cytokines recruitment of eosinophils and epithelial remodeling
RECRUITMENT OF CLERKS AND PROBATIONARY OFFICERS pot
... Bhubaneswar, Guwahati and Kozhikode for the post of Clerk and at Thiruvananthapuram, Ernakulam and Kozhikode for the post of Probationary Officer depending upon the number of candidates The Bank ... Probationary Officer Place of domicile Place of domicile of the candidates shall be in any of the states viz Tamilnadu, Karnataka, Maharashtra, Gujarat, Rajasthan, Punjab, Haryana, Odisha, Assam, Nagaland, ... the link titled Recruitment of Clerks & Probationary Officers – 2012” (v) Print the Recruitment Notification and Application Fee Payment Challan and make payment of the prescribed application...
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Báo cáo khoa học: Recruitment of transcription complexes to the b-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells docx
... indicating that dimethylation of H3K4 and recruitment of RNA Pol II and TBP to the LCR occurs before activation of any of the globin genes The presence of H3 dimethylated at K4 indicates that ... HS2 and HS3 The transcripts originating in between HS4 and HS3 are strand-specific proceeding unidirectional toward 750 Fig Quantitative analysis of RNA Pol II recruitment and association of H3 ... Pol II recruitment Our data show that RNA Pol II and dimethylated H3 lysine are detectable at LCR elements HS2 and HS3 at day We next examined whether recruitment of RNA Pol II to HS2 and HS3...
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Báo cáo khoa học: DNA mediated disassembly of hRad51 and hRad52 proteins and recruitment of hRad51 to ssDNA by hRad52 pot
... Disassembly and recruitment of hRad51 and hRad52 proteins shorter and thicker nucleoprotein filaments when ssDNA is added [28] Tumour suppressors BRCA2 and p53 interact with the oligomerization domain of ... effect of DNA on hydrodynamic radius (Rh) of hRad51 hRad51 (1 lM) was incubated with 0, 1, 3, and lM of oligo PUC+ (in the absence of any nucleotide cofactor) followed by the measurement of hydrodynamic ... et al Disassembly and recruitment of hRad51 and hRad52 proteins A B C D Fig DNA induced solublization of Human Rad51 protein (A) Native gel assay to visualize oligomeric state of hRad51 hRad51...
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Báo cáo khoa học: Recruitment of coregulator complexes to the b-globin gene locus by TFII-I and upstream stimulatory factor doc
... between USF and p300 This suggests that the recruitment of CBP ⁄ p300 to the LCR, at least in K562 cells, is mediated by proteins other than USF, and potential candidates are GATA-1 and NF-E2, ... negative mutant of USF exhibited a reduction in Pol II loading to LCR element HS2 and to the b-globin gene promoter [20] At the same time, we observed a reduction in the recruitment of CBP and p300 ... Coregulators of USF and TFII-I in erythroid cells A B C D Fig CBP ⁄ p300 interact with the b-globin gene locus and with USF1 in MEL cells but not in K562 cells (A) Schematic of the organization of the...
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báo cáo hóa học: " Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures" pot
... levels of IL-1b and HMGB1 (A), IL1b and IL-6 (B), IL-1b and TNF-a (C), and IL-6 and TNF-a (D) in febrile patients (N = 82) IL-1b levels are significantly correlated with HMGB1, IL-6, and TNF-a ... matched for age and temperature criteria and had no convulsions during the febrile illness and no known history of previous febrile seizures Control blood serum was collected and frozen as above ... 3, p = 07 and p = 0.05) There were no differences in serum IFN-g and TNF-a levels between febrile seizure patients and fever only controls (Table 3) In comparisons of the subgroups of febrile...
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Báo cáo y học: "Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27" pptx
... IL-27 expression Ligation of TLR9 with double stranded DNA leads to strong induction of IL-27 in murine bone marrow derived DCs and engagement of TLR2 with its synthetic ligand (Pam3Cys) promotes ... the broad distribution of this shared receptor component, the distinct functions and tissue tropisms of GP130 associated cytokines are determined by the availability of ligand specific co-receptors ... augment proliferation and secretion of IFN-γ by naïve CD4+ T cells [3,39,40] and when combined with The paradoxical pro- and anti-inflammatory properties of IL-27 Through ligation of its cognate receptor,...
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Báo cáo y học: "Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases" docx
... genes and initiate epithelial- mesenchymal transition Complexes of Smad7 and Smurf1 or Smurf2 promote ubiquination and degradation of activated receptors limiting the intensity and duration of signaling ... TGF-β ligands to their tetrameric type I and II receptors causes sequential activation of MKK-4/JNK and the complex of Smad 2/3 and Smad proteins (Figure 2) This complex can enter the nucleus and ... region of the same breast (counterpart fibroblasts) CAFs were more competent in supporting in vivo growth of tumor cells and enhanced tumor angiogenesis and the recruitment and mobilization of endothelial...
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Báo cáo y học: "Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathie" doc
... Center of Excellence (Credit number EF/05/15) of KU Leuven, the Fund for Scientific Research of Flanders (FWO-Vlaanderen), the Concerted Research Actions (GOA) of the Regional Government of Flanders, ... A: Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers Chemical synthesis of MCP-2 and development of a specific ... infiltration of activated Th1 lymphocytes and natural killer cells to the site of inflammation In conclusion, a network of interactions between cytokines, chemokines and proteases controls the recruitment...
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Báo cáo y học: "Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation" doc
... subsets have similarities in expression of CD11c (75% and 65%), CD54 (70% and 90%), CD172a (60% and 66%), CD11a (60% and 96%), CD32 (50% and 95%), and/ or CD5 (20% and 32%) The two subsets also have ... adoptive transfer of AA to investigate the effects of a pulse of pathogenic T cells on recruitment of mDC-like cells to inflamed synovial tissues Data are presented also on recruitment of other blood-derived ... transfer of arthritis, expressed as proportion of cells positive for each marker (c) and numbers of cells expressing the markers (d) MHC, major histocompatibility complex ment of monocytes and PMN...
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báo cáo khoa học: " Salivary a-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells" docx
... imaging software cell® (Olympus, Hamburg, Germany) and quantified by counting Page of 12 Cells from F344 (P1 and P2) and Lewis (only P2) were counted in three different wells and portion of SA-bgal-positive ... F344 and Lewis rats Preparation of the dissected mammary gland complexes produced comparable amounts of epithelial cells in F344 and Lewis rats Marked differences between cells from F344 and Lewis ... the excised mammary gland complexes per single animal were cultured together Identification of epithelial and mesenchymal cells by immunocytochemistry The proportion of epithelial cells in culture...
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Báo cáo y học: "Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines" ppsx
... secretion of cytokines, chemokines, and inflammatory lipids from activated macrophages Our results show that TMP can inhibit production of both prostaglandins and several key inflammatory cytokines and ... prostaglandin production was linked to effects on levels of COX-2 mRNA and protein and to inhibition of COX-2 enzymatic activity • TMP inhibited production of several key inflammatory cytokines and ... between COX-2 and TMP and elucidate the mechanism of inhibition Our results suggest that TMP is a potent, direct inhibitor of COX-2 activity, and the magnitude of this effect may be Page 13 of 18 (page...
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Báo cáo y học: " Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses" doc
... qualitative and quantitative differences in the profiles of cytokines/ chemokines induced by influenza viruses of different pathogenicity H5N1 was a more potent inducer of inflammatory cytokines/ chemokines; ... tissue culture flasks for the inoculation of virus isolate at a multiplicity of infection (m.o.i.) of one After hour of adsorption, the virus was removed and ml of fresh RPMI-1640 media with 2% FBS, ... concentrations of cytokines/ chemokines in cell culture supernatants were measured (Figure 3, Table 3) The results showed that the epithelial cells secreted high amounts of IL-6, IL-8, CXCL-10/IP-10, and...
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Báo cáo y học: "Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial " pptx
... numbers of eosinophils, reduced TGF-b1+ eosinophils, and reduced airway remodeling Although several studies show an important role for eosinophils, TGF-b1, and Smad signaling in airway remodeling ... of Siglec-F deficient mice may have application to understanding the role of the human paralog of Siglec-F (i.e Siglec-8) [42] in humans with asthma and airway remodeling Page 13 of 14 List of ... IL-13, and RANTES ELISA assays each had a sensitivity of 31 pg/ml, and the eotaxin-1 assay a sensitivity of 16 pg/ml Lung LTC4 levels As leukotriene C4 (LTC4) is a product of eosinophils [19], and...
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Báo cáo y học: " Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats" pps
... DIVA software on LSR II and analyzed with FlowJo v8.8.6 Measurement of right ventricular hypertrophy The ventricles and septum of the animals were collected and the wet and dry ventricle and septal ... effect of CXCR4 in development of pulmonary hypertension and vascular remodeling in chronically hypoxic rats An important pathological feature of pulmonary hypertension is vascular remodeling of ... that inhibition of systemic CXCR4 through administration of AMD3100 will inhibit hypoxia-induced pulmonary hypertension and vascular remodeling in rats and that specific inhibition of the CXCR4...
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Báo cáo y học: " Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells" potx
... human airway epithelial cells and in a variety of transformed alveolar epithelial cells Respir Res 2006, 7:132 Publish with Bio Med Central and every scientist can read your work free of charge ... evidence of apoptosis in primary human small airway epithelial cells Cigarette Cigarette smoke extract caused necrosis with no or little evidence of apoptosis in primary human small airway epithelial ... ethidium bromide and appeared red Percentage of viable (white bars), apoptotic (grey bars) and necrotic/late apoptotic (black bars) determined by counting as described in Materials and Methods Results...
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Báo cáo y học: "Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling" pptx
... exposed7to in the subepithelial counted under electron microscopy filtered air and to ppm ozone for 4, from 12 Mean number of myofibroblastszone of specimens 8, andmice Mean number of myofibroblasts ... evidence of airway remodeling rather than inflammation in a subepithelial zone of the entire transmission electron microscopy section, and the counts were expressed per 0.1 mm2 of tissue Myofibroblasts ... filtered air and to ppm ozone for 4, 8, and 12 Goblet cell counts in the epithelium of bronchioles of mice Goblet cell counts in the epithelium of bronchioles of mice exposed to filtered air and to...
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Báo cáo y học: " Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells" pps
... endogenous levels of glutathione status and the amount of 4-HNE is formed IL-8 and IL-6 are important in the recruitment and activation of inflammatory cells The induction of these proinflammatory ... variety of alveolar epithelial cells and in primary human small airFigure way epithelial cells Cigarette smoke extract differentially caused cytotoxicity in a variety of alveolar epithelial cells and ... panel of human and rodent alveolar epithelial cell lines, such as human lung cancer cells (H1299), human lung epithelial cells (H441), murine type II epithelial cells (MLE-15), and rat lung epithelial...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... and secretion of cytokines In the absence of an appropriate signal, activated T helper lymphocytes rapidly become apoptotic and are eliminated Several cytokines, including IL-2, IL-4, IL-7, and ... responsible for the production of IL-5 and other cytokines that promote the development of eosinophilia On the basis of our current knowledge of the differentiation of IL-5-producing TH2-like lymphocytes, ... and IL-5, Asthma has been linked to chromosome 5q31–33 through genome searches and screening of candidate genes [21,22] This locus includes the genes for the TH2 cytokines IL-4, IL-5, IL-9, and...
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Báo cáo y học: " Eotaxin and the attraction of eosinophils to the asthmatic lung" ppt
... other important effects of interleukin-5, such as stimulation of differentiation and proliferation of bone marrow eosinophils and suppression of eosinophil apoptosis at sites of inflammation C-C ... levels of mRNAs for eotaxin and its receptor CCR3 were observed, and were associated with airway hyperresponsiveness and predominant colocalization of eotaxin mRNA to bronchial epithelial and endothelial ... expression of eotaxin and CCR3 mRNA and protein in atopic asthma Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" pptx
... explants H441 cells resemble bronchiolar epithelial Clara cells in phenotype and produce both SP-A and SP-B mRNA and protein [14] The hormonal regulation of SP-A and SP-B gene expression in H441 cells ... additional 1, 4, and 24 hours The cells were then rinsed and trypsinized, and nuclei from control and treated cells were harvested The transcription elongation reaction Page of 10 (page number ... representative of experiments (A) Total MAPK (p44 and p42, arrows) The total amount of MAPK was not altered by insulin treatment at any time-point (B) Phospho-p44 and p42 MAPK (P-p44 and P-p42, arrows)...
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