from genetic study to clinical management

... HRQoL – Health-related quality of life; RF – Risk factor; SHIELD – Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes; U.S – United States; VAS – Visual analog ... investigation was to compare EQ-5D scores of individuals diagnosed with diabetes and those with varying levels of cardiometabolic risk, using data from the Study to Help Improve Early evaluation and management ... risk Reported reductions in HRQoL may be due to related comorbidities or to overall health burden Reducing cardiometabolic risk factors may lead to significant improvements in HRQoL even before...

Ngày tải lên: 18/06/2014, 22:20

Ngày tải lên: 08/08/2014, 18:20

... role of From Tacit Knowledge to Knowledge Management RESEARCH ARTICLE information management in the performance of their business are unlikely to leapfrog into KM (Murray, 1999) The Cranfield study ... term ‘proctorment’ (proctoring, proctorship) or some other nongender terminology that connotes management activities may overcome some of the contextual problematic ‘Proctor’ has historically ... and skills) needed to meet product or customers’ needs, structural capital (organizational capability to respond to market demands) and customer capital (the strength of a customer base) The availability...

Ngày tải lên: 24/01/2014, 00:20

... TTOA01_vol1 3/9/07 10:46 AM Page i TEXTBOOK OF Hepatology From Basic Science to Clinical Practice TTOA01_vol1 3/9/07 10:46 AM Page ii Textbook of Hepatology Third Edition ... highlighted in the text TTOA01_vol1 3/12/07 4:44 PM Page iii TEXTBOOK OF Hepatology From Basic Science to Clinical Practice THIRD EDITION SECTIONS 110 AND INDEX EDITORS ASSOCIATE EDITORS Juan Rodộs MD ... Consultant Hepatologist Beth Israel Deaconess Medical Center Boston, MA, USA Nazia Selzner MD PhD Transplant Hepatology Fellow Multiorgan Transplant Program Toronto General Hospital Toronto, ON, Canada...

Ngày tải lên: 06/03/2014, 09:21

... 2007-1 Progestins and the Mammary Gland From Basic Science to Clinical Applications O Conneely, C Otto Editors With 43 Figures 123 Series Editors: G Stock and M Lessl Library of Congress Control ... hormone receptors to regulate distinct gene expression profiles in different tissues has been exploited in recent years in the clinical development of novel hormone receptor modulators that have ... is toxic to cells; perhaps cells that can efflux the dye are able to form mammary glands and mammospheres simply because they are left unharmed when compared to the cells which are unable to efflux...

Ngày tải lên: 15/03/2014, 09:20

... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... diastole and adds little to systolic pressure but tends to increase early diastolic pressure The former eVect keeps pulse pressure to a minimum and the latter may be important with regard to coronary...

Ngày tải lên: 22/03/2014, 20:21

... invited 10 clinical management experts to a further meeting on HFMD in Singapore to review the draft guidance document and consolidate up -to- date knowledge and experiences on the clinical management ... are needed to determine if such measures can truly improve the overall outcome Finally, there is a need to carry out clinical studies to gather more evidence and to improve the clinical management ... A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD) WHO Library Cataloguing in Publication Data A Guide to clinical management and public...

Ngày tải lên: 28/03/2014, 09:20

... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add...

Ngày tải lên: 30/03/2014, 22:20

... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add...

Ngày tải lên: 27/06/2014, 09:20

... functions as high affinity receptor 10 Pulmonary Hypertension – From Bench Research to Clinical Challenges and a cofactor for plasma factors VII/VIIa, the initiator of blood coagulation TF is ... leukocyte apoptosis IL-6-driven STAT3 activation is thought to limit the recruitment of neutrophils as well as pro-inflammatory cytokine However, IL-6 also rescues cells from apoptosis via the ... as inositol triphosphate receptor (IP3R), heterodimeric GTP binding protein, Ca2+ Pulmonary Hypertension – From Bench Research to Clinical Challenges ATPase and several transient receptor potential...

Ngày tải lên: 27/06/2014, 17:20

... coefficient was derived from fitting to clinical data 12 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice 3.2 Urea KT/V and creatinine clearance for the kidneys To assess the ... of total solute mass removal from the body, dMR/dt, during hemodialysis is: dM R = K ( Ce − Cd ) + K rCe dt (9) Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice The total ... patient less prone to IDH in this vulnerable period 30 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice Biofeedback system While monitoring may help to understand how...

Ngày tải lên: 28/06/2014, 03:20

... costs, e-commerce solutions permit customers to custom order products based on individual needs and preferences Retailers are able to allow customers to mass customize orders based on virtually thousands ... trying to give supply chain management a customer orientation and study its results The authors highlight the synergistic advantage of linking supply chain management with customer relationship management ... costs, e-commerce solutions permit customers to custom order products based on individual needs and preferences Retailers are able to allow customers to mass customize orders based on virtually thousands...

Ngày tải lên: 03/07/2014, 16:06

... activated in response to virtually all mitogenic factors Second, several studies have reported that the mitogenic response to growth factors is correlated with their ability to induce sustained ... mediated by growth factor binding to receptor tyrosine kinases See text for details GF, growth factor; RTK, receptor tyrosine kinase distinct MAP kinase pathways (Fig 2A) Aside from MEK1/MEK2, the ... and c-Kit receptors To what extent the inhibition of Raf signaling contributes to the clinical activity of the drug is not clear Future clinical trials of more selective Raf inhibitors will help...

Ngày tải lên: 10/08/2014, 22:20

... in clinical practice it is rare to find a patient suffering from panic disorder who did not develop agoraphobia to a certain extent This, however, is in contrast to the results from the NCS study, ... strategy, to me, to focus on such counter-intuitive findings since they are likely to lead to real novelties DYSPNEA The other aspect of the spontaneous panic attack that differentiates it from fear ... the follow-up from the different modalities It is conceivable that the differences observed to date result not from any preventive effect attributable to cognitive therapy but rather from a greater...

Ngày tải lên: 12/08/2014, 00:22

... c:0 GENETICS OF ANXIETY DISORDERS: PART I —————————————— 29 that Serotonin Re-uptake Inhibitors (SRI) are effective in the reduction of symptoms and selective agonists of serotonergic receptors ... are not completely reliable From a genetic perspective, there are not even fully reliable markers to define clinical groups suitable for genetic studies The responses to challenge tests (35% CO2 ... Heritability estimates ranged from 35% to 47% (Lyons et al., 1993) A genetic association study on subjects who had been exposed to severe combat conditions in Vietnam and suffer from PTSD shows linkage...

Ngày tải lên: 12/08/2014, 00:22

... actions Due to his repetitive thoughts, he had the urge to commit certain acts (compulsions) in order to prevent harm to his relatives and friends (such as moving a rock from the road in order to prevent ... with anger towards the father) Sadistic feelings were the basis of the symptoms, together with fears of punishment, and the present disorder Anxiety Disorders: An Introduction to Clinical Management ... doubt, only to have it replaced by a new obsessional doubt Resistance, which in this case is the attempt to refrain from checking, leads to difficulty in concentrating and to exhaustion from the endless...

Ngày tải lên: 12/08/2014, 00:22

... AND BEHAVIOURAL ASPECTS Predictors and Risk Factors Genetic Factors There are indications that genetic factors may contribute to the susceptibility to PTSD symptomatology Comparison of monozygotic ... twins suffering from PD Thus, PD seems to be influenced by hereditary factors GAD did not seem to be influenced by these factors This study also strongly suggests that GAD could be related to life events ... able to block their repetitive ‘‘attacks’’ that represented their worse symptoms In contrast, subjects who did benefit from benzodiazepines failed to report Anxiety Disorders: An Introduction to Clinical...

Ngày tải lên: 12/08/2014, 00:22

... 1993a) Psychophysiological responses to specific stimuli have been shown to discriminate PTSD from non-PTSD subjects but not to an extent to make it feasible for clinical diagnosis, let alone for ... Aversive reinforcer (1) excitatory conditioning (3) inhibitory conditioning (5) inhibitory conditioning (2) excitatory conditioning (4) inhibitory conditioning (6) inhibitory conditioning LEARNING ... points to the activation of an inhibitory mechanism related to the cognitive processing of traumatic stimuli (Bleich et al., 1996) In an attempt to resolve the conflicting results, with respect to...

Ngày tải lên: 12/08/2014, 00:22

... CCK receptors in the brain which fall into two classes CCK A and B CCK A receptors are involved in eating behaviour and CCK B receptors, Anxiety Disorders: An Introduction to Clinical Management ... from (absent) to (very considerable) The total score for the scale therefore varies from to 12 A score of P indicates the presence of anxiety, a score of O corresponds to mild or absent symptoms: ... refers to symptoms similar in character to premorbid symptomatology and should be no more severe in intensity than the original symptoms It occurs slowly over a period of weeks or months after stopping...

Ngày tải lên: 12/08/2014, 00:22

... patients to gain a better insight in the symptoms of his/her disease; also the ability to reproduce the patients’ symptomatology in the laboratory might help psychiatrists/ psychologists to gain ... exacerbation of anxiety results from an initial decrease in synaptic 5-HT, through its action on the inhibitory 5-HT1A autoreceptor, Anxiety Disorders: An Introduction to Clinical Management and Research ... ever imaginable) ∑ DSM IV symptom list, with a total of 13 symptoms, each with a possible value ranging from ‘‘0’’ (not at all) to ‘‘4’’ (very intensive) giving a total maximum possible score...

Ngày tải lên: 12/08/2014, 00:22