diagnostic prognostic and therapeutic value of gene signatures

... Academy of Medical Sciences Diagnostic and Therapeutic Problems of Pulmonary Tuberculosis in Elderly Patients To identify differences in the clinical, radiologic, and microbiologic features of pul- monary ... Chung Division of Respiratory and Critical Care Medicine, Department of Internal Medicine; Department of Radiology * , Seoul National University College of Medicine, Seoul; Department of Radiology  , ... (<64 yr) and elderly ( ≥ 65 yr), we performed a retrospective analysis of the medical charts and chest radiographs of 207 young and 119 elderly pulmonary TB patients. Hemoptysis and a febrile...

Ngày tải lên: 15/03/2014, 03:20

... central part of South-East Asia and occupies a total land area of 330,434 square kilometres. The land mass comprises three main components: Peninsular Malaysia and the two states of Sabah and Sarawak, ... overall development plans and land use decisions. • Department of Town and Country Planning (Ministry of Local Government) Controls land use patterns and pace of development as the Department ... the standards and procedures for handling the various types of domestic and industrial wastes. Stakeholders and Water Resource Management The conservation, use, and management of water...

Ngày tải lên: 06/03/2014, 15:21

... a shift of the labour supply curve, and this may tend to increase or decrease the effects of the tax rate increase on the quantity of labour supplied and the quantity of leisure demanded. ... to the economy of displacing $50 worth of private consumption and $50 worth of private investment: • the loss of $50 worth of private consumption costs $50 • the $50 worth of private investment ... estimate of the value of information. The value of information rises as: • the initial capital cost, K, rises; • the return in the low price environment, R L , falls; • the probability of a low...

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... Society and the Centers for Disease Con- trol and endorsed by the Infectious Disease Society of America. The Diagnostic Standards are intended to provide a framework for and understanding of the diagnostic ... (148–150). Genetic variability of the subjects vaccinated, the nature of the mycobacteria endemic in different parts of the world, the use of different strains of BCG for immunization, and the use of ... focus of such studies has been rifampin re- sistance because of the pivotal role of rifampin in the treat- ment of tuberculosis, the conserved nature of the genetic basis for resistance (Ͼ 96% of...

Ngày tải lên: 15/02/2014, 12:20

... control of gene expression. As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and transla- tion rate is essential for the control of the expression of ... was recovered and mixed with an equal volume of SDS buffer (0.2 m Tris, pH 7.5, 0.3 m NaCl, 25 mm EDTA, 2% SDS) and twice extracted with phenol ⁄ chloroform, once extracted with chloroform, and precipitated ... the nucleus and the cytoplasm. Genes Dev 12, 55–66. 31 Gui JF, Tronche ` re H, Chandler SD & Fu XD (1994) Purification and characterization of a kinase specific for the serine- and arginine-rich...

Ngày tải lên: 16/02/2014, 15:20

... neuron degeneration In 2001, Oosthuyse et al. [18] reported that deletion of the hypoxia-response element of the VEGF-A gene promoter and a reduction in VEGF-A expression cause the degeneration of ... form of Ras is less frequent. Gene amplification and activation of EGFR occur in more than one third of cases, the highest incidence among human tumors. Malignant glioma cells secrete a variety of ... the Ministry of Education, Culture, Sports, Science and Technology of Japan, a grant from the program ‘Research for the Future’ of the Japan Society for the Promotion of Science, and the program...

Ngày tải lên: 18/02/2014, 11:20

... Kishi 1 and Toshihiro Yasuda 2 1 Department of Legal Medicine and Medical Genetics, Gunma University, Japan 2 Division of Medical Genetics and Biochemistry, University of Fukui, Japan 3 Division of ... exon 7 of fragment C represents a dele- tion of 39 bp. The thick lines indicate intron 6 of 75 bp in fragments B and C, 3¢ portion of 35 bp in intron 5 in fragments C and D, and 3¢ portion of 25 ... PCR and quantitative real-time RT-PCR, the locations of the primers DN)105 and DN)9 used in ChIP assays, the locations of the primers DN+232 and DN+254 utilized in 5¢-RACE, and the locations of...

Ngày tải lên: 19/02/2014, 06:20

... of a novel transcriptional silencer in the protein-coding region of the human CYP2C9 gene. Gene. 209, 123–129. 59. Willis, A .E. (1999) Translational control of growth fa ctor and proto-oncogene ... Jingyue Yang 1,2 and Richard W. Gross 1,2,3,4 1 Division of Bioorganic Chemistry and Molecular Pharmacology, and Departments of 2 Medicine, 3 Chemistry and 4 Molecular Biology and Pharmacology, ... min at 50 °C and 10 m in at 95 °C, followed by a total of 40 two- temperature cycles (15 s at 95 °C and 1 min at 60 °C). For the generation o f s tandard curves, s erial dilutions of a cDNA sample...

Ngày tải lên: 19/02/2014, 16:20

... that sensitivity and specificity of Doppler US for the diagnosis of rejection was 43 and 67%, respectively, with a threshold RI of 0.90. The complex and heterogeneous nature of rejection physiopathology ... rate of volume change of a vessel as a function of pressure. A pulsating artery expanding in systole and contracting in diastole is a visual manifestation of the effect of compliance. The aim of ... circulation), REFLEX- 1 and REFLEX-2 (the activities of sympathetic nerve and vagus nerve, and heart rate), TEMP (heat generation and consumption in body temperature), EXER (control of exercise), DRUGS...

Ngày tải lên: 19/02/2014, 23:20

... with K i values of 190 n M and 160 n M for ATP and AMP, respectively. Ap5A also inhibited growth of L. donovani promastigotes in vitro (Fig. 7) with IC 50 value of 27 ± 5 l M . The effect of Ap 5 A ... 29, 24 and 12 h at temperatures of 4, 13 and 26.5 °C, respectively. Inhibition of AK by the specific inhibitor Ap5A and its effect on growth of L. donovani promastigotes in vitro The effect of the ... inhibitor of AK, competitively inhibited activity of the recombinant enzymes with estimated K i values of 190 n M and 160 n M for ATP and AMP, respectively. Ap 5 A also inhibited the growth ofL. donovani...

Ngày tải lên: 21/02/2014, 00:20