... hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... gabapentin in patients with HCV [55] These findings suggest that valproate can be used for some patients with HCV without adversely affecting ALT levels Obtaining pretreatment baseline ALT levels in ... shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution in patients...
Ngày tải lên: 25/10/2012, 10:51
... cytokines, including IL-1b, TNF-a and IFN-c (B) Chemokines expressed in the joint recruit leukocytes into the joints In addition to functioning in cell trafficking, several chemokines have other biological ... concentrations of several chemokines Chemokines in the joints of patients Table Chemokines and chemokine receptors expressed in the joint of RA patients Systemic name CC chemokines CCL2 CCL3 CCL5 CCL13 ... subclasses include the CC chemokines (where the cysteines are neighboring) and the CXC chemokines (where the cysteines are separated by one amino acid) The CXC chemokines mainly act on neutrophils...
Ngày tải lên: 18/02/2014, 18:20
Symptomatology of Gynecological Malignancies: Experiences in the Gynecology Out-Patient Clinic of a Tertiary Care Hospital in Kolkata, India pot
... translation Pre-testing of the checklist and the schedule were done in the gynecology out -patient clinic of the same hospital before starting of the study on 10 patients and accordingly necessary ... (9.2) (0.4) Figures in the parentheses indicate percentages *Multiple responses; @includes bleeding during examination and sexual intercourse; #include dysfunctional uterine bleeding, fibroid uterus, ... micturition, pain in urination, difficulty in urination, haematuria, true incontinence of urine Out of these 29 patients who had miscellaneous symptoms, 17 patients (58.6%) had ovarian cancer and patients...
Ngày tải lên: 28/03/2014, 14:20
Báo cáo hóa học: " Red blood cell transfusion in the critically ill patient" docx
... cardiac output However, in the absence of bleeding, the increase in hemoglobin concentration could very well be offset by a decrease in cardiac output because of the increase in blood viscosity associated ... really happen in clinical practice? It is obvious that RBC transfusions can be lifesaving in situations of acute severe anemia or in bleeding patients in whom RBC administration can increase both ... hemoglobin or hematocrit trigger, and for the same level of hemoglobin, some patients will well, whereas others will not Thus, the decision to transfuse a patient should be individualized, taking into...
Ngày tải lên: 20/06/2014, 23:20
Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx
... all patient types encountered in real-world settings Furthermore, the findings reported here should also be interpreted within the context of the open-label study design Additional limitations include ... aripiprazole to their previous medication(s), as assessed using the preference of medication scale scores during the switching treatment phase This finding, coupled with the improvement in QOL ratings, ... enrolled in the study, 106 patients (69.2%) were compliant with treatment During the 12-week switching period, no patients received diphenhydramine and five patients received lorazepam for the treatment...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx
... illustration of the anatomy and detection of inflammation in the bone marrow The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased ... systematic histological study of zygapophyseal joints in patients with AS [10] In the present study, we first examined whether inflammation in the spine of patients with AS, as detected by histopathology, ... detected by histopathology in the zygapophyseal joints of the lumbar spine was found by MRI in three of eight patients with AS (Table 1) Most interestingly, in these patients a good correlation...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years" ppt
... was the principal investigator of the OASIS study and is the principal investigator who assisted in designing the ATLAS study WPM is the principal investigator and assisted in designing the Canadian ... Goldstein N, Braun J, Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group: Radiographic findings following two years of infliximab therapy in patients ... radiographs of the lateral cervical and lumbar spine in patients in the OASIS and the adalimumab cohorts were scored using the mSASSS scoring method [17,18] Radiographs from the OASIS cohort and the adalimumab...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: " Relative adrenal insufficiency and hemodynamic status in cardiopulmonary bypass surgery patients. A prospective cohort study" ppt
... activity for the severity of the patient' s illness [4] In our study, the overall incidence of RAI was 77.5% In agreement with previous studies describing the incidence of RAI in patients with ... drugs in elective cardiac surgery patients undergoing CPB The use of etomidate should be minimized in elective cardiac surgery in order to decrease the hemodynamic disorders in postoperative patients ... a short acting intravenous anaesthetic used for the induction of general anaesthesia, was administered according to anesthetist criteria using a dosage of 0.3 mg/kg Systemic heparinization, CPB,...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Left ventricular diastolic dysfunction of the cardiac surgery patient; a point of view for the cardiac surgeon and cardio-anesthesiologist" pptx
... patterns" The search terms were combined using the Boolean operator term "or" to find all abstracts pertaining to the chosen search terms These individual terms were then combined using the Boolean ... According to this classification, the main difference between HFNEF and HFREF is the degree of ventricular remodeling accompanied by increased ventricular volume in HFREF [78] In other words, distinction ... (PCWP) [44,45] Therefore, additional measurement of PCWP by using a Swan-Ganz catheter may be in this phase useful in estimating the time course of diastolic dysfunction and the effect of therapeutic...
Ngày tải lên: 10/08/2014, 10:20
báo cáo khoa học: " Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study" pot
... Clustering: Average density in the local neighborhoods of individuals rather than in the total network Here it is defined as the density in the networks of others connected to an individual (leaving ... person was involved in professional contacts so far Knowing each other was defined in the questionnaire as ‘knowing the face, having talked to each with other, or having heard of.’ Having professional ... respect to their prominence and influence in the network The aim of this study was to examine the connectedness in a newly established regional ParkinsonNet of health professionals involved in the treatment...
Ngày tải lên: 10/08/2014, 11:20
Báo cáo y học: "Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy" ppsx
... this is sustained The findings further indicate that the use of US imaging of the foot would be more beneficial than clinical examination alone in the refinement of diagnosis and the implementation ... monitoring of biologic therapy [14-16] The aim of this study was to evaluate by means of US, the effects of antiTNF therapy in RA patients with specific focus on the forefoot using the hypothesis ... regress within the forefeet In previous work, within the MCP joints of the hands a reduction in sonographically detectable synovial hypertrophy was noted at eighteen weeks following infliximab therapy,...
Ngày tải lên: 10/08/2014, 21:24
Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... determined from the kinetic rate constants (ka and kd) The binding curves were processed by double referencing and were globally fitted to a 1:1 binding model The stoichiometry of binding was ... of BLyS The molecular mass of the heterotrimers was confirmed by SEC-MALS mass distribution LS/UV/RI 3-detector analysis Binding kinetics and affinity studies The binding affinities and kinetics ... cells The interaction with TRAFs induces the nuclear factor (NF)-B signaling pathway, which plays a pivotal role in regulating diverse aspects of immune function, including mediating inflammatory...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: " Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome" potx
... Finally, intensivists are strongly motivated by the ‘rule of rescue’ Intensivists feel obliged to offer some therapy, any therapy, to a patient in imminent danger of dying [16] As is often the ... life-saving therapy from a patient with ARDS by deciding not to put the patient in the prone position Clinicians who choose ventilation in the prone position are applying experimental therapy and must ... ventilator-induced lung injury [8] Clinical experience Prone positioning has improved arterial oxygenation in all studies in patients with ARDS that have examined the question, especially in the early phase...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
... of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over 30 years Two metaanalyses in the mid-1990s seemed ... and newer, yet preliminary, The patient described in the present scenario is improving in all aspects of organ failure, but remains catecholamine dependent A thorough examination and review of ... controlled trials is confined to the most severely ill [12–15] This does not fit with the patient described in the aforementioned scenario Clinical case In view of conflicting older, yet strong,...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt
... used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the necrotic ... there is no definitive, level one, data supporting the use of intravenous antibiotics in the treatment of patients with severe pancreatitis, even in the setting of pancreatic necrosis The few prospective ... undergoing the antibiotic regimen Other large trials utilizing gastrointestinal decontamination in groups of critically ill patients have failed to demonstrate a decrease in mortality or intensive...
Ngày tải lên: 12/08/2014, 19:22
Báo cáo khoa học: "Protocolized resuscitation with esophageal Doppler monitoring may improve outcome in post-cardiac surgery patients." ppt
... less intense with respect to routine care than in other institutions Alternatively, there could be contamination bias between arms, resulting in more aggressive monitoring and intervention in the ... outside the clinical research arena Nevertheless, the results strongly merit the conduct of a confirmatory trial, along with evaluation of the impact of this intervention on other endpoints Furthermore, ... baseline, suggesting randomization was successful, and the results seem to argue strongly in favor of the protocolized arm The intervention is attractive for a number of reasons First, in comparison...
Ngày tải lên: 12/08/2014, 22:22
Báo cáo khoa học: "Recent evolution of renal replacement therapy in the critically ill patient" pptx
... Bordoni V, Cardona X, Inguaggiato P, Pilotto L, d’Intini V, Bellomo R: Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis Artif Organs ... lot remains to be done For sure, the progress of technology in critical care nephrology has been enormous and more will come in the near future Competing interests The author declares that they ... Figure The technological evolution from continuous arteriovenous hemofiltration (CAVH) to the last generation of continuous renal replacement therapy machines (a) CAVH machine; (b) the BSM32 machine;...
Ngày tải lên: 12/08/2014, 23:22
Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt
... after FVIIa administration is low, and in this case, although the patient is in extremis, the potentially life-saving benefit of correcting the patient s coagulopathy and ceasing his hemorrhage ... Stein Dr Rizoli presents accurate and important information concerning the off-label use of rFVIIa The clinical situation presented, however, is more akin to the coagulopathy seen in trauma, in ... rFVIIa in American academic hospitals [16], which reported that only 52% of the patients stopped bleeding within hours of rFVIIa administration and 9% suffered adverse events The latter finding...
Ngày tải lên: 12/08/2014, 23:24
Báo cáo khoa học: "The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter" pps
... time the diagnosis of adrenal insufficiency in these patients may best be made based on the free cortisol level or the total cortisol level stratified by serum albumin (Table 1) [14,15] Because these ... criteria alone Competing interests The author declares that they have no competing interests References 10 11 12 13 14 15 Salgado DR, Verdeal JC, Rocco JR: Adrenal function testing in patients with ... with corticosteroids Although the diagnosis of ‘adrenal insufficiency’ may not be clinically relevant in most critically ill patients, there may be groups of patients in whom this diagnosis may...
Ngày tải lên: 13/08/2014, 03:20
Báo cáo y học: "Bench-to-bedside review: The value of cardiac biomarkers in the intensive care patient" pdf
... elevated in patients with unstable angina but not in those with variant angina caused by vasospasm, indicating that CRP is associated with inflammation in the coronary artery rather than in the ischemic ... circulatory level [37] Other uses of CK-MB include estimating the infarct time, the infarct size and expansion, and reinfarction [38] Troponins Troponin T and troponin I are part of the contractile apparatus ... reuptake, increasing the glomerular filtration rate and inhibiting angiotensin action on the proximal tubule [7] BNP also induces vasodilatation, thereby reducing afterload [8] The peptide therefore...
Ngày tải lên: 13/08/2014, 10:20
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