drugs and poisons in humans a handbook of practical analysis

... transformation in rats. J Pharm Sci 74:780–782 10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations. ... manufacturing drugs or as reagents for synthesis in industries; they are also used as aromatics. Because of their pharmacological e ect, alkyl nitrites are being abused as uncontrolled inhalant drugs ... consisting of the concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical axis.  e concentration of the analyte in a specimen is calculated using the calibration curve. Assessment...

Ngày tải lên: 18/10/2013, 00:15

... For quantitative analysis of DAEMS, various concentrations of DAEMS are spiked into blank serum specimens containing a  xed amount of DAEMO (IS) each and extracted as described before. Since ... gradually and carefully. If VX itself remains, there is a danger of the secondary exposure for an analyst; the manipulations including the above evaporation should be done inside a dra chamber. f) ... base peaks of DAEMS and DAEMO (IS) equally appear at m/z 114, the SIM measurements should be made using this single ion to construct a cali- bration curve for DAEMS consisting of peak area ratio...

Ngày tải lên: 18/10/2013, 00:15

... GC/MS analysis of ∆ 9 -THC-11-oic acid in urine 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimens a Reagents and their preparation • Extraction and puri cation ... CBD, CBN and 5α-cholestane. GC analysis of cannabinoids in plant specimens 192 Cannabinoids and their metabolites  e Substance Abuse and Mental Service Administration (SAMSA) in USA set the ... resin of the cannabis plant. Since the main component of cannabis, ∆ 9 -tetrahydrocannabi- nol ( ∆ 9 -THC), has various psychopharmacological e ects including hallucination, the can- nabis and...

Ngày tải lên: 24/10/2013, 19:15

... Matsubara K, Fukushima S, Akane A et al. (1992) Increased urinary morphine, codeine and tetrahydropapavero- line in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: a possible ... GC/MS analysis 204 Morphine and its analogues As a result of analysis of 203 fatal cases with morphine and heroin, three parameters were reported to be related to the fatality; they are a blood ... Pharmaceutical Society of Japan (ed) (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary –, 4th edn. Nanzando, Tokyo, pp 230–234 (in Japanese) 200 Morphine and its analogues ⊡...

Ngày tải lên: 24/10/2013, 19:15

... (1987) Cyanosis in infants caused by nitrates in well water. JAMA 257:2788–2792 12) Fan AM, Steinberg VE (1996) Health implications of nitrate and nitrite in drinking water: an update on methe- moglobinemia ... methemoglobinemia be- comes severe, it causes cyanosis, headache, easy fatigability, respiratory and conciousness dis- turbances and  nally death.  e fatal methemoglobinemia is rare, but fatal ones a ... was disclosed that he had ingested nitrate.  e analytical results for nitrite and nitrate in his blood and stomach contents are shown in > Table 5.2. An example of the gas chromatograms...

Ngày tải lên: 24/10/2013, 19:15

... 285, 290 alternative specimens 9 Amanita neoovoidea 480 Amanita pantherina 469 Amanita phalloides 469 Amanita verna 469, 474 Amanita virosa 469, 473 amanitin 473, 477, 479 amido-type local anesthetic ... 137 aldicarb 566 aldrin 529 alkylated adducts 85 alkylated DNAs 85 alkylation 30 alkyl nitrites 153, 655 allobarbital 305, 308 allylesterase 624 allyxycarb 566 alminoprofen 325, 330, 332 alprazolam ... phenomenon that the absorbance maximum of weakly acidic Met-Hb at 630 nm disappears by addition of cyanide. Met-Hb concentration can be easily determined as the ratios of the absorbance changes in- duced...

Ngày tải lên: 24/10/2013, 19:15

... for urine sampled 0–1 h a er cocaine inhalation; the ratio was 10.6 on average for urine sampled 0–8 h a er the inhalation.  e ratios increased according to the increase in time interval between ... USA, but in Japan the number of such cases is limited.  e author et al. experienced a fatal cocaine poisoning case and measured concentrations of cocaine and its metabolites in body  uids and ... in blood, a satisfactory mass spectrum can be obtained. For BE, Metabolic pathways of cocaine. ⊡ Figure 4.4 Toxic and fatal concentrations 212 Cocaine and its metabolites and tablets of 3,4-methylenedioxymethamphetamine...

Ngày tải lên: 29/10/2013, 01:15

... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis.  e peak area ratio of a test specimen is applied to the calibration curve to obtain its pentazocine ... Determination of pentazocine in human plasma by high performance liquid chromatography. Pharmazie 46:464–465 8) Seno H, Kumazawa T, Ishii A et al. (2000) Determination of pentazocine in human whole ... cases of pentazocine abuse especially for medical and co-medical workers.  e drug is being regulated as a subclass compound of narcotics (DEA class: IV). Pentazocine in both antemortem and postmortem...

Ngày tải lên: 29/10/2013, 02:15

... tract is rapid and distinct visual hallucination takes place 45 min–1 h a er oral intake of about 20 µg of LSD [1].  e hallucination becomes most marked 2–3 h a er the intake and lasts for ... powerful hallucinogenic drugs of abuse. LSD was explosively abused in U.S .A. in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller than that of methamphetamine. ... 8–12 h. In this chapter, a detection method by TLC and con rmatory analysis by GC/MS for LSD are presented. Reagents and their preparation • LSD can be obtained from each local bureau of drug...

Ngày tải lên: 08/11/2013, 01:15

... H, Nakajima K, Nishikawa M et al. (1991) Determination of methamphetamine and amphetamine in urine by headspace gas chromatography/mass spectrometry. Anal Sci 7:19–22 25) Shima N, Kamata T, ... per tablet) as the primary ingredient, sometimes smaller amounts of amphetamines and/ or other pharmaceutical agents, such as ca eine and ketamine [4, 5]. Structures of MDA and its analogues. ⊡ ... intestinal tract and reaches its peak concentration in plasma about 2 h a er oral administration [21, 22].  e doses of 50, 75 and 125 mg in the usual “recreational” range for healthy human...

Ngày tải lên: 08/11/2013, 01:15

... ElSohly MA, Lee LF, Halzhauer LB et al. (2001) Analysis of urine samples in cases of alleged sexual assault: case history. In: Salamore SJ (ed) Benzodiazepines and GHB: Detection and Pharmacology. ... respectively. γ-Hydroxybutyric acid 244 Phencyclidine Center. At admission, he stared straight ahead, following commands but not responding verbally; the levels of serum creatinin kinase and aspartate aminotransferase ... Ishii and Yoshinao Katsumata Introduction Phencyclidine ( PCP) (> Fig. 8.1), a synthetic arylcyclohexylamine hallucinogen, had been  rst applied as an anaesthetic to animals and then to humans...

Ngày tải lên: 08/11/2013, 01:15

... MO, USA). Pure powder of perazine and clospi- razine was donated by Mitsubishi Welpharma, Osaka, Japan; that of  upentixol by Takeda Chem. Ind. Ltd., Osaka, Japan; that of thioproperazine by ... Yoshinao Katsumata Introduction Phenothiazine drugs, including chlorpromazine and levomepromazine, have been being widely used as neuroleptics ( major tranquilizers), antiparkinsonian drugs and ... qualitative and quantitative analysis of phenothiazines in human body  uids using useful GC/MS and LC/MS are presented. GC/MS analysis Reagents and their preparation i. Reagents Chlorpromazine, tri...

Ngày tải lên: 15/12/2013, 12:15

... (ECD). Since, in this chapter, poisoning cases with ingestion of large amounts of drugs are assumed, HPLC analysis with a photodiode array detector can be realized for several ten ng/mL of the drugs. ... 13) Igarashi K, Kasuya F, Abe T et al. (1995) Simultaneous determination of haloperidol and its neurotoxic metabo- lite in plasma and brain tissue from schizophrenic patients treated with haloperidol ... Forensic and Pharmaceutical Chemists. Walter de Gruyter, Berlin, pp 707–718 20) Uges DRA, Conemans JMH (2000) Antidepressants and antiphychotics. In: Bogusz MJ (ed) Handbook of Analytical Separations...

Ngày tải lên: 15/12/2013, 12:15

... the reuptake of norepinephrine and serotonin and by accerelating the release of them at synaptic terminals of neurons in the brain. As characteristic structures of such drugs showing antidepressive ... Chromatograms for tricyclic and tetracyclic antidepressants and carbamazepine obtained by HPLC-UV. A: carbamazepine, B: desipramine, C: maprotiline, D: nortriptyline, E: amoxapine, F: setiptiline, ... by Takeda Chem. Ind. Ltd., Osaka, Japan; dosulepin by Kaken Pharmaceutical Co., Ltd., Tokyo, Japan; lofepramine by Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan; and setip- tiline by Mochida...

Ngày tải lên: 15/12/2013, 12:15

... chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS). A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam and 50 ng of alprazolam were added ... analysis of triazolam, and its metabolites 4-hydroxy- triazolam and α-hydroxytriazolam is also presented. GC/MS analysis of benzodiazepines in blood and urine Reagents and their preparation • ... containing drugs, such as nitrazepam, nimetazepam, clonazepam and  unitrazepam, the nitro group is rapidly metabolized into an amino group (in the 7-position) a er being absorbed into human...

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15