... Design of the Study The paper is designed in four chapters Chapter one: The introduction – presents the rationale of the study, the aims of the study, scope of the study, methods of the study, ... Chapter three: The analysis of the text “Torquay?, but I said Turkey!” is aimed at the meanings and structures of the text The last chapter: The conclusion – summarizes the results of the study ... called Theme and Rheme The Theme “served as the point of departure of the message” (Halliday 1994:37), which in English coincides with the initial element(s) of the clause; and the Rheme is the
Ngày tải lên: 07/09/2013, 13:48
... the (door) the (ladder) the (planet) the (woman) her (arm) It she the (man) we the (air) It them their they the (plants) they they their the (man) the (controls) he I the ... describing the state of being of the things under the observation of the astronauts in the new planet. Most of the processes are in the simple past tense (25/36). They are used in the narrative ... 36 The spaceship The planet They There The spaceship The two astronauts The woman It She We It Both of them They All plants and Animals They They Everything The man
Ngày tải lên: 12/02/2014, 20:20
Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... (Leu104–Pro111) Indicative of the tightness of the fit, there are a large number (30) of atom-to-atom van der Waals’ contacts between the Tyr205 side chain and importin-a (Table 2) The numbers of contacts are ... competes for the importin-a binding site, reducing binding affinity for cargo proteins and helping to facilitate the release of the cargo within the nucleus [10,11] The removal of the autoinhibitory ... its location with the hydroxyl group reaching the importin-a main chain near the C-terminus of the ARM1 H3 helix Most of the hydrophobic contacts with importin-a residues lining the P4 pocket are
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Đề tài " The causal structure of microlocalized rough Einstein metrics " pptx
... take the use of the spe- cial structure of the Einstein equations one step further by deriving unexpected regularity properties of optical functions which are essential in the proof of the Main Theorem. ... for the proof of Theorem 2.5. In Section 4 we obtain some crucial properties of the components of the Riemann curvature tensor R αβγδ . The remaining sections are occupied with the proof of the ... derivatives of the traceless part of χ. A similar observation holds for another null component of the Hessian of the optical function, η. The role of the Raychaudhuri equation is taken by the transport
Ngày tải lên: 16/02/2014, 05:20
Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc
... molecules of the asymmetric unit of the wild-type structure Neither the mutation nor the different crystallization conditions evoked structural differences The crystal was grown in the presence of phytate, ... out of the catalytic pocket upon phytate binding Here, PhyK mimics the phytate-bound structure of AppA, even in the absence of sulfate ions The side chain of the corresponding Glu212 bends out of ... is the only direct contact between the protein backbone and the substrate The side chain of Thr292 is found to recognize the 2-phosphate in both the binding model of PhyK and the crystal structure
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... mecha- nism of transphosphorylation, which implies the A B Fig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-site residues of the 20 conformers of the solu- tion structure ... electrostatically with the other charged groups. In the NMR structures, this side chain of D40 is a short distance (£ 3A ˚ ) from the side chains of H42 and R95. Finally, the aromatic ring of F126, placed ... second- ary structure elements. As in other ribotoxins, these A B C Fig. 2. Representation of the 3D structure of HtA in solution. (A) Superposition of the 20 best structures obtained in this work (PDB
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Unusual metal specificity and structure of the group I ribozyme fromChlamydomonas reinhardtii23S rRNA pptx
... Mn2+ Because of these and other properties of Cr.LSU, the tertiary structure of the intron from 23S.5DGb was examined using Fe2+-EDTA cleavage The ground-state structure shows evidence of an unusually ... whereas binding of a minimum of m Mn2+ ions forms the inactive complex The sizes of the active and inactive fractions are the result of competitive metal binding to RNA The values of n and m are ... The Cr.LSU pattern is distinct in that the first three nucleotides of P7, and the 3¢-half of J8 ⁄ 7, are not protected The first three nucleotides of P7 are part of the G binding site, as are the
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx
... arrangement, and the side chain of Ser97 in VPRK is too short One side of the loop is involved in the binding of the P2–P4 residues of a substrate The other side of the loop is close to Arg94 (Lys ... a residue forming a part of the S2 site of the enzyme The disulfide bridge restricts the flexibility of a tight loop which is part of the S2 site The tight loop is further stabilized by a tight ... the carbonyl oxygen atom of the scissile bond in other subtilase–inhibitor complexes (data not shown) The Ca positions of the tripeptide occupy almost the same positions as the Ca positions of
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework of the enzyme or the active site. The active sites of the enzymes are shown in stick format with the sigmaA ... (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive conformation. Rescue of the unreactive conformation involves ... re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT. (C) As for panel B except the spectral changes are recorded over an extended time period and show degradation of the hydride-Meisenheimer
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: "Untangling the Cross-Lingual Link Structure of Wikipedia" pptx
... because the dis- tances in this extended graph are based on the so- lution of the LP. The properties of this algorithm are given by the following two theorems (proofs in Appendix A). Theorem 2. The ... (2) The first summand accounts for the edges en- tirely within the region, and the second one ac- counts for the edges in C(v, r) to the extent that they are within the radius. The definition of ... v ) otherwise, where P(u, v, E ) denotes the set of acyclic paths between two nodes in E . We further fix ˆc f = (u,v)∈E d(u, v) w(e) as the weight of the fractional solution of the LP (ˆc f is
Ngày tải lên: 20/02/2014, 04:20
Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... However, the packing of the two dimers in the tetramer is different from that of the PDCs of known structure, best described as a 20° rotation of one dimer towards the other when compared to the Z. ... on the other hand involving the C-terminal part of the polypeptide chain (Fig. 7). In the latter, differences in the conformation of the loop between Fig. 6. Stereo picture of the model of the a-carbanion/enamine ... catalytic residues The active site cavity in IPDC extends from the thiazolium ring of the cofactor to the surface of the protein. The entrance of the active site cleft is covered by the C-terminal helix
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... superimposed on the X-ray structure (dark blue colour) and (B) structure alignment of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII Residue ... sequence and structure alignment Residue number range in the X-ray structure of AII Fig (A) Sequence alignment of the fragment 4–7 of the backbone of the 13 ensemble solution structures of AII (brown ... alignment of the two structures by using the program Profit1.8 Remarkably, the superposition of the solution state and the bound structure of AII exhibits small RMSD positional differences between the
Ngày tải lên: 20/02/2014, 23:20
Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
... was used to back calculate the NOESY cross-peaks from the calculated structure to assess the quality of the structure. The final family was made up of 30 structures with the lowest target function. ... A ˚ , respectively, for the backbone of the two subunits. The difference between rmsd of monomeric and dimeric species is due to the indetermination of the reciprocal orientation of the two subunits. The average ... also similar t o the solution structure of the monomeric mutants with the exception of the s ignificantly better definition of the first part (49–63) of loop IV, which is disordered in the monomers
Ngày tải lên: 21/02/2014, 03:20
Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
... the overall structure is shown in Fig 3A The enzyme exists as a dimer of the abc heterotrimer There is a noncrystallographic twofold axis around the center of Fig 3A The structure of an abc heterotrimer ... of the a subunit The substrate propane-1,2diol and essential cofactor K+ are bound inside the (b/a)8 barrel above the corrin ring of cobalamin K+ is heptacoordinated by the two hydroxyls of the ... irradiation [59] Therefore, we believe that the structure reported in this paper is also that of the glycerol dehydratascob(II)alamin complex The dihedral angle of the northern and southern least-squares
Ngày tải lên: 21/02/2014, 03:20
Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... established. Of two possible dimeric structures of LPL, the head-to- head and the head-to-tail models, the studies of the chimeric proteins of hepatic lipase and LPL and the tandem repeat approach of LPL ... modeling of the dimeric structure of LPL. Two dimeric model structures of LPL were constructed using INSIGHT II version 2000 on a Silicon Graphics workstation. The model structure of the closed ... on the crystal structures of the human, porcine, and horse PLs (Fig. 1). A frontal view illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the
Ngày tải lên: 21/02/2014, 15:20
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... for the N structure The G and TG structures were solved using the N structure as a search model, and the TG structure was used in phasing of the T structure The structures were refined using the ... typically increased the free R values by 0.1% Although the R and free R values of the four structures were in the range of the values of the published structures, those of the N and G structures were ... in the G and TG structures The electron density of l-glutamate became more pronounced upon the addition of Tris The location and orientation of l-glutamate were determined on the basis of the
Ngày tải lên: 06/03/2014, 09:22
Tài liệu High-level Expert Group on reforming the structure of the EU banking sector docx
... to the intensification of the sovereign debt crisis in the euro area. The pricing of risk in the repo market has become more dependent on the geographic origin of both the counterparty and the ... maintaining the integrity of the single market. Finally, Chapter 5 draws together the analysis of the previous chapters. It reiterates the importance of banks in the EU economy, summarises the key ... mandate, the Group also expects the on-going fundamental review of the trading book by the Basel Committee to improve the control of market risk within the banking system. The Group sees the Commission's...
Ngày tải lên: 16/02/2014, 10:20
The transformation of the American class structure, 1960-1990
... to the expansion of the expert-manager category. These trends of intensi®ed proletarianization in the labor process generate the prediction of an expansion of the working class, an expansion of ... faced with the problem of extracting labor effort from workers. In the arsenal of strategies of social control available to the capitalist class, one of the key weapons is the degradation of work, ... uniquely attributed either to changes within sectors or to changes in the sectoral composition of the labor force. Rather, they result from the interaction of these two forces. This contribution to the overall...
Ngày tải lên: 01/11/2013, 07:20
the structure of central banking and the bank of canada
... 1 Chapter 15 The Structure of Central Banking and the Bank of Canada Copyright 2011 Pearson Canada Inc. 15 - 4 Formal Structure of the Bank of Canada I • Responsibility for the operation of the ... operated by the CPA • acts as the holder of deposit accounts of the federal government, the directly clearing members of the CPA, international organizations such as the IMF, and other central ... with a Board of Directors, which consists of fifteen members: • the governor (currently Mark Carney, who is the chief executive officer and chairman of the Board of Directors) • the senior deputy...
Ngày tải lên: 05/01/2014, 16:57
Tài liệu Gravitational Physics: Exploring the Structure of Space and Time pdf
... as the circular structure in the lower half of the dewar. The rest of the internal components are structures for cooling the bar to 4.2 K, for bringing out the signal from the transducer on the ... properties of the geometry of space in the vicinity of black holes that are predicted by general relativity. • The measurement of the dragging of inertial frames due to the rotation of Earth at the ... some of the important achievements of the past decade illustrates this point: • The confirmation of the existence of gravitational waves by the observed shortening of the orbital period of a...
Ngày tải lên: 12/02/2014, 16:20
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