development of gi outcome measures for clinical trials and clinical management

... Acknowledgements for Advanced Computations in Engineering Science (ACES) and Department of Mechanical Engineering, for their material support to every aspect of this work v Table of contents Table of contents ... dissertation is submitted for the degree of Doctor of Philosophy in the Department of Mechanical Engineering, National University of Singapore (NUS) under the supervision of Associate Professor, Zeng Kaiyang ... equations [8-10] Therefore, the development of a robust numerical simulation tool for fracture analyses can lead to a better understanding of the influence of failure on the reliability of thin film systems...

Ngày tải lên: 10/09/2015, 08:26

... Deflection-depth profiles of drilled shaft #29 and 31 at War 48 test 184 8-15 Tension and compression strain profile of test shaft #29 of War 48 test 185 8-16 Tension and compression strain profile of test ... by Randolph (1981) through use of the FE method (FEM) Solutions presented by Randolph cover a wide range of conditions for flexible drilled shafts and the results are presented in the form of ... lateral force exerted by the shaft; N1 = normal force on joint, and R1 = tangential force on joint The principal of static limit equilibrium for the forces on the wedge can be used to solve for ultimate...

Ngày tải lên: 04/07/2016, 17:26

... guidance updates and replaces ‘Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control’ (developed by the National Collaborating Centre for Chronic ... and management of both latent and active TB, and measures for its prevention and control  indicates areas suitable for clinical audit  provides a choice of guideline versions for differing audiences ... practice and resources, and to identify areas where these did not match the clinical need This collected information through a review of the epidemiology of TB in England and Wales, and a review of...

Ngày tải lên: 22/03/2014, 18:20

... Clinical Guideline 33 Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control Ordering information You can download ... the performance of NHS organisations in meeting core and developmental standards set by the Department of Health in ‘Standards for better health’ issued in July 2004 Implementation of clinical ... documented in the contact’s clinical notes, for the attention of the contact’s consultant The contact should be given ‘Inform and advise’ information, and their GP should be informed D(GPP) 1.8.6.3...

Ngày tải lên: 31/03/2014, 13:20

... MEK1/MEK2, the MAPKKs MKK4 and MKK7 phosphorylate and activate the c-Jun N-terminal kinase (JNK) isoforms, MKK3 and MKK6 phosphorylate and activate the p38 isoforms, and MEK5 selectively activates ... The strategic position of MEK1 and MEK2 in the Ras-dependent ERK1/2 pathway in conjunction with a promising pre -clinical profile have provided strong rationale for the development of smallmolecule ... mutated in ~20% of all cancers and in more than 40% of melanomas [57] The majority of these mutations are clustered in the kinase domain of B-Raf and lead to the stimulation of ERK1/2 activity...

Ngày tải lên: 10/08/2014, 22:20

... measurement of the impact of interventions on these health outcomes is fundamental to advancing clinical practice and research The current use of patient-oriented outcome measures in research and practice ... Jones G, Gianopoulos I: The use of outcome measures to formulate intervention strategies Ear Hear 2000, 21:15S-23S Thomas J, Miller P, Silaj A, King ML: Application of physiotherapy outcome measures ... quality of care, evaluation of how clinicians use new information to make decisions is critical Simple measures of the use of concrete behaviors – prescription practices or completion of outcome...

Ngày tải lên: 11/08/2014, 05:22

... incubation for days in medium containing a concentration of G418 (Invitrogen) of 400 lgÆmL)1 G418-resistant colonies were picked and expanded for PCR genotyping and the formation of embryoid ... and maintenance of murine endothelial cells from various developmental stages and locations is important for dissecting molecular and cellular mechanisms of endothelial development and function ... specialized techniques and expertise that are required for immunological isolation of ECs [23,24] to prevent proliferation of tsA58T Ag-expressing non-ECs Results and Discussion Generation of a transgenic...

Ngày tải lên: 18/02/2014, 17:20

... period of 1961-1990 and results are given as array files on a standard 2.5x2.5 degree latitude/longitude grid The first step to use the software is to select a pair of emissions scenarios: with and ... of observed data, predictands, time and areas for predicting SCENGEN converts changes of regional model into exact values of selected climate variables It means that SCENGEN can replace a regional ... resolution of 2.5x2.5 degree latitude/longitude for all emission scenarios instead of 5x5 degree latitude/longitude IPCC recommends that MAGICC/SCENGEN software can be used as a useful tool for nations...

Ngày tải lên: 05/03/2014, 16:20

... handy and useful in viewing, checking and presenting input data and the output meshes The software package has been initially used as a tool for 3D structured mesh generation for simulations of ... parametric space [1, 2, 5, 6] For short, the formulae for Y and Z coordinates are the same and they are not written here In this method, to control the density of the distribution of the mesh points, an ... input topographical elevation data of the top (upper) surface of any 3D objects in the form of digitized contour lines Once the input file has been read, the software will show the contour map...

Ngày tải lên: 14/03/2014, 13:20

... targeted financial support for technical development and production of appliances, and for infrastructure for marketing and transport may be justified For example in the case of the improved stoves ... of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures 6.4 Estimates of Costs The estimation of costs for scaling up and ... indicators and systems for data collection at national level and for poor rural and urban communities where the need for information and action is greatest | 15 Addressing the Impact of Household...

Ngày tải lên: 15/03/2014, 16:20

... the work and wrote the manuscript Acknowledgements This study was funded by the National Institute of Biomedical Imaging and Bioengineering, and the Clinical Center Radiology and Imaging Sciences ... STEM)[73,74,88], and the sizes of Gd-G7 and Gd-G8 dendrimer particles are large enough for estimation of particle diameters, which are approximately 11 nm for Gd-G7 dendrimers and approximately 13 nm for ... imaging of intracranial metastases: Effect of dose on lesion detection and delineation Journal of Magnetic Resonance Imaging 2001, 14:525 Levin VA, Landahl HD, Freeman Dove MA: The application of...

Ngày tải lên: 18/06/2014, 15:20

... design of the study, data analysis and interpretation of results, and drafted the manuscript LS participated in the design of the study and interpretation of results, and suggested edits and revisions ... when – because of timing, lack of foresight or cost considerations – only descriptive (rather than preference-based) measures of quality of life are available and some other means of obtaining ... clinical trials into the common metric of QALYs While this constitutes a second best approach, it represents an Page of 19 (page number not for citation purposes) Health and Quality of Life Outcomes...

Ngày tải lên: 18/06/2014, 18:20

... -125°/s (e and f), and -200°/s (g and h) jects of force-time integrals of -25°/s (a and b), -75°/s (c and d, f, and h) of experimental versus predicted forces for six subPlots at Plots of force-time ... c, e, and g) and peak forces (b, d, f, and h) of experimental versus predicted forces for six subjects at shortening velocities of -25°/s (a and b), -75°/s (c and d), -125°/s (e and f), and -200°/s ... used for model development and validation Overview of the distribution of subjects used for model development and validation See text for details about the characteristics of the parameterizing and...

Ngày tải lên: 19/06/2014, 08:20

... Cite this article as: Giesinger et al.: Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients Health and Quality of Life Outcomes 2011 9:19 ... implementation of CAT into clinical routine and trials requires adequate software solutions for item administration Such software packages have to include as a minimum, a CAT algorithm for item selection, ... coverage of fatigue In addition, the use of a specific item format (EORTC item style) Giesinger et al Health and Quality of Life Outcomes 2011, 9:19 http://www.hqlo.com/content/9/1/19 Page of 10...

Ngày tải lên: 20/06/2014, 15:20

... distortion level, the radius of curvature of outlet size of distorted region tends to be increased whatever the inlet size of distorted region is 92 Chapter A Development of Novel Integral Method ... outlet size of distorted region vs θ with smaller inlet size of distorted region of 0.1 4.3 Results and Discussion 93 When inlet flow angle is very small, the outlet size of distorted region will ... size of distorted region vs α ( ) with smaller inlet size of distorted region of 0.1 To ease in comparing the results between different inlet sizes of distorted region, we define the level of distortion...

Ngày tải lên: 21/06/2014, 21:20

... Education of farmers to allow better understanding of the benefits of diagnostic technologies Development of cell culture capability for virus propagation, isolation from field samples and for serology ... and the testing of sera in each laboratory was discussed Training of staf at RAHCHCMC in the use of molecular techniques for the detection of FMD and the sequencing of FMD isolates Training of ... capability for FMDV diagnosis and serology Control strategies for understanding of FMD epidemiology have been implemented through veterinary and laboratory training workshops and laboratory testing for...

Ngày tải lên: 22/06/2014, 12:20

... effectiveness of border control and origin of circulating FMDV Improved diagnostic capacity for FMD allows for the early detection and identification of disease enabling better control of disease and helps ... reason for vaccine failures Regional laboratories were set up with the reagents and methods to allow a diagnostic capability for FMDV diagnosis and serology Control strategies for understanding of ... to operate as regional laboratories Protocol manuals for submission and handling of samples and provision of feedback of results Laboratory Quality Control procedures documented and tested Internal...

Ngày tải lên: 22/06/2014, 12:20

... effectiveness of border control and origin of circulating FMDV Improved diagnostic capacity for FMD allows for the early detection and identification of disease enabling better control of disease and helps ... vaccine failures Regional laboratories were set up with the reagents and methods to allow a diagnostic capability for FMDV diagnosis and serology Control strategies for understanding of FMD epidemiology ... capacity for FMD (and other disease) surveillance and diagnosis at both a laboratory and field level, and to investigate the serotypes of FMDV circulating in Vietnam and the reason for vaccine...

Ngày tải lên: 22/06/2014, 12:20

... Australia and internationally and recognition of the achievements made in relation to the understanding and control of FMD in Vietnam FMD is a disease of importance in Vietnam and of strategic significance ... outbreaks of AI and PRRSV Nevertheless, the management and implementation of highly effective measures for the diagnosis and control of FMD was particularly successful in the south of Vietnam ... establishment of an effective laboratory network for the diagnosis and control of FMD will provide a greater understanding of FMD epidemiology and will facilitate the coordination and implementation of...

Ngày tải lên: 22/06/2014, 12:20

... Education of farmers to allow better understanding of the benefits of diagnostic technologies Development of cell culture capability for virus propagation, isolation from field samples and for serology ... capability for FMDV diagnosis and serology Control strategies for understanding of FMD epidemiology have been implemented through veterinary and laboratory training workshops and laboratory testing for ... Objectives of the project: To establish an effective laboratory network for the diagnosis and control of FMD by the provision of resources and training of staff in required methods and quality...

Ngày tải lên: 22/06/2014, 12:20