from theory to the clinic

... were initially used These studies are hypothesisbased and genes are selected on the basis of their known function and the assumption that they are involved in the development of the disease (so-called ... factors for rupture of aneurysms For presence of aneurysms, atherosclerosis, a familial pre­ pon­ erance and polycystic kidney disease are the main d risk factors On the other hand, only the ... transcription factor that has a pivotal role in endothelial cell function [23] .The strongest associated SNP within the 9p locus lies close to CDKN2A, which encodes the cyclin-dependent kinase inhibitor p16INK4a...

Ngày tải lên: 11/08/2014, 12:20

... affect to the extent of the intensity of the exposure and the degree of susceptibility to the disease or the intrinsic factors that modi‐ fy the form in which the child's bodily tissues respond to ... application to the clinic There are four sections in the book The first section is about the hypothesis on the etiology of ALL; two chapters were selected at this point The model for identifying the ... of these components, less is need‐ ed of the other two components in order to develop the illness (Fig 1) 10 Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic...

Ngày tải lên: 17/03/2014, 12:20

... Suzuki, Hidetoshi, Panasonic e-mail: Suzuki.Hidetoshi@jp.panasonic.com Tomatis, Fabrizio, ST-Ericsson e-mail: fabrizio.tomatis@stericsson.com Tosato, Filippo, Toshiba e-mail: filippo.tosato@toshiba-trel.com ... differentiator of the LTE system design compared to some other systems has been the recognition of these ‘typical deployment constraints’ from the beginning During the design process, emphasis was therefore ... order to fully appreciate the thinking that conceived this technology, however, it is necessary to have followed the subject from the very beginning and to have witnessed the discussions that took...

Ngày tải lên: 27/10/2014, 00:57

... basically involving the industrial metabolism process, aims to minimize the amount of waste emitted to the environment, together with maximize the economic benefits The model based on the theory of industrial ... recycle them in other factories Thus, the expected capacity was set for each factory due to the calculation above so that each member can get most benefit from the others As a result, the chain has ... development are the goals that this district would like to achieve Building an EIP for this area is one of the measures to help achieving these goals The aim of this research is to apply the theory of...

Ngày tải lên: 13/02/2014, 12:20

... vector is our prediction for the distribution of daily liquidity The bank with the highest value in the stationary vector is predicted to hold the most liquidity throughout the day and is thus the ... transactions in the LVTS from October 1st 2005 to October 31st 2006 This data set consists of 272 days in which the LVTS was running The participants in the sample consist of members of the LVTS and the ... points since as the optimizer gets close to (for example) the unit vector it will stop moving (or slow down in its movements) due to the flatness 13 The broad range in the estimates of the θi ’s are...

Ngày tải lên: 16/02/2014, 12:20

... accounts:— "1580, August Paid to Savage, the foot post, to go to Wellington with a letter to the Recorder touching the holding of the Sessions, and if not there to go to Wimborne Minster, where ... in riding from Winchester to Southampton In December, Lord Arlington complained to the postal authorities that the King's letters from Bristol and other towns were delayed from ten to fourteen ... sent to the Right Hon Wm Pitt, representing the great benefits received from the plan, and requesting a continuance of the same, together with the extension of the same plan to other parts of the...

Ngày tải lên: 17/02/2014, 02:20

Ngày tải lên: 08/03/2014, 01:20

... among the many that may be posed to theory is the one already mentioned concerning the amount of metal-metal bonding Another important one is about the geometry of a cluster and its relation to the ... ligated clusters, they tend to be too large for this level of theory A severe limitation to the HF mean field approach is that it ignores the spatial correlation of the electrons Thus, the absolute ... and the very special linearized muffin tin orbitals (LMTO) are used [37] The use of GTO’s or STOs facilitates a direct comparison between the one-electron functions in the LDA to those in HF theory...

Ngày tải lên: 16/03/2014, 04:20

... assigned solely from analyzing these spectra, as it could either result from partially reduced FMN or from the Fe-Fe centre From these spectra, it is evident that at k > 550 nm the absorption ... (t ẳ 10 s) from the remainders Arrow depicts 560 nm as a suitable wavelength to monitor the redox changes of the [Fe-Cys4] centre in FlRd (C) Optical contribution of the Rd-domain to the difference ... proximity to the Fe-Fe site of the other monomer It is therefore likely, though not proven yet, that the dimer is the functional unit of this enzyme, ensuring fast electron equilibration between the...

Ngày tải lên: 16/03/2014, 11:20

... purposes The terminology makes no special claim except that the classes of these words are likely to be confused with each other but not with other classes In addition to the ACP word class there ... process of tokenization stays to the reader’s naïve perception the better off you are Readers will say that in the sentence “Don’t that” ‘that’ is the third word You not want to have to explain them ... keeps apart what the author intended to keep together For a variety of reasons, both practical and theoretical, NUPOS takes the second route At the simplest level, you must “tokenize” words before...

Ngày tải lên: 24/03/2014, 19:20

... computable The theory of Turing machine and the theory of recursive functions are in fact identical They are part of the theory of effectively computable functions The reader will refer to [11,129] ... steps) that the read/write head may perform at a rate of one operation per unit time, are: – moving to the next cell to the right on the tape – moving to the next cell to the left on the tape – ... “raw materials”, by another automaton? Or, starting from the other end and extending the question, what class of automata can be constructed by one, suitably given, automaton? The variable, but essentially...

Ngày tải lên: 25/03/2014, 11:11

... the web And it was also not on the minds of fans showing their devotion to the fantasies offered to them by the entertainment industry The formalization of rules arises out of conflict From the ... employees of the State Even if researchers are in a position to exercise the rights on their works, they may, nevertheless, be required to transfer these to a publisher in order to get their article ... with the full force of the legal system to counter other breaches of their terms, such as the requirement to release modifications under the same license and to include the license with the work...

Ngày tải lên: 28/03/2014, 21:20

... connected them with the vast empire of the Han The Han Empire radiated out from its base in the North China Plain to the Yangzi and southward to Vietnam, and from the Pacific coast to the oases ... subordinate to the Puyo who never organized themselves into a state From ˘ their home in Manchuria, they conducted raids during the summer into northeastern Korea; the peoples along the coast appear to ... Korean people and their culture from the varied tribal peoples who settled in the peninsula to the two Koreas today The first chapter deals with the origins of the Korean people, from the earliest...

Ngày tải lên: 04/04/2014, 12:22

... Yugoslavia today, to the consumer-goods sector where it has at least the one advantage of protecting the interests of the consumer ANARCHISM: FROM THEORY TO PRACTICE - PAGE 26 ANARCHISM: FROM THEORY TO ... other Their offence, however, was that they were outside the control of the Party and a ANARCHISM: FROM THEORY TO PRACTICE - PAGE 42 ANARCHISM: FROM THEORY TO PRACTICE - PAGE 35 A new factor then ... claiming to moralise and civilise them I want society, and collective or social property, to be organised from the bottom up ANARCHISM: FROM THEORY TO PRACTICE - PAGE 66 ANARCHISM: FROM THEORY TO PRACTICE...

Ngày tải lên: 18/04/2014, 15:27

Ngày tải lên: 30/05/2014, 13:49

... uses the camera and the sampler to generate a ray out into the scene and then uses the integrators to compute the light arriving along the ray at the image plane This value is passed along to the ... reflection due to the light, the integrator multiplies dE by the value that the BSDF returns for the fraction of light that is scattered from the light direction to the outgoing direction along the ray ... was to bring the opportunity to this to a wider audience You are encouraged to use the system to render the example scenes on the companion CD as you progress through the book Exercises at the...

Ngày tải lên: 04/06/2014, 11:58

... ought not to focus on the ways in which they have failed to profit from reflexion on the later theories that were unknown to them Our task is to look for the best statement we can find of their essential ... attributes some of the doctrines found in the Platonic dialogues to Socrates, and others to Plato The Stoics criticize Plato, but not Socrates, on some ethical questions The division that these readers ... philosopher to uncritical endorsement of the appearances He requires us to explore the relevant puzzles, to see the genuine difficulties that they raise, and seeks to solve them by reference to the ‘most...

Ngày tải lên: 11/06/2014, 10:28

... served from January 2006 to March 2008 as Research Associate of the project, and whose contributions to the project, from the March 2006 workshop to the March 2007 conference, and then to this ... sought to explore.1 These were not a rigid frame to be imposed on the contributors to this book, who were invited to focus on those questions most pertinent to the cases which they addressed Their ... his country, he told the NATO Council: I am happy to have this opportunity to tell from this rostrum today the truth: the North Atlantic Alliance has been, and remains pursuant to the will of democratically...

Ngày tải lên: 11/06/2014, 10:33

... over the second half of the twentieth century, from the rise of single mothers among the poor to the recent time crunch faced by many families, are tied to the failure to consider this half of their ... forced to take on the production of goods for sale They then faced serious problems, as they had little time to grow their own food or carry out other tasks still crucial to their survival They ... “How stupid it is to permit the mothers of young children to spend themselves in the coarser work of the world!” Rather than free women from household tasks, these reformers fought to curtail employers’...

Ngày tải lên: 11/06/2014, 12:49

... barrier to early man, but several passes were routinely used for travel to and from southern France to the west and the central Danube to the east Although the Po Valley was the last area of Italy to ... compact range along the southern side of the Po Valley, but after they turn southeastward to run the length of the peninsula, they diverge into parallel ranges separated from one another by deep gorges ... Roman history for the fifth and first half of the fourth centuries B.C remains extremely problematic due to the nature of the surviving ancient historical tradition Then from the middle of the fourth...

Ngày tải lên: 11/06/2014, 13:04