gr mediated corticotropin releasing hormone gene expression
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... (1992) Corticotropin- releasing hormone in humans Endocr Rev 13, 164–191 De Souza, E.B., Insel, T.R., Perrin, M.H., Rivier, J., Vale, W.W & Kuhar, M.J (1985) Differential regulation of corticotropinreleasing ... pharmacology of corticotropin- releasing factor Pharmacol Rev 43, 425– 473 13 Gilligan, P.J., Robertson, D.W & Zaczek, R (2000) Corticotropin releasing factor (CRF) receptor modulators: progress and ... and human Corticotropin releasing hormone Int J Peptide Protein Res 47, 383–393 Pallai, P.V., Mabilia, M., Goodman, M., Vale, W & Rivier, J (1983) Structural homology of corticotropin- releasing...
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báo cáo hóa học:" Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter" pptx
... analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over -expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter ... following groupings: mock vs VP16 transfected cells (group NA); mock vs Mad transfected cells (group NR); and Mad vs VP16 transfected cells (group RA) The cumulative listings of genes for these groups ... lists genes common to all groups Sheet lists 22 common genes Sheet lists 29 common genes Sheet lists 21 common genes Sheet lists 155 genes unique to KK1 & E16 Sheet lists 177 genes unique to KK1 &...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... modification/remodeling Gene activation Fig Mixed lineage leukemias (MLLs) are coregulators for nuclear receptor (NR) -mediated gene activation During hormone -mediated gene activation, NRs bind to the hormone ... histone methylation and target gene expression MLLs are critical for HOX gene regulation and embryonic development Homeobox genes are a group of evolutionarily conserved genes that encode transcription ... regulate gene expression during development There are more than 200 homeobox genes in vertebrates that are classified into two major groups, class I and II Class I homeobox-containing genes share...
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Tài liệu Báo cáo khoa học: Characterization and functional expression of cDNAs encoding thyrotropin-releasing hormone receptor from Xenopus laevis Identification of a novel subtype of thyrotropin-releasing hormone receptor ppt
... acromegaly express thyrotropin -releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin -releasing hormone receptor gene Biochem Biophys Res Commun ... human prepro thyrotropin -releasing hormone Mol Endocrinol 4, 551–556 17 Lee, S.L., Stewart, K & Goodman, R.H (1988) Structure of the gene encoding rat thyrotropin releasing hormone J Biol Chem 263, ... injection of thyrotropin -releasing hormone Gen Comp Endocrinol 60, 86–89 ´ Tonon, M.C., Leroux, P., Leboulenger, F., Delarue, C., Jegou, S & Vaudry, H (1980) Thyrotropin -releasing hormone stimulates...
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Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot
... be mediated by an immediate early gene, early growth response (Egr-1) [114] The importance of Egr-1 to reproduction and GnRH expression was shown by the use of Egr-1 knockout mice as well as Egr-1 ... (1999) Negative regulation of gonadotropinreleasing hormone and gonadotropin -releasing hormone receptor gene expression by a gonadotrophinreleasing hormone agonist in the rat hypothalamus J Neuroendocrinol ... 5¢-monophosphate -mediated repression of mediated repression of gonadotropin -releasing hormone gene expression Mol Endocrinol 14, 212–228 Nelson SB, Lawson MA, Kelley CG & Mellon PL (2000) Neuron-specific expression...
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Báo cáo khoa học: A (1fi3)-b-D-glucan recognition protein from the sponge Suberites domuncula Mediated activation of fibrinogen-like protein and epidermal growth factor gene expression pot
... increase in the expression of SDFIBI occurs Likewise, a strong expression pattern was determined for the SDEGFI-PREC gene (Fig 6) The level of expression of the housekeeping gene, tubulin, was ... curdlan Fig Steady-state expression of the SDGLUBP gene [(1fi3)-b-Dglucan-binding protein], the SDFIBI gene (fibrinogen-like protein) and the SDEGFI-PREC gene (epidermal growth factor EGF precursor) ... growth factor: expression and site-directed mutagenesis of epidermal growth factor gene Biochemistry 27, 7289–7295 52 Engler, D.A., Montelione, G.T & Niyogi, S.K (1990) Human epidermal growth factor...
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Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc
... COUP-TF I and II genes Genomics 29, 240±246 Maroulakou, I.G., Papas, T.S & Green, J.E (1994) Dierential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis Oncogene 9, 1551±1565 ... galactose promotor dependent gene expression in yeast Oncogene 6, 357±360 12 Wasylyk, B., Wasylyk, C., Flores, P., Begue, A., Leprince, D & Stehelin, D (1990) The c-ets proto-oncogenes encode transcription ... the expression levels of COUP-TFI are high at this stage of development [1] The expression patterns of COUPTFI, Ets-1, Ets-2, ETV1 and PEA3 were studied (Table 1) There were several areas of coexpression...
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Báo cáo khoa học: Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR, HR3, E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera ppt
... seeded at 1.5 · 106 per flask and cultured under normal growth conditions for 36 h Cells were then grown for 36 h in Grace’s medium containing no hormone or only 20E at 10)7 M or in combination with ... Cherbas, P & Cherbas, L (1996) Molecular aspects of ecdysteroid hormone action In Metamorphosis: Postembryonic Reprogramming of Gene Expression in Amphibian and Insect Cells (Gilbert, L.I., Tata, ... finger Genetics 129, 385–397 21 Hiruma, K., Shinoda, T., Malone, F & Riddiforf, L.M (1999) Juvenile hormone modulates 20-hydroxyecdysone-inducible ecdysone receptor and ultraspiracle gene expression...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... enhancing PTTH gene expression Results Expression of the PTTH reporter gene is regulated by two cis-elements To determine the cis-elements participating in the regulation of PTTH gene expression, ... each hemisphere [14] Regulation of PTTH gene expression by controlling BmMEF2 expression To investigate whether the expression of BmMEF2 affects PTTH gene expression, we constructed two recombinant ... promoter enhance expression of the EGFP reporter gene in PTPCs and are important for binding of the BmMEF2 protein Furthermore, overexpression of the BmMEF2 gene can induce PTTH gene expression Thus,...
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Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance docx
... Figure Concordance of gene expression determined by microarrays and RT-PCR Concordance of gene expression determined by microarrays and RT-PCR Expression ratios of representative genes in (a) cerebellum ... expressed genes identifies gene clusters with biological associations Gene- expression patterns are shown in rows; tissue profiles in columns Degree of color saturation reflects the magnitude of the expression ... 5, Article R31 Miller et al Background Thyroid hormone (T3) regulates growth, development and differentiation These actions are mediated by high-affinity thyroid hormone receptors (TRs) that bind...
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Báo cáo y học: "RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals" docx
... of a relatively low abundance gene product, TATA binding protein (TBP) The S-AS mRNA expression levels were 5% to 13% of that of β2M, as expected for genes with low expression, and TBP levels were ... this phenomenon is a translation block or other kind of RNA mediated regulation of gene expression, without alteration of mRNA levels Expression assessment and evaluation of mRNA levels would be ... investigation, Jen et al [28] pursued a meta-analysis of NAT expression and suggested that RNA degradation by dsRNA formation is not a predominant route of gene regulation in Arabidopsis thaliana Additionally,...
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Báo cáo sinh học: "The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression" docx
... RB15-Treated Figure The effect of rAAV2-TTR-RB15 -mediated gene expression in LDLR-/-Apobec1-/- mice The effect of rAAV2-TTR-RB15 -mediated gene expression in LDLR-/-Apobec1-/- mice (A) The DNAs ... enzyme (Apobec1-/-) genes [7-9], to evaluate the duration of gene expression by the AAV2 vector and the effect of apoB mRNA-specific hammerhead ribozymes on apoB mRNA gene expression An improved ... is essential to explore other gene delivery vectors for prolonged gene expression We sought to use adeno-associated viruses (AAV) for the longevity of transgene expression [4] Furthermore, the...
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Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death
... Regulation of NHE-1 gene expression regulates cells’ response 106 to death triggers IV.7 Superoxide mediated cell survival is NHE-1-dependant 107 IV.8 NHE-1 gene expression is growth factor regulated ... were able to show that NHE1 gene is redox-responsive Changes in NHE1 gene expression were translated into NHE1 protein expression By over-expressing or silencing NHE-1 gene we show that cell response ... promoter activity 69 III.5.a Small GTPase Rac1 -mediated survival is dependent upon NHE-1 71 protein expression III.5.b Rac1 -mediated NHE-1 protein expression is a function of its 74 ability to...
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Gene expression of thyroid hormone receptors TR alpha and TR beta during early development in tilapia, oreochromis mossambicus
... addition, thyroid hormones also play important roles during embryogenesis and organogenesis (Sachs et al., 2000) Thyroid hormones exert their effect by binding to multiple thyroid hormone receptors ... Thyroid hormones have been shown to affect gene expression in metamorphosing tissues The rising concentration of endogenous thyroid hormones following embryonic development and subsequent tadpole growth ... two different genes TRα and TRβ Alternative splicing from each gene generates multiple TR isoforms, including TRα1, TRα2 and TRα3 from the TRα gene and TRβ1 and TRβ2 from the TRβ gene (Lazar,...
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Báo cáo y học: "Differential gene expression in HIV/SIV-associated and spontaneous lymphomas"
... part of the λIg gene, the mitochondrial genes of NADH dehydrogenase subunit (ND4), the interferon-inducible gene 6-16 (Inf-ind), the 16S rRNA gene (most probably the humanin gene [17]) These ... the calpain subunit gene, ND4 – the NADH dehydrogenase subunit gene, IL5 – the interleukin gene, λIg – the λ-chain of immunoglobulin gene, γIg – the γ-chain of immunoglobulin gene, IFN-ind – the ... lymphomas In this group of upregulated genes there were the a-myb oncogene, the interleukin receptor gene (IL4R), the gene of the transporter protein TAP2, the gene of protease calpain small subunit...
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Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"
... software (BD) Results Gene expression changes were identified by comparing gene expression profiles across the indicated age groups to the gene expression profiles of the month age group (Figure 1) ... 100 changed genes Red represents up-regulation of gene expression, and green represents down regulation of gene expression http://www.medsci.org Int J Med Sci 2009, 56 Table Top genes that increased ... for the genes with the greatest differences in expression levels when comparing the oldest age group, 24 months, to the youngest, month As can be seen, most of the genes which increased expression...
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Báo cáo y học: "Transporter Molecules influence the Gene Expression in HeLa Cells"
... effect on gene expression and affected the expression of 19 genes, the HIV-1 Tat peptide the expression of 18 genes and the two Yersina-derived delivery systems TP6287 genes and TP6288 genes respectively ... differential gene expression Genes detected and in following investigated for validation A) an induced expression of the PKN1 gene B) a repressed expression of the ZCD1 gene C) a repressed expression ... gene expression patterns, when analyzing the efficacy and the genetic consequences of targeted gene therapy in vitro (and in vivo) Microarray Study Differential Gene Expression Differential gene...
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Analysis of gene expression
... indirect detection of gene expression expression standard RT-PCR was performed showing specific amplification of the TNF gene For in situ RT-PCR the transduced cell line was grown, fixed and DNAse ... possible to interrogate the gene expression patterns in particular cells To investigate which genes are expressed in particular cell types, or which genes are altered in their expression in response ... cells: reverse genetics coming of age Oncogene 23: 8401–8409 19 Waterhouse PM, Graham MW, Wang MB (1998) Virus resistance and gene silencing in plants can be induced by simultaneous expression of...
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Tài liệu Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR pptx
... compared gene expression in 42 AD and 18 SQ clinical tumor samples and systematically analyzed their expression patterns using gene ontology This group identified 14 tight junction genes and ... interaction Figure Gene networks and pathways of 11 genes from PCA analysis The network was analyzed using Ingenuity Pathways Analysis software and is displayed graphically as nodes (genes /gene products) ... low-expressing genes, we calculated the expression ratio of each gene in each cancer cell line relative to the normal cell line From this, we identified 18 differentially expressed candidate genes based...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... its role on the expression of reporter gene bearing an ARE in its 3¢ UTR We showed that overexpression of ASF ⁄ SF2 specifically down-regulated the expression of an ARE reporter gene Moreover, ... SF2-CP expression were tested for statistical significance compared to the ratio obtained upon CP expression using a two-tailed Student’s test Dark grey bars, 0MS2; light grey bars, 8MS2 (B) Expression ... might modulate the expression of ARE-containing genes Accordingly, we tested the effect of overexpressing ASF ⁄ SF2 on the expression of Renilla luciferase (Rluc) reporter genes carrying (or...
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