estimated factor loadings in the corporate bond yield functions

... Brothers Bond Indexes and Treasury Yields Corporate bond yields are from Lehman Brothers Corporate Bond Indexes Bonds with maturities between one and ten years are included in Intermediate Indexes; ... bill yield are much more important than innovations in the Treasury slope in explaining the variance of future Baa yield spreads When the ordering of the bill yield and the slope are reversed, the ... Therefore an increase in the slope of the Treasury yield curve, holding the zero-coupon bond yield spread constant, raises the yields on Treasury bonds relative to yields on corporate bonds of equal...

Ngày tải lên: 06/03/2014, 04:20

... to incorporate information and news.2 In this paper I investigate the extent to which corporate bond prices re‡ informaect tion about future volatility An increase in volatility increases the ... at explaining variation in observed spreads than spreads calculated using only historical volatility I interpret these findings as evidence that the corporate bond market is forward looking with ... prices to be slow to incorporate information and news In this paper I examine the U.S corporate bond market using transaction prices from 1995 to 1999 I investigate whether or not information about...

Ngày tải lên: 16/02/2014, 02:20

... periodical shaking Then, the suspension was placed on ice for h, which stabilizes the thermo-labile bond between the cobalt atom of Cbl and the amino group At that point the matrix can be either used ... terms of the IFCblOH2 spectrum, the relative afnity to Cbl or the analogue Cbi, and the binding to the IF receptor cubilin Comparison between recombinant plants and yeast in terms of yield, expenses ... (1991) Eect of the cobalt-N coordination on the cobamide recognition by the human vitamin B12 binding proteins intrinsic factor, transcobalamin and haptocorrin Eur J Biochem 199, 299303 Kristiansen,...

Ngày tải lên: 21/02/2014, 00:20

... noitazidirbyherp eht gniniatnoc erutxim eht htiw derevoc erew sedils eht ,reffub noitazidirbyherp eht fo lavomer retfA rh rof C 73 ta detabucni dna edimamrof dezinoied %05 gniniatnoc reffub noitazidirbyherp ... slavretni yad-2 htiw 12 ot 31 syad tnangerp eht fo gninrom eht ni dellik erew )puorg rep star 6( staR selam ot erusopxe thginrevo gniwollof gninrom eht ni gulp yrotalupoc a ro mreps lanigav fo ... ,ujniJ ,retneC gnideerB laminA yrotarobaL ,ytisrevinU lanoitaN gnasgnoeyG ,g 003-052 gnithgiew( star yelwaD-eugarpS elamef tludA o utis ni o noitaraperp eussit dna slaminA o la te sdohteM dna slairetaM...

Ngày tải lên: 07/08/2014, 18:21

... viability These findings provide a basic rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the ... might be minimized in the DCs during the treatment of taxol, 48 h NF-κB is closely involved in the survival and maturation of DCs [11,17,20] To investigate further the mechanisms of taxol-induced ... The mobilization of NF-κB p65 molecules in DCs was detected by staining with an anti-NF-κB p65 antibody and confocal microscopy Arrows indicate the nuclei of DCs (A) In the inhibitor assay, the...

Ngày tải lên: 07/08/2014, 23:22

... promotes or initiates osteoarthritis (OA) in the murine knee joint In contrast to conditional knockout mice, the chemical inhibition allows one to investigate the effects in adult joints in an otherwise ... role in the disease process rather than promoting the progression of the disease To further prove this hypothesis, we established two animal models The first model served to investigate whether inhibition ... growth factors or cytokines involving the phosphatidylinositol 3-kinase or extracellular signal-regulated kinase/mitogen-activated protein kinase pathway [8-10] In osteoarthritic cartilage, the...

Ngày tải lên: 09/08/2014, 13:22

... staining compared to 3% in the control 34% of the nuclei are moderately stained in the IgA nephropathy and 23% are moderately stained in the control In the control most nuclei are weakly stained ... staining from the four cases of minimal change and the control Darker staining can be observed in the patients compared to the control This is corroborated by independent scoring by a trained ... single blind conditions Fig shows the scoring data 41 Control Nephrectomy Minimal change case Minimal change case Minimal change case Minimal change case Fig 8: Diaminobenzidine staining of Minimal...

Ngày tải lên: 16/10/2015, 15:38

... wrote the manuscript COMPETING FINANCIAL INTERESTS The authors declare no competing financial interests Published online at http://www.nature.com/naturemethods/ Reprints and permissions information ... medetomidine (0.03 mg/kg) and buprenorphine (0.01 mg kg−1) administered intramuscular and maintained with 1–3% isoflurane gas Prior to abdominal incision the medetomidine was reversed with an intramuscular ... of multiple inbred strains of cat, a current limitation, could be addressed in a focused breeding project Introducing a lentiviral restriction factor( s) into the genome of the cat has specific...

Ngày tải lên: 14/04/2016, 18:15

... Journal of Inequalities and Applications in the spaces of generalized functions Also, we obtain the general solution and prove the Hyers-Ulam stability of 1.1 in the spaces of generalized functions ... see the following topological inclusions: F Rn → S Rn , S Rn → F Rn 2.5 From the above inclusions, it suffices to say that one considers 1.2 and 1.3 in the space F Rn In order to obtain the general ... x A x In addition, Jung 16 investigated Hyers-Ulam stability of 1.1 on restricted domains, and applied the result to the study of an interesting asymptotic behavior of the quadratic functions...

Ngày tải lên: 22/06/2014, 02:20

... stability of the linear mapping in Banach spaces,” Proceedings of the American Mathematical Society, vol 72, no 2, pp 297–300, 1978 ´ [4] J Chmielinski, “Stability of the orthogonality preserving property ... completes the proof As a direct consequence of the above lemma, we present the general solution of the cubic functional equation in the spaces of ᏿ (Rn ) and Ᏺ (Rn ) Theorem 3.2 Suppose that u in ᏿ ... Applications Stability in ᏿ (Rn ) and Ᏺ (Rn ) We are going to prove the stability theorem of the cubic functional equation in the spaces of ᏿ (Rn ) and Ᏺ (Rn ) We note that the Gauss transform ψ...

Ngày tải lên: 22/06/2014, 18:20

... bigger the future demand, leading more customers to invest in the expansion of the network [15] Increasing returns explain why the cellular phone caught on more quickly in Europe than in the United ... are unable to match each other’s investments, like in the microprocessor industry or in the software industry For instance, in 2002, Intel invested more than $200 million in more than 100 companies ... is emerging today in the cellular phone industry with the deconstruction of the integrated model Companies such as Nokia or Motorola focus increasingly on the design and the marketing of the new...

Ngày tải lên: 24/10/2013, 07:20

... equations of the first kind (the “hedging equations”) have solutions Furthermore, the integral operators appearing in these equations (the “hedging operators”) turn out to be adjoint of the martingale ... counting processes (Jarrow–Madan also consider the interplay between the stock- and the bond market) In the present paper we focus primarily on the case of an in nite mark space, but the interest ... Writing (3) in integrated form, we obtain t f (t, s) = f (0, s)+ α(u, s)du+ t σ(u, s)dWu + t δ(u, x, s)µ(du, dx) E Inserting this expression into (9), splitting the integrals and changing the...

Ngày tải lên: 16/02/2014, 02:20

... growth-inhibitory properties of GIF in AD There have been extensive studies examining the role of GIF in AD, linked to its initial discovery as a factor deficient in the AD brain There remains no ... explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory ... zinc in their axon terminals [7] In addition, the synthesis of GIF within cultured cells led to a significant increase in intracellular Zn(II) stores within those cells [7] GIF, through its zinc-binding...

Ngày tải lên: 16/02/2014, 15:20

... located in the vicinity of the active site and sensed by the peptidyl substrate are inuenced, in contrast to the remote exosites, e.g in the vicinity of the activation pocket, that affect FX binding, ... conned to the substrate binding cleft (the 170 loop) in the active site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and the active ... min, samples were withdrawn, diluted in buffer Hydrogen bonds involving Gly372 in factor VIIa containing mgặml)1 bovine serum albumin, and the residual amidolytic activity was measured using the...

Ngày tải lên: 18/02/2014, 08:20

... binuclear DNA-binding zinc cluster at the N-terminus, whereas the acidic activation domain is usually present at the C-terminus The middle homology region (MHR) bridging the DNA-binding and the activation ... conformation rather than altered structure of the kinase targets themselves Further, the residue changes in War1-42p not involve serine, threonine, tyrosine or histidine (Fig 3A) In any case, the nonphosphorylated ... unaffected, we determined whether War1-42p still binds to the WARE in the PDR12 promoter To clarify this, we performed in vivo footprinting experiments in cells expressing War1-42p The strains YPH499 (wild-type),...

Ngày tải lên: 19/02/2014, 00:20

... of the heparin-binding site in these three crystallized protein–heparin complexes were given as starting point for the docking search [30] At least one conformation of the simulated protein–peptide ... divided into two equal parts and transferred into new reaction tubes containing either heparin or buffer Monitoring of FVa activity in these two tubes was continued for another 25 min, during which ... facilitated the determination of loss of FVa cofactor activity during the initial stage of inactivation and minimized the in uence of the k306 Ó FEBS 2004 Heparin and APC-catalyzed inactivation...

Ngày tải lên: 19/02/2014, 13:20

... 1A,C) These findings indicate that the region between amino acids 28 and 139 of DEC1 (including the bHLH domain) is sufficient for the suppressive activity of DEC1 The C-terminal region (amino acids ... Taken together with the results shown in Figs 1–3, these findings indicate that the region required for the suppressive activity of DEC1 is also required for the interaction with BMAL1 Binding of ... Arg65, is responsible for the E-box binding Determination of the region in BMAL1 for binding to DEC1 To identify the region in BMAL1 required for the binding to DEC1, we constructed expression...

Ngày tải lên: 19/02/2014, 16:20

... rRNA termini are present in both the 50S and the 70S fractions We then investigated whether the observed extended termini present in the 23S processing stem mutants were incorporated into the 50S ... [29–32] Taking these findings together, we suggest that the R69L mutant of IF1 allows premature subunit joining by either failing to discriminate between certain TIR elements in mRNA, or inducing a ... terminus was more prominent Thus, there were apparent differences between the mutant plasmids in extended termini, depending on the mutated position in the processing stem Taken together, these...

Ngày tải lên: 06/03/2014, 00:21

... 73.5 lM) The lower panels show the binding isotherm and the best-fit curve according to the three sequential binding sites model BIAcore analysis of the GS–TnrA interaction The results of the immunoprecipitation ... GlnK–TnrA interaction in the presence of mm ATP On the other hand, 2-oxoglutarate did not in uence the GlnK–TnrA interaction, either alone, in the absence of divalent metals, or in combination ... Fig ITC of ATP binding to GlnK The raw data were fitted with a three-site binding model for a PII trimer The upper panel shows the raw data in the form of the heat effect during the titration of...

Ngày tải lên: 06/03/2014, 00:21

... an arginine residue located in Rfc4 (RFC-B) The side chain of the arginine is referred to as an arginine finger and the finger protrudes into the ATP-binding site of the neighbouring subunit The ... whereas insertion F45 disrupts a8 These insertions are likely to affect the positioning of the arginine finger in site D, thereby blocking DNA binding by RFC–PCNA Of the remaining three inactivating ... protein Mapping the insertions onto the structure of Rfc2: insertions into the N-terminal AAA+ domain The 3D structure of the Rfc2 protein comprises three separate domains Domains I and II together...

Ngày tải lên: 07/03/2014, 02:20