i m looking right at the other half of me
Tài liệu New York Times - Looking Back At The Crash Of 1929Pdf doc
... Fear Waningbanking institutions in reducing margin requirements upon security loans. This move was announced at midday at the time of the first meeting of the banking group. According to the announcement ... announcement the institutions participating in the group, together with other leading banks of the city, had agreed upon a reduction of margin requirements to 25 per cent of the market price of the ... hold their commitments without being forced to put up more margin. In addition to the large offers of funds which the banking group has received from other banking institutions, offers of money...
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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
... between the smooth muscle cells in the tu-nica media of iliac arte-ries from the normal group. Panel B: Cx40 staining was distributed in both the tunica me- dia and neointima with more prominent ... angiotensin-converting enzyme inhibitors (ACEI) can inhibit the Ang II induced proliferation and migration of smooth muscle cells (5). However, little is known about the relationship between the up-regulation ... identified in the VSMCs (2). A variety of in vitro and in vivo experiments have proved that GJ may be involved in the injury or dis-ease induced activation of vessel wall cells. It is indi-cated...
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LECTURE SLIDES ON NONLINEAR PROGRAMMING BASED ON LECTURES GIVEN AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS DIMITRI P. BERTSEKAS
... primal-dual methods LOCAL AND GLOBAL MINIMAf(x)xStrict LocalMinimumLocal Minima Strict GlobalMinimumUnconstrained local and global minima in one dimension. LEAST-SQUARES PROBLEMSminimize ... Characterization of minima Necessary conditions Sufcient conditions Lagrange multiplier theory Sensitivity Dualityã Computation by iterative algorithms Iterative descent− Approximation methods− ... while maintaining the fast convergence rate CHOICES OF STEPSIZE I ã Minimization Rule: kis such thatf(xk+ kdk) = min0f(xk+ dk).ã Limited Minimization Rule: Min over [0,s]ã Armijo...
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Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... involved in binding thiamindiphosphate (ThDP) in all ThDP-dependent enzymes. The role of individual residues in this set of conserved aminoacids in the E1a chain was investigated by means of ... aliphatic residue) at the N-terminal end,and -DP- (or -DHP-) at the C-terminal end (Fig. 2).Choice of mutations The importance of the loop region in the a-subunit of the B. stearothermophilus ... domain for the E. coli PDH complex is estimatedto have a dissociation constant in the millimolar range orhigher despite the fact that the K m is c. 20 l M [37,38].Another difference in the...
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Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc
... child that a mathematicianis someone who does “scientific arithmetic”. Others think that a mathemati-cian is someone who spends all day hacking away at a computer.Neither of these contentions ... acquaint the reader with the culture of mathematics: who mathematicians are, what they care about, andwhat they do. We also give indications of why mathematics is important, andwhy it is having ... theorem). Euclid’s formalism, andhis methodology, has become the model—even to the present day—for es-tablishing mathematical facts.What is interesting is that a mathematical statement of fact is...
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Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc
... Michaelis–Menten equations. The reaction rates were measured from the linear part of the initial time-course.GST–hGK fluorescence measurementsITF measurements were performed on a Perkin-Elmer ... of the missing residues was followed byenergy minimization and 3-ns MD simulation (allowingonly the inserted residues to move). The first 2 ns of simu-lation were performed in an implicit water ... reduce the binding affinity of MgATP2)[11,12], which is compatible with a direct interaction of these residues with the nucleotide at the active site. The catalytic mechanism of GK has been the...
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RESULTS BRIEFING SESSION: THE FIRST-HALF OF THE FISCAL YEAR ENDING MARCH 31,2009 pptx
... changes. The forward -looking statements regarding earnings contained in these materials were valid at the time these materials were drafted. SQUARE ENIX GROUP assumes no obligation to update or revise ... GROUP. These statements are based on management's assumptions and beliefs in light of information available to it at the time these material were drafted and, therefore, the reader should ... place undue reliance on them. ,, pAlso, the reader should not assume that statements made in this document will remain accurate or operative at a later time. A number of factors could cause...
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Báo cáo khoa học: Specific cleavage of the DNase-I binding loop dramatically decreases the thermal stability of actin pot
... light-scatteringmeasurements showed complete polymerization of all the Mg-G-actin species to Mg-F-actin after 1.5 h of incubation with 100 mm KCl and 1 mm MgCl2in the presence of 1 mm ATP (Fig. ... subtilisin-cleaved Mg-G-actins(3 mgặmL)1) were polymerized by the addition of 100 mmKCl and 1 mm MgCl2in the presence of 1 mm ATP. Poly-merization was monitored by an increase in intensity ... the low thermal stability of F-actin assembled from ECP-cleaved monomersstrongly correlates with the high dynamics of this actinspecies [17], supporting the idea of the monomer disso-ciation...
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Báo cáo khoa học: Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme pot
... study, the first evidence for the involvement of some amino acidresidues in the catalytic activity of this enzymehas been obtained by site-directed mutagenesis afterin silico docking. Two histidine ... residue could affect the FAD environment, modulating the catalyticrate of the enzyme. Finaly, L315 affects the enzyme kcat, although it is notlocated in the near vicinity of the cofactor. The ... activity was measured spectrophotometrically bymonitoring the oxidation of veratryl alcohol to veratralde-hyde [9]. The reaction mixture contained 8 mm veratrylalcohol in air-saturated 100 mm...
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Trends in the European Investment Fund Industry in the Second Quarter of 2011 and Results for the First Half of 2011 potx
... Long-term UCITS attracted EUR 87 billion during the first half of the year, down from net inflows of EUR 142 billion for the same period in 2010. This reduction reflects the change in investor ... DDoo m m i icc i ill i iaatt i ioonn The combined assets of the investment fund market in Europe, i. e. the market for UCITS and non-UCITS, edged slightly lower in the second quarter of 2011 ... 7,65912,5359,65616,42123,12843,028-30,102-39,0737,80714,64418,14947,555(1) In EUR millions for EFAMA members for which data are available; (2) including funds of funds, except for France, Germany and Italy for which the funds of funds data areincluded in the other...
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Trends in the European Investment Fund Industry in the Second Quarter of 2012 and Results for the First Half of 2012 pdf
... countries recorded net inflows into UCITS during the first half of 2012, with five countries attracting net inflows in excess of EUR 5 billion: Ireland (EUR 44 billion), Luxembourg (EUR 31 billion), ... -27,957-19,25541,83791,346-7,283326-1,07420,7831,7415,0697,26398,742(1) In EUR millions for EFAMA members for which data are available; (2) including funds of funds, except for France, Germany and Italy for which the funds of funds data areincluded in the other ... DDoo m m i icc i ill i iaatt i ioonn The combined assets of the investment fund market in Europe, i. e. the market for UCITS and non-UCITS, increased by 0.9 percent in the second quarter of...
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Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot
... andthawed in boiling water to minimize postincubation signal-ling modifications in the cells and protein modificationsduring immunoprecipitation [22]. Equal amounts of cells (i. e. total cell volume), ... for genomic control via amitogenic signalling pathway. This may also be medi-ated by IRS; insulin activation of the G-protein Rasleads to phosphorylation and activation of mitogen-activated ... and the different signal mediators of the hormone were performed on the same cell sam-ple from the same individual. Responses for the differ-ent signal mediators are therefore directly comparable.The...
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Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
... and initial velocities were calculated, taking intoaccount both the consumption of the substrate and the lib-eration of the arylamine with the time. The kinetic experi-ments with each substrate ... feature of the PGA catalytic reaction. It is probably a cumulativeresult of intrinsic amino acid interactions in the activesite of the E. coli enzyme that differentially (de)stabi-lize the ... AA& Berezin IV (1977) Phenylmethanesulfonylfluorideinactivation of soluble and immobilized penicillinamidase from E. coli. Kinetic analysis and titration of active site. Bioorg Khim 3, 547–553.25...
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Báo cáo khoa học: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane ppt
... be inde-pendent of CRB1 and did not affect the association of CRB1 with MPP5. In addition, MPP3–MPP5 interac-tion requires the GuK domain of MPP3, indicating amechanism for binding similar ... CRB1 interact physic-ally. The PDZ domain of MPP5 binds the C-terminalERLI motif of CRB1 [23]. The GuK domain of MPP4, another MPP subfamilymember, binds the SH3 ⁄ HOOK domain of MPP5 in293 ... intermolecularbinding. This mediator might be missing in the retinaor is competed out by another protein that does notfacilitate the binding of Mpp3 and Mpp4. Alternat-ively, Mpp3 and Mpp4 are transported...
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