... is one of the most important downstream processing steps of active pharmaceutical ingredients (APIs), signified by the fact that ∼90 % of all APIs are formulated as crystals The outcome of crystallization ... extensive use of such devices for research purposes took off with the development of rapid prototyping techniques, most notably soft lithography [97] Microfluidics offers a diverse toolbox of stationary ... population of particles and a lack of knowledge regarding the formation mechanism of the individual SAs While microfluidic devices are well known to be capable of generating monodisperse emulsions of...
Ngày tải lên: 09/09/2015, 11:29
... ix Investigations on Co-milling of Active Pharmaceutical Ingredients LIST OF TABLES Table Title Page Table 1.1 Mechanism of milling, advantages and disadvantages of mills used for API milling Table ... milling of CAM Effect of cryomilling on surface energetics of CAM 121 Table 5.2-5.3 Table 5.4 Table 5.5 Table 5.6 54 90 136 136 144 x Investigations on Co-milling of Active Pharmaceutical Ingredients ... (DSC)…………………………………….49 iv Investigations on Co-milling of Active Pharmaceutical Ingredients 2.3.1.3 Determination of Tg…………………………………………………….…… 49 2.3.2 Sieving of IB……………………………………………………………… 50 2.3.3 Milling...
Ngày tải lên: 11/09/2015, 10:06
Understanding dynamics in thin film spherical crystallization of active pharmaceutical ingredients from microfluidic emulsion
... values of classical nucleation theory parameters Comparison of simulated and experimental data at 65 ◦ C Summary of the model validation exercise Summary of the experiment results of ... affecting bioavailability of the API Thus, the efficient production of API crystals of desired size and polymorphic form is one of the primary challenges in downstream processing of pharmaceutical products ... tens to hundreds of micrometers[26], [27] One obvious characteristic of microfluidics is its small scale, which increases the specific surface area in microfluidics by a few orders of magnitude,...
Ngày tải lên: 30/09/2015, 10:11
active learning for sequential screening and classification of molecular and genomic data
Ngày tải lên: 14/11/2014, 08:19
Báo cáo y học: "Classification of hip joint infections"
... the knee joint [8] This classification system consists of stages (Table 1) and combines intraarticular findings of the soft tissues as well as radiological alterations of the infected joint Infections ... site of an aseptic loosening of hip arthroplasties also in the assessment of infected total hip replacements The Paprosky- [7, 19], and the AAOS (American Academy of Orthopedic Surgeons) [5-6] classifications ... assessment is needed at the time of surgery Both classification systems allow for the prior choice of which prosthesis to use at the time of reimplantation, and which type of graft depending on whether...
Ngày tải lên: 26/10/2012, 09:57
DETERMINATION OF THE DIGESTIBILITY OF SOME PLANT INGREDIENTS FOR GRASS CARP (Ctenopharyngodon idella)
... ADC of DM of test ingredient (%) = (ADC of DM of the test diet - 0.7 x ADC of DM of the reference diet)/0.3 ADC of nutrient of test ingredient (%) = [(nutrient in test diet x nutrient ADC of the ... determination of chromium III (trivalent) that involves digestion of organic matter, solubilisation of chromium and determination of chromium was Table Chemical compositions of studied ingredients Ingredients ... quality of cassava meal sources between studies 3.3 The digestibility of ash The digestibility of ash (or crude ash) of three plant -ingredients is reported in table The digestibility of ash of rice...
Ngày tải lên: 28/08/2013, 09:14
iec 60079-10 electrical apparatus for explosive gas atmospheres - classification of hazardous areas
... adjacent sources of release overlap and are of different zonal classification, the higher risk classification will apply in the area of overlap Where overlapping zones are of the same classification, ... Type of zone The likelihood of the presence of an explosive gas atmosphere and hence the type of zone depends mainly on the grade of release and the ventilation NOTE A continuous grade of release ... pressure and the geometry of the source of release The size of a cloud of flammable gas or vapour is determined by the rate of flammable vapour release and the rate of dispersion Gas and vapour...
Ngày tải lên: 25/12/2013, 10:41
Tài liệu Báo cáo " DETERMINING FLOW ENERGY AND EROSION COEFFICIENT FOR CLASSIFICATION OF POTENTIAL EROSION IN BINH DINH PROVINCE " ppt
... CSIC, 1998) The results of erosion potential classification - Based on Binh Dinh profile’s file (Vietnam Association of Soil Sciences, 1997), values of K for 117 hill soil profiles throughout the ... coefficient 39 The method of erosion potential classification in Binh Dinh Province The classification of erosion potential M in Binh Dinh Province is based on the numerical value of the flow energy ... of erosion potential for all pixels of the four basins Table K values of main soil groups and classification by erosive characteristics Symbology Number of profiles Pc-h Speck aluvial soil Pc-fe...
Ngày tải lên: 13/02/2014, 12:20
Tài liệu Gait Pattern Classification of Healthy Elderly Men Based on Biomechanical Data ppt
... developed of the Yl family in the (A) sagittal, is overlaid in bold distance of 8.7 and 13.7, respectively They form one family of 10 trials, El, and a smaller one, E2, of 6, all consisting of elderly ... center of a 10-m walkway to cover the volume required for at least one complete gait cycle of the right lower limb A third camera was placed in front of the subject and aligned along the axis of ... side), in terms of the effect of the combined 31 gait parameters The optimal number of clusters can be determined in several ways Winters and coworkers*’ calculated the criterion of Hartigan and...
Ngày tải lên: 14/02/2014, 07:20
Tài liệu Đề tài " Classification of local conformal nets. Case c doc
... ρI (A(I))] of ρI , if I ⊃ I0 The (statistical) dimension d(ρ) of ρ is the square root of the index The unitary equivalence [ρ] class of a representation ρ of A is called a sector of A 2.1.2 ... cf [2]) is often difficult to prove by other methods Furthermore, the nondegeneracy of the braiding, also called modularity CLASSIFICATION OF LOCAL CONFORMAL NETS 495 or invertibility of the S-matrix, ... Thus, while our main result concerns nets of single factors, our main tool is the theory of nets of subfactors This is the key of our approach The outline of this paper is as follows We first identify...
Ngày tải lên: 14/02/2014, 17:20
Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... somewhat of an over-simplification, as some active genes reside within heterochromatin Drosophila polytene chromosomes offer one of the clearest examples of active chromatin domains whereby active ... borders of active genes within polytene chromosome puffs [78] One of the proposed mechanisms of BE function involves the recruitment of chromatin modifying complexes that create islands of active ... simplest level, loss of histone H1 is sufficient to reduce the level of compaction of the chromatin fibre, and at active genes the amount of histone H1 is reduced compared with inactive genes [95–97]...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Diagnostic Standards and Classification of Tuberculosis in Adults and Children doc
... variability of the subjects vaccinated, the nature of the mycobacteria endemic in different parts of the world, the use of different strains of BCG for immunization, and the use of different doses of ... should be made of the technique of administration (Mantoux or multiple-puncture), the kind and dose of tuberculin, and the size of reaction in millimeters of induration D Interpretation of Skin Test ... concentration of a drug is the level of drug that inhibits the growth of most cells within the population of a “wild” type strain of tubercle bacilli without appreciably affecting the growth of the...
Ngày tải lên: 15/02/2014, 12:20
Tài liệu Đề tài " The topological classification of minimal surfaces in R3 " pptx
... interior of W Let S denote the collection of ends of planes and catenoids defined above which arises from the collection of nonsimply connected components W of Hi − ∪Di It follows from the proof of ... ordering of ends The proof of the case where F has two limit ends is similar Let W be the set of closures of the components of H1 −∪D1 and H2 −∪D2 Given W ∈ W, let P(W ) be the collection of planes ... TOPOLOGICAL CLASSIFICATION OF MINIMAL SURFACES 687 two slabs each containing fewer ends of F Since the number of ends of F ∩ S is finite, the existence of the required collection of planes follows by...
Ngày tải lên: 16/02/2014, 06:20
Performance Evaluation of Active Suspension for Passenger Cars.Using MATLAB
... animation of both the systems along with the graphs of Displacement Vs time just below the animation window of each of the suspension system By comparing the performance of the passive and active ... passive and active systems Fig Body Acceleration Fig 10 Wheel Displacement Analysis of Active Suspension System Using Animation To realize the effect of Road variation on the Passive and Active suspension ... from the help of sensors as an input Sensors will give the data of road profile to the controller Therefore, an active suspension system shown is Fig is needed where there is an active element...
Ngày tải lên: 16/02/2014, 09:13
Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate specificity docx
... the binding of the feedback inhibitor dTTP and the position of Mg2+ in the active site Mg ion that coordinates the phosphates of dTTP (Fig 3) Discussion Mutation of residues in the active site ... ª 2007 FEBS L Egeblad-Welin et al Active site mutation of deoxyribonucleoside kinase Table Kinetics of dThd and dCyd phosphorylation for active- site mutants of Dm-dNK AraC, AraT and BVDU were ... levels of phosphorylation expressed in relation to percentage dThd phosphorylation of the wild-type Relative phosphorylation expressed as a relation of the percentage of dThd phosphorylation of the...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt
... description of the exact role, electrostatic properties, and hydrogen bonding potentials of active site residues provides an optimized model of the ligand-binding potential of the active site, ... catalysis P von Wettstein-Knowles et al A B Fig The active sites of the K328R mutant protein (A) Active site of the C monomer; (B) active site of the D monomer Dotted lines represent possible hydrogen ... orientation of T300 (Fig 3D versus Fig 3E) Structures of KAS I H298Q and the H298Q–C12 complex The H298Q overall structure, including that of its active site, is similar to those of H298E and...
Ngày tải lên: 19/02/2014, 08:20
Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... the roles of these DHSs on the transcription of Ig-b gene and on the maintenance of the active chromatin state Results Generation of DT40/Cre cells with a long deletion in one allele of the Ig-b ... genes A member of the OCT family transcription factors appeared to be involved in the transactivation of the region which had the highest enhancing activity of the three DHSs The state of acetylation ... the mechanism of B cell-specific transcription of the Ig-b gene, we generated DT40 ⁄ Cre cells with a 16 kb deletion (16 kb Del) in one allele of the Ig-b locus (Fig 1) Introduction of the 16 kb...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf
... data to measure the impact of each of the four subsets of features explained in Section Table shows the cross validation results when cumulatively adding each set of features Applying the 1-vs-all ... minority classes was weak For example, most of Present R Absent P R The micro-averaged F1-measure of our new system is 94.17%, which now outperforms the best official score reported for the 2010 i2b2 ... assertion classification task was tackled by participating researchers The best performing system (Berry de Bruijn et al., 2011) reached a micro-averaged F1measure of 93.62% Their breakdown of F1...
Ngày tải lên: 20/02/2014, 05:20
Tài liệu Báo cáo khoa học: "Semantic Classification of Noun Phrases Using Web Counts and Learning Algorithms" ppt
... relations Over the set of semantic relations defined by Nastase and Szpakowicz (2003), they achieve an accuracy of 45.7% for the task of assigning one of semantic relations to each of the 600 modifier-noun ... motivation in this paper was twofold Firstly, we wanted to compare the performance of different machine learning algorithms on the task of mapping from a vector of web frequencies of paraphrases containing ... web frequencies for queries of the form “head joining term modifier” We did not collect queries of the form “modifier joining term head”; in the majority of paraphrases of noun phrases the head...
Ngày tải lên: 20/02/2014, 12:20
Tài liệu Báo cáo Y học: Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis docx
... Total number of observations Number of unique reflections Completeness (%)
Ngày tải lên: 22/02/2014, 04:20