case of forward linkages, industries in Thailand and in Vietnam ... outside the country, say, Vietnam This new demand for the output of the suppliers in Vietnam will create an increase in their output and, directly and indirectly, the output of other industries in...
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An Analysis of Business Administration Students Interest in the area of production and Operations pot
Ngày tải lên :
23/03/2014, 05:22
... Disciplines in the area of Production and operations are inserted in the dimension of professional education, along with disciplines in the areas of Marketing, Human Resources, Finance and others In ... consistent interest in pursuing a career in the area, while the interested ones, despite pointing out high interest in the other constructs, have little interest in moving to this area in their professional ... On the other hand, the analysis of means indicate that student security in the command of management requirements of the area did not reach high levels in any of the groups For the group of the...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... the amount of the interacting proteins but also on the affinities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in ... Conclusions HIP-1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor of HIPPI, and the wild-type N-terminal Htt, which interacts ... [29] The ANTH ⁄ ENTH domain of HIP-1 interacts with 3-phosphate containing inositol lipids and stabilizes the growth factor receptor tyrosine kinases by increasing their half-life following ligand...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
Ngày tải lên :
23/03/2014, 13:20
... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus of ... promoter reporter These two motifs (DR1 and IR1) contain identical half sites and the same intervening single base, the difference being the orientation of the second half site as in the same direction ... both the dEcR and USP in nuclear extracts are in the complex that binds to the DR1 motif in EMSA, and this overexpression of EcR increases the activation of DR1JHECore by 20OHE We infer from these...
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THE MYTH OF HIAWATHA, AND OTHER ORAL LEGENDS, MYTHOLOGIC AND ALLEGORIC, OF THE NORTH AMERICAN INDIANS pot
Ngày tải lên :
29/03/2014, 11:20
... by the ancestors of the present race of Indians in the East, they have been obliterated, in the course of their long, dark, and hopeless pilgrimage in the forests of America The prevalence of ... said they "By and by, when we get into the lodge, it shall be done." In they all dove into the lake; and, in passing large heaps of limbs and logs at the bottom, he asked the use of them; they ... Puck Wudj Ininees; or, the Vanishing Little Men90 Pezhiu and Wabose; or, the Lynx and Hare95 Peboan and Seegwun An Allegory of Winter and Spring96 Mon-daw-min; or, the Origin of Indian Corn99...
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Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
Ngày tải lên :
29/03/2014, 21:20
... neurons in the brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the ... SP9155) Decrease in vasopressin release Increase in the release of ACTH, oxytocin, vasopressin and prolactin Increase in the release of ACTH, oxytocin and prolactin ? ? No effects Increase [52,53] ... hypothalamus The administration of RFRP increases Fos expression in the hypothalamic paraventricular nucleus and in hypothalamic oxytocin neurons, and facilitates the release of ACTH and oxytocin into the...
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