complications of intrathecal drug delivery
Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc
... the delivery of DCU via intravenous (IV) infusion route was explored Similar to oral delivery, IV delivery of DCU was limited by the poor aqueous solubility of DCU The poor aqueous solubility of ... [27] to estimate the amount of drug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, D is the drug dosed, Ke is the stomach ... SC drug depot should continuously provide a slow release of drug to the bloodstream providing a longer and sometimes steady drug supply Combined, both effects may result in a drug plasma profile...
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Development of controlled drug delivery systems using uniform nanoporous materials as matrices
... surface of the polymer, resulting in a release rate that is proportional to the surface area of the drug delivery system (See Figure 2.5b) a Drug Drug Drug- loaded biodegradable particles b Drug Drug ... application of SBA-15 in the delivery of the small molecule model drug of ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release of IBU Chapter ... the rate of erosion exceeds the rate of water permeation into the bulk of the polymer This is often considered to be a desirable mechanism of erosion in drug delivery because the kinetics of erosion,...
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Development of novel drug delivery system lipid microemulsion of tributyrin
... ligands Of course, targeted colloidal carriers will be much more effective if they are also sterically stabilized 1.2.2 Samples of Drug Delivery Systems As far as the physical form of drug delivery ... for the delivery of drugs (lipophilic drugs, hydrophilic drugs provided with lipophilic moieties, or ionic drugs complexed with ionic lipids) to specific cell types, provided that these drugs: ... development of delivery systems which will allow the fate of drugs within the patient to be controlled by modifying these processes Although drug carriers usually act on the second process – drug distribution...
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Chemical Aspects of Drug Delivery Systems pptx
... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS ... imposed by the nature of the various routes of administration available for drug delivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OF DRUG DELIVERY SYSTEMS The principal routes of administration ... for Drug Delivery and Targeting P York The Use of Bioadhesive Polymers as a Means of Improving Drug Delivery Slobodanka Tamburic and Duncan Q.M Craig Some Novel Aspects of Transdermal Drug Delivery...
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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
... A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug? Prodrug is an inactive precursor of a drug Prodrug reconversion ... and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery system is a formulation or a device that safely ... MUCOSAL DRUG DELIVERY Advantages: avoid the first-pass effect of drug cleareance ORAL MUCOSAL ROUTE Classification: Sublingual delivery Buccal delivery Local delivery Sublingual delivery...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
... construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems ... schematic illustration of the strategy for the preparation of the CNT-based drug delivery systems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
... molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the goals of this work was to demonstrate ... toxicity of CuCNPs upon reduction of Cu content water, which has a neutral to slightly acidic pH While this feature is promising in terms of the stability of solutions of CuCNPs over long periods of ... http://www.nanoscalereslett.com/content/6/1/445 capable of inducing oxidative stress, which is of great concern in terms of the nanotoxicology of particles being pursued for a variety of consumer products Furthermore,...
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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx
... acquire most of the characteristic properties of sympathetic neurons Other salient responses to NGF include cessation of proliferation, generation of long neurites, acquisition of electrical ... for the entrapment and/or delivery of a variety of biological agents [8] Alginate is a co-polymer extracted from some types of brown algae and it is made up of two uronic acids: D-mannuronic acid ... a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, bovine serum albumin (BSA, A3156...
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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx
... process(es) Over the past couple of decades, the field of drug delivery has been revolutionized with the advent of nanoparticles, wherein these particles act as inert carriers for drugs and genes to target ... progression of the T cell-dependent chronic phase of the inflammatory response [20] Clearly, this warrants further evaluation and selective delivery of this class of compounds for treatment of CF lung ... [14,29-31] To test the efficacy of our novel therapeutic drug delivery vehicle we have tested the sustained release and delivery of FDA approved proteasome inhibitor drug, PS341 in murine lungs by...
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Development of multi functionalized polymeric carriers for delivery of anticancer drug combinations
... characterization of drug- loaded polymeric micelles 81 4.3.3 In vitro drug release and drug loading of singe drug- loaded micelles 82 4.3.4 In vitro drug release and drug loading of dual drug- loaded ... IC50 of different micellar treatments: (1) delivery of single drug- loaded micelles, (2) co -delivery of two singe drug- loaded micelles at the ratio of CDDP/DOX at XII 20/1, and (3) delivery of dual ... between the co -delivery of two single drug- loaded carrier systems and the delivery of dual-drugs-loaded carrier system using different pair of drugs have been investigated XI LIST OF TABLES Table...
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Application of biologically active micelles in drug delivery across the blood brain barrier
... modification of the drug molecules may change the therapeutic properties of the drug, resulting in the dysfunction of drug Therefore, a better drug delivery strategy is required to transport a drug with ... Nanoparticles in the brain drug delivery 27 4.1 Ideal properties of nanoparticles for brain drug delivery .28 4.2 Some successfully developed nanoparticles in brain drug delivery 29 4.2.1 PBCA ... introduce a drug in the brain by temporally opening the BBB; pharmacologically-based strategy to increase permeability of drugs to the BBB through the modification of molecular features of drugs;...
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Application of HCRSV protein cage for anticancer drug delivery
... al., 1997; Lu and Low, 2002] Proof of concept of the folic acid-mediated targeting systems has been obtained with the delivery of drugs and liposomes to a variety of cancer cells [Leamon and Low, ... model drug in the development of targeting drug delivery platforms [Kalra and Campbell, 2006; Sun et al., 2006; Nasongkla et al., 2006] Figure 1-1 Chemical structure of doxorubicin 1.2 Targeted drug ... because of the lack of polarization of these cells Consequently, cancer cells with overexpressed FR are susceptible to folic acid-conjugated drug delivery systems circulating in the blood [Toffoli...
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Design and fabrication of microneedles for drug delivery
... the implementation of time varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic ... Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which have sophisticated compounds ... used for local delivery of other drugs, for example, drugs in anti-restenosis and anti-tumor therapies In transdermal drug delivery, microneedles are designed to painlessly deliver drugs into subcutaneous...
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Development of non aqueous ethylcellulose gel for topical drug delivery
... topical drug delivery as this is the main focus of the present study I-B1 Advantages and limitations of topical drug delivery The principal advantage of topical drug delivery lies in targeting the drug ... topical drug delivery Transdermal drug delivery involves transport of drug through the skin into the systemic circulation for treatment of disorders remote from the site of application As the drug ... LIST OF FIGURES xiv LIST OF SYMBOLS xix LIST OF EQUATIONS xxiv I INTRODUCTION I-A The human skin I-B Transdermal and topical drug delivery I- B1 Advantages and limitations of topical drug delivery...
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Design of functional polymeric micelles as a carrier for anticancer drug delivery
... further innovation of drug delivery systems Figure 1.1: Timeline of nanotechnology-based drug delivery Reproduced from [13] with permission The nanoscale feature of these drug delivery systems ... on drug delivery systems Drug delivery is defined as the system to dispense a pharmaceutically active compound in the body to attain a therapeutic effect In an extension of free drugs, drug delivery ... of liposomes changed the face of soft drug delivery systems, there are problems inundated with the use of liposomal drug delivery systems Firstly, the preparation of liposomes is a complex procedure...
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Evaluation of advanced paclitaxel drug delivery implants for controlled release post surgical treatment against glioblastoma multiforme in the brain
... the area under the curve of a plot of axis between Concentration of the drug vs the duration of exposure to the drug and is used here to provide consistency in the design of the control groups with ... matrix, control of the rate of polymer degradation can be achieved thereby changing rate of release of the drug Our study focuses on developing controlled releases implants in the form of discs for ... pressure quench and rapid solidification of drug- polymer melt This thesis presents a step-by-step approach in the analysis of the use of foams for controlled release of Paclitaxel as implants within...
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Study on drug delivery for paclitaxel of the lactobacillus strains
... of standard The acceptable range for the variation of retention time was less than 5% 3.2.8 Calculation of the number of drug molecules (MacDiarmid et al., 2007b) The number of molecules of drug ... biochemical drugs constitute novel delivery vehicles, capable of being targeted to specific cells Because of the benefits of delivering chemotherapeutics drugs for cancer treatment, the practice of synthesizing ... therapy of cancer (Alexis et al., 2010) 2.1.3.2 Tumor-targeted drug delivery nanoparticles In recent years, the rapid advent of nanotechnology has stimulated the development of many novel drug delivery...
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Model development and numerical simulation of thermo sensitive hydrogel and microgel based drug delivery
... mass of drug- loaded microgels Lref reference parameter Mt absolute cumulative amount of drug released at time t M∞ absolute cumulative amount of drug released at time t=∞ R mean radius of dry ... 4.3.3 Effect of effective crosslink density 51 - iii - Table of Contents 4.3.4 Effect of initial polymer volume fraction 54 Chapter Transient Model Development for Simulation of Drug Delivery from ... simulation of the swelling equilibrium of temperature-sensitive hydrogels with fixed charges 1.2.2 Microgel-based drug delivery system In development of bioengineering and biotechnology, one of studies...
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Drug Delivery Systems
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... terms of duration of clinical use and Table 15.1 Use of a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/or formulation is physically removed from the site of ... polyanhydride-based delivery system of the drug, 5-nitrourea, that concentrates the drug at the site of the tumor In contrast to Zoladex, Gliadel provides local delivery of a toxic drug that must...
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Management of Complications of Chronic Liver Disease: “When to Refer to Transplant?” docx
... Purification, transformation and clearance of: – – – – – ammonia bilirubin hormones drugs toxins LIVER FUNCTIONS • Regulation of: – glucose – cholesterol • Storage of: – – – – – – glucose fat-soluble ... • The success of pediatric liver transplantation has made the recognition of the importance of nutritional support in the pretransplant period imperative to optimize the success of the transplant ... correlate with the degree of vitamin or trace mineral deficiency or the degree of hepatic dysfunction Nutritional Assessment of the Child with Liver Disease • A number of obstacles complicate the...
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