d its metabolites and clinically relevant analogs

... out the study conception and design, drafted the manuscript, and performed treatment planning PD carried out the study conception and design and drafted the manuscript MBP performed treatment ... TMB and SB performed physics checks/plan evaluation Patient accrual and radiation field design were performed by CHC, MED, SK, and PD CHC provided mentorship for this work All authors read and ... dose of X Gy Maximum dose was expressed as D1 %, minimum dose as D9 9%, mean dose as Dmean, and maximum point dose as Dmax The homogeneity index (HI) and conformality index (CI) were calculated...

Ngày tải lên: 09/08/2014, 09:20

... processes (outlined on the next slide) completely altered the atmosphere, enabling plants and animals to leave the oceans, and survive and evolve on land ♦ Between 450 million years ago and 350 million ... humankind emerged☻ as the dominant species and a number of “advanced” civilizations developed (and, in some cases, disappeared) ♦ Agriculture and the domestication of animals for human consumption, ... dangerous solar ultraviolet radiation ♦ Unfortunately, the ozone layer is being threatened by our development and use of CFCs (as discussed in the next slide) ♦ On the other hand, low altitude...

Ngày tải lên: 04/04/2013, 10:51

... the credit assigns a misplaced weight to studies that looked at a period before the credit had reached maturity and is overly dismissive of studies that covered later periods and provided careful ... R &D tax credit Corporate R &D tax credits and R &D spending by industry group, 2005 ($ millions) NAICS codes Corporate R &D tax credit claims % of total Total R &D expense Credit as % of R &D spending ... Corporate R &D Tax Credit and U.S Innovation and Competitiveness The tax expenditure for the deduction of R &D expenses is the difference between the actual amount of the deduction and the estimated “baseline”...

Ngày tải lên: 16/02/2014, 03:20

... of 5· SDS-sample buffer and samples separated by SDS ⁄ PAGE, transferred to membrane, dried and exposed to film at )80 °C Following autoradiography membranes were blocked and immunoblotted as necessary ... cDNA or with HA-PPIA or flag-CrmA-DQMD cDNAs into 293T cells as indicated Two days after transfection the cells were washed and lysed Immune complexes and total cell lysates were separated on denaturing ... Mst2 cDNAs into 293T cells as indicated Two days after transfection total cell lysates were prepared and separated by SDS ⁄ PAGE, transferred and sequentially immunoblotted as indicated on the...

Ngày tải lên: 19/02/2014, 06:20

... well drained, and provided with bridges and good roads, think of the risk and hardships undergone by the first explorers of a new land, however great its capabilities, and whatever may be its ... brought forward, and placed in the midst of the armed body of men; then each youth was made to sit down, holding his head downwards, with his hands clasped, and his legs crossed under him, in which ... round upon their hands and feet, in imitation of the dogs of that country, and throwing upon the boys, as they passed, sand and dirt with their hands and feet The youths were perfectly still and...

Ngày tải lên: 20/02/2014, 08:20

... halves Middle: cartoon representation of the D5 3P mutant with a shorter D- strand and an extended and protruding CD loop Right: monomeric wild-type b2m displays a regular D- strand Residues 53 and 56 ... predicted by Debelouchina et al [19] b-strands C, D and E are labeled as ssC, ssD, and ssE, respectively The CD and DE loops are marked as lCD and lDE; B, b-bulge Residue 53 is marked as X (C) ... conformation, are held to resemble the b2m amyloidogenic intermediate [12,29], present different conformations of the D- strand: a regular D- strand (in the P32A mutant) [12] and a bulged D- strand (in the...

Ngày tải lên: 06/03/2014, 00:20

... amide-bound acyl residues in M huakuii lipid A The 2,3-diacylamido-2,3-dideoxyglucose, obtained by mild solvolysis [35] followed by mild hydrolysis of the dephosphorylated lipid A, was reduced ... species Crude lipid A was purified and separated into subfractions according to a modified procedure described by Que and coworkers [9] Briefly, lyophilized lipid A ( 30 mg) was dissolved in 20 mL of ... A and lipid A–P were dissolved in a mixture of dimethylsulfoxide (DMSO -d6 ) and chloroform (CDCl3) for NMR experiments Figure shows the one+P dimentional proton spectrum of de-O-acylated lipids...

Ngày tải lên: 07/03/2014, 15:20

... that possessed them greater reproductive fitness than undefended plants had Thus the defended plants left more descendants than undefended plants, and they passed their defensive traits on to the ... compounds formed by the reduction of molecular oxygen, including the superoxide anion (O2• –), hydrogen peroxide (H2O2) and the hydroxyl radical (•OH) An NADPH-dependent oxidase located on the ... acid bases adenine and guanine The pyrrolidine (five-membered) ring of nicotine arises from ornithine; the pyridine (six-membered) ring is derived from nicotinic acid Secondary Metabolites and...

Ngày tải lên: 07/03/2014, 20:20

... the dreary Hades!" And placed beneath a delightful climate, and endowed with a vivacious and cheerful temperament, they yielded readily to the precept Their religion was eminently glad and joyous; ... dawned, and they found themselves abandoned by their associates and surrounded by the foe, they fled to the Areopagus and the altars of the Furies; the refuge was deemed inviolable, and the Dorians ... states and colonies perhaps equally civilized) in the midst of enlightened despotisms; and in the ancient world, despotism invented and sheltered the arts which liberty refined and perfected [99]:...

Ngày tải lên: 08/03/2014, 12:20

... agriculture, healthcare and industry, ex-situ and in-situ gene banks for crops and endangered medicinal and aromatic plants, medium and high throughput screening facilities for drugs and pharmaceuticals, ... biotechnology and geneticallymodified seeds and food 70 See 2.2 Indian scientific and technological research system 71 N K Kumar et al., “Indian biotechnology –rapidly evolving and industry led”, Nature ... provided, the information regarding chemistry manufacturing control, the nonclinical data, and the proposed phases I and II studies Regarding the nonclinical data and the phases I and II studies,...

Ngày tải lên: 13/03/2014, 21:49

... to gold Modern acupuncture needles are made of surgical steel and are very fine and flexible; four of them could fit inside a typical hypodermic needle They are sterile and disposable, intended for ... boldenone undecyclenate (Equipoise) nandrolone decanoate (Deca-Durabolin) nandrolone phenpropianate (Durabolin) testosterone cypionate (Depo-Testosterone) androstenedione (“Andro”) creatine dehydroepiandrosterone ... collectively The androgen in greatest abundance in a man’s body is TESTOSTERONE The testes and, to lesser extent, the adrenal glands produce androgens Androgens initiate and maintain male secondary sex...

Ngày tải lên: 14/03/2014, 23:20

... either double-stranded DNA or transiently singlestranded DNA target sites, and that priming may include random nonspecific opposite-strand nicks, a nascent leading strand or de novo initiation of cDNA ... GE Healthcare) and 100 units of T4 polynucleotide kinase (New England Biolabs Inc., Ipswich, MA, USA) The double-stranded DNA substrates (dsDNA70) used in top-strand cleavage and reverse splicing ... recipient plasmid containing the intron DNA target (2017 bp) and an extra band when the recipient plasmid has been invaded (3901 bp) Single- and double-stranded DNA cleavage assays DNA cleavage...

Ngày tải lên: 15/03/2014, 09:20

... and eternal Being, whose attributes by modification take the innumerable shapes of sun, moon, and stars, and mountains and river, and tree and flower, and bird and beast, and man And the winds ... true sense of the word— and saints, for both are represented by Kepler and Hooker, Newton and Jeremy Taylor, Descartes and Spinoza, Leibnitz and Wesley, Spencer and Newman And even these have authority ... Political Ideals; Capitalism and the Wage System; Pitfalls in Socialism; Individual Liberty and Public Control; National Independence and Internationalism Bertrand Russell Mysticism and Logic and Other...

Ngày tải lên: 15/03/2014, 12:20

... purgatorial And none but those who have drunk the bitter cup to its dregs feel and know its death, death, double death! These afflicted ones die daily and the graves to them seem pleasant and delightful ... But I had disregarded this honest advice, sincerely given, had spent my money and my time and what had I gotten? Would I not have been better off if I had listened to the advice and stayed at home? ... other legal rights INDEMNITY You will indemnify and hold Michael Hart, the Foundation, and its trustees and agents, and any volunteers associated with the production and distribution of Project...

Ngày tải lên: 15/03/2014, 19:20

... coal, and full one hundred and twenty-five cords of wood, to keep its devouring furnaces ablaze and its wheels in motion The round trip between these two points is made, including the landings, ... fund, and this has already amounted to a large sum two million five hundred thousand dollars; and these normal school buildings are an evidence alike of the wisdom of the measure and magnitude ... The towns of Wabasha and Reed's Landing. Lake Pepin and Maiden's Rock. Romantic story. An old fort. Lake City and Frontenac. Red Wing and Hastings. Red Rock The first landing in Minnesota, going...

Ngày tải lên: 15/03/2014, 20:20

... engineering devoted to the design and production of extremely small electronic devices and circuits built from individual atoms and molecules • Nanotechnology comprises any technological developments ... Trend towards Miniaturization Trend towards Digitization Trend to cell-level biological control Trend to Pervasive Computing What is Nanotechnology? • Nanotechnology is a branch of science and ... applications spanning voice and data communication – Remote monitoring, and position finding • Examples of current mobile wireless: – Cell phones, Pagers – Personal digital assistants (PDAs) – Global positioning...

Ngày tải lên: 15/03/2014, 23:53

... skills demanded and skills delivered increases, reliability of repair increases, or the match increases between the schedule demanded for delivery and the schedule met in delivery Speed and responsiveness ... hospital DA Department of the Army DEP Delayed Entry Program DHP Defense Health Program DMSS Defense Medical Surveillance System DNBI disease and non-battle injury DoD Department of Defense DOTMLPF doctrine, ... Stabilizing soldiers at posts and in units demands different personnel and training routines from those that supported the Army’s long-standing “individual replacement” system Developing and fielding an...

Ngày tải lên: 16/03/2014, 14:20

... new bits and saddles: and they bore three hundred and sixty gold and silver cups, the king's trumpeters going before and sounding their trumpets; so that so wonderful a novelty produced a laudable ... interpreted, God with us And Joseph arose from his sleep, and did as the angel of the Lord commanded him, and took unto him his wife; and knew her not till she had brought forth a Son; and he called ... lands of Africa and the ice-bound Arctic coasts, in India and China, at the Antipodes, in Australia and New Zealand, and in the Islands of the Pacific; in short, throughout the civilised world...

Ngày tải lên: 17/03/2014, 13:20

... industry •By giving advice on health and safety, ensuring that accidents are avoided and risks carefully assessed and minimized •By promoting industrial initiatives meeting Health, Safety and ... improve the production by reducing waste, raw material and production time •Ensure the availability of skilled people and relevant tools in order to drive and optimize workflow management and operational ... SMEs to plan and manage their investments, raise quality, reduce costs and improve delivery times by reducing waste in labour, materials and time •To raise quality and to reduce costs and to improve...

Ngày tải lên: 18/03/2014, 02:20

... GMSK DV Node Adapter board and firmware by Satoshi Yasuda, 7M3TJZ • D- Star Hotspot Windows software by Mark McGregor, KB9KHM Overview Q: Do I need a DVDongle? A: NO, AMBE encode and decode is done ... G6LVB • Dutch*Star Project – D- Star Modem, Terminal and full transceiver kits – By Fred N Van Kempen, PA4YBR – http://www.dutch-star.nl/ 16 References • GMSK DV Node Adapter – http:/ /d- star.dyndns.org/ ... repeater and G2 gateway – Uses Node adapter and Linux computer – By David, G4ULF – http://g4ulf.blogspot.com/ • D- Star Speaker/Mic – Connects to an analog radio like the Node Adapter – By Howard, G6LVB...

Ngày tải lên: 19/03/2014, 22:14