crystallization in the pharmaceutical and bioprocessing industries

... costs and returns in the pharmaceutical and biotechnology industries The final section examines recent policy developments and issues surrounding patent lifetime and generic competition in this industry ... have a significant influence on the rate of innovation in particular industries Among the key industrial policies influencing the innovative process in pharmaceuticals are the public support ... considers whether the biotech industry is different than the pharmaceutical industry in terms of R&D costs Section V considers the distribution of returns on R&D in these industries The final section...

Ngày tải lên: 13/03/2014, 21:59

... Srinivasan) of the first author (KS) for all the support during the final phase of the book and the wife (Kozue Takamura) of the third author (JdSA) for all the help with the typing and editing ... taking into account the molecular characteristics 14 Efficiency and Sustainability in the Energy and Chemical Industries and properties of those molecules making up the mixture in a particular thermodynamic ... between and passing states that all have the same thermodynamic probability On the one hand, these processes proceed without driving forces; on the other hand, and this is inconsistent and unrealistic,...

Ngày tải lên: 01/04/2014, 11:38

... studies in finance that also examine the investment and financing decisions of pharmaceutical firms Lemeret al (2003) examine the role that the availability of equity financing has on the bargaining ... embedded in the multi-stage innovative investment project, and the authors analyze their interaction in determining the risk premium and value of the project over its life-cycle Specifically, there ... decisions involving upfront irreversible cost commitments in the face of uncertainty and the choice of incurring additional costs in the future Under these conditions, a firm’s investment policy includes...

Ngày tải lên: 30/09/2015, 16:34

... TASKS FOR THE LAUNDRY UNIT Introducing the Work in the Laundry Operating Laundry Machines 73 The Washing Machines 73 The Dryers 78 The Pressing and Folding Machines Stacking and Packing Finished ... the words and phrases for indoor maintenance workers The two glossaries contain all the words used in the book and are arranged in alphabetical order, the first from English to Spanish, and the ... THE INDOOR 115 MAINTENANCE TEAM Routine Cleaning of Public Rooms 116 Tools and Equipment 118 Keeping the Hotel in Good Repair 120 Routine Tasks for the Maintenance Team Special Projects for the...

Ngày tải lên: 04/05/2014, 12:46

... temporary dose discontinuation in 3/20 (15%) Forns and colleagues used relatively high-dose interferon/ribavirin therapy in their cohort of 30 patients awaiting transplantation in Spain in an effort to ... low initial dose, with increases every two weeks toward standard target doses Duration of therapy was intended to be 24 weeks in genotypes and and 48 weeks in genotype infection Hematologic inclusion ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin [13, 14] Finally, growing experience with antiviral therapy in this high-risk group...

Ngày tải lên: 31/10/2012, 17:11

... is therefore possible that CKBM could induce cytokine release including TNF-α in these animals and inhibit tumor growth However, further study is needed to determine how they are induced and the ... compounds including lunasin and lectins that were shown to induce apoptosis in malignant cells [13] As CKBM contains these compounds, this would partially explain why it inhibits tumor growth in the ... through the induction of apoptosis and inhibition of proliferation of gastric cancer cells However, further clinical trials in humans are needed to examine the pharmacokinetics and the therapeutic...

Ngày tải lên: 03/11/2012, 09:54

... another The grandmother held the floor most of the time from the beginning of the story in her decision where to go, in her introduction of the scenery along the journey While the father, the mother ... character and setting Technique has to with the structuring of the story into the plot so that the writer can convey the theme and the manipulating of the language in order to express the ideas of the ... “Everything That Rises Must Converge.”, however, the differences in the behaviors and attitudes of the grandmother, the father and the mother and the children at least cause discontent to one another...

Ngày tải lên: 07/11/2012, 15:01

... Conclusions, including the results of the November 2001 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches  APEC and the MRCWG have a role in liaising with ... NACA to enhance the effectiveness of existing instruments within APEC  Institutional arrangements for managing the marine environment is fragmented in most economies  Baseline surveys to identify ... Within APEC little is known on the introduction of marine pests  Little practical information on measures to prevent introductions  Lack of knowledge in what individual countries are doing...

Ngày tải lên: 28/10/2013, 11:15

... nuclear issues in general, the feeling grew in the environmental movement that Yeltsin was increasingly yielding to the demands of the Ministry of Atomic Power and the nuclear-industrial lobby.99 ... nuclear matters, including the Navy and the Ministry of Atomic Power, have consolidated their control over domestic decisionmaking and are themselves becoming increasingly involved in cooperative ... dumping, as these prescriptions figure prominently in the unequivocal argument made in the Yablokov Report on the severity of past dumping and the need to invest more in storage and decontamination...

Ngày tải lên: 01/11/2013, 09:20

... cells, single lymphocytes scattered in the lamina propria and intraepithelial lymphocytes spread in the intestinal epithelia The immune system of infants is not fully developed The structures of the ... demonstrated their capacity to stimulate the production of intestinal mucines, their trophic effect on intestinal epithelium, the reestablishment of the intestinal mucosa integrity, the stimulation of the ... Probiotics and infections The most valid indication of the probiotic remains the decrease of intestinal infections In fact, the literature shows that the probiotic can reduce the severity and number...

Ngày tải lên: 12/02/2014, 16:20

... emigrated, and were either residing in our Colonies or in other parts of the world, and the only method I could discover of obtaining information regarding several of viil INTRODUCTION them, was ... health; in others, to the rowers being by nature constitutionally delicate; and in others again, to their having thoroughly overdone it, to their being in boating language "stale." As regards the ... rowing as to be of little or no service in maintaining the theory of rowing being injurious to the health At the same time I have never doubted that his early death, at the age of twenty-nine,...

Ngày tải lên: 14/02/2014, 21:20

... adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s ... heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data validity score as covariates, they ... vaccination of adults and the type of vaccine strain administered precluded the inclusion of these factors as covariates in the random-effects regression model However, these researchers determined...

Ngày tải lên: 15/02/2014, 13:20

... of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly within the injured or diseased brain In the case ... deficient in the AD brain There remains no clear consensus on the role of GIF in the pathogenesis of AD, and therefore we will briefly review some of the current thoughts on the role of GIF in AD There ... investigated whether GIF acts in a neuroinhibitory manner when administered directly into the brain following traumatic brain injury In one such study, the injection of GIF into the site of a stab wound...

Ngày tải lên: 16/02/2014, 15:20

... inflation by taking the fee breakpoints available in 2010 and multiplying by the Consumer Price Index in December 2000 and dividing by the Consumer Price Index in December 2010 The front-end ... endowments, and other institutional investors investing for their own accounts, rather than on behalf of retail investors Stock Funds The average fees and expenses paid by stock fund investors declined ... paid for investing in bond funds declined by basis point in 2010, to 72 basis points (Figure 2) This reflects a basis-point drop in the annualized cost of load fee payments and no change in the average...

Ngày tải lên: 19/02/2014, 15:20

... declined in 2011 owing to declines in the expense ratios of individual funds, an increase in the demand for index funds, and a continuing shift by investors in both actively managed and index ... Although growing investor demand for index funds has contributed to the overall decline in fund expense ratios, the average expense ratios incurred by investors in both index and actively managed ... the steep decline in the average expense ratio of money market funds reflects developments stemming from the current low interest rate environment In 2007 and 2008, to stimulate the economy and...

Ngày tải lên: 19/02/2014, 15:20

... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... postcultures and photographs were taken Enzyme kinetic study The Km (Michaelis constant) and Vmax (maximum velocity) values were determined by incubating the diluted recombinant proteins in the standard ... gauze and suspended in NaCl/Pi containing 100 lgÆmL)1 penicillin/ streptomycin at 37 °C for h After incubation the tissues were removed, and the larvae were collected from the bottom of the tube The...

Ngày tải lên: 20/02/2014, 11:20

... On the other hand, in the far Northeast, along the Mekong River, over 2030 mm is received annually Variation in the average amount of rainfall is therefore notable in the Northeast During the ... pineapple and upland rice (RRIT 2005) Cherdchom et al (2002) reported four main integrated rubber farming systems in the South of Thailand emerging during the financial crisis in the late 19 1990's The ... introduced in Asia in 1876, when seeds were first shipped from the Amazonas to the United Kingdom and further to Ceylon and planted there In the following year, rubber trees were planted in Singapore and...

Ngày tải lên: 21/02/2014, 04:20

Ngày tải lên: 21/02/2014, 05:20

... dominant because they learn the language and the mother and the father lose their roles The boundaries and the hierarchies are changing Children interpret for their parents, they know everything' ... organised into three main parts PART ONE is the INTRODUCTION This includes an outline of the CONTEXT and main themes, the motivation and purpose of the study - the why and how PART TWO is THE REASEARCH ... process: The first step towards the integration of refugees must be to identify and help with their most pressing needs Finding and settling them into safe and appropriate housing, accessing employment...

Ngày tải lên: 24/02/2014, 18:20

... cells from their environment During integrin outside in signaling, the binding of integrins to their extracellular ligands changes the integrin conformation and promotes integrin clustering The unidirectional ... signalings, in fact, are often closely linked, as ligand binding associated with outside in signaling stimulates integrins and, conversely, integrin activation increases ligand binding for inside–out ... from and possible recycling for further molecule processing within the sending cell on the one hand, surface signaling, signaling during endocytosis into the receiving cell and receptor recycling...

Ngày tải lên: 05/03/2014, 22:21