preventing venous thromboembolism in the medical cancer patient

... Homocysteine metabolism 2.1 Plasma homocysteine As mentioned in the introduction homocysteine is a sulfur–containing intermediate in the normal metabolism of the essential amino acid methionine, ... mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and decreases methionine ... with increasing evidence for their role in venous thromboembolism This chapter will explore the role of these MP in the physiology of haemostasis as well as pathology of thromboembolism The final...

Ngày tải lên: 19/02/2014, 23:20

... Homocysteine metabolism 2.1 Plasma homocysteine As mentioned in the introduction homocysteine is a sulfur–containing intermediate in the normal metabolism of the essential amino acid methionine, ... mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and decreases methionine ... with increasing evidence for their role in venous thromboembolism This chapter will explore the role of these MP in the physiology of haemostasis as well as pathology of thromboembolism The final...

Ngày tải lên: 27/06/2014, 09:20

... hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... gabapentin in patients with HCV [55] These findings suggest that valproate can be used for some patients with HCV without adversely affecting ALT levels Obtaining pretreatment baseline ALT levels in ... shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution in patients...

Ngày tải lên: 25/10/2012, 10:51

... for the whole breast in early breast cancer patients Data about the impact of IMRT on the adjuvant radiotherapy of the chest wall in postmastectomy patients are scarce in the literature There ... recommendations Accordingly, the target volume should be surrounded by the 95% isodose line The planning target volume (PTV) definition for the chest wall was done according to the breast cancer atlas ... and ribs may be excluded in the target volume of the whole breast, whereas these structures are included in the target volume of the chest wall Due to these differences in the target volume, results...

Ngày tải lên: 09/08/2014, 09:20

... particularly in pulmonary medicine [31] and VTE [32], could better inform clinical decisions and minimize the dissemination of nondiscriminating and unnecessary tests Pressing investigations in this ... Topics to address included the test properties and risk:benefit ratio of noninvasive VTE investigations in the ICU setting, accurate profiling of both the thrombotic and bleeding risk among critically ... projects, industry-initiated projects, or funding agency directives An alternative approach to set intensive care research priorities in the United Kingdom and Ireland incorporated a survey, then nominal...

Ngày tải lên: 12/08/2014, 18:21

... to other nuclear receptors, there is a carboxyl-terminal ligand binding domain and an amino-terminal DNA-binding domain CAR forms a heterodimer with RXRα (Suino et al., 2004) The ligand binding ... inStephen 2004 in frame deletion of 37 amino acids in the ligand-binding domain The lack of ligand binding ability might be responsible for the failure of this transcript in transactivating the target ... elucidating the genetic basis of inherited differences in docetaxel pharmacokinetics and pharmacodynamic in local Chinese nasopharyngeal cancer patients (N = 50) The following genes involved in the...

Ngày tải lên: 10/09/2015, 09:08

... cytokines, including IL-1b, TNF-a and IFN-c (B) Chemokines expressed in the joint recruit leukocytes into the joints In addition to functioning in cell trafficking, several chemokines have other biological ... concentrations of several chemokines Chemokines in the joints of patients Table Chemokines and chemokine receptors expressed in the joint of RA patients Systemic name CC chemokines CCL2 CCL3 CCL5 CCL13 ... subclasses include the CC chemokines (where the cysteines are neighboring) and the CXC chemokines (where the cysteines are separated by one amino acid) The CXC chemokines mainly act on neutrophils...

Ngày tải lên: 18/02/2014, 18:20

... micturition, pain in urination, difficulty in urination, haematuria, true incontinence of urine Out of these 29 patients who had miscellaneous symptoms, 17 patients (58.6%) had ovarian cancer and patients ... carcinoma of the vulva (5%), choriocarcinoma (4.7%) and carcinoma of the vagina (1.2%) Chhabra et al (2002) observed in a study conducted in a rural institute in India, that cervical cancer was the ... translation Pre-testing of the checklist and the schedule were done in the gynecology out -patient clinic of the same hospital before starting of the study on 10 patients and accordingly necessary...

Ngày tải lên: 28/03/2014, 14:20

... committee and informed consents were obtained from all parents of each patients participating in the study This study included 70 pediatric cancer patients (38 males and 32 females) attending the National ... from a research tool into being an essential clinical diagnostic test, very much as HCV genotyping did One hurdle in the introduction of HBV genotyping to clinical practice is the lack of a simple, ... containing the second sets of each of the inner primer pairs, each of the deoxynucleotides, Taq DNA polymerase, and PCR buffer, as in the first reaction These were amplified for 40 cycles with the...

Ngày tải lên: 18/06/2014, 18:20

... committee and informed consents were obtained from all parents of each patients participating in the study This study included 70 pediatric cancer patients (38 males and 32 females) attending the National ... from a research tool into being an essential clinical diagnostic test, very much as HCV genotyping did One hurdle in the introduction of HBV genotyping to clinical practice is the lack of a simple, ... containing the second sets of each of the inner primer pairs, each of the deoxynucleotides, Taq DNA polymerase, and PCR buffer, as in the first reaction These were amplified for 40 cycles with the...

Ngày tải lên: 20/06/2014, 01:20

... outcome in clinical studies involving breast cancer patients [49], and the fact that HRQL questionnaires are routinely used in clinical research This reflects the scant attention paid to the information ... to reflect the research made in Spain on HRQL in Breast Cancer patients In brief, there is clearly insufficient information available on the HRQL of Spanish women with breast cancer Since HRQL ... published in medical journals, and so PubMed is the bibliographic database with most information In the case of Germany and The Netherlands, however, there are similar numbers of papers in PsycINFO...

Ngày tải lên: 20/06/2014, 15:20

... cardiac output However, in the absence of bleeding, the increase in hemoglobin concentration could very well be offset by a decrease in cardiac output because of the increase in blood viscosity associated ... really happen in clinical practice? It is obvious that RBC transfusions can be lifesaving in situations of acute severe anemia or in bleeding patients in whom RBC administration can increase both ... hemoglobin or hematocrit trigger, and for the same level of hemoglobin, some patients will well, whereas others will not Thus, the decision to transfuse a patient should be individualized, taking into...

Ngày tải lên: 20/06/2014, 23:20

... remains to be seen whether recent changes in lifestyle will increase the incidence of breast cancer in carrier families In conclusion, our findings suggest that the norms of accepting breast cancer ... for the low incidence of breast cancer in the Maghreb These factors are difficult to identify precisely, but their combined effect has serious consequences, as the clear increase in breast cancer ... country [12, 13], arguing for environmental and lifestyle factors in the difference in incidence On the other hand, studies in the United States have shown that breast cancer in African-American...

Ngày tải lên: 08/08/2014, 17:20

... all patient types encountered in real-world settings Furthermore, the findings reported here should also be interpreted within the context of the open-label study design Additional limitations include ... aripiprazole to their previous medication(s), as assessed using the preference of medication scale scores during the switching treatment phase This finding, coupled with the improvement in QOL ratings, ... judged by the investigator to complicate the evaluation of the study treatment were also excluded, as were those having participated in another study or taken the investigation drug within month...

Ngày tải lên: 09/08/2014, 01:21

Ngày tải lên: 09/08/2014, 01:22

... illustration of the anatomy and detection of inflammation in the bone marrow The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased ... systematic histological study of zygapophyseal joints in patients with AS [10] In the present study, we first examined whether inflammation in the spine of patients with AS, as detected by histopathology, ... detected by histopathology in the zygapophyseal joints of the lumbar spine was found by MRI in three of eight patients with AS (Table 1) Most interestingly, in these patients a good correlation...

Ngày tải lên: 09/08/2014, 08:22

... language for reporting adverse events occurring in cancer clinical trials In the current study, the CTC criteria [10] constituted the basis of the therapy-related morbidity documentation The acute adverse ... and drafted the manuscript JS was also involved in the clinical patient management KE participated in the study development especially by helping to define the Page of study endpoints KE was ... grade at measurement point t1 to 28.6% grade and 0% grade at measurement point t8 These findings support the assumption that the postoperative healing process in the axilla and the ipsilateral arm...

Ngày tải lên: 09/08/2014, 09:20

... was the principal investigator of the OASIS study and is the principal investigator who assisted in designing the ATLAS study WPM is the principal investigator and assisted in designing the Canadian ... Goldstein N, Braun J, Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group: Radiographic findings following two years of infliximab therapy in patients ... radiographs of the lateral cervical and lumbar spine in patients in the OASIS and the adalimumab cohorts were scored using the mSASSS scoring method [17,18] Radiographs from the OASIS cohort and the adalimumab...

Ngày tải lên: 09/08/2014, 14:22

... Clustering: Average density in the local neighborhoods of individuals rather than in the total network Here it is defined as the density in the networks of others connected to an individual (leaving ... person was involved in professional contacts so far Knowing each other was defined in the questionnaire as ‘knowing the face, having talked to each with other, or having heard of.’ Having professional ... respect to their prominence and influence in the network The aim of this study was to examine the connectedness in a newly established regional ParkinsonNet of health professionals involved in the treatment...

Ngày tải lên: 10/08/2014, 11:20

... this is sustained The findings further indicate that the use of US imaging of the foot would be more beneficial than clinical examination alone in the refinement of diagnosis and the implementation ... monitoring of biologic therapy [14-16] The aim of this study was to evaluate by means of US, the effects of antiTNF therapy in RA patients with specific focus on the forefoot using the hypothesis ... regress within the forefeet In previous work, within the MCP joints of the hands a reduction in sonographically detectable synovial hypertrophy was noted at eighteen weeks following infliximab therapy,...

Ngày tải lên: 10/08/2014, 21:24