go analysis of triangles in the observed ppi subnetwork of yeast
Development of multi functionalized polymeric carriers for delivery of anticancer drug combinations
Ngày tải lên :
10/09/2015, 09:06
... unchanged recently while the incidence rates of female increase Although the incidence rates increase in general, the declining in the mortality rates are still observed In addition, the 5-year relative ... further improve the treatment efficacy The synergism in combination therapy depends on many factors such as the therapeutic mechanism of the drugs, the respond of certain cell lines to drugs, the ... concentration as increasing TAM in the combined TAM/PTX from - 33% The combined treatment effects were presented as the combination index (CI) of different combined ratios versus factional effect of the drugs...
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Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers
Ngày tải lên :
02/09/2015, 13:31
... Content The spray-drying technique PT Main advantages of the spray-drying process RI Main challenges of the spray-drying process Developments of the spray-drying technology SC 4.1 Introduction of the ... with angle of repose of 29.7 and 42.2, respectively, indicating excellent flow property in the first case and poor in the second one [26] Finally, regarding the yield of the process, at industrial ... that the diameter of the orifices of the vibrating mesh spray is smaller than the nozzles of conventional spray-dryers (500-700 m), resulting in higher processing times and preventing the use of...
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analysis and deformulation of polymeric materials paints, plastics, adhesives, and inks
Ngày tải lên :
02/04/2014, 16:27
... limitation in that the molecule of the plastic itself may be larger than the resolving power of the instrument; the aggregate of the replica can interfere, then, with the fine details of the surface of ... illustrating the scope of the instrument, the resolution obtained, and the limitations of the methods • Contrast theory The problem now is to interpret the electron images obtained by the two ... beam of electrons (Duncumb, 1969) The accelerating voltage of the electrons (typically 10–30 kV) determines the depth of penetration into the specimen The degree of beam focusing determines the...
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design, synthesis, and characterization of polymeric materials for uses in energy storage applications
Ngày tải lên :
13/11/2014, 11:13
... of the growing polymer chain Upon transfer of the active site to another polymer chain, branching sites can arise causing a change in the morphology of the final polymer On the other hand, if the ... chains to become closely packed together favoring the formation of crystalline regions A branched polymer contains branching sites along the polymer chain, which disrupts the ability of the chains ... copolymer Although, the chemical structure of the monomer units plays an integral role in determining the physical properties of the polymer, the architecture of the polymer chain can have an equeally...
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A mechanism based approach void growth and coalescence in polymeric adhesive joints
Ngày tải lên :
11/09/2015, 21:51
... various stages of loading, the value of the J-integral is calculated on a number of contours around the crack using the domain integral method (Moran and Shih, 1987) The domain integral value ... at the cracktip in a nonhardening pressure-insensitive material (α = 0) Here, the crazing zone is assumed to be in the shape of a narrow plastic strip located in the plane of the crack Thin and ... controlling the intrinsic yield point Γ fracture resistance Γss steady-state fracture toughness ν, ν s Poisson’s ratio of film/substrate η index controlling the softening-rehardening shape of the...
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Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery
Ngày tải lên :
12/09/2015, 08:20
... encapsulated in the hydrophobic center of the micelle, the dosage of the drug in these vehicles is much higher than the conventional treatment or the use of liposomes Finally, the small size of the micelles ... cause the breakdown of the liposome prior to its entry into the tumor In addition, the size of the liposome (~250 nm) could hinder extravasation into certain areas of the tumor Despite these ... Once in the cell, they can be degraded in the endosome, allowing the drug to enter the cell Finally, the liposomes can be internalized into the lipid bilayer cell membrane This would further...
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Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres
Ngày tải lên :
17/09/2015, 17:20
... measure of the flexibility of the polymer chain and may be an indication of the ease of hydrolysis of the ester bonds [Baker, 1992]; (2) DSC/DTA are useful in evaluating the form of the drug in the ... enough so that their images can fall on at least two cells of the retina Moving an object closer to the eye has the effect of increasing the size of the image on the retina, making the object ‘look’ ... four binding sites for biotin It binds to the biotin using one of these sites, and the other free binding sites are available for the attachment of biotinylated ligand motifs, which can then be...
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Design of functional polymeric micelles as a carrier for anticancer drug delivery
Ngày tải lên :
30/09/2015, 06:07
... to the drugs alone The easiest method to improve the loading levels of a drug within the carrier is by increasing the initial amount of drug to be loaded [46] Drug incorporation into the core of ... Drug loading capacity of polymeric micelles can be controlled further by modifying other parameters such as increasing the core-forming segment of the copolymers [86], increasing the number of functionalities ... determined by the molecular size of copolymers in the micellar structure, the hydrophobicity of the core-forming block of the copolymers and the relative block length in the copolymers [89] Intermolecular...
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Báo cáo y học: "Pravastatin Provides Antioxidant Activity and Protection of Erythrocytes Loaded Primaqe"
Ngày tải lên :
25/10/2012, 11:40
... of pravastatin The erythrocytes were treated with 2mM of primaquine in the third group And in the fourth group the erythrocytes were exposed to pravastatin plus primaquine 2mM After 30 min, the ... primaquine is due to interaction of ROS with NPSH oxidizing them On the contrary, statins have ability to inhibit the production of ROS as well as maintains the antioxidants activity in the cell [24] ... antioxidants enzymes to maintain and keep up the membrane integrity [34] The major alteration in the shape of erythrocytes is the spherocytes formation in the presence of primaquine These observations...
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Báo cáo khóa học: Conformational changes of b-lactoglobulin in sodium bis(2-ethylhexyl) sulfosuccinate reverse micelles A fluorescence and CD study docx
Ngày tải lên :
07/03/2014, 15:20
... dislocation of local quenchers The inset of Fig shows a decrease in the intrinsic Trp fluorescence as x0 increases The line through the data points was fitted to Eqn (1) The value of Kd ¼ 0.16 ... requiring a penetration mechanism In the case of CCl4, the indole group may be more accessible to collisions with the quencher owing to a certain unfolding of the protein Although a red shift of the ... consequence of the loss of most of the helical and sheet secondary structure This apparent bfia transition cannot be interpreted only in terms of the decrease of the dielectric constant of the surrounding...
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Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
Ngày tải lên :
08/03/2014, 23:20
... density but the position of the first atom of the cis C9–C10 bond was used to model the remaining part of thsis moiety in a similar manner to the model of one of the alkyl chains in the TLL complex ... tryptophan of the TLL and that the lid region is directly involved in the binding of TLL to micelles of the pentaoxyethylene octyl ether (C8E5) detergent [32] In the absence of NaTDC, with cis-PnA The ... carboxylic group and the alkyl chain between C2 and C9 The remaining atoms of the OA in molecule A, C10–C18, were included in the final protein model for the sake of overall clarity but their occupancies...
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inorganic polymeric nanocomposites and membranes (advances in polymer science) (advances in polymer science)
Ngày tải lên :
02/04/2014, 16:28
... effect of the organo-ion and 3rd stage – the crosslinking of the epoxy residing in the gallery with the amine, in the presence of the amine (note: DDS was largely used in preference to 4, -diaminodiphenylmethane, ... distribution of the polymers A strong in uence of the DMS segment length and of the presence of H-bonding interactions on the thermal properties of the resulting polymers was observed The Tg decreased ... ‘epoxyphilic’, and the catalyzing effect of the exchanged ion on the polymerization reaction in the galleries [31] The charge density of the smectite determines the concentration of ions in the interlayer...
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buchmeiser - polymeric materials in organic synthesis and catalysis (wiley, 2003)
Ngày tải lên :
03/04/2014, 12:15
... substantially retain their individuality The residual monomers in the porogen phase continue to polymerize and weld the microgel particles together, but there is not excessive in- filling of the fine porous ... made them an intense subject of research effort, in practice the specific combination of their physical characteristics coupled with the rather inconvenient method of synthesis, and resulting ... pore-filling when the resin has dry state porosity This can occur with or without a volume change depending on the degree of interaction between the solvent and the resin and the nature of the resin,...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
Ngày tải lên :
21/06/2014, 04:20
... be explained through the geometry of propofol location in the micelles and reflected the propofol incorporation stability The initial burst happened within the first h, especially within the first ... stronger the hydrophobic interaction between the hydrophobic segments the lower the CMC of micelle-forming material [27,28] In the case of our experiment, the hydrophobic segments forming the core of ... play a key role in determining the fate of micelles after administration, the effects of the addition of Solutol HS15 on the properties of plain micelles were evaluated As shown in Table 2, micelles...
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Báo cáo hóa học: " Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules" ppt
Ngày tải lên :
21/06/2014, 17:20
... targeting effect [26] Interestingly, lecithin microemulsion has shown the highest deposition of fluorescent dye in the dermis layer as the time of treatment increased due to the presence of lecithin ... Particle size was the primary in uencing factor on the CI of CoQ10, while the ratio of CoQ10/GTCC was the key factor affecting the crystallisation point of CoQ10 When the particle size of CoQ10LNCs ... bar, resulting in a smaller size of 200–140 nm, the melting point of CoQ10 was absent from the heating DSC 123 curves, indicating no heating enthalpy change and a high likelihood of a supercooled...
- 9
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Báo cáo hóa học: " Facile Preparation of Crosslinked Polymeric Nanocapsules via Combination of Surface-Initiated Atom Transfer Radical Polymerization and Ultraviolet Irradiated " docx
Ngày tải lên :
22/06/2014, 00:20
... as the macroinitiators in the surface-initiated atom transfer radical polymerization (SI-ATRP) of styrene, using CuBr/2,20 bipyridine as the catalyst system After the SI-ATRP of styrene, the ... some carbonized products The hollow structure of the crosslinked polymeric nanocapsules (CPNs) obtained could be observed in the TEM analysis (Fig 3c) The inner diameter of nanocapsules was 20–50 ... crosslinked polymeric shells during the etching in DMF maybe due to the lower crosslinking degree [29] and the osmotic pressure between the inner and outer of the nanocapsules CPNs 20 100 200...
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Báo cáo hóa học: " Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap" ppt
Ngày tải lên :
22/06/2014, 01:20
... immersed in 100 lL of fresh culture medium before being illuminated using a 488 nm argon-ion laser with energy density of 4.35 J/cm2 from the underside of the culture plate After 10 illumination, ... spectra of mother liquor and aqueous dispersion of the PHPP-SMNPs at same concentration The emission signal from the PHPP in the PHPP-SMNPs was almost 20% of the all solution Fluorescence intensity ... were rinsed with PBS and then incubated with culture medium containing 0.5 mg mL-1 MTT reagent for h The medium was then removed and the formazan crystals formed were dissolved in 100 lL DMSO The...
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Báo cáo hóa học: " Fabrication of Highly Ordered Polymeric Nanodot and Nanowire Arrays Templated by Supramolecular Assembly " pot
Ngày tải lên :
22/06/2014, 01:20
... due to the capillary action of cylindrical nanopores the formation of interpolymer hydrogen bonding complex between the PVP in the inner pore surface of the nanotemplate and the phenolic resin As ... restrained by dioxane in a certain extent due to the good solubility of dioxane for all the blocks, with the addition of nitromethane which is a good solvent only for the minor PVP/HABA block, the ... vapor annealing of a thin film was applied to improve the order of nanodomains Alternatively, the samples were treated in vapors of chloroform to arrange parallel alignment of the nanodomains Nanoporous...
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Báo cáo lâm nghiệp: "Strength properties of thermally modified softwoods and its relation to polymeric structural wood constituents" pot
Ngày tải lên :
07/08/2014, 16:21
... to the grain (which occurs during compressive loading parallel to the grain) Furthermore, lignin is the main component of the middle lamella [15] and an increased cross linking of the lignin ... increase of the MOE The increased cross linking of the lignin network probably also affects the MOE, since it is expected that an increased cross linking improves the rigid structure around the cellulose ... Degradation of the hemicelluloses, disrupting the load-sharing capacity of the lignin-hemicelluloses matrix, and increase of the relative amount of crystalline cellulose could contribute to the increase...
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Báo cáo khoa hoc:" Evaluation of triblock copolymeric micelles of δvalerolactone and poly (ethylene glycol) as a competent vector for doxorubicin delivery against cancer" doc
Ngày tải lên :
11/08/2014, 08:20
... better intensity of fluorescence in both the cell lines when incubated with VEVDMs in comparison to its free state For a quantitative analysis of intracellular uptake, the fluorescence intensity in ... was that the thermodynamic as well as kinetic stability of micelles is expected to increase with the increase in the hydrophobicity and state of the micelle core [31] VEV showed good thermal stability ... index detector using tetrahydrofuran (THF) as the eluent (1.0 ml/min) In addition, thermal stability of the polymer was measured by differential thermal analysis (DTA) and thermogravimetric analysis...
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