from preclinical research to clinical trials

... functions as high affinity receptor 10 Pulmonary Hypertension – From Bench Research to Clinical Challenges and a cofactor for plasma factors VII/VIIa, the initiator of blood coagulation TF is ... as inositol triphosphate receptor (IP3R), heterodimeric GTP binding protein, Ca2+ Pulmonary Hypertension – From Bench Research to Clinical Challenges ATPase and several transient receptor potential ... Hypertension – From Bench Research to Clinical Challenges Angiolillo DJ, Ueno M, Goto S Basic principles of platelet biology and clinical implications Circ J 2010; 74:597-607 Atkinson C, Stewart S, Upton...

Ngày tải lên: 27/06/2014, 17:20

... activated in response to virtually all mitogenic factors Second, several studies have reported that the mitogenic response to growth factors is correlated with their ability to induce sustained ... proven to be invaluable academic research tools to investigate the role of the ERK1/2 MAP kinase pathway in normal cell physiology and disease To date, eleven MEK1/2 inhibitors have been tested clinically ... and c-Kit receptors To what extent the inhibition of Raf signaling contributes to the clinical activity of the drug is not clear Future clinical trials of more selective Raf inhibitors will help...

Ngày tải lên: 10/08/2014, 22:20

... Critical Care Vol 13 No Truong et al option, with potential to improve clinical outcomes Through ongoing preclinical and clinical research into the mechanisms, prevention, and treatment of ICU-acquired ... Critical Care Vol 13 No Truong et al inflammatory cytokines TNF-α and IL-1β [9,62] Taken together, antioxidant formation and a shift toward anti-inflammatory cytokines during moderate exercise may play ... effects on muscle, immobility can lead to a pro-inflammatory state caused by increased systemic inflammation via increases in pro-inflammatory cytokines In addition to immobility, critically ill patients...

Ngày tải lên: 13/08/2014, 16:20

... TTOA01_vol1 3/9/07 10:46 AM Page i TEXTBOOK OF Hepatology From Basic Science to Clinical Practice TTOA01_vol1 3/9/07 10:46 AM Page ii Textbook of Hepatology Third Edition ... highlighted in the text TTOA01_vol1 3/12/07 4:44 PM Page iii TEXTBOOK OF Hepatology From Basic Science to Clinical Practice THIRD EDITION SECTIONS 110 AND INDEX EDITORS ASSOCIATE EDITORS Juan Rodộs MD ... Consultant Hepatologist Beth Israel Deaconess Medical Center Boston, MA, USA Nazia Selzner MD PhD Transplant Hepatology Fellow Multiorgan Transplant Program Toronto General Hospital Toronto, ON, Canada...

Ngày tải lên: 06/03/2014, 09:21

... 2007-1 Progestins and the Mammary Gland From Basic Science to Clinical Applications O Conneely, C Otto Editors With 43 Figures 123 Series Editors: G Stock and M Lessl Library of Congress Control ... hormone receptors to regulate distinct gene expression profiles in different tissues has been exploited in recent years in the clinical development of novel hormone receptor modulators that have ... is toxic to cells; perhaps cells that can efflux the dye are able to form mammary glands and mammospheres simply because they are left unharmed when compared to the cells which are unable to efflux...

Ngày tải lên: 15/03/2014, 09:20

... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... diastole and adds little to systolic pressure but tends to increase early diastolic pressure The former eVect keeps pulse pressure to a minimum and the latter may be important with regard to coronary...

Ngày tải lên: 22/03/2014, 20:21

... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add...

Ngày tải lên: 30/03/2014, 22:20

... “Advanced Research Workshops”, and the NATO Science Series collects together the results of these meetings The meetings are co-organized by scientists from NATO countries and scientists from NATO’s ... permission from http://www.photon.t.utokyo.ac.jp/~maruyama/agallery/agallery.html) A SWCNT is constituted from a one atomic layer thick sheet with graphitelike structure (graphene sheet) rolled into ... added to Fe/Y catalysts on the yield of nanotubes and their properties We chose Fe instead of Ni because it is much easier to remove it from the arc product Our primary aim is to find satisfactorily...

Ngày tải lên: 04/06/2014, 15:13

... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add...

Ngày tải lên: 27/06/2014, 09:20

... coefficient was derived from fitting to clinical data 12 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice 3.2 Urea KT/V and creatinine clearance for the kidneys To assess the ... of total solute mass removal from the body, dMR/dt, during hemodialysis is: dM R = K ( Ce − Cd ) + K rCe dt (9) Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice The total ... patient less prone to IDH in this vulnerable period 30 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice Biofeedback system While monitoring may help to understand how...

Ngày tải lên: 28/06/2014, 03:20

Ngày tải lên: 08/08/2014, 18:20

... of the 82 trials had no qualitative research linked to them For ten (12%) of the trials, some form of qualitative data collection was referred to briefly in the paper or in emails from authors, ... randomised trials 52 trials: no qualitative data 10 trials: qualitative data collection referred to but not available Figure Flow chart trials: qualitative data collection carried out pre-trial 14 trials: ... doi:10.1186/1748-5908-6-53 Cite this article as: Glenton et al.: Still too little qualitative research to shed light on results from reviews of effectiveness trials: A case study of a Cochrane review on...

Ngày tải lên: 10/08/2014, 10:23

... study Low Any other type of research evidence High Further research is not likely to change our confidence in the effect estimate Moderate Further research is likely to have an important impact ... need to consider refinement of how we currently classify the quality of evidence according to study design At a minimum, this should include principles on how to classify device and protocol trials ... consideration in the context of trials of equivalency or non-superiority and for trials that are stopped at interim analyses for early benefit [21-23] Finally, future trials need to address whether estimates...

Ngày tải lên: 13/08/2014, 03:20

... sector into consideration, the main challenge of the project was to come to precise and manageable research priorities, which strengthen specific areas in the food sector The difficulty was to ... and initiatives were minimised to ensure a creative approach to the topic The resulting thematic landscape of research issues, which included a broad range of topics from e.g functional food over ... Chain – From the Plate to the Farm” From an economic point of view, this development corresponds to experiences already achieved in other markets – the shift from supply-driven markets to demand-driven...

Ngày tải lên: 22/02/2014, 05:20

... therapeutic goods Clinical trials - an overview Classification of clinical trials Clinical trials of medicines Medical device trials Regulation of medicine and medical device clinical trials in Australia ... Regulations relevant to their operation The provisions specifically relating to clinical trials have been shaded Access to unapproved therapeutic goods - clinical trials in Australia October 2004 Page ... summary of the preclinical data and clinical data For medical device trials the TGA examines the design specifications and preclinical data The TGA Delegate decides whether or not to object to the proposed...

Ngày tải lên: 07/03/2014, 08:20

Ngày tải lên: 08/03/2014, 01:20

... the cytoskeleton Many of these regulatory actions related to cell morphol‐ ogy are achieved through rapid, non-classical signaling of sex steroid receptors to kinase cascades, independently from ... Wolffian ducts, develop into the epididymis, vas deferens and seminal vesicles This action of androgens is supported by a hormone from Sertoli cells, Steroids - From Physiology to Clinical Medicine MIH ... produce estradiol from androgens Testosterone contributes to the production of estradiol, while the estrogen estrone is made from androstenedione Phytoes‐ trogens have analogous effects to those of...

Ngày tải lên: 16/03/2014, 21:20

... development FGF from the myotome induces epithelial to mesenchymal transition and translocation of dermomytomal cells into the central region of the myotome [57], a process known to contribute to the ... M, Uramoto I, Totsuka T (2000) Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor and leukemia 22 Skeletal Muscle – From Myogenesis to Clinical ... receptor, either activin receptor-like kinase (ALK4 or ActRIB) or ALK5 to stimulate the phosphorylation of receptor Smad and the Smad2/3 transcription factors in the cytoplasm This leads to the...

Ngày tải lên: 16/03/2014, 21:20

... these children would have to be exposed to Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic some environmental factor in order to develop ALL, as has been ... this book, it is shown how exposure during pregnancy to inhibitors of topoisomerase II is a risk factor for the offspring of the pregnancy to develop ALL with the presence of genetic rearrangements ... many risk factors that act at the same time to provoke the development of the illness [1] Ac‐ cording to the multicausal theory, illnesses must have at least two risk factors that lead to the development...

Ngày tải lên: 17/03/2014, 12:20

... think particularly speaking to the research community, but also to the clinical community, we tend to focus particularly as researchers or clinicians on victories You want to win You want cures One ... Total mastectomy Positive nodes m Radical mastectomy m Total mastectomy + irradiation N O AT RISK Probability (%) A 27 32 59 56 59 25 21 22 FROM CANCER PATIENT TO CANCER SURVIVOR * Lumpectomy + Chemotherapy ... fortunate to have the opportunity to before today, From Cancer Patient to Cancer Survivor, is that it is a monumental piece of work, both for the science and the public policy that it brings to the...

Ngày tải lên: 22/03/2014, 20:21