dpp 4 activity as bm for dose selection and go nogo decisions

... Carbon and Alloying Elements on Parameters Q, K, and n in Eq (31) Steel, wt.% 0.4C–0.24Ni 0.39C–3.0Ni 0.37C–5.6Ni 0.4C–0.32Mn 0.4C–1.32Mn 0.4C–2 .43 Mn 0.4C–0.2Cr 0.4C–2.1Cr 0.4C–3.6Cr 0.4C–6.7Cr 0.4C–0.37Si ... 0.4C–2.75Si 0.4C 1.4C 1.2C–2.0Mo Q, cal=mol Ln K n 21,532 22, 643 23,599 21,196 20,298 19 ,40 6 20, 848 15, 348 10,992 2,005 21,929 23,7 64 25,368 21 ,42 9 30,000 26, 343 15.3 64 17 .48 1 18,575 15.737 14. 241 ... 15.737 14. 241 13.713 15.366 10.076 5 .48 1 1.698 16.351 15.2 34 10.050 16.72 40 .881 29.768 0.26 0.22 0. 24 0. 24 0.22 0. 24 0.21 0. 24 0 .42 2.32 0.19 0.22 0.15 0. 24 0.07 0.08 Copyright 20 04 by Marcel...

Ngày tải lên: 10/08/2014, 12:21

... mask in one hand and the bands in the other Place and hold the mask over your nose, mouth, and chin, then stretch the bands over your head and secure them comfortably as shown; one band on the ... personnel and visitors and is required for both Standard and Expanded Precautions Hand hygiene should be performed immediately after removing PPE, even during PPE changes and removal if necessary, and ... carefully and discard it in the receptacles provided Then immediately perform hand hygiene before going on to the next patient 20 Sequence* for Donning PPE • Gown first • Mask or respirator • Goggles...

Ngày tải lên: 08/03/2014, 13:20

... and adjuncts is useful for generating the correct preposition Baseline System The work of Chodorow et al (2007) and T&C08 treat the tasks of preposition selection and error detection as a classification ... the Stanford parser for the phrase many local groups around the country Evaluation In Section 4. 1, we compare the T&C08 and +Parse models on the task of preposition selection on well-formed texts ... the 41 st Annual Meeting of the ACL, pages 42 3 43 0, Sapporo, Japan Dan Klein and Christopher D Manning 2003b Fast exact inference with a factored model for exact parsing In Advances in Neural Information...

Ngày tải lên: 30/03/2014, 21:20

... mucosa-associated lymphoid tissue and gastric lymphoma J Clin Invest 1999, 1 04: R49-R 54 45 Fox RI, Saito I: Criteria for diagnosis of Sjögren’s syndrome Rheum Dis Clin North Am 19 94, 20:391 -40 7 46 ... thyroiditis [38,39] and chronic infections such as those by human immunodeficiency virus (HIV) [40 ,41 ], hepatitis C virus [42 ,43 ] and Helicobacter pylori [44 ] Delineation of common and diverse mechanisms ... inflammatory rheumatic diseases, such as pSS, RA and SLE, and in infectious diseases, there is increasing evidence that diseases associated with immunological hyperactivity can be characterized...

Ngày tải lên: 09/08/2014, 10:20

... http://arthritis-research.com/content/11/6/255 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 B, Trentin L, Feruglio C, Chilosi M, Pizzolo G: Increased serum levels of soluble interleukin-2 receptor ... disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated by the SLEDAI and the Systemic Lupus Activity ... Santana-Sahagun E, Rassenti LZ, Weisman MH, Tamura N, Kobayashi S, Hashimoto H, Kipps TJ: The soluble CD40 ligand sCD1 54 in systemic lupus erythematosus J Clin Invest 1999, 1 04: 947 -955 Davas EM, Tsirogianni...

Ngày tải lên: 09/08/2014, 14:22

... 0.001550 10.7 64 0.0000610 24 35.315 0.0022 046 0.2 248 1 0.7376 8.8508 0. 145 037 0. 145 037 8F ¼ (1.8 8C)þ 32 25 .40 0 0.3 048 645 .16 0.092903 16387 0.028316 45 3.59 4. 448 22 1.3558 0.1130 6.8 947 9 6.8 947 9 8C ¼ ... Standardization: ISO 145 88: Blind rivets— terminology and definitions www.iso.ch Copyright 20 04 by Marcel Dekker, Inc All Rights Reserved 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 International ... Meier and Mr T Riehl for performing and evaluating a large number of investigations and testings, Mr W Thomala for valuable discussions, Dr G E Totten, Dr K Funatani, Dr L Xie, and Mr R Johnson for...

Ngày tải lên: 10/08/2014, 12:21

... of formulation for the cases of grain edge and grain corner nucleations Table shows all the extreme cases For all cases, the increase of the volume of new phases for the case of small as conforms ... Retaining, and Sealing, Girard S Haviland 45 Couplings and Joints: Design, Selection, and Application, Jon R Mancuso 46 Shaft Alignment Handbook, John Piotrowski 47 BASIC Programs for Steam Plant ... transformation and solidification involved with elastic-plastic, viscoplastic and creep deformation as they relate to quenching, forging, and casting processes Modeling and simulation of mechanical properties,...

Ngày tải lên: 10/08/2014, 12:21

... Phys 1939, 7, 1103 4b Avrami, M.J Chem Phys 1 940 , 8, 212 4c Avrami, M.J Chem Phys 1 941 , 9, 177 Johnson, W.A.; Mehl, R.F Trans AIME 1939, 135, 41 6 Cahn, J.W Acta Metall 1956, 4, 44 9 Umemoto, M Proceedings ... ISIJ Int 1992, 32, 297 43 Enomoto, M.; Atkinson, C Acta Metall Mater 1993, 41 , 3237 44 Enomoto, M Tetsu-to-Hagane 19 94, 80, 653 ˚ 45 Agren, J ISIJ Int 1992, 32, 291 ˚ 46 Anderson, J.-O.; Hoglund, ... and Other Metals; ISIJ: 1988; 799 17 Nishizawa, T Tetsu-to-Hagne 19 84, 70, 19 84 18 Sellars, C.M.; Whiteman, J.A Met Sci 1979, 14, 187 19 Sellars, C.M International Conference on Working and Forming...

Ngày tải lên: 10/08/2014, 12:21

... temperature, and stress=strain in the forging process associated with strain-induced phase transformation has been developed The material is considered as elastic–plastic and takes into account the phase ... VC VN TiC TiN NbC NbN ZrC ZrN A B 7,130 1 .46 3 9,500 6.72 7,985 3.09 8,872 4. 04 15,573 3.82 7,7 14 3.27 10 ,44 0 3.87 8 ,46 4 4. 96 13,968 3.08 Copyright 20 04 by Marcel Dekker, Inc All Rights Reserved ... transformation or solidification as well as inelastic behavior involved with elastic–plastic, viscoplastic and creep deformation will be introduced The theory and simulation technology also are...

Ngày tải lên: 10/08/2014, 12:21

... strip and roll is shown in Fig 44 (a) and (b) for the casting speeds of 40 0 and 600 mm=sec Copyright 20 04 by Marcel Dekker, Inc All Rights Reserved Figure 35 Isothermal lines by effect of casting ... temperature and stresses, such as ingot size, casting speed, and initial temperature, to provide fundamental data for optimizing the operating condition Finite Element Model and Casting Conditions ... shown in Fig 42 (b) is treated for the analysis Copyright 20 04 by Marcel Dekker, Inc All Rights Reserved Figure 33 Calculated stresses by (a) elastic–viscoplastic model and (b) elastic– plastic models...

Ngày tải lên: 10/08/2014, 12:21

... Applications, Cleveland; 19 84; 108–112 46 Bodner, S.R.; Partom, Y Constitutive equations for elastic-viscoplastic strain hardening materials J Appl Mech., Trans ASME 1975, 42 , 385–389 47 Bodner, S.R.; ... after plastic deformation Proceedings of International Conference on Phase Transformations, Cambridge, England, July 6–10, The Institute of Materials: 1987; Lorimer, G.W., Ed; 45 1 45 4 Inoue, ... Viscoplastic constitutive equations for copper with strain rate history and temperature effects J Appl Mech., Trans ASME 1978, 100, 388–3 94 48 Chaboche, J.L.; Rousseler, G On the plastic and viscoplastic...

Ngày tải lên: 10/08/2014, 12:21

... during the elastic deformation by DsF ¼ 2sF and then gradually by Dsi during the plastic deformation of the half cycle On the next reverse (À_ ) to (þ_ ), a stress decreases first by DsF and then ... 75 MPa, b ¼ 36.6, C ¼ 14, 844 MPa and g ¼ 86.3 As a loading condition, a line load with a total compressive force F is applied at the midlength of the upper surface The force follows a sinusoidal ... increasing strain rates is the same, as long as the values of DG ¼ kT lnð_ à =_ Þ are equal in both cases e e Depending upon the formulation of the function V à ðsà Þ; different _ _ relations for...

Ngày tải lên: 10/08/2014, 12:21

... later, the mesh and the stress distribution look completely different, as shown in Fig 24c and d for the time instants of reaching the maximum compressive strain of the 14th cycle and the maximum ... dislocation motion and increase the resistance to deformation The strength depends mainly on the size and the volume fraction of the dispersoids as well as on the consolidation process and the matrix ... separately and eq ( 54) is rewritten as ! s À si À s p n _ e¼C sgnðs À si Þ ð59Þ sF ð1 À DÞ A Damage Function Different formulations can be applied for the damage function D Kachanov and Rabotnov...

Ngày tải lên: 10/08/2014, 12:21

... e ¼ @u=@x The forces acting on the element are As and A½s þ ð@s=@xÞ dxŠ The mass inertia force is rA dxð@ u=@x2 Þ Therefore, Að@s=@xÞ dx ¼ rA dxð@ u=@x2 Þ ð96Þ In the case of elastic behavior, ... increases as well, so that higher tensile forces are needed for the continuation of extension Other specimen regions undergo additional deformation, so that the uniform elongation increases with ... is stochastically changed by adding random values to the grain node coordinates (Fig 47 ) The network determined in this manner has to be considered as a quarter of the idealized body and to be...

Ngày tải lên: 10/08/2014, 12:21

... Rights Reserved 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 Lemaitre, J.; Chaboche, J.L Mechanics of Solid Materials; Cambridge University Press: Cambridge, 1990 ABAQUS=Standard Version ... method for estimating multiaxial elastic–plastic notch stresses and strains, part Trans ASME 1985, 107, 250–2 54 Hoffmann, M.; Seeger, T.A A generalized method for estimating multiaxial elastic-plastic ... Phys IV 19 94, 4, C8- 149 –C8-170 13 Perzyna, P The constitutive equation for rate sensitive plastic material Quart Appl Math 1963, 20, 321–332 ¨ 14 Ludwik, P Uber den Einfluß der Deformationen...

Ngày tải lên: 10/08/2014, 12:21

... friction zone Therefore, the selection of titanium carbo-nitride for cermets and titanium nitride as the hard phase in Sandvik Coronites seems to be completely reasonable from the standpoint of tribological ... after and 30 of DCPM-tool operation As the wear time increases, the spectra display a somewhat increased intensity of peaks at 6.8 and 3.1 eV Peaks corresponding to plasmon losses (p1 and p2) ... DCPM tool [20,22] In this case, the nature of the phase transformation differs significantly from that found on heating a TiC standard up to 823 K for 30 Figure 14( b) and (c) presents electron...

Ngày tải lên: 10/08/2014, 12:21

... to a decrease in flank wear as soon as the running-in stage is completed, and the tool life is significantly increased (Figs and 31) Unfortunately, not every mode of the running-in phase leads ... binding energy of 44 4.8 eV Deconvolution of the spectra from the oxidized sample gave an additional peak, initially located at about 44 5.7 eV and, after a 25-min exposure, at 44 5.8 eV These higher ... increases and extensive precipitation occurs on cooling The volume of the surface layer increases on nitriding and as a result compressive residual stresses are formed This effect is typical for...

Ngày tải lên: 10/08/2014, 12:21

... 1,638 2, 041 2,553 187.0 223.5 272.7 397.2 42 0.7 44 4.8 45 7 .4 4 74. 6 717.3 988 1,303 2,1 84 2,721 3 ,40 4 210.3 251 .4 306.8 44 6.9 47 3.3 500 .4 5 14. 5 5 34. 0 806.9 1,112 1 ,46 6 2 ,45 7 3,061 3,830 262.9 3 14. 2 ... 3 .45 4. 89 8.90 14. 1 20.5 21 .4 28.1 30.3 38.1 40 .7 46 .8 52.6 59.5 73.8 85.7 0.10 0 .47 1. 14 2.01 3. 24 4.58 8. 34 13.2 19.2 20.1 26.3 28 .4 35.7 38.1 43 .9 49 .3 55.8 69.2 80 .4 0. 14 0.63 1.52 2.68 4. 32 ... Reserved M 24 Â M27 M30 M36 ( Â 4) M36 Â M36 Â M36 Â 1.5 M39 M48 M56 M 64 M80 M90 M100 3 84. 4 45 9 .4 560.6 816.7 8 64. 9 9 14. 5 940 .3 975.8 1 ,47 5 2,032 2,678 4, 490 5,5 94 6,998 52.6 62.8 76.7 111.7 118.3...

Ngày tải lên: 10/08/2014, 12:21

... 33.0 44 .9 58.6 94. 7 139.5 193.3 244 575 1,021 1,6 24 10.3 14. 0 18.8 23.9 30.1 44 .0 59.8 78.1 126.3 186.0 257.7 326 766 1,362 2,165 13.8 18.6 25.0 31.9 40 .1 58.6 79.8 1 04. 1 168 .4 248 .1 343 .6 43 5 ... 52 .4 70.5 89.6 112.9 1 64. 8 2 24. 4 292.8 47 3.5 697.7 966 .4 1,222 2,873 5,106 8,120 42 .6 57.6 77.5 98.6 1 24. 1 181.3 246 .8 322.0 520.9 767 .4 1,063 1, 345 3,160 5,616 8,932 46 .5 62.9 84. 5 107.5 135 .4 ... 3=8– 24 7=16–20 1=2–20 9=16–18 5=8–18 3 =4 16 7=8- 14 1–12 1 =4- 12 1=2–12 3 =4 12 2–8 3–8 4 6 5–6 56.6 76.6 103.0 131.0 165.0 241 .0 328.0 42 8.0 692.3 1,020 1 ,41 3 1,787 4, 200 7 ,46 5 11,871 7. 74 10.5 14. 1...

Ngày tải lên: 10/08/2014, 12:21