... in the expression ofthe oncogene protein but in the alteration in the DNA by the oncogene In the case of Bcr-Abl, it is the observed 9–22 chromosome translocation that affects the behavior of ... respectively The theoretical values are within the range ofthe experimental data We have used entropy as a measure of change for transformation; not only because entropy is a linear function and often ... When the oncogene inhibitor is applied to the transformed cell, T, the cell maintains constant phenotypic entropy and therefore does not return to its normal state As a result ofthe loss of the...
... in the context of drug resistance in cancer cells, but the high-throughput technologies now available could provide the means for a definitive experiment Although the development of targeted therapies ... pathway Like nutlin (a cis-imidazole), these drugs sensitize the tumors to the effects of other therapies in combination, while reducing side effects on normal cells The screen, encompassing 34,000 ... treating the cells withthe drug and identifying the genetic alterations in resistant clones Fascinatingly, the resistance was found to be mediated by deletions within BRCA2 that removed the original...
... morbidity than thepatient herself, and the QoL ofthe partner is sometimes worse than that ofthepatient [85] Nevertheless, the process of response shift has also been found in the partners ... associated with not meeting the guidelines for fruit and vegetable consumption, with smoking and with overweight or obesity [77] As many as 20% of cancer survivors deny or have ‘forgotten’ their former ... ethnicity Research should also compare patient results with those of women ofthe same age from the general population, as many ofthe survivors’ symptoms are those of menopause and aging It is important...
... Survey of health facilities and programs The heads ofthe facilities providing ART services in the four countries were the key informants at the program level The survey looked at the types of HIV/AIDS ... Network for Rational Use of Drugs in Kenya and Tanzania for helping in the preparation ofthe assessment in their respective countries We also appreciate the support ofthe AIDS control programs of ... services provided, the existence of guidelines for management of ARVs and related commodities, the qualification of healthcare workers managing the supply of pharmaceuticals, existence of any ongoing...
... number of symbols without the formation ofthe candidate phrase and r j is the frequency ofthe jth symbol in the candidate phrase Model costs require a method for not only spelling out the candidate ... after substitution, li is the length ofthe code phrase, L is the length ofthe model, and Ri is the frequency ofthe code phrase in the string An improved version of this heuristic, SCR 2006, ... provide the metrics shown in Figure The numbers across the top indicate the frequency of each symbol, while the numbers along the left indicate the frequency of phrases Here we see that the initial...
... meet the demand for effective, affordable breast cancer carefor patients who would otherwise be left without scientifically valid treatment options Methods This communication reviews examples of ... an example ofthe possibilities for inter- Page of (page number not for citation purposes) World Journal of Surgical Oncology 2009, 7:44 rupting the continuity of a treatment course without compromising ... example of new applications for relatively old and less expensive drug is the use of Cisplatin in triple negative breast cancer patients [11] Generic equivalents for off-patent drugs offer the possibility...
... of patients responded to chemotherapy with an improvement in neurological deficits [3] Often these syndromes present a problem as there is no apparent tumour and therefore unknown receptors For ... malignancy [4] The severity of this patient' s symptoms and the level of her serum CK appeared to correlate with her tumour load The improvement in the biochemical markers (of the paraneoplastic ... available free of charge to the entire biomedical community Written informed consent was obtained from thepatientfor publication of this case report A copy ofthe written consent is available for review...
... need of information [16] Patients may seek information through formal or informal information sources Part ofthe information seeking behaviour used may also involve efforts to obtain information ... patients seek information when they are in need of specific information Patients are often routinely provided with large amounts of information; however, not all of this information meets their needs ... ICC of 0.44 The 95% limits of agreement varied for each item withthe mean difference being 4.42 The most variation was seen for 'getting the information you require', where the variation in the...
... management ofthepatient and interpretation of data; KES was responsible ofthe interpretation of pathology; HDS was supervisor of clinical management ofthepatient and interpretation of data ... was responsible ofthe acquisition of data, drafting the manuscrips; KHJ was responsible ofthe clinical management ofthe patient, scientific revision, discussion and editing ofthe manuscript; ... agents, a clinical trial of FOLFOX-4 therapy for urothelial cancer seems to be warranted[23] Consent Written informed consent was obtained from thepatientfor publication of this case report and...
... proliferation of specific cell types [34-37] ERK1/2 signaling is required forthe progression of cells from the G0/G1 to S phase [20,38] Activation ofthe ERK1/2 pathway is associated with induction ofthe ... mutated in ~20% of all cancers and in more than 40% of melanomas [57] The majority of these mutations are clustered in the kinase domain of B-Raf and lead to the stimulation of ERK1/2 activity ... in the Ras-dependent ERK1/2 pathway in conjunction with a promising pre-clinical profile have provided strong rationale forthe development of smallmolecule inhibitors of MEK1/2 for chemotherapeutic...
... observed Figure shows the effect ofthe concentration ofthe polymer on the flocculation of kaolin clay When the polymer concentration was changed from zero to 12.5 ppm, the extent of flocculation ... (Tris-HCl) buffer of pH 8.0 Elution was done withthe same buffer at a flow rate of ml/h and ml fractions were collected The void volume ofthe column was determined by the elution volume of Blue Dextran ... sonication forThe sludge suspension was centrifuged at 1,000 rpm for to remove the remaining floc The supernatant was further centrifuged at 8,500 rpm for 30 to collect deflocculated cells The deflocculated...
... teachers are often faced with choosing the kind of relationship they wish to establish with their students Some prefer a strict division between the student-teacher relationship while others prefer ... effective if the instructor adopts a consistent style of instruction to allow learners to adapt within the bounds of their own personalities without being coerced to behave outside their own cultural ... After 10 minutes, learners close their books and can volunteer to perform the memorized dialogue With books still closed, the teacher plays the same dialogue from the tape again allowing learners...
... From the fact that the sixth day before the calends of March (February 24) appeared twice every leap year to make up forthe extra time Patriotism is supporting your country all the time and the ... The fifteenth day of March, May, July, or October, and the thirteenth day ofthe other months in the ancient Roman calendar From Middle English, from Old French, from Latin idus ● “And on another ... adjective Of or pertaining to the end of a century, especially the nineteenth century, and its climate of sophisticated world-weariness and self-doubt From French fin de siècle, literally, the end of the...
... ● “It [the petition] demands that the traffic of cials of Grahamstown ‘return to being polite public servants, working forthe good and safety ofthe community, rather than the rude and of cious ... around the Sun in the same way as it has in the past and will bring the summer to ripen the mangoes Patterns are good, too—most ofthe time They help us find our shoes easily among an array of other ... open their doors for people to come in and save I wrote home: W Dear Mother and Father, Today is Memorial Day in the United States On this day we recognise the sacrifices of members ofthe armed forces...
... learners often learn Meaning 3: informs about hearing without the knowledge ofthe new words by compiling page upon page of vocabulary lists withthe speaker translation in their mother- tongue ... classes of words: the open classes or full word-forms outstanding individual property ofthe word.” And the lexical and the closed classes or empty word-forms And in this paper, we meaning ofthe ... Features of WIRHs in English number of transitive verbs is much more than the number of 4.2.1.1.Meaning 1: Perceiving sound withthe sense of hearing The English verbs and idioms used to express the...
... Design ofthe study My graduation paper includes three main parts: Part I, INTRODUCTION includes reason ofthe study, aims ofthe study, scope ofthe study, method ofthe study, design ofthe ... funded with ODA Loans ofthe Bank and other Japanese ODA, observe the highest standard of ethics during the procurement and execution of such contracts.” (Guidelines forthe Employment of Consultants ... produces an analogy of form in the translation by either exploiting formal possibilities of TL, or creating new forms in TL Although equivalence translation is deferent point of view of theorists, it...
... reproduces the matter without the manner, or the content with out ofthe form ofthe original The advantage of this type of translation is that the text in TL sounds more natural On the contrary, the ... is the most important part Part I is the INTRODUCTION in which reason ofthe study, aims ofthe study, scope ofthe study, method ofthe study, design ofthe study are presented Part II is the ... Therefore, systematism is seen as one ofthe most important features of terminology There is the difference in viewpoints ofthe characteristics of terminology among terminologists Some say the...
... as the reliability ofthe forecasts the weather Scope ofthe study The terms used in the weather forecast field would be a great amount of effort and time to study The writer only focuses the ... and explain what the weather is, how the weather is, and how the life will be without the knowledge about the weather We often face up withthe difficulties in the daily weather phenomenon and ... weakness ofthe thesis ……………………………… … 45 Suggestion forthe further research 46 Conclusion 46 REFERENCE PART I: INTRODUCTION Rationale ofthe study Weather is the condition of the...
... (prisoner) in the river / the lake / the sea / the at the seaside / at sea ocean at the top ofthe page / of + N 24 at the end ofthe road at the corner ofthe street in the corner ofthe room at the front ... on the left, on the right in Oxford Street/ in the street on the way (enroute) In the corner (of the room) On the corner (of two streets) In a piece of paper on page In the front/ back (of the ... in (the ocean) on (the beach) in (the desert) in (the mountains) at (the post office) on (MK Street) on / at (the corner) in (the street) on (the island) in (the west) at (the top of) on (the...