clinical analysis of adverse drug reactions
R INTE S OF MEDIC REPORTING ADVERSE DRUG REACTIONS DEFINITIONS OF TERMS AND CRITERIA FOR THEIR USE ppt
... involved in a number of ways They can be reporters of suspected adverse drug reactions, assessors of adverse drug reactions (when they are working within regulatory bodies or drug companies), responders ... harmonization of reporting of adverse drug reactions The terms concerned have been mainly those liable to be misinterpreted and those that designated serious adverse reactions The outcome of the project ... series of ‘‘Definitions and Basic Requirements for the Use of Terms for Reporting Adverse Drug Reactions ’, CIOMS continues its special effort to address this concern Reporters of adverse reactions...
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Who Pays for Medical Errors? An Analysis of Adverse Event Costs, the Medical Liability System, and Incentives for Patient Safety Improvement ppt
... Patient Safety Indicators cover just a small part of the universe of adverse events—health insurers will continue to pick up some of the costs of adverse events and, therefore, have an economic ... costs of the clinical interventions that could help prevent injuries Deterrence of medical injury at the level of the organization will hinge critically on this marginal analysis: How the costs of ... (1997) “The Costs of Adverse Drug Events in Hospitalized Patients,” 277 J of the American Medical Association 307 17 Classen, D C., S L Pestotnik, R S Evans et al (1997) Adverse Drug Events in...
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Women and Adverse Drug Reactions Reporting in the Canadian Context pot
... reporting of adverse drug reactions by health care professionals, available at http://www.hc-sc.gc.ca 29 There is some confusion over the terms adverse drug reaction” and adverse drug event” ... number of deaths due to adverse drug reactions in Canada, using a 1:10 ratio of the population of Canada to that of the US, would total 7,600 annually – 10% of the estimated 76,000 deaths due to adverse ... all of these matters, including the approval, use and regulation of prescription drugs The purpose of this paper is to provide an overview of how Canada’s program for reporting Adverse Drug Reactions...
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Phản ứng có hại của thuốc (Adverse Drug Reactions; ADR) pdf
... Gemfibrozil gây phản ứng có hại nhiều fenofibrat (Hoa Kỳ) Kiểm tra lại báo cáo phản ứng có hại (ADR) năm 1999 2002 có liên quan tới gemfibrozil (Lopid) fenofibrat (Lipantyl), quan Thực Dợc phẩm ... với 80,1 phần triệu đơn kê cho fenofibrat (nguy tơng đối = 1,24, khoảng tin cậy 95% 1,15 1,34) Đặc biệt gemfibrozil có tỷ lệ cao rõ rệt tiêu vân so với fenofibrat [nguy tơng đối = 10,84 (8,44 ... phản vệ amiodaron * Tổ chức ADR quốc tế nhận đợc 19 báo cáo choáng phản vệ sử dụng amiodaron (theo Reactions Weekly; Số 1022; 09/10/2004) Liệu pháp insulin làm tăng nguy ung th đại trực tràng (Hoa...
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Phản ứng có hại của thuốc (Adverse Drug Reactions; ADR) docx
... chống viêm không steroid, alendronat v.v (Theo J.national cancer Jnit 95; số 13; 7/2003) (Theo Reactions Weekly, 01/11/2003; số 975) Australia nhận đợc 42 báo cáo phản ứng gan với minocyline,...
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báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot
... 59.5% of the radioactivity was bound The addition of 10 μg of unlabeled fragment, which reduced the percentage of bound radioactivity to an average of 3.5%, demonstrated the specificity of the ... comprised of a single product consistent with the Mr of a F(ab’) (data not shown) The final yield of this preparation was appreciably higher than the digestion of 100 mg with a final yield of 56% ... those of the F(ab’)2 fragment with a higher overall detection of tumor lesions The authors postulate that the success of these studies was the result of careful selection and matching of the...
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Báo cáo khoa học: "Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma" pot
... time of local control was defined as the duration from the beginning date of SBRT to the date of local recurrence The time of survival was duration from the beginning date of SBRT to the date of ... on analysis of prognostic factors of local tumor control in this study, both clinical stage and tumor size were significant factors in Univariate analysis (Table 3, 4) (p < 0.05); however, clinical ... future clinical study to explore the optimal doses should be delivered for tumors of different size Based on the analysis of prognostic factors of overall survival rate in this study, clinical...
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Báo cáo y học: "Cross-sectional analysis of adverse outcomes in 1,029 pregnancies of Afro-Caribbean women in Trinidad with and without systemic lupus erythematosus" ppsx
... There was, however, no strong evidence of an effect of SLE on risk of early miscarriage (OR, 1.4; 95% CI, 0.6–3.1, regardless of time of diagnosis) Odds of late miscarriage were almost doubled ... association of district with risk of SLE Woman-based analyses Table presents data for the characteristics of the 122 female participants with SLE and of the 203 women in the Page of 11 (page ... cases Analyses were performed using different markers of socioeconomic status, including years of education and district of residence The unit of analysis was a pregnancy The association between the...
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Báo cáo y học: " A comparative analysis of HIV drug resistance interpretation based on short reverse transcriptase sequences versus full sequences" pps
... calculated FC per drug is interpreted using cut-off values The virco®TYPE report uses clinical cut-offs (CCOs), where available [20] Clinical cut-offs are used to facilitate the interpretation of fold ... Subtype-specific analysis demonstrated that at least 95% of HIVDR call-concordance was observed for the majority of the drugs with the exception of d4T However, across the different drugs, subtype ... particular drug (EFV and NVP), biological cut-offs (BCOs) are used A biological cut-off is based on laboratory observations of viruses derived from treatment naïve patients, and gives an indication of...
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Báo cáo y học: " Parkinsonism caused by adverse drug reactions: a case series." pps
... neuroimaging studies The clinical findings in our two patients are unusual adverse reactions of quinine or halothane administration The response to levodopa was an indication of loss of dopamine in the ... instability are less prominent in DIP [12] Treatment of DIP involves discontinuation of the offending drugs, which usually promotes remission of the Parkinsonian syndrome within a short time, although ... caused by adverse drug reactions: a case series Journal of Medical Case Reports 2011 5:105 Acknowledgements The authors declare that no funding was obtained for the writing and submission of the...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
... trials of to weeks, 88% of the doses were 200 mg daily In trials of 12 weeks' duration, 46% of doses were 200 mg and 46% were of 400 mg daily In trials of 24 weeks or longer, 92% of doses were of ... http://arthritis-research.com/content/7/3/R644 Figure Summary of main comparisons of treatment of arthritis with celecoxib or other drugs and placebo AE, adverse event; GI, gastrointestinal; L, licensed of treatment of arthritis with celecoxib ... assessment of Withdrawals Adverse arthritis events Physician's global assessment Serious adverse of arthritic events condition No of swollen joints Laboratory tests ACR -20 responder index No of tender/painful...
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A CFD analysis of transport phenomena and electrochemical reactions in a tubular-shaped PEM fuel cell
... dehumidification of the membrane may occur, resulting in deterioration of protonic conductivity In the extreme case of complete drying, local burnout of the membrane can result Figure shows profiles for ... the magnitude of phase change inside the GDL, expressions are required to relate the level of over- and undersaturation as well as the amount of liquid water present to the amount of water undergoing ... simulated in six different shapes of micro-channels which have been already developed and newly designed as well The result of analysis shows that characteristics of flow such as velocity, uniformity,...
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Tài liệu Color Atlas of Pharmacology (Part 8): Adverse Drug Effects pptx
... child Extent of transfer of drug into milk Infant dose Distribution of drug in infant Rate of elimination of drug from infant Drug concentration in infant´s blood Sensitivity of site of action Effect ... Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license Adverse Drug Effects Reaction of immune system to first drug exposure Drug (= hapten) ... A Adverse drug effect: allergic reaction Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 73 74 Adverse Drug Effects Drug...
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Báo cáo khoa học: Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans docx
... spotted onto PEI cellulose sheets with lL of nonradioactive tracer (100 lg of 5-FU and 100 lg of uridine for the UP assay mixture; 100 lg of 5-FU and 100 lg of deoxyuridine for the TP assay mixture) ... presence of uracil and thymine, respectively The enzymatic activities of three mutant UPP-1 proteins were very low as compared with that of wild-type UPP-1 in vitro The TP activity of UPP-1 is ... phenotype analysis Analysis of 5-FU sensitivity was performed on plates containing 5-FU (800 nm) Synchronized embryos were transferred to 5-FU plates After 60 or 72 h, the numbers of L4 larvae...
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Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf
... Con:28 of 44 Stage II Exp:1 5of 33 Con:21 of 77 Exp:15 of 33 Con:29 of 77 Exp:14 of 80 Exp:17 of 80 Con:12 of 40 Jadad’s grades (year) Exp:18 of 73 Stage III ATC-BCG Con:31 of 109 Exp:16 of 73 ... Con:17 of 40 Stage III 7.6 B C Exp:1 6of 44 [23] ATV-NDV Stage I-IV Exp:20 of 44 Con:16 of 25 NO C Exp:1 2of 25 [24] 17-1 [25] Antibody ATC Stage III Con:48 of 76 Con:54 of 76 B Stage I-IV Exp:39 of ... characteristics of ASI, including the number of evaluated CRC patients, the type of vaccine, the route of vaccination, adjuvants, the toxicity, and the objective clinical responses Meta -analysis of ASI...
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Báo cáo sinh học: " The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting" doc
... status of 55 GIST and the clinical outcome The size of 50 tumors was known, 21 tumors had a diameter ≤ cm and none of them had evidence of metastasis, 29 tumors Maleddu et al Journal of Translational ... P, Casali PG: The natural history of imatinib-naive GIST: A retrospective analysis of 929 cases with long-term follow-up Proceedings of The American Society of Clinical Oncology (ASCO) Annual Meeting: ... Maleddu et al.: The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting Journal of Translational Medicine 2011 9:75 Page of Submit your next manuscript...
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báo cáo hóa học: " Clinical implications of gait analysis in the rehabilitation of adult patients with "Prader-Willi" Syndrome: a cross-sectional comparative study ("Prader-Willi" Syndrome vs matched obese patients and healthy subjects)" docx
... into consideration the peculiar clinical picture of patients with PWS, aim of our study was to characterize the gait pattern of these subjects by using 3D-Gait Analysis The results were compared ... the analysis of articular mobility ROM was calculated as difference between absolute maximum (MAX) and absolute minimum (MIN) of the curve of joint movement Beside this, the mean values of MAX ... underwent clinical assessments and attended a rehabilitation program All patients showed the typical PWS clinical phenotype [16] Cytogenetic analysis was performed in all subjects; 13 out of them...
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báo cáo hóa học:" The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting" docx
... status of 55 GIST and the clinical outcome The size of 50 tumors was known, 21 tumors had a diameter ≤ cm and none of them had evidence of metastasis, 29 tumors Maleddu et al Journal of Translational ... P, Casali PG: The natural history of imatinib-naive GIST: A retrospective analysis of 929 cases with long-term follow-up Proceedings of The American Society of Clinical Oncology (ASCO) Annual Meeting: ... Maleddu et al.: The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting Journal of Translational Medicine 2011 9:75 Page of Submit your next manuscript...
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