gene expression changes and metabolic model
Báo cáo y học: "The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics" ppt
... the 19 GENE TARGET PROPERTIES Codon Adaptation Index Codon Bias Connector Disorder Essentiality 5125 GENES Essentiality Expression 5125 GENES Expression Gene Duplication # of Interactors Gene Duplication ... transcription factors and their associated targets in the yeast regulatory network, relationships between gene properties such as expression and binding status and breast cancer type, and finally using ... extensive downstream remodeling of transcriptional programs, and the genes and molecular mechanisms affected by this dichotomy are of particular interest Identification of gene signatures of specific...
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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding specificity and target candidates doc
... NRE(A+B)); and in both Box A and B, NRE(A–B–) (C) Qualitative analysis of LacZ reporter activation in the interaction of APUM-2 and APUM-7 with NRE WT and NRE mutants The iron responsive element RNA and ... human and mouse possess two; and Drosophila and Dyctiostelium have only one member [5] Recently, new studies have revealed the presence of ten, two and one homologs in Trypanosome, Plasmodium and ... Francischini and R B Quaggio 14 Parisi M & Lin H (1999) The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were ... was novel and unexpected SMO activity assays of SMO ⁄ PAOh1 and SMO5 overexpressing nuclear and cytoplasmic extracts corroborate these data, showing spermine oxidase activity and H2O2 generation...
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Báo cáo khoa học: "Learning to Translate with Source and Target Syntax" pot
... language models: one on the combined English halves of the bitexts, and one on two billion words of English These were smoothed using modified Kneser-Ney (Chen and Goodman, 1998) and stored using randomized ... DeNeefe, Wei Wang, and Ignacio Thayer 2006 Scalable inference and training of context-rich syntactic translation models In Proc COLING-ACL 2006, pages 961–968 Mary Hearne and Andy Way 2003 Seeing ... David Talbot and Thorsten Brants 2008 Randomized language models via perfect hash functions In Proc ACL-08: HLT, pages 505–513 Ashish Venugopal, Andreas Zollmann, Noah A Smith, and Stephan Vogel...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
... iron and steel and motor vehicles (2.8 per cent and 5.3 per cent respectively) and approximately the same size as the international trade in textiles (7.5 per cent), oil and gas (8.6 per cent) and ... Europe: Belgium, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country ... Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom); National price and purity data have...
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Báo cáo khoa học: "Bridging Morpho-Syntactic Gap between Source and Target Sentences for English-Korean Statistical Machine Translation" pot
... and an objective particle , and insert them after the corresponding dependents Eugene and guitar respectively on content-words, which can deteriorate the performance of candidate generation ... any English words, and can simply and easily be removed by referring to their POS information The unaligned words are case particles, final endings, and auxiliary particles, and they call these ... 2005; Xia and McCord, 2004; Zwarts and Dras, 2007) Some reordering approaches have given significant improvements in performance for translation from French to English (Xia and McCord, 2004) and from...
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Báo cáo khoa học: "Resolving Translation Ambiguity and Target Polysemy in Cross-Language Information Retrieval" potx
... by UTT model (evasion, tax), (income, land), (tax, surtax) b-yATWCO model (evasion, poundage), (income), (tax) by UTWCO model by ATTWCO model (evasion, tax), (income), (tax) by UTTWCO model (evasion, ... first two rows list the original English query and the Chinese query Rows and demonstrate the English translation by select-all model and co-occurrence model by resolving translation ambiguity only ... E mk k=l Thus six new models, i.e., A1W, ATW, ATTW, U1W, UTW and UTTW, are derived Finally, we apply Co -model again to disambiguate the pseudo contexts and devise six new models (A1WCO, ATWCO,...
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the effect of the hydrothermal treatment with aqueous naoh solution on the photocatalytic and photoelectrochemical propertiesof visible light-responsive TiO2thin films
... patterns of Vis-TiO2/Ti and NaOH(X)-Vis-TiO2/Ti and (b) the expanded XRD patterns of (a) (2u = 5–158) Fig XPS spectra of the Ti 2p (right) and Na 1s (left) peaks of the Vis-TiO2/Ti and NaOH(X)-Vis-TiO2/Ti ... (Laforet Engineering, XD50D) and the evolved H2 and O2 were analyzed by a gas chromatograph (GC, G2800-T, Yanaco) with a thermal conductivity detector (TCD) Results and discussion Photoelectrochemical ... by photogenerated holes occurs on these electrodes under UV (l ! 300 nm) and visible light (l ! 420 nm) irradiation Furthermore, significant increase in the anodic photocurrent under UV and visible...
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financial statement analysis Abbott Laboratories and Target
... retail and credit card Target is known for their operations in general merchandise and food items Their general merchandise segment includes household essentials, electronics, apparel and accessories, ... stores, expansions and remodels could increase our costs and capital requirements Our future growth is dependent, in part, on our ability to build new stores and expand and remodel existing stores ... 23.83% Property and equipment Land Buildings and improvements Fixtures and equipment Computer hardware and software Construction-inprogress Accumulated depreciation Property and equipment, net...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... cellular and genetic understanding of the expression and regulation of those enzymes We are even making progress toward reliable prediction of the fates of xenobiotic substances in human beings (Anderson ... hydroxylamines and oximes and secondary amines to N-hydroxy and nitrone products Aromatic amines and amides are not substrates Thioethers can be oxidized to sulfoxides; and thiols, thioamides, and thiocarbamates ... Lee, and Guodong Chen Characterization of Impurities and Degradants Using Mass Spectrometry Mike S Lee and Mingshe Zhu Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... well as anionic drugs and dyes, but also neutral ⁄ basic amphipathic drugs and even oxyanions Previously, it has been assumed that the oxyanions arsenite and antimonite and the neutral ⁄ basic ... membrane is unstirred and dense with proteins Moreover, TMRM and anticancer drugs, such as anthracyclines, are positively charged and therefore bind to acidic groups in proteins and membranes Thus, ... lines MRP1 transports, on the one hand, organic anions, such as glutathione conjugates, and, on the other hand, basic hydrophobic drugs, such as daunorubicin and vincristine [14] It has been suggested...
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For Medicare Advantage Plans, Medicare Advantage Prescription Drug Plans, Prescription Drug Plans, and 1876 Cost Plans ppt
... covers both brand name drugs and generic drugs A generic drug is approved by the FDA as having the same active ingredient as the brand name drug Generally, generic drugs cost less than brand name ... membership rules, subscriber agreements, member handbooks and wallet card instructions to enrollees Communications to members about contractual changes, and changes in providers, premiums, benefits, ... name(s) or brand(s) of the co-branding entity or entities on its marketing materials to signify a business arrangement Co-branding arrangements allow a plan sponsor and its co-branding partner(s)...
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Báo cáo khoa học: "Combining Source and Target Language Information for Name Tagging of Machine Translation Output" ppt
... previous token F4 and F5 are used to help resolve the type conflicts, and F6 and F7 to resolve boundary conflicts When there is a conflict, we need the confidence information from both ET and English ... and William J 2005 HMM Word and Phrase Alignment for Statistical Machine Translation Proc Human Language Technology Conference and Empirical Methods in Natural Language Processing Fei Huang and ... translation and bilingual named entity extraction Proc Fourth IEEE Int'l Conf on Multimodal Interfaces A McCallum, D Freitag and F Pereira 2000 Maximum entropy Markov models for information extraction and...
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fragment based drug discovery and x-ray crystallography
... Davies and Ian J Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening 61 Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey, and Roderick E Hubbard Combining NMR and ... free energy changes for the binding to a protein of a molecule, A–B, and of its component parts, A and B, in terms of the “intrinsic binding energies” of A and B, DGAi and DGBi, and a “connection ... metal-coated chip and ligands are allowed to flow past Ligands that bind to the protein cause changes in the reflectivity properties of the metal that are related to the mass of the ligand and the mass...
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báo cáo hóa học: " Simultaneous buried object detection and imaging technique utilizing fuzzy weighted background calculation and target energy moments on ground penetrating radar data" potx
... Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets, Orlando, USA (13-17 April 2009) DJ Daniels, P Curtis, O Lockwood, Classification of landmines ... Development of dual sensor hand-held detector, in SPIE Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets, Orlando, ABD, (5-9 April 2010) M ... EMI and GPR sensors for hand-held land mine detection IEEE Trans Geosci Remote Sens 42(1), 249–263 (2004) doi:10.1109/TGRS.2003.817804 Y Bahadırlar, GB Kaplan, Frequency-domain preprocessing and...
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Báo cáo hóa học: " Target estimation algorithm design using quantity data and target feature" pptx
... efficient and accurate estimations Simulations In the simulation, the target motion models are assumed according to aerospace knowledge obtained from the popular aerospace textbook and articles ... multiple -model estimator and neural algorithm for radar system Int J Innov Comput Inform Control 31(2):4809–4817 (2009) B Sugandi, H Kim, JK Tan, S Ishikawa, Real time tracking and identification of ... main works for conducting image processing is shown in Figure 1, and the descriptions are given as follows (1) Gray transformation and spatial filtering: In order to effectively determine the attribute...
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DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE pptx
... and efficient means of bringing safe and effective products to the market Success along the development path hinges on using appropriate and robust models and biomarkers, which are relevant and ... article published by Sharma and Chandola, discusses the details of “Prameha” of Ayurveda and its correlation with obesity, metabolic syndrome, and diabetes mellitus (Sharma& Chandola 2011) The authors ... can be utilized to expand the current understanding of obesity, metabolic syndrome, and diabetes 2.3 Discovery through pre-clinical studies for understanding mechanism and targets for Ayurvedic...
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Báo cáo khoa học: "SemiFDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma" potx
... (66.7%) cases and disease-free and overall survival (DFS and OS) rates were 66.7% and 77.8% respectively Acute and late toxicity higher than grade (RTOG/EORTC) was observed in 7/27 (25.9%) and 1/27 ... study and drafted the manuscript MEM, LT, CB and LD were involved in data collection and review EM, BC and MC worked on analysis of data EI and MB participated in the design of the study and contributed ... was given by cisplatin and 5-fluorouracil in 15 cases and mytomicin and 5-fluorouracil in cases Statistical analysis PET-GTV and PET-CTV were respectively compared to CT-GTV and CT-CTV by Wilcoxon...
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Báo cáo y học: " Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohort" ppt
... one NRTI and at least one PI and at least one NNRTI, 3) an abacavir- or tenofovir-containing regimen with at least NRTIs, 4) a regimen containing ritonavir and saquinavir and one NRTI, and no NNRTIs ... contributions to conception and design, acquisition of data, and analysis and interpretation of data; 2) have been involved in drafting the manuscript; and 3) have read and given approval of the ... HAART Alcohol use** Smoking** Employed** Legal Income
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