filaments and their involvement in disease

... other known cysteine-containing chitin-binding domains [14], such as plant chitin-binding proteins and horseshoe crab antimicrobial peptides with chitin-binding affinity [15–17] Rebers and Willis reported ... chitin-binding proteins in T tridentatus Amino acid compositions of high molecular mass (HMM) chitin-binding proteins HMM chitin-binding proteins resolved by 2D SDS ⁄ PAGE were categorized into ... with asterisks Numbers on the right indicate amino acid residue numbers and DE29 is involved in chitin binding In insects, cuticular proteins containing cysteine residues have not been reported,...

Ngày tải lên: 07/03/2014, 21:20

... formation, indicating that Sec14p and the two homologues act as inhibitors of Plb1p in vivo This observation explains at least in part the low Plb1p activity in wild-type cells Interestingly, the inhibitory ... strain containing the integrative version of the SFH2-yEGFP using primers F(SFH2-EGFP) and R(SFH2-EGFP) This 2778 bp PCR fragment was cut with NsiI and BglII restriction enzymes and inserted into ... microinjection into fetal bovine heart endothelial cells, PITP-a was predominantly present in the nucleus and in the cytoplasm [48] Ó FEBS 2003 Fig Phosphatidylcholine turnover in strains overexpressing...

Ngày tải lên: 23/03/2014, 18:20

... case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing ... aB-Crystallin R120 corresponds to aA-crystallin R116 and both are conserved a-crystallin domain arginines R120G aB-crystallin permits intermediate filament self association in vitro, although binding ... aAcrystallin requires this domain [66] Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases...

Ngày tải lên: 19/02/2014, 18:20

... directed against proteins containing the nonstandard amino acid citrulline [3,4] Citrulline is generated by the deimination of arginine, a post-translational modification occurring during apoptosis ... metacarpophalangeal and wrist joints in the forepaws and the metatarsophalangeal and ankle joints in the hind paws In brief, point signifies swelling of one group of joints, points signifies two ... permeabilising agents during staining procedures Our finding that citrullinated synovial proteins could not be encountered before disease onset might explain the failure in detecting anti-citrullinated...

Ngày tải lên: 09/08/2014, 06:22

... HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth factor-2 (IGF-2) HIF-1 IGF-binding protein-1 HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins ... cytokine with anti-inflammatory properties, it might counteract the effects of proinflammatory cytokines For example, the expression of IL-1 and IL-8 are also induced in hypoxic ECs [4,5] and...

Ngày tải lên: 12/08/2014, 18:20

... grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one stream and the sampling point St.4 is ... and periphery of the Seto Inland Sea The location of the research area and the distribution of the citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island in ... grove were investigated and their behaviors in the collecting reservoirs were discussed The main results obtained from the investigation are as follows: 1) Nitrogen concentration in grove soil...

Ngày tải lên: 05/09/2013, 10:17

... confusing in defining, memorizing and using them To overcome these, some solutions are introduced in chapter III such as learning by heart, reading books, magazine, stories pictures and studying ... an insight into the similarities and differences in the use of language and images in English and Vietnamese idioms and proverbs II Some popular English idioms and proverbs relating to food and ... difference and similarities between English and Vietnamese idioms and proverbs Chapter 2: An investigation into English idioms and proverbs relating to food and their equivalence in Vietnamese...

Ngày tải lên: 11/12/2013, 23:48

... commit errors when learning and using possessive determiners in English Errors in using “a” and “the” in possessive determiners In process of studying “possessive determiners”, Vietnamese learners ... determiners use for feelings and thoughts to the person [81] Too many people blame their failings and their unhappiness on luck Scientists have taken a great interest in his ideas (Collin Cobuild, ... when using “possessive determiners” and suggested solutions Errors in word order of possessive determiners and the head noun Errors in using “a” and “the” in possessive determiners ...

Ngày tải lên: 11/12/2013, 23:53

... hydrophobins HFBIII of H jecorina and T longibrachiatum, and SRH1 and HFB1 of T atroviride, involving signal peptides, Kex2type processing, and C-terminal amino acid cleavage (Table 2) In addition, the recorded ... terminal amino acid residues of all six hydrophobins providing this single match A rapid means of identifying peaks corresponding to hydrophobins in MALDI-TOF mass spectra was elaborated, making ... mass peak was missing (Fig 3B) Deviating post-translational processing of hydrophobins in H jecorina strains To investigate strain diversity with respect to metabolite production and low-mass proteomics...

Ngày tải lên: 19/02/2014, 02:20

... resolving cysteine (Cys-SR) In typical 2-Cys, Sp at the N terminus and SR at the C terminus of the protein belong to different subunits and condense to form an intersubunit disulfide bond; in atypical ... the N terminus and SR at the C terminus belong to different subunits and condense to form an intersubunit disulfide bond; in atypical 2-Cys, Sp at the N terminus and SR at C terminus, originate from ... or protein instability caused by oxidative stress conditions, are important in determining the level of Bcp2 protein Similar results are observed for genes and related proteins involved in oxidative...

Ngày tải lên: 07/03/2014, 12:20

... start with training a model using a baseline set of features, and then add each remaining feature individually, recording the gain (w.r.t the fmeasure (f (0.5), to be precise)), and choosing the best-performing ... said in the introduction, the main task we want to tackle is to align (certain kinds of) NSUs and their antecedents Now, what characterises this kind of NSU, and what are their antecedents? In ... Computing Meaning, volume Kluwer Raquel Fern´ ndez, Jonathan Ginzburg, and Shalom Lappin a 2004b Classifying ellipsis in dialogue: A machine learning approach In Proceedings of COLING 2004, Geneva,...

Ngày tải lên: 08/03/2014, 04:22

... as the metal binding event would be totally independent of the interactions involved in the enzyme–substrate complex The binding of MUG and Mg2+ are not independent, however, but instead are highly ... donor involved in the transferase Fig Diagram showing the thermodynamic equilibria and their dissociation constants involved in the binding of UDP-Glc, MUG and Mg2+ to TcdA Values shown in parentheses ... containing varying concentrations of UDP-Glc (0–145 mM) were studied The variable concentrations of UDP-Glc were obtained by starting with a stock solution containing all of the components including...

Ngày tải lên: 08/03/2014, 22:20

... being an enzyme inhibitor, can have deleterious effects on membrane structure and function by binding to the ligands such as phosphate and the cysteinyl and histidyl groups of proteins (Collins ... 0.87% C different soils: River sand, Gley, Gray lowland, Andosol and Humic Andosol (pH 5.7–8.5) different soils—River sand, Gley, Gray lowland, Andosol and Humic Andosol (pH 5.7–8.5)q2% sludge ... ecophysiological indicator of heavy metal stress in soil (Anderson and Domsch, 1990; Brookes, 1995) qCO2 decreased in the heavily Cd contaminated soil over that in control during the first 2-d incubation (Landi...

Ngày tải lên: 15/03/2014, 23:21

... YA and MA in spring wheat lands, respectively, and 46 and 20 times in corn lands, respectively Soil Zn concentration at WA was and 1.5 times higher than the contents found at YA and MA in spring ... Ž1994., who, in their pot experiment, concluded that the contents of Cd and Zn in spring wheat parts Žstraw and grain increased with increasing the two metal concentrations in sandy soils The ... patterns of cadmium and zinc contents in different parts of the two crops grown in the field in uenced by non-ferrous metal mining and smelting operation; Ž2 transfer ratios and relationship models...

Ngày tải lên: 15/03/2014, 23:22

... have a strong stake in maintain ing extended agreements in order to protect their ability to receive returns on the time and money they have invested in their clients during earlier, less profitable ... entered into an oral contract with one another stating that, in exchange for Waisbren’s assistance in developing Peppercorn’s projects, managing its business affairs, supervising its publicity, and ... (“The Wachs court intended to distinguish between the personal manager who, while operating in good faith, inadvertently steps over the line in a particular situation and engages in conduct which...

Ngày tải lên: 16/03/2014, 17:20

... respectively Determinants, their elements, their rejecter and retainer minors, their simple and scaled cofactors, their row and column vectors, and their derivatives have all been expressed in a notation ... (2) and (3) can be obtained formally from (B) and (D), respectively, by interchanging the symbols a and A and either raising or lowering all their parameters 3.5 3.5.1 The Adjoint Determinant ... or uninterested in the outstanding contributions to the theory and application of determinants made in the course of research into problems in mathematical physics These usually appear in Section...

Ngày tải lên: 17/03/2014, 14:29

... working temperature of 250 °C and 40% relative humidity (RH) An appropriate amount of ethanol vapor was injected into the closed chamber by a microinjector, and the sensor was exposed to air again ... diameter of about 10-15 nm and a length of about 200 nm After being calcined at 300 °C for h, the sample still maintains the rodlike 1-D morphology, as is shown in Figure 3c and d Compared with the ... carried out, and the resultant products were investigated by TEM (see Figure S1 in the Supporting Information) At a shorter reaction time of only min, there are almost no nanorods formed, and the...

Ngày tải lên: 19/03/2014, 16:48

... different in respect of only one sound segment The series of words pin, bin, tin, din, kin, gin, chin, fin, thin, sin, shin, win supplied with 12 words which are distinguished simply by a change in ... listening: Hands up when you hear the word beginning with /θ/ Second listening: Hands up when you hear the word beginning with /ð/ Third listening: Hands up when you hear the word beginning with ... differ only in this feature: /p/ and /b/ (pin, bin) /θ/ and /ð/ (think, the) /f/ and /v/ (fast, vast) /t∫ / and /dȜ / (choke, joke) /∫ /and / Ȝ / (ship, vision) /k/ and /g/ (core, gore) /t/ and /d/...

Ngày tải lên: 20/03/2014, 01:26

... and 20 and in Recycling (code 370) over 1996-2000 in county 19 For the corresponding years, there are no enterprises registered in the corresponding industries and counties, and submitting financial ... 20 Fernandez , Martinez and Saurina (2000) study cyclical behaviour of bank loans, loan losses and loan loss provisions in Spain and show that housing prices, asset prices and lending margins have ... are found in the following industries: Agriculture and forestry (code 111) in 1990-1992, Raising of fish (code 051) in 1988-1993, Fishery (code 052) in 1988-1993, Publishing, printing and reproduction...

Ngày tải lên: 22/03/2014, 20:21

... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... overlapping ligand-binding pockets The difference of the binding pocket is easy to understand by looking at the superimposition between PonA and BYI06830 shown in Fig Ligand-binding affinity Typically, ... for retaining the ligand-binding activity They found two high-affinity binding sites (Kd1 = 0.24 nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The...

Ngày tải lên: 23/03/2014, 04:20