Ngày tải lên: 05/09/2013, 10:15
Ngày tải lên: 05/09/2013, 15:28
Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... molecular mode of action of glypho- sate and the molecular basis for glyphosate resistance. Structure and function of EPSPS EPSPS catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate ... 4% of the total soluble protein content of the cell [48]. Fig. 3. Microbial mechanisms of glyphosate degradation. (A) Two principal pathways of glyphosate degradation are known. Top: cleavage of ... however, was devoid of substrate or inhibitor, and consequently did not reveal the nature of the active site or the mode of action of glyphosate. A dec- ade later, the crystal structure of EPSPS was...
Ngày tải lên: 14/02/2014, 14:20
Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... phos- phorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members. However, each type of cancer has its own way of disrupting the balance of the networks of signaling cascades ... with stimulation of ERK1 ⁄ 2 and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibi- tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cells with ... inhibi- tion of Akt- and ERK1 ⁄ 2-dependent pathways eventu- ally change the expression level of one or more of these Bcl-2 family members. Bad Bad is one of the ‘death-promoting’ members of the Bcl-2...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... centre of geometry of the NarG(1–15) peptide. Only the best structures of each of the 10 best clusters are depicted ( HADDOCK score). Surface residues of NarJT in brown form the bottom of the ... the complex by 10-fold, as judged by k off . The physiological chaperone cycle probably consists of the rapid binding of the N-terminus of the partner, regardless of whether it is a twin-arginine signal ... completion of the maturation process of the partner. The nature of the signal that may trigger dissociation of the complex remains unclear; however, we propose that a local perturbation of the hydrogen...
Ngày tải lên: 16/02/2014, 14:20
Tài liệu Research evaluation of economic, social, and ecological implications of the programme for commercial tree plantations: case study of rubber in the south of Laos PDR pptx
... Resources of the National Land Management Authority, Office of Prime Minister, Laos, the Foundation for Ecological Recovery, and the Faculty of Social Sciences, Chiang Mai University (list of researchers ... management of land, under which the people of Laos have use rights as granted by the state. This has always formed the central core of the definition of land. More recent changes to the definition of ... strategic direction of the forest management highlighting the importance of conservation of biological forest resources, the efficient development of the forest, and the regeneration of forest resources....
Ngày tải lên: 21/02/2014, 04:20
Tài liệu The Basis of Early Christian Theism ppt
... not of certainty, but of mere opinion. And this estimate of the function of philosophy with respect to theological truth, which the Fathers worked out on the basis of the concrete example of the ... the truth, but each only from one point of view, and on the basis of only one method of approach. The conclusions of each were the result of a process of more or less complete abstraction, and ... scholar of the Church University Board of Regents from July, 1895, to the present time. End of the Project Gutenberg EBook of The Basis of Early Christian Theism, by Lawrence Thomas Cole *** END OF...
Ngày tải lên: 21/02/2014, 08:20
Tài liệu Ecological footprint of British city residents ppt
... almost their entire fair share of global hectares on housing alone (1.77 of 1.8 gha). 5. The citizens of St Albans use most of their fair share just on transport (1.7 of 1.8 gha). 6. Leicester ... Ecological Footprinting? Most people now know what a carbon footprint is. It is a measure of how much CO 2 is emitted as a result of all aspects of our everyday lives. This is a good way of ... there is a mismatch of location between consumption and the implications of consumption. Ecological Footprinting helps to show people just how much pressure their patterns of consumption are...
Ngày tải lên: 25/02/2014, 01:20
Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
... the occurrence of an outcome of interest. This might be a study of time until disease pro- gression or overall survival. In these types of study designs, it is the person-years of follow-up that ... Panos When you hear hoofbeats behind you, don’t expect to see a zebra. Theodore E. Woodward, MD, University of Maryland, Circa 1950 (1) Abstract The National Institutes of Health Of ce of Rare Diseases ... there are many different types of study designs; some of which require only a fraction of the number of subjects required to the randomized controlled trial, which is often considered the gold standard. Alternate...
Ngày tải lên: 05/03/2014, 23:20
GENOMIC DISORDERS The Genomic Basis of Disease doc
... typical integration is then finished off by the formation of a second-strand nick and integration of the end of the cDNA (Fig. 2A). However, significant portions of the events appear to complete ... genomic rearrangements. Most of the Alu–Alu recombination events are between nearby elements, generally spanning distances of less than 50 kb and often only a few kb in length. There are also a number of cases of chromosomal ... required further explanation of the need for their samples. I often thought of the irony of the situation. At these reunion parties, Dr. Garcia would oversee the administration of the electrical shocks...
Ngày tải lên: 05/03/2014, 23:20
Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
... different species [23–25]. The success of the series of studies shows that the stable framework structure of Fv enables the transfer of function by means of CDR replacement. Barbas et al. first ... the CDR loop of the single variable heavy chain of a heavy-chain camel antibody (VHH) (Fig. 1B) by com- paring topologies between VHH and NCS (Fig. 2A); grafting of the CDR 3 loop of antilysozyme ... sequence of charyb- dotoxin with one of toxin a to express a new binding function. Comparison of the X-ray crystal structures between charybdotoxin and toxin a showed the struc- tural resemblance of...
Ngày tải lên: 06/03/2014, 11:20
Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... Left lane: 14 C-methylated protein markers of 200, 97.5, 66, 46 and 30 kDa, from the top of the gel. N. Numa et al. Molecular basis of perinatal form of hypophosphatasia FEBS Journal 275 (2008) ... gel. Molecular basis of perinatal form of hypophosphatasia N. Numa et al. 2730 FEBS Journal 275 (2008) 2727–2737 ª 2008 The Authors Journal compilation ª 2008 FEBS Molecular basis of perinatal ... GPI-anchorless soluble version of the mutant protein. The K cat ⁄ K m value of the mutant TNSALP was less than one-tenth of the K cat ⁄ K m value of the soluble form of the wild-type enzyme, indicating...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: "Ecological Evaluation of Persuasive Messages Using Google AdWords" pdf
... scenario and some pilot studies to test the feasibility of our approach. 2 Advantages of Ecological Approaches Evaluation of the effectiveness of persuasive sys- tems is very expensive and time consuming, ... performance of each single ad (its persuasiveness, from our point of view): • CTR, Click Through Rate: measures the num- ber of clicks divided by the number of impres- sions (i.e. the number of times ... total of 38 thousand subjects and a cost of 30 euros (see Table 1 for the complete description of the experimental setup). It was meant to test broadly how affective variations in the body of the...
Ngày tải lên: 07/03/2014, 18:20
Báo cáo khoa học: "Clustering Hungarian Verbs on the Basis of Complementation Patterns" pot
... the Basis of Complementation Patterns Kata G ´ abor Dept. of Language Technology Linguistics Institute, HAS 1399 Budapest, P. O. Box 701/518 Hungary gkata@nytud.hu Enik ˝ o H ´ eja Dept. of Language ... on the basis of their complementation patterns, yielding a set of basic classes and hints about the features that determine ver- bal subcategorization. The resulting classes serve as a basis for ... attempt to cluster verbs on the basis of their syntactic proper- ties with the further goal of identifying the seman- tic classes relevant for the description of Hungarian verbs’ alternation...
Ngày tải lên: 08/03/2014, 03:20
Báo cáo khoa học: "Shallow parsing on the basis of words only: A case study" pptx
... entry of a word than the identity of the word itself, e.g. MAJOR and other HEAD fea- tures in (Pollard and Sag, 1987). In the early days of statistical parsers, POS were explicitly and often ... (2000) give an overview of the CoNLL shared task of chunking. The types and definitions of chunks are identical to the ones used here. Training material again consists of the 9000 Wall Street ... addition, the effect of our mix of sentences from different corpora on top of WSJ is not clear. Ferro et al. (1999) describe a system for find- a different category, as in the case of VP/S-NOM in the...
Ngày tải lên: 08/03/2014, 07:20
Greasy palms - The social and ecological impacts of large-scale oil palm plantation development in Southeast Asia docx
... flowering plants, 17% of all species of birds, 12% of all species of mammals, 16% of all species of reptiles, and 16% of all species of amphibians. 36 PNG covers only 0.3% of the Earth's ... achieve a series of objectives such as the development of isolated rural areas, accumulation of property for landless farmers, better development and use of natural resources, creation of jobs, ensuring ... on emissions of waste-water • use of integrated pest management • significant reduction in the use of pesticides and transparency in the amount of pesticides used • recycling of POME 7. Companies...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo khoa học: "Predicting Strong Associations on the Basis of Corpus Data" pdf
... associations. the magnitude of asymmetry. In a similar vein, Wettler et al. (2005) successfully predict associa- tions on the basis of co-occurrence in text, in the framework of associationist learning ... theory of acquisition, induction and rep- resentation of knowledge. Psychological Review, 104(2):211–240. Dekang Lin. 1998. Automatic retrieval and cluster- ing of similar words. In Proceedings of ... contigu- ities between words in texts. Journal of Quantitative Linguistics, 12(2/3):111–122. 656 Proceedings of the 12th Conference of the European Chapter of the ACL, pages 648–656, Athens, Greece,...
Ngày tải lên: 08/03/2014, 21:20
Molecular basis of heredity - Bio Cơ sở phân tử của di truyền - sinh học
Ngày tải lên: 13/03/2014, 17:04
Báo cáo khoa học: Molecular basis of toxicity of Clostridium perfringens epsilon toxin ppt
Ngày tải lên: 14/03/2014, 22:20
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