genetic basis of biological sexuality

Ngày tải lên: 22/03/2014, 22:20

Ngày tải lên: 11/06/2014, 05:26

Ngày tải lên: 28/06/2014, 11:20

... reached a consensus on all of the items. Data extracted from these articles in- cluded the first author’s name, year of publication, country of origin, ethnicity, number of cases and con- trols, ... power of the selected studies by using the DSTPLAN4.2 software, in order to assess the probability of detecting an association between RANTES polymorphisms and asthma at the 0.05 level of significance, ... located in epithelial cell of the mouth throat or lungs and adenocarcinoma is composed of cells of glandular tissue. Over the past 5 decades, many changes in the prevalence of esophageal cancer...

Ngày tải lên: 25/10/2012, 11:40

Ngày tải lên: 05/09/2013, 08:40

... it is often claimed (e.g., Depew and Weber 1998) that the nor- mativity of biological functions can be fully naturalized in terms of Wright’s (1998) analysis, in which a function is a part of a ... sense. Of course, science often looks to history to explain how the present state of a system came into being, but the present causal powers of a system must nevertheless be explicable in terms of ... stability of the oscillator. This dynamical interpretation of semantic information provides us with a new physical picture of the cognitive component of adaptive functional action. Most, if not all, of...

Ngày tải lên: 01/11/2013, 08:20

... molecular mode of action of glypho- sate and the molecular basis for glyphosate resistance. Structure and function of EPSPS EPSPS catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate ... 4% of the total soluble protein content of the cell [48]. Fig. 3. Microbial mechanisms of glyphosate degradation. (A) Two principal pathways of glyphosate degradation are known. Top: cleavage of ... however, was devoid of substrate or inhibitor, and consequently did not reveal the nature of the active site or the mode of action of glyphosate. A dec- ade later, the crystal structure of EPSPS was...

Ngày tải lên: 14/02/2014, 14:20

... have a high prevalence of sexual dysfunction, some of which is medication-induced, some of which is illness-induced, and some of which is simply part of the difficulties of living. 4. El-Defrawi, ... my partner? How Handbook of Clinical Sexuality for Mental Health Professionals Jeffrey W.Janata, PhD is Assistant Professor in the Department of Psychiatry and Director of the Behavioral Medicine ... of the Department of Forensic Medicine in the University of Ulm in Germany S.Michael Plaut, PhD is Assistant Dean for Student Affairs and Associate Professor of Psychiatry at the University of...

Ngày tải lên: 15/02/2014, 02:20

... phos- phorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members. However, each type of cancer has its own way of disrupting the balance of the networks of signaling cascades ... with stimulation of ERK1 ⁄ 2 and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibi- tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cells with ... inhibi- tion of Akt- and ERK1 ⁄ 2-dependent pathways eventu- ally change the expression level of one or more of these Bcl-2 family members. Bad Bad is one of the ‘death-promoting’ members of the Bcl-2...

Ngày tải lên: 16/02/2014, 09:20

... centre of geometry of the NarG(1–15) peptide. Only the best structures of each of the 10 best clusters are depicted ( HADDOCK score). Surface residues of NarJT in brown form the bottom of the ... the complex by 10-fold, as judged by k off . The physiological chaperone cycle probably consists of the rapid binding of the N-terminus of the partner, regardless of whether it is a twin-arginine signal ... completion of the maturation process of the partner. The nature of the signal that may trigger dissociation of the complex remains unclear; however, we propose that a local perturbation of the hydrogen...

Ngày tải lên: 16/02/2014, 14:20

... not of certainty, but of mere opinion. And this estimate of the function of philosophy with respect to theological truth, which the Fathers worked out on the basis of the concrete example of the ... the truth, but each only from one point of view, and on the basis of only one method of approach. The conclusions of each were the result of a process of more or less complete abstraction, and ... scholar of the Church University Board of Regents from July, 1895, to the present time. End of the Project Gutenberg EBook of The Basis of Early Christian Theism, by Lawrence Thomas Cole *** END OF...

Ngày tải lên: 21/02/2014, 08:20

... may affect the estimation of Young’s modulus of biological fibers. 10 Further, for validation of our computational model for biological protein materials consisting of protein crystals, as shown ... illustration of biological protein materials composed of protein crystals. (a) cartoon of a fiber, made of protein crystals, under mechanical loading. (b) protein crystal lattices constituting the biological ... degree -of- fold, Q, is responsible for high yield stress of biological protein materials through breakage of hydrogen bond of β-sheet structural motif. For deeper understanding the role of native...

Ngày tải lên: 22/02/2014, 08:20

... the occurrence of an outcome of interest. This might be a study of time until disease pro- gression or overall survival. In these types of study designs, it is the person-years of follow-up that ... Panos When you hear hoofbeats behind you, don’t expect to see a zebra. Theodore E. Woodward, MD, University of Maryland, Circa 1950 (1) Abstract The National Institutes of Health Of ce of Rare Diseases ... there are many different types of study designs; some of which require only a fraction of the number of subjects required to the randomized controlled trial, which is often considered the gold standard. Alternate...

Ngày tải lên: 05/03/2014, 23:20

... started his PHD on genetics of Alzheimer disease, but because the families were still being sampled, he initially spent a lot of effort in 22 Part II / Genomic Structure 0.1% of human genetic disease, ... typical integration is then finished off by the formation of a second-strand nick and integration of the end of the cDNA (Fig. 2A). However, significant portions of the events appear to complete ... genomic rearrangements. Most of the Alu–Alu recombination events are between nearby elements, generally spanning distances of less than 50 kb and often only a few kb in length. There are also a number of cases of chromosomal...

Ngày tải lên: 05/03/2014, 23:20

... different species [23–25]. The success of the series of studies shows that the stable framework structure of Fv enables the transfer of function by means of CDR replacement. Barbas et al. first ... the CDR loop of the single variable heavy chain of a heavy-chain camel antibody (VHH) (Fig. 1B) by com- paring topologies between VHH and NCS (Fig. 2A); grafting of the CDR 3 loop of antilysozyme ... sequence of charyb- dotoxin with one of toxin a to express a new binding function. Comparison of the X-ray crystal structures between charybdotoxin and toxin a showed the struc- tural resemblance of...

Ngày tải lên: 06/03/2014, 11:20

... characterizations of the mutant forms of the Tus protein, many aspects of the mechanism of replication fork arrest at Tus-Ter complexes have been determined. This and a brief description of the current ... is a problem word in genetics for some people. This volume has another purpose - to be accessible to those who fear the power of genetics. Those of us who know modern genetics understand that ... complete understanding of genetics, humankind will reach an important new stage. Humans will be able to change their own genes. Of course, evolution will continue to be an agent of genetic change;...

Ngày tải lên: 06/03/2014, 23:20

... Left lane: 14 C-methylated protein markers of 200, 97.5, 66, 46 and 30 kDa, from the top of the gel. N. Numa et al. Molecular basis of perinatal form of hypophosphatasia FEBS Journal 275 (2008) ... gel. Molecular basis of perinatal form of hypophosphatasia N. Numa et al. 2730 FEBS Journal 275 (2008) 2727–2737 ª 2008 The Authors Journal compilation ª 2008 FEBS Molecular basis of perinatal ... GPI-anchorless soluble version of the mutant protein. The K cat ⁄ K m value of the mutant TNSALP was less than one-tenth of the K cat ⁄ K m value of the soluble form of the wild-type enzyme, indicating...

Ngày tải lên: 07/03/2014, 05:20