degradable polymeric carriers for parenteral controlled drug delivery
Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery
Ngày tải lên :
12/09/2015, 08:20
... physiology of normal and tumor tissues can be used for designing drug delivery systems facilitating tumor-specific delivery of the drug or prodrug and specific drug activation (1) Enhanced permeability ... drug loading content, drug release etc.) are important for controlled release and targeting applications Results obtained from this study can be useful for the design of micellar system for controlled ... Chapter the quality of life for patients Therefore, scientists focus on the research of drug delivery systems (DDS) to decrease the side effects The design of an effective drug delivery system must...
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Development of multi functionalized polymeric carriers for delivery of anticancer drug combinations
Ngày tải lên :
10/09/2015, 09:06
... Therefore, many researches are still on going to further optimize the more suitable polymeric micelles for drug delivery system Table 2.5 Drug- loaded polymeric micellar formulations Carrier* Drug ... characterization of drug- loaded polymeric micelles 81 4.3.3 In vitro drug release and drug loading of singe drug- loaded micelles 82 4.3.4 In vitro drug release and drug loading of dual drug- loaded ... multifunctional polymeric carriers for active drug delivery [24] 29 Figure 2.11 Schematic of a passive targeted drug delivery system [31] 30 XIV Figure 2.12 Active drug targeting...
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Development of controlled drug delivery systems using uniform nanoporous materials as matrices
Ngày tải lên :
13/09/2015, 19:46
... of the drug delivery system (See Figure 2.5b) a Drug Drug Drug- loaded biodegradable particles b Drug Drug Drug- loaded biodegradable particles Figure 2.5 The polymer degrades to release drug molecules ... application of polyesters as drug carriers Polyorthoesters The motivation for designing polyorthoesters for drug delivery was the need to develop biodegradable polymers that inhibited drug release by diffusion ... to small molecular drug IBU, the fabrication of controlled drug delivery system for large protein model drug BSA is more complicated, as it involves not only the properties of drug matrix itself...
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Stimuli responsive PEGylated nano assemblies for cancer targeted drug delivery
Ngày tải lên :
19/05/2016, 10:45
... micelles and drug throughout the tumor tissue.41 6.2 Previous studies of stimuli-response for controlled drug delivery These stimuli-responsive polymeric nanocarriers have demonstrated improved drug ... that are introduced by using nanocarriers for drug delivery are beyond that posed by conventional hazards imposed by chemicals in classical delivery matrices For nanocarriers the knowledge on particle ... a delivery vehicle design that was described as the basic anatomy of a drug delivery vehicle Self-assembled nanocarrier for drug delivery Nanoparticles are now available that are attractive for...
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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx
Ngày tải lên :
11/08/2014, 00:22
... nanotechnology–implications for drug targeting and gene therapy Trends Biotechnol 1997, 15:217-224 11 Panyam J, Labhasetwar V: Biodegradable nanoparticles for drug and gene delivery to cells and tissue Adv Drug Deliv ... 1999, 103:309-312 29 Rytting E, Nguyen J, Wang X, Kissel T: Biodegradable polymeric nanocarriers for pulmonary drug delivery Expert Opin Drug Deliv 2008, 5:629-639 30 Yang W, Peters JI, Williams RO: ... protein-processing machinery (proteostasis) The nano -drug delivery system used here provides a feasible alternative for controlled and sustained PS-341 delivery to lungs for selective inhibition of proteostasis...
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Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers
Ngày tải lên :
02/09/2015, 13:31
... of drugs applied MA Spray-drying to overcome biopharmaceutical D 5.1 Production of pure drug particles TE 5.2 Production of drug- loaded polymeric carriers AC CE P 5.2.1 Prolonged and targeted drug ... MANUSCRIPT Advantages and challenges of the spray-drying technology for the PT production of pure drug particles and drug- loaded polymeric carriers SC RI Alejandro Sosnik1* and Katia P Seremeta2,3,4 ... MA to produce pure drug particles [39] Table summarizes the main advantages of spraydrying over conventional methods for the production of pure drug particles and D polymeric carriers A remarkable...
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Controlled release alginate based microparticulate systems for drug delivery and chemoembolization
Ngày tải lên :
13/09/2015, 20:39
... time -controlled and/or target -controlled 22 INTRODUCTION delivery of drug In time -controlled delivery, the drug is released in a pre-determined rate while in target -controlled delivery, the drug is delivered ... frequency of drug administration C1 Concepts of controlled release Controlled drug delivery is an attempt to control the drug availability at the target site This is achieved by time -controlled ... The successful formulation of a stable and effective dosage form therefore depends on the careful selection of excipients The use of polymers in the formulation of controlled drug delivery systems...
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Design of functional polymeric micelles as a carrier for anticancer drug delivery
Ngày tải lên :
30/09/2015, 06:07
... micellar structures for drug delivery Besides the benefits conferred by using polymeric micelles as drug delivery carriers, there are disadvantages in utilizing such systems Firstly, the polymeric micelle ... opportunities for further innovation of drug delivery systems Figure 1.1: Timeline of nanotechnology-based drug delivery Reproduced from [13] with permission The nanoscale feature of these drug delivery ... on drug delivery systems Drug delivery is defined as the system to dispense a pharmaceutically active compound in the body to attain a therapeutic effect In an extension of free drugs, drug delivery...
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Evaluation of advanced paclitaxel drug delivery implants for controlled release post surgical treatment against glioblastoma multiforme in the brain
Ngày tải lên :
05/10/2015, 21:33
... vehicle for deep penetration into the tissue before releasing them in the free form for tissue binding Another alternative would be for molecular modification of paclitaxel based on a pro -drug concept ... been working on controlled release for other drugs such as doxorubicin [1] and paclitaxel 2.2 Paclitaxel Paclitaxel (see Figure A for chemical structure), a chemotherapeutic drug originating ... on ice for 10 minutes before adding 50 µl of 2x Reaction Buffer (containing 10 mM DTT) to each sample µl of the mM DEVD-AFC substrate were then added before incubating at 37oC for hours before...
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A study on the ph temperature sensitive biodegradable hydrogels for controlled protein and drug delivery
Ngày tải lên :
13/05/2016, 10:14
... OSM-PCLA-PEG-PCLA-OSM 1.2.2 Controlled drug/ protein delivery 1.2.2.1 Controlled drug/ protein delivery In past few years, controlled drug/ protein release to treatment for dangerous diseases such ... since 1980s [3-7] for controlled drug/ protein delivery For examples, microspheres made of poly(methacrylic acid)poly(ethylene glycol) [8] were studied and used as a nasal drug delivery system to ... block copolymer hydrogels 1.2.2 Controlled drug/ protein delivery .8 1.2.2.1 Controlled drug/ protein delivery .8 1.2.2.2 Drug/ protein release mechanisms ...
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nanoparticle technology for drug delivery, 2006, p.427
Ngày tải lên :
04/06/2014, 15:15
... purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, ... Clark 148 Polymeric Drug Delivery Systems, edited by Glen S Kwon 149 Injectable Dispersed Systems: Formulation, Processing, and Performance, edited by Diane J Burgess 150 Laboratory Auditing for Quality ... edited by Simon Benita 159 Nanoparticle Technology for Drug Delivery, edited by Ram B Gupta and Uday B Kompella Nanoparticle Technology for Drug Delivery edited by Ram B Gupta Auburn University...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
Ngày tải lên :
20/06/2014, 22:20
... photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro ... suitable candidates for a nanoparticle-based drug delivery system to improve their pharmacological performance For this purpose, a “longboat delivery system” has been prepared for the platinum warhead ... system provided the first instance for nanocarriers to deliver drugs into neurons in the central nervous system, opening the door for the drug delivery system for the treatment of the tumors in...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
Ngày tải lên :
21/06/2014, 02:20
... observed for CuCNPs containing 3, or wt.% Cu Discussion Synthesis and characterization of Cu-loaded polymeric nanoparticles A prototypical approach for sequestering and releasing metal ions from a delivery ... targeted drug delivery, such as PLGA, chitosan, or dextran Thus, the metal/ligand chemistry is readily adaptable to, and independent from, the desired polymeric material used as the delivery ... nanoparticles for therapeutic applications Nat Rev Drug Discov 2010, 9:615-627 Davis ME, Chen Z, Shin DM: Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug Discov...
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Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc
Ngày tải lên :
21/06/2014, 03:20
... the drug In order to overcome these limitations, a suitable formulation was needed to maximize the potential of DCU in vivo Several formulations strategies for SC dose have been assessed Formulations ... discovery: the potential impact of formulation on pharmacokinetic parameters Curr Op Drug Discov Devel 2002, 5(1):59-71 17 Barrett R: Nanosuspensions in drug delivery Nat Rev Drug Discov 2004, 3:785-796 ... formulation can provide for orally dosed DCU is not well understood [14] In order to understand the degree of improvement provided by an oral nanosuspension formulation, simulations were performed...
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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx
Ngày tải lên :
22/06/2014, 00:20
... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, ... be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building ... this article, the authors demonstrated that a thin polymeric film-based drug delivery system can be combined to a CNT array and efficiently exploited for biomedical applications The system proposed...
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Báo cáo hóa học: "Single-component Polymer Nanocapsules for Drug Delivery Application" docx
Ngày tải lên :
22/06/2014, 01:20
... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death Bansal notes that it is highly desirable for antitumor applications, that the size of the delivery vehicle ... attachment of targeting ligands to the drug- conjugated capsules through established coupling protocols will further provide functional capsules for targeted drug delivery applications 267 Overall,...
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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps
Ngày tải lên :
09/08/2014, 06:22
... for investigating in vitro binding and internalization contained 0.1 mol% Texas red-phosphatidylethanolamine (Molecular Probes Europe) Liposomes used for studying drug delivery in vitro and for ... Diego, California, USA) For statistical analysis of CD134 expression in vivo and liposomal drug delivery in vitro, a one-way analysis of variance with Dunnett's post-hoc test was used For analysis ... internalization determined the strategy of drug delivery We here employed the mechanism of lipid-coupled drug transfer between membranes to achieve intracellular drug delivery When anti-CD134 liposomes...
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Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc
Ngày tải lên :
09/08/2014, 14:20
... retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a delivery modalities Thus, our aim was to use biodegradable ... per group, Page of 10 (page number not for citation purposes) was necessary for at least two reasons First, there was a need to perform these control tests for the correct evaluation of the action ... Coencapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intraarticular delivery J Microencapsul 2008, 25:339-350 El Hakim IE, Abdel-Hamid...
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Drug delivery systems for antiangiogenesis and anticancer activities
Ngày tải lên :
11/09/2015, 09:58
... Integrin targeted drug and gene delivery Expert opinion on drug delivery 2010; 7(2), 159-171 Wang Z., Chui WK Ho PC Nanoparticulate delivery system targeted to tumor neovasculature for combined anticancer ... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... Antiangiogenesis inhibitors 10 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 15 1.3.1 Conjugation of drug with ligand for vascular targeting 15 1.3.2...
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Application of HCRSV protein cage for anticancer drug delivery
Ngày tải lên :
11/09/2015, 14:22
... 1.2 Targeted delivery systems 1.2.1 Rationale 1.2.2 Targeting strategies 1.3 Nano-scale drug delivery systems 10 1.3.1 Rationale 10 1.3.2 Classification 11 1.4 Virus-based drug delivery systems ... could be reassembled in vitro into uniformly sized and precisely structured virus-like protein cages (PC) The PC could be an attractive platform for drug delivery as its cavity could serve as ... anticancer drug delivery systems The hypothesis for this project was that PC derived from the Hibiscus Chlorotic Ringspot virus (HCRSV) could be developed into a targeting anticancer drug delivery...
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