economics of pharmacogenomic testing in clinical practice

... and coping behaviors of nursing students in clinical practice ENGLISH ABSTRACT Background According to a report, nursing students have high levels of stress, in some cases higher than those of other ... physio-psychosocial status and coping behaviors of nursing students in clinical practice, the differences in stress, physio-psycho-social status and coping behaviors among nursing students of different demographic ... PARTICIPATE IN RESEARCH Title of the study: Stress, physio-psycho-social status and coping behaviors of nursing students in clinical practice Researcher: Ho Thi Lan Vi Faculty of Nursing – Duy

Ngày tải lên: 30/11/2021, 12:47

... the clinical use of the SSA lanreotide in combination with targeted agents in Spanish patients with advanced NETs in the setting of routine clinical practice As expected, in the majority of patients, ... currently ongoing: SUNLAND (ClinicalTrials.gov NCT01731925) is a clinical trial aimed at evaluating the activity of sunitinib, alone or in combination with lanreotide, in midgut carcinoids In addition, ... analysis was to define the efficacy and safety of the SSA, lanreotide, in combination with antiangiogenic targeted therapies or inhibitors of the mTOR pathway in the routine clinical practice, to help

Ngày tải lên: 28/09/2020, 09:59

... Systematic Review; Family Functioning; questionnaires INTRODUCTION Understanding what is going on in the family is a challenge in clinical practice: clinicians in primary care, paediatrics and ... impact of family functioning on development and require robust standardised measures that can be administered effectively in busy clinical settings The importance of family functioning in the ... overview of published measures of family functioning METHOD A literature search of internet-based bibliographic databases was completed covering the area of interest, family functioning Following

Ngày tải lên: 18/10/2022, 13:21

... result of early successes, the majority of clinical trials investigating the combination of surgery and systemic therapy have involved the adjuvant approach. The rationale for administration of ... just beginning. In such instances, the experiences related to more common tumor types may inform trials on these more rare clinical entities. Interest in neoadjuvant chemotherapy also intensifies ... online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Neoadjuvant Chemotherapy – Current Applications in Clinical Practice,

Ngày tải lên: 27/06/2014, 13:20

... glycoprotein with a single transmembrane domain and is targeted to axons underlying paranodal regions of myelin sheaths in the CNS and PNS (Einheber et al., 19 97) This protein participates in ... members are claudins 1 and 7 In an analogous... the hypervariable or complementary-determining regions (CDR), Light chain Heavy chain Antigenbinding site VH Complementarydetermining regions (CDR) ... Expression of cytokines by recombinant vaccinia viruses: A model for studying cytokines in viral infections in vivo Immunol Rev, 12 7, 15 7–82 Reynolds, D.S., Boom, W.H and Abbas, A.K 19 87 Inhibition

Ngày tải lên: 10/08/2014, 00:20

... deficient in. .. criteria of dissemination in time 2 Incorporation of spinal cord lesions into the imaging requirements: A spinal lesion characteristic of MS (little or no swelling in the ... components of myelin in the mammalian CNS and PNS 19 of the protein. Cell-type specific alternative splicing between neurons and myelinating cells accounts for two of the splice isoforms; neuronal isoforms ... 20 01; Pettinelli and McFarlin, 1981) Myelin basic protein is one of these proteins T cells reactive with myelin basic protein can be demonstrated in individuals with MS and in normal controls

Ngày tải lên: 10/08/2014, 00:20

... disabling in MS, and significantly interfere with professional and social functioning. The combination of abnormal- ities in attention, planning, working memory, speed of information processing ... anti-CD4; integrin inhibitors Inhibitors of intracellular Lymphocyte-specific cytoplasmic protein – tyrosine kinase P56lck; zeta-associated activation, signaling and protein (ZAP )-7 0; protein kinase ... guidelines also recommend that any scanner used in clinical routine practice should operate at a field strength higher than 1.0T. With the introduction of 3T MRI systems into clinical practice,

Ngày tải lên: 10/08/2014, 00:20

... Progressive Efficacy Clinical Trial of Recombinant Interferon-beta-1a in MS (SPECTRIMS) Study Group. 2001. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: Clinical results. ... monophasic and 68% in the relaps- ing group (Wingerchuck et al., 1999). Predictors of relapsing course included longer interattack intervals between the first two clinical (index) events, older ... immune profile testing These CSF tests, shown in Box 5 .4, are of considerable importance in the evaluation of patients suspected of having MS, since approximately 95% of all individuals who

Ngày tải lên: 10/08/2014, 00:20

... diagnosis of ON is made on the basis of a combination of clinical and laboratory findings In subtle cases, diagnosis can be clinically supported by loss of red vision (“red desaturation”), or by loss of ... Saperstein, 2001 Definite: clinical phenotype, NCS, CSF, and biopsy Probable: clinical phenotype, NCS, and CSF Possible: clinical phenotype and NCS Definite: clinical major, NCS, and CSF Probable: clinical ... instances the entire spine is involved as well as some of the brainstem In some instances the in? ??ammatory sensitization involves both central and peripheral (e.g spinal root) myelin (Abramsky and Teitelbaum,

Ngày tải lên: 10/08/2014, 00:20

... T-helper cells by inhibit- ing calcineurin. While a controlled, double-blind clinical trial has shown its effectiveness in MG (Tindell et al., 1993), significant side effects and drug interactions ... terminal. Guanidine increases calcium within the nerve ter- minal by inhibiting uptake of calcium by subcellular organelles (Kamenskaya et al., 1975). While guani- dine is occasionally utilized in ... yield of obtaining a meaningful biopsy result It also may be helpful in distinguishing active in ammation from atrophy The MRI techniques used include T1and T2-weighted images with T2 being

Ngày tải lên: 10/08/2014, 00:20

... out of nine patients with RE (Watson et al., 2005). These antibodies blocked acetylcholine-induced increase in intracellular free calcium and inhibited 125 I-α-bungarotoxin bind- ing in cells ... the infarcts involve varying segments of the retina with striking or unnoticed subjective visual impairment, depending on the central or peripheral location of infarcts (Fig. 15.1). Fluorescein ... but imaging is unrevealing in about half of the patients. Autopsy reports usually reveal perivenular and arteriolar in? ??ltration by pre- dominantly T lymphocytes throughout the brain including the

Ngày tải lên: 10/08/2014, 00:20

... perivascular in? ??ammation of the adventitia, and intimal prolifera- tion resulting in narrowing of arterial lumina. Later investigators (Kernohan and Woltman, 1938) sum- marized the clinical and ... occlusion of cerebral vessels, but only 10% of lesions were clinically apparent. In PAN the vasculitic lesion proceeds in a charac- teristic manner, commencing with invasion of the intima, media, ... in PAN. Small- vessel involvement is considered the definite diag- nostic criterion of MPA, and is of the caliber involved in epineurial arteries leading to polyneuropathy in up to a quarter of

Ngày tải lên: 10/08/2014, 00:20

... allowing direct coupling of glycolysis to the proton pump (Lu et al., 2001). The monomer of pyruvate kinase acts as thyroid hormone (T3) bind- ing protein. Binding of T3 to pyruvate kinase inhibits ... conflicting evidence regarding disseminated brain involvement (Table 21.2). The clinical similarities of SC to HD may have in? ??uenced early reports of degener- ative changes in the pathology of SC ... in bold... proteins 17–19 claudin 11 17–18 claudin 19 18 contactin 18 contactin-associated protein 18 neurofascin 18–19 INDEX peripheral autonomic neuropathies 142 peripheral myelin protein

Ngày tải lên: 10/08/2014, 00:20

... in mind during the independent peer review of the preclinical data Only when the compelling preclinical data are available, careful and incremental testing in patients is justified Preclinical ... preclinical and clinical investigators, is strongly encouraged The clinical trials of SC based interventions must follow internationally accepted principles governing the ethical conduct of ... been summarized in the “Guidelines for the Clinical. .. Translation of Stem Cells published in 2008 Conclusions This review shows the most interesting clinical trials in SC biology

Ngày tải lên: 10/08/2014, 10:20

... use of research findings in clinical practice within mental health care settings Journal of Advanced Nursing 1995, 22(5):855-861 89 Linde BJ: The effectiveness of three interventions to increase ... implement research findings Journal of Advanced Nursing 1986, 11(4):389-394 16 Bircumshaw D: The utilization of research findings in clinical nursing practice Journal of Advanced Nursing 1990, 15:1272-1280 ... 4) Extent of research use in general, use of specific research findings and research use according to kinds The use of research in general was measured in 36 studies, including those in which

Ngày tải lên: 10/08/2014, 10:23

... points gained for attendance of the QC meetings and? ?in case of blended learning–for the online modules. Intervention AllGPsinoneQCwererandomisedasaclusterto study arm A (blended learning–online ... was conducted in a setting of GPs QCs in urban and ru ral areas of the wes- tern part of Germany [25]. QCs are regular regional meetings of GPs to discuss clinical topics, guidelines, and other ... approved the final manuscript. Competing interests None of the investigators involved in the study have a conflict of interest. The work was supported by a grant from the Federal Ministry of Education

Ngày tải lên: 11/08/2014, 05:21

... points gained for attendance of the QC meetings and? ?in case of blended learning–for the online modules. Intervention AllGPsinoneQCwererandomisedasaclusterto study arm A (blended learning–online ... was conducted in a setting of GPs QCs in urban and ru ral areas of the wes- tern part of Germany [25]. QCs are regular regional meetings of GPs to discuss clinical topics, guidelines, and other ... approved the final manuscript. Competing interests None of the investigators involved in the study have a conflict of interest. The work was supported by a grant from the Federal Ministry of Education

Ngày tải lên: 11/08/2014, 16:20

... Targets in Clinical Practice: Glycemic Targets in Clinical Practice: Postprandial vs Preprandial Postprandial vs Preprandial and Fasting? and Fasting? Steven D Wittlin MD Steven D Wittlin MD ... University of Rochester School of Medicine and University of Rochester School of Medicine and Dentistry Dentistry Rochester, New York Rochester, New York In all affairs it’s a healthy In all ... 1998;21:336–40 Changes in Postprandial Glucose Metabolism in. .. analogues  DPP-IV inhibitors Pramlintide  Glycemic Index/Load  Importance of Post-Prandial Control in Managing Gestational

Ngày tải lên: 13/08/2014, 09:38

... understanding of information related to clinical trials The appreciation of children and adolescents and their parents of what a clinical trial involved and their reasoning about participation in a clinical ... am something special" or "I think I will be something like a guinea pig": information and assent of legal minors in clinical trials – assessment of understanding, appreciation and reasoning Michael ... need further information As the aim cannot be to obtain informed consent in a legal meaning from legal minors or young children, the primary target of clinical investigators in clinical studies

Ngày tải lên: 13/08/2014, 18:21

... to the outcome of interest: intention of health professionals to implement shared decision-making in their practice Finally, these results provide some insight into the type of interventions that ... relevant to each of the main outcomes of interest (barriers or facilitators to the implementation of shared decision-making in clinical practice) Each unit of text was then coded according to the relevant ... implementation of shared decision-making in clinical practice Implementation Science 2006, 1:16 decision making[63] Therefore, in order to not increase inequity in health (patients who are not invited...

Ngày tải lên: 11/08/2014, 05:22