Ngày tải lên: 31/03/2014, 21:20
... precisely by the set of edges GEOMETRY OF THE UNIFORM SPANNING FOREST 475 We will need the following known lemma, which is a corollary of the main result of von Weizs¨acker (1983). Its proof is included ... allow for future applications. The bulk of the paper is devoted to the proof of the upper bound on max N(x, y) in (1.1). We now present an overview of this proof. Let U (n) be the relation N(x, y) ... then dim S (LR) = min{dim S (L) + dim S (R),d} . GEOMETRY OF THE UNIFORM SPANNING FOREST 483 event has positive probability), is the union of E 1 with the set of edges of a UST on the graph obtained from...
Ngày tải lên: 14/02/2014, 17:20
Tài liệu Đề tài "Gr¨obner geometry of Schubert polynomials " ppt
... multidegree of X equals the sum of multidegrees of components of Y that happen also to be compo- nents of X. By hypothesis, the multidegrees of X and Y coincide, so the sum of multidegrees of the ... formulae for the multidegrees of ladder determi- nantal rings. The proofs of the main theorems introduce the technique of “Bruhat in- duction”, consisting of a collection of geometric, algebraic, ... closure Bw T B + of the B × B + orbit on M n through the permutation matrix w T . Thus X w is irreducible of dimension n 2 − length(w), and w T is a smooth point of it. Proof. The stability of X w under...
Ngày tải lên: 16/02/2014, 05:20
Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... Drug Application ORA Office of Regulatory Affairs ORO Office of Regional Operations OSD Office of the Secretary of Defense PB pyridostigmine bromide PEO Program Executive Officer PHSA Public Health ... recognized in the official United States Pharmacopoeia, official Home- opathic Pharmacopoeia of the United States, or official National Formulary, or any supplement to any of them; and (B) articles ... Matter of Perspective 3 Background 4 Organization of the Report 7 Research Methods 8 Chapter Two THE CHALLENGES OF ACQUISITION 11 Licensing 12 The Department of Defense’s Organization for FDA Interaction...
Ngày tải lên: 17/02/2014, 11:20
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... cycles of steepest descent followed by 50 cycles of conjugate gradients and 50 cycles of steepest descent). No clashes were detected at the dimer interface of the models or in the surroundings of ... carboxylates of residues Asp38 and Glu111. In RNase-AA-GG the ‘basic sur- face’ is more similar to that of BS-RNase because of the removal of the four carboxylates. The ‘basic sur- face’ of the mutant ... shows the shape of the electrostatic field of BS-RNase seen from different directions. Figure S3 compares the electrostatic field of different Fig. 5. Plot of the EIE values as function of rotation...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Characterization of the interaction between the plasma membrane H+-ATPase of Arabidopsis thaliana and a novel interactor (PPI1) doc
... downstream of the first 88 amino acids of PPI1 may participate in the interaction with the H + -ATPase and makes PPI1 588 His 6 a suitable tool to study the mechanism of action of PPI1. The analysis of ... novel interaction partner for the C-termi- nus of Arabidopsis thaliana plasma membrane H + -ATP- ase (AHA1 isoform): site and mechanism of action on H + -ATPase activity differ from those of 14-3-3 ... that the site of interaction with the PM H + -ATPase was localized in the N-terminus of PPI1. To further characterize the biological activity Fig. 4. pH dependence of the activation of A. thaliana...
Ngày tải lên: 19/02/2014, 07:20
Báo cáo khoa học: A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis doc
... nature of the interaction of zinc with GDH, we have thoroughly investigated the effect that variation of the amino acid substrate concentration has on the ability of zinc to inhibit the activity of ... observed. Effects of zinc on the stability of the enzyme The thermal stability of the enzyme was determined using differential scanning calorimetry in the presence and absence of zinc under a variety of conditions. ... maximal activity of the enzyme, thus resulting in a potent inhi- bition of the overall maximum rate of the oxidative deamination of L-glutamate. This further emphasizes the vital role that subunit–subunit interactions...
Ngày tải lên: 05/03/2014, 23:20
Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... greater detail below. Instability of the mutant enzyme Further analysis of the kinetic parameters of the G167E mutant was hindered by rapid inhibition of the activity of the bc 1 complex during the ... concentrations of > 40 l M (Fig. 4A) may be a result of the weakly chaotropic nature of the substrate and the inherent partioning of quinol into the Q o site. The Fig. 3. Steady-state level of the ... mitochondria. Studies of the mechanism of assembly of the bc 1 complex suggest that the ISP is one of the last subunits to be integrated within the membrane-bound subcomplex [2]. The integration of the ISP...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p pptx
... parts of the N-terminal fragment and ⁄ or the second cassette; AB DC EF Fig. 5. Effects of point mutation of the WalkerA and B motifs of the AAA-cassettes of Pex6p on the morphological appearance of ... point mutations in WalkerB of D2 in both AAA-peroxins AB DC EF Fig. 4. Effects of point mutation of the WalkerA and B motifs of the AAA-cassettes of Pex1p on the morphological appearance of peroxisomes. ... binding sites and elucidated the importance of ATP-binding and -hydrolysis of Pex1p and Pex6p for their interaction. We show that the interaction of Pex1p and Pex6p involves their first AAA-cassettes...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Mapping of the interaction site of CP12 with glyceraldehyde-3-phosphate dehydrogenase from Chlamydomonas reinhardtii Functional consequences for glyceraldehyde-3-phosphate dehydrogenase pot
... date, mapping of the interaction site of CP12 had not studied but our results give some clues with regard to the binding of CP12 to GAPDH. The impact of CP12 binding on the activity of GAPDH is ... dissociation was observed with the A 8 B 8 isoform of GAPDH lead- ing to the A 2 B 2 isoform with a higher NADPH- dependent activity [39]. By analogy with the CTE of the isoform of GAPDH [15,37], we hypothesize ... occurs. The interaction site might thus be present at the level of this fragment of molecular mass of 2347 Da (residues 26–48), corresponding to the central part of CP12. Moreover, fragments of high...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: Intermonomer cross-linking of F-actin alters the dynamics of its interaction with H-meromyosin in the weak-binding state ppt
... field vector H. This geometry minimized distortion of the signal due to incomplete alignment of F-actin filaments. (B) shows the spectra of filaments of F-actin with three sorts of cross-links: (a) ... RW, Seidel JC & Gergely J (1971) The stochio- metry of the reaction of the spin labeling of F-actin and the effect of orientation of spin-labelled F-actin fila- ments. Arch Biochem Biophys ... Morales MF (1971) Interaction of globular actin with myosin subfragments. J Mol Biol 60, 249– 261. 17 Pope D, Lednev VV & Jahn W (1987) Methods of pre- paring well-oriented sols of F-actin containing...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo Y học: Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins doc
... necrosis factor-a production (Fig. 10). The comparison of the results of the interaction of LPS with HDL to those published for the interaction of the former with another serum protein, albumin, ... cm )1 (Fig. 2). These values are indicative of acyl chains with a large amount of gauche conformers. Importantly, the interaction of HDL with LPS leads to a reduction of the wavenumber by more than one ... sugar units, lipid A two of each) which may be connected with different conformations of the molecules. Differential scanning calorimetry measurements of the interaction of LPS with HDL (Fig. 3)...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo khoa học: Structures and mode of membrane interaction of a short a helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy pdf
... intensities of the NOE connectivities are indicated by the widths of the stripes. Ó FEBS 2002 Mode of interaction of lytic peptides (Eur. J. Biochem. 269) 3873 Structures and mode of membrane interaction ... Jelinek 2 1 Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel; 2 Department of Chemistry, Ben Gurion University of the Negev, Beersheva, Israel The interaction of many lytic ... Mode of interaction of lytic peptides (Eur. J. Biochem. 269) 3875 The results of the FTIR study in PtdCho/cholesterol and PtdEtn/PtdGro membranes [19] have revealed that the majoramideIbandofK 4 L 3 l 4 Wislocatedat%...
Ngày tải lên: 17/03/2014, 11:20
Báo cáo khoa học: "CONYEXR OF DIALOGUE INTERACTION" pdf
... about the world. State of M at moment z (i.e. M ) is a consistent subset of propositions from {~}, each of which being characterized by index of certainty. The machinery of interaction between ... structure of c~,~nicative context in dia- logue interaction. The relationships between the in- teracting partners are considered as a system of three automata. TWo of them represent the agents of ... conditions of desactivation of the contract, respectively; T is a set of interact/on topics related to given contract. The interaction between the agents is realized by means of communicative...
Ngày tải lên: 18/03/2014, 02:20
Báo cáo khoa học: Investigation of the interaction between the atypical agonist c[YpwFG] and MOR docx
... obtain an energy gradient of < 10 )4 , using the twin-range cutoff method for nonbonded interactions, with a long-range cutoff of 14 A ˚ and a short-range cutoff of 8 A ˚ . Acknowledgements We ... after QM ⁄ MM geometry optimization, showing the indole NH of d-Trp3 hydrogen bonded to Asp147 of TMH III, plus other interactions with key receptor residues. The absence of the ionic interaction ... modulation of helix motions needed for the activa- tion of the receptor after binding of compound 3. Finally, in order to assess the contribution of the QM ⁄ MM polarization to the ligand, the interaction energy...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Vps4 regulates a subset of protein interactions at the multivesicular endosome doc
Ngày tải lên: 23/03/2014, 09:20
Báo cáo khoa học: A spectroscopic study of the interaction of isoflavones with human serum albumin pdf
Ngày tải lên: 23/03/2014, 11:20
The Geometry of a Setellite - Ballistic Missile Engagemnet pot
Ngày tải lên: 23/03/2014, 12:20
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