hypothesis of an infectious etiology in bipolar disorder

... cerns, including improving inter-episode functioning and perceived quality of life Our review found that there is growing interest in characterizing QoL in bipolar disorder populations, and determining ... number of manic and depressive episodes on SF20 and GAF scores in euthymic patients (N = 64), finding that number of past episodes of depression was a stronger determinant of HRQOL than number of ... making it challenging to measure reliably and accurately Yet, there is a growing body of evidence to suggest that QoL is an important indicator of well-being, and one that we should be attempting...

Ngày tải lên: 20/06/2014, 15:20

... effects of mood states on executive functioning and rumination in bipolar disorder Neural correlates of bipolar disorder and rumination Research into neural correlates of bipolar disorder has increased ... present in patients with bipolar disorder in euthymic states is exacerbated in mania and depression In fact, in studies using tests of executive functioning, including attentional setshifting [65, ... [65, 66], planning ability [67] and decision making [66, 67], researchers consistently find deficits in executive functioning in mania And the finding by MartinezAran et al [63] of executive...

Ngày tải lên: 21/06/2014, 19:20

... examination including weight and blood pressure, biochemical screening including full blood count, urea and electrolytes, and measurement of liver and renal functioning Patients who had any another ... http://www.annals-general-psychiatry.com/content/4/1/14 determined regions of interested were examined Region of interest (ROI) images were constructed using automated anatomical labeling software [17] running with MRIcro software [18] In the present ... signal intensity change) is expressed in percentage of whole brain mean Because the global brain mean in the voxel-wise analysis was scaled to 100, this signal change represents the percentage of...

Ngày tải lên: 08/08/2014, 21:20

... olanzapine-fluoxetine combination are approved for the treatment of acute bipolar depression, and olanzapine, quetiapine and aripiprazole are approved for maintenance phase treatment http://www.annals-general-psychiatry.com/content/8/1/27 ... clinician should have in mind, such as that the maintenance effect is proven only in patients with an index manic episode that responded to aripiprazole during the acute phase Higher and ever-increasing ... restrictions of RCTs, as well as the gaps in our current knowledge and understanding and treating of bipolar illness The first point is that although acute mania is generally considered one of the...

Ngày tải lên: 08/08/2014, 23:21

... concerning bipolar depression or the maintenance phase The use and usefulness of antidepressants in bipolar disorder is controversial because of the risk of inducing Fountoulakis et al Annals of ... mania and antipsychotics (FGAs and SGAs against acute mania and SGAs in maintenance protecting from mania) Four effect cases are not adequately studied (FGAs against acute bipolar depression and ... Tollefson GD, Thase ME, Briggs SD, Van Campen LE, Case M, Tohen M: Onset of antidepressant effect of olanzapine and olanzapine/ fluoxetine combination in bipolar depression Bipolar Disord 2007, 9:618-627...

Ngày tải lên: 09/08/2014, 01:21

... 10 min, sections were incubated in secondary antibody, a solution of goat biotinylated anti-rabbit IgG in 1% NGST (1:200, Vector, BA-1000) for h After again rinsing in 0.1 M PBS for 10 min, sections ... frontal and insular cortex but higher in the orbitofrontal cortex [37] When the effect of [D-Pen2, D-Pen5] enkephalin in spinal Page 12 of 14 and supraspinal analgesia was tested, μ- and δ-opioid ... as anxiety and depressive responses In summary, the oversensitivity hypothesis of enkephalin deficit-induced PTSD provides a launching point for investigating the pathological mechanisms of PTSD...

Ngày tải lên: 10/08/2014, 05:21

... ill, and in need of treatment considered to be effective in treatment resistant depression ECT and the combination of antidepressant (including irreversible MAOI), atypical antipsychotics and ... use in assessing global illness severity and change in patients with BD The revised scale and manual provide a focused set of instructions to facilitate the reliability of these ratings of mania, ... symptoms of melancholia and atypical depression and has scaling items allowing for detection of milder levels of symptoms It has a more balanced weighting of items than the Hamilton Depression Rating...

Ngày tải lên: 11/08/2014, 16:22

... significantly lower risk of hospitalization than ziprasidone, olanzapine and quetiapine, and not significantly different than risperidone Table summarizes the results of these models, in which pre-index ... Observational studies can provide important insights into the outcomes of clinical practice in real-world settings, where dosing, titration and concomitant medications are not constrained by trial protocols ... than ziprasidone, olanzapine and quetiapine, and lower mental health costs than ziprasidone and quetiapine in the year following initial prescription Total healthcare costs of patients treated...

Ngày tải lên: 11/08/2014, 16:22

... the time of the interview was identified as an "informant" At each interview where an informant was present, assessment of the informant of the health status of the elderly person was obtained Results ... (83.5%) of the total group, others not being able to so, due to injury or an illness Best performance was in "standing from chair without using arms" (84%), semi tandem stand was completed by 78% and ... significantly associated with increased ability to complete the physical performance tests and in carrying out ADL (Table 6) Informants were present in 1167 (97%) of the interviews Comparison of the...

Ngày tải lên: 14/02/2014, 06:20

... beads and incubated with total HeLa nuclear extract Coomassie staining of the SDS–PAGE gel showed a very prominent change in the binding profile of protein bands migra6102 ting in the 60 kDa range ... 1C) In particular, the intensity of these bands was greatly increased in the del_a mutant but absent in del_c Direct sequencing of these bands using MS identified them as polypyrimidine tract binding ... PTB binding was increased for the del_a mutant, suggesting that its binding might be responsible for the increased exon skipping in the del_a mutant In contrast, PTB showed reduced binding to...

Ngày tải lên: 16/03/2014, 04:20

... barrier in intestinal disease Lab Invest 84, 282–291 12 Tran QK, Watanabe H, Zhang XX, Takahashi R & Ohno R (1999) Involvement of myosin light-chain kinase in chloride-sensitive Ca2+ in ux in porcine ... domain in myosin light chain kinase A Fig Prediction for a conserved aggregation domain in the 4Ig region of L-MLCK and recombinant expression of MLCK variants (A) The sequences of the N-terminal ... in intracellular cytoskeletal proteins, including titin, MyBP-Cm, MyBP-M, MyBPH, myotilin, and palladin [30–35] As Ig-C2 domains may serve as molecular spacers and bind to a diversity of ligands,...

Ngày tải lên: 30/03/2014, 04:20

... Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination ... participated in the study design and data analyses All authors read and approved the final manuscript Acknowledgements We thank Drs Bing Sun and Qi Jin for providing the CVA16 virus We also thank Dr Andy ... development and testing of candidate live attenuated vaccines and antiviral therapeutics against CVA16 Methods Cells and viruses RD and Vero cells were grown in DMEM (Gibco, Grand Island, NY, USA)...

Ngày tải lên: 18/06/2014, 18:20

... Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination ... participated in the study design and data analyses All authors read and approved the final manuscript Acknowledgements We thank Drs Bing Sun and Qi Jin for providing the CVA16 virus We also thank Dr Andy ... development and testing of candidate live attenuated vaccines and antiviral therapeutics against CVA16 Methods Cells and viruses RD and Vero cells were grown in DMEM (Gibco, Grand Island, NY, USA)...

Ngày tải lên: 20/06/2014, 01:20

... acquisition of data, analysis and interpretation of data, drafting the manuscript and revising it critically, and guiding the experiment; BP and JYH contributed in acquisition of data, revising the manuscript ... determined by local transplantable factors that are expressed prior to transplantation by interactions between the inducing factors and inherited genomes We can explain the increase in length of ... critically, and giving the final approval; SWS contributed in conception and design of data, drafting the manuscript, and giving the final approval; JHY, YHP, JML and YHK have contributed in analysis of...

Ngày tải lên: 20/06/2014, 07:20

... Springer, Berlin, Germany, 1999 Fixed Point Theory and Applications 11 M A Khamsi and W A Kirk, An Introduction to Metric Spaces and Fixed Point Theory, Pure and Applied Mathematics, Wiley-Interscience, ... Khan, A.-A Domlo, and H Fukhar-ud-din, “Common fixed points Noor iteration for a finite family of asymptotically quasi-nonexpansive mappings in Banach spaces,” Journal of Mathematical Analysis and ... for mappings with unbounded domain in Banach spaces,” International Journal of Mathematics and Mathematical Sciences, no 10, pp 1643–1653, 2005 H Fukhar-ud-din, A R Khan, D O’Regan, and R P Agarwal,...

Ngày tải lên: 21/06/2014, 07:20

... selection of the right vaccine and improving the efficacy of vaccination 5.3 Capacity Building Training and education of field veterinarians in disease prevention, disease investigation and sample ... for the training of field veterinarians This workshop information and the lectures were used to run workshops for the field veterinarians in the South and Centre of Vietnam and this information ... Veterinary laboratories in Vietnam and the training of DAH veterinarians in disease investigation and control This will strengthen the profile of DAH which will play a vital role in making Vietnam more...

Ngày tải lên: 22/06/2014, 12:20

... provision of resources and training of staff in required methods and quality assurance To provide accurate data to explain failure of vaccination to control FMDV and to develop new effective vaccine ... strategies Completing these objectives will improve the diagnostic capability of the veterinary laboratories in Vietnam and the training of DAH veterinarians in disease investigation and control This ... sequencing techniques Training and education of field veterinarians in sample and data collection showed an impact with an increase in quality and numbers of samples collected and submitted to the laboratory...

Ngày tải lên: 22/06/2014, 12:20

... molecular and sequencing techniques Training and education of field veterinarians in sample and data collection showed an impact with an increase in quality and numbers of samples collected and submitted ... outbreak of FMD in pigs in the province in that year, which would increase willingness of farmers to present piglets for vaccination and sampling and enhanced awareness and enthusiasm on the part of ... been instrumental in supporting this and other international projects and has provided advice and training to field and provincial veterinarians They have also been crucial to investigation of...

Ngày tải lên: 22/06/2014, 12:20

... publicity in Vietnam, Australia and internationally and recognition of the achievements made in relation to the understanding and control of FMD in Vietnam FMD is a disease of importance in Vietnam and ... the course of this project Nevertheless, it was clearly evident that continued training and support of field veterinarians and the greater integration and coordination of “lab-to-field” and “field-to-lab” ... development and quality assurance in the laboratory was the driving force behind more effective training and education of field veterinarians realised project objectives and resulted in effective FMD management...

Ngày tải lên: 22/06/2014, 12:20

... Determine the efficacy of the FMD vaccine in protecting against FMD isolates circulating in Vietnam Comparison of FMD genotypes to vaccine Results of sero-surveillance Hold information and training ... emphasizing the importance of Quality Assurance in the laboratory focusing on test maintenance, record keeping and data collection • A consultant from AAHL completed training of HCMC-RAHC staff in ... supplying training for AI Training in data analysis by DAH staff is also an area that needs further input 10 7.2 Options The government of Vietnam is looking at increasing the support to DAH and...

Ngày tải lên: 22/06/2014, 12:20