from basic science to clinical practice

... TTOA01_vol1 3/9/07 10:46 AM Page i TEXTBOOK OF Hepatology From Basic Science to Clinical Practice TTOA01_vol1 3/9/07 10:46 AM Page ii Textbook of Hepatology Third Edition ... highlighted in the text TTOA01_vol1 3/12/07 4:44 PM Page iii TEXTBOOK OF Hepatology From Basic Science to Clinical Practice THIRD EDITION SECTIONS 110 AND INDEX EDITORS ASSOCIATE EDITORS Juan Rodộs MD ... Cataloging-in-Publication Data Textbook of hepatology : from basic science to clinical practice 3rd ed / edited by Juan Rodộs [et al.] p ; cm Rev ed of: Oxford textbook of clinical hepatology 2nd ed 1999 Includes...

Ngày tải lên: 06/03/2014, 09:21

... MMMM An Introduction to Vascular Biology From basic science to clinical practice SECOND EDITION Edited by Beverley J Hunt Departments of Haematology and Rheumatology, Guy’s and St Thomas’ ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate...

Ngày tải lên: 22/03/2014, 20:21

... 2007-1 Progestins and the Mammary Gland From Basic Science to Clinical Applications O Conneely, C Otto Editors With 43 Figures 123 Series Editors: G Stock and M Lessl Library of Congress Control ... hormone receptors to regulate distinct gene expression profiles in different tissues has been exploited in recent years in the clinical development of novel hormone receptor modulators that have ... the Ernst Schering Foundation held a symposium on ‘Progestins and the Mammary Gland From Basic Science to Clinical Applications’ The present volume covers the different areas of progestin research...

Ngày tải lên: 15/03/2014, 09:20

... µm Localization in epidermis Up to stratum spinosum Up to granular layer Receptors (receptor for growth factors, other receptors) trkA, p75, e.g Histamine receptor, Trp-group c-RET, binding of ... IL-1 to its receptor and can be found in high concentrations in keratinocytes Mice deficient in IL-1ra have been shown to be more susceptible to lethal endotoxemia and this cytokine is thought to ... receptor stimulation, direct injury to keratinocytes, or APC-mediated triggers, the innate immune system functions to contain infection Inflammatory mediators originating from its effector cells...

Ngày tải lên: 22/03/2014, 21:20

... Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application Roger L Lundblad Boca Raton ... explanation without intent to infringe Library of Congress Cataloging-in-Publication Data Lundblad, Roger L The evolution from protein chemistry to proteomics : basic science to clinical application ... separate from translational processing as such modifications are of major interest to investigators using proteomics to study toxicology and environmental health The reader is directed to several...

Ngày tải lên: 22/03/2014, 21:20

... Department of Clinical Psychology, Washington State University, Spokane, Washington William W Stoops, PhD, Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky ... among persons ages 12 to 65 in 1998 and 2005 Use of amphetamine/ MA by males in Tijuana increased from 0.7% to 1.6%, and use by males in Juarez increased from 0.1% to 2.0% (Villatoro et al., 2006) ... Library of Congress Cataloging-in-Publication Data Methamphetamine addiction: from basic science to treatment / editors, John M Roll  .  [et al.]    p cm   Includes bibliographical references...

Ngày tải lên: 06/03/2014, 09:21

... University of Bristol The School of Medical Sciences University Walk, Bristol BS8 1TD UK E-mail: p.kuwabara@bristol.ac.uk Eric Lader, PhD QIAGEN, Inc 19300 Germantown Rd Germantown, MD 20874 USA ... Contributors Yerramilli V B K Subrahmanyam, PhD QIAGEN, Inc 19300 Germantown Rd Germantown, MD 20874 USA E-mail: subu.yerramilli@qiagen.com Asako Sugimoto, Ph.D Laboratory Head Laboratory for ... recognized to permeate the genomes of all multi-cellular organisms These tiny RNA regulators are being implicated in diverse biological pathways, ranging from development to neuronal differentiation to...

Ngày tải lên: 06/03/2014, 09:21

... research He is the Editor of RNA Interference: From Basic Science to Drug Development (2005) To my wife Shyamala for her 25 years companionship MicroRNAs FROM BASIC SCIENCE TO DISEASE BIOLOGY Edited ... incorporated into an Argonaute containing silencing complex (RISC) (Du and Zamore, 2005) From this * Author to whom correspondence should be addressed MicroRNAs: From Basic Science to Disease Biology, ... post-doctoral researchers, and professors from academic research institutions who wish to initiate microRNA research in their own laboratories Additionally, this book will serve MicroRNAs: From Basic...

Ngày tải lên: 06/03/2014, 09:21

... potential of prevention into view As Editors, our intention is that this book will provide insight along the entire continuum from basic science to clinical practice The basic science chapters present ... Disease Inflammatory Bowel Disease Translating basic science into clinical practice EDITED BY STEPHAN R TARGAN MD Director, Cedars-Sinai Division of Gastroenterology and Inflammatory Bowel and ... Inflammatory Bowel Disease Translating basic science into clinical practice EDITED BY STEPHAN R TARGAN MD Director, Cedars-Sinai Division of Gastroenterology and Inflammatory Bowel and...

Ngày tải lên: 22/03/2014, 21:20

... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically...

Ngày tải lên: 30/03/2014, 22:20

... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... Regeneration – From Basic Biology to Clinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically...

Ngày tải lên: 27/06/2014, 09:20

... TNF receptor-associated factor 2, TRAIL – TNF-related apoptosis inducing ligand Bladder Cancer Biology 13 The export of cytochrome c into the cytoplasm and its binding to APAF1 (apoptotic peptidase ... Bladder Cancer – From Basic Science to Robotic Surgery Another IAP – cIAP2 (BIRC3) – that regulates apoptosis by binding to the TNFR-associated factors TRAF1 and TRAF2, has been shown to provoke chemoresistance ... factors bind to their corresponding growth factor receptors on the cell surface leading to receptor activation and via several signal transduction events to the activation of downstream factors...

Ngày tải lên: 27/06/2014, 13:20

... coefficient was derived from fitting to clinical data 12 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice 3.2 Urea KT/V and creatinine clearance for the kidneys To assess the ... of total solute mass removal from the body, dMR/dt, during hemodialysis is: dM R = K ( Ce − Cd ) + K rCe dt (9) Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice The total ... patient less prone to IDH in this vulnerable period 30 Progress in Hemodialysis – From Emergent Biotechnology to Clinical Practice Biofeedback system While monitoring may help to understand how...

Ngày tải lên: 28/06/2014, 03:20

... research into clinical practice, ranging from the need to evaluate whether treatments shown to be efficacious in clinical trials continue to be effective in real-world practice, and the need to better ... delivery systems and clinical practice to support clinical research in community practices After review of candidate bios, publications, and references pertinent to their clinical, published, ... aims to bridge the gap between basic science (e.g., the mapping of the genetic code) and clinical applications Placebo controlled studies, may not be a viable option in some community practice clinical...

Ngày tải lên: 10/08/2014, 10:23

... they would need to value clinical research and believe that it is potentially beneficial to their patients and practices to be willing to invest the time and energy necessary to evaluate whether ... to incorporate into their practices research that could inform clinical questions, methods, analyses, and clinical recommendations built upon their own patients These strategies are derived from ... crafted to emphasize the multiple ways that clinical research can benefit clinicians and their patients It might emphasize the potential of research within clinical practice to (1) contribute to evidencebased...

Ngày tải lên: 10/08/2014, 10:23

... activated in response to virtually all mitogenic factors Second, several studies have reported that the mitogenic response to growth factors is correlated with their ability to induce sustained ... Frémin and Meloche: From basic research to clinical development of MEK1/2 inhibitors for cancer therapy Journal of Hematology & Oncology 2010 3:8 Submit your next manuscript to BioMed Central and ... proven to be invaluable academic research tools to investigate the role of the ERK1/2 MAP kinase pathway in normal cell physiology and disease To date, eleven MEK1/2 inhibitors have been tested clinically...

Ngày tải lên: 10/08/2014, 22:20

... however, their cost has led to efforts to ensure that their use is focused onto clinically appropriate indications Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics ... paper) Hematopoietic growth factors Therapeutic use Hematopoietic growth factors Mechanism of action Cancer-Chemotherapy [DNLM: Hematopoietic Cell Growth Factors therapeutic use Hematopoietic ... Factors in Oncology: Basic Science and Clinical Therapeutics Edited by: G Morstyn, M A Foote, and G J Lieschke © Humana Press Inc., Totowa, NJ Part I / Basic Research Fig Hematopoietic tree EPO,...

Ngày tải lên: 16/02/2014, 07:20

... mo) Up to 9.0 Up to 10.0 Up to 10.0 Up to 12.0 Up to 10.0 Up to 12.0 Up to 10.0 Up to 9.5 Hematocrit (packed cell volume, %)* Up to 2–5 6–12 13–16 M 13–16 F 16+ M 16+ F Pregnant Up to 28 Up to 30 ... 33+ — — — Up to 2.8 Up to 3.0 Up to 2.5 Up to 3.0 Up to 3.5 2.8–3.4 3.0–3.4 2.5+ 3.0+ 3.5+ 3.5+ 3.5+ Up to 1–5 6–16 16+ Pregnant — — — Up to 6.0 Up to 5.5 Up to 5.0 Up to 5.5 Up to 6.0 6.0–6.4 ... 6–12 12+ M 12+ F Up to 30 Up to 40 Up to 50 Up to 60 Up to 40 — — — — — 30+ 40+ 50+ 60+ 40+ Transferrin saturation (%)* Up to 2–12 12+ M 12+ F Up to 15.0 Up to 20.0 Up to 20.0 Up to 15.0 — — — —...

Ngày tải lên: 16/02/2014, 07:20

... in tandem with E6 to drive differentiated epithelial cells to continue to divide E7 is known to bind to many endogenous cell cycle proteins, including pocket proteins retinoblastoma protein (Rb), ... book emerged from a desire to provide an up -to- date survey of human oncogenic viruses and their pathogenic properties The 21 chapters in this book bring together teams of expert authors from all ... differentiated epithelial cells to continue to divide when they otherwise would not They no longer recognize signals from DNA damage through the p53 pathway to go through apoptosis or senescence, and...

Ngày tải lên: 06/03/2014, 09:21

... and regulatory hormones takes place, and intake of different food stores can cause the muscle to adjust its fuel combustion to a large degree The initiation of signals from motor centers to start ... treatment: from recreational sports to elite athletes In many situations the transformation from overload symptoms to a sports injury is poorly dened and understood Intensied research in anatomy, ... muscle strength are likely to be attributed to genetic factors Rather than discourage humans from starting training on this background, it is fascinating to identify factors responsible for training...

Ngày tải lên: 15/03/2014, 09:20