chemotherapy induced hemostatic activation and thrombosis in cancer
Báo cáo y học: " Ventilator-induced endothelial activation and inflammation in the lung and distal organs" docx
... pro-inflammatory cytokines IL-1β and TNF-α were observed (Figures 2e and 2f) In addition, MV induced an increase in mRNA expression of the chemokine KC (Figure 2g) Granulocyte recruitment To investigate ... RT-PCR In addition, we studied ventilator -induced pulmonary inflammation by measuring mRNA expression of the pro-inflammatory cytokines (e) IL-1β and (f) TNF-α and the chemokine (g) keratinocyte-derived ... major finding was that MV induced de novo synthesis of various adhesion molecules represented by an elevation of E-selectin and VCAM-1 mRNA in pulmonary tissue and a rise in E-selectin, VCAM-1 and...
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Báo cáo y học: "Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy" pptx
... (arrows) involved in thrombus formation Tissue section in E was stained with iron staining; tissue section in F, G, H, and I were stained with H & E staining Elevated pAkt and eNOS expression in simvastatin ... http://www.jbiomedsci.com/content/18/1/26 loading and G-CSF to mice to test our hypothesis by examining the incidence of cardiovascular thrombosis Interestingly, intra-cardiac thrombus formation was observed in iron and G-CSF (I+G) ... fibrinogen (or GPIIb/IIIa) did not have major role in this inflammation -thrombosis process [27] Our in vivo mouse model could be a novel avenue for investigating inflammation and thrombosis interactions...
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Báo cáo y học: " Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers" pptx
... Conclusion: Tourniquet induced forearm ischaemia-reperfusion injury results in increased adhesiveness, trapping and activation of leukocytes We report that, even following a mild ischaemic insult, this ... concentration during ischaemia and reperfusion resulted in an increase in vWF concentration from baseline and peaking at 30 minutes reperfusion (1.07 ± 0.11 – 1.42 ± 0.19) (Figure 8) Following 24 hours ... during ischaemia-reperfusion injury This investigation verified leukocyte involvement during ischaemia-reperfusion injury, and provided evidence of increased endothelial cell damage, following...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... carcinoma Bladder cancer Glioblastoma multiforme Autocrine-paracrine loop Glioma Autocrine-paracrine loop PDGFR and PDGF IGFR and IGF I and II Breast cancer Table Protein kinase inhibitors in clinical...
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Tài liệu Psychotherapy and Survival in Cancer: The Conflict Between Hope and Evidence pptx
... needed for conducting, reporting, and interpreting randomized clinical trials This knowledge cannot be inferred from an understanding of conventional experimental design in the social and behavioral ... randomization, introducing bias Forty patients were each initially randomized to intervention and control conditions In the intervention group, patient was excluded owing to death, owing to incomplete ... emphasized reducing denial while preserving hope, completing unfinished business, and taking an active role in treatment decisions, but “above all else, simply listening, understanding, and sometimes...
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The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... hospitals in Shanghai, Beijing, and other areas in China, with a total 189 patients The double-blind study used the same doses and test materials as the previous study, and examined PSP against the...
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Báo cáo khoa học: " Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells" pptx
... lines IR -induced Akt activation was dependent upon the presence of serum factors, and could be inhibited by the EGFR inhibitor Inhibiting PI3K, EGFR and Akt activation during irradiation increased ... failed to undergo IRinduced Akt activation, indicating that activation of EGFR by IR is required for IR -induced Akt phosphorylation in these cells Pharmacological inhibition of PI3K and EGFR enhances ... such that Akt activation was not altered during clone formation and clone formation efficiency remained constant Using U87MG cells we showed that inhibiting IR -induced Akt activation increases radiosensitivity...
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Báo cáo khoa học: "Cysteine protease activation and apoptosis in Murine norovirus infection" docx
... remained viable and morphologically indistinct from control cells Blebbing, swelling, and cytoplasmic leaking were evident in cells infected in the presence of the caspase inhibitor (Figure 4) In ... RAW264.7 cells induced apoptotic changes To establish the initial events during infection that lead to survivin down-regulation and PCD, we investigated caspase activation early in the infection process ... better understanding of the different processes that were occurring in the caspase inhibited and non-inhibited infected RAW264.7 cells, two additional stains were used Hoechst staining is commonly...
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Báo cáo y học: " Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice" doc
... Increased interleukin-4, interleukin-5, and interferon-gamma in airway cd4+ and cd8+ t cells in atopic asthma Am J Respir Crit Care Med 2005;171(3):224-230 22 32 Wills-Karp M Interleukin-13 in ... proinflammatory cytokines including TNFα and IL-4 and inhibit the production of antiinflammatory mediators exemplified by IFNγ Our findings suggest that designing an inhibitor specially targeting CXCR3 ... Millner A, Quan S, Hansen JB, Dissing S, Malling HJ, Skov PS, et al Cxcr3 expression and activation of eosinophils: Role of ifn-gamma-inducible protein-10 and monokine induced by ifn-gamma J Immunol...
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Báo cáo y học: " Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model" pot
... microscopy were processed and embedded in paraffin Sections (five micron) were cut onto the polyL-Lysine coated slides and used for hematoxylin and eosin staining and immunostaining Pieces of the left ... recruited PIMs in endotoxin -induced mortality in a BDL rats It is striking that depletion of a single inflammatory cell results in remarkable reduction in key inflammatory 11 Competing interests The ... response in BDL rats in the absence or presence of PIMs PIM reduction protects against LPS -induced mortality in BDL rats We delineated role of PIMs by comparing LPS -induced lung inflammation and mortality...
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Báo cáo y học: "Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers" ppt
... When one eats foods containing capsaicin, the burning sensation is elicited by TRPV1-containing peptidergic nociceptors surrounding taste buds in the tongue [16] Capsaicin -induced cough may not ... between and between capsiate -induced cough induced reflex sensitivities (A), capsaicin- andcapsaicin- and capsiateCorrelations chemesthesis sensitivities (B) Correlations between capsaicin- and capsiate -induced ... saline to make testing solutions starting at a concentration of 0.49 µM and increasing it by doubling the concentration up to 1000 µM Capsiate was extracted from CH-19 sweet (kind gift from Ajinomoto...
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Báo cáo y học: "Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo" pot
... Involvement of Rho pathway in ventilator -induced lung inflammation and barrier dysfunction In the following experiments, we investigated a role of Rhodependent signaling in lung injury induced by mechanical ... that, in comparison with static conditions, pathologic strain promoted thrombin -induced Rho activation during the acute phase and suppressed Rac activation during the recovery phase of thrombin -induced ... experimental group) were agarose-inflated in situ, fixed in 10% formalin, and used for histologic evaluation by hematoxylin and eosin staining as described in Materials and methods Histological analysis...
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Báo cáo y học: "Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism." ppt
... enoxaparin in the initial treatment phase resulted in a more rapid decline in soluble fibrin, D-dimer, and fibrinogen/fibrin degradation products, compared to enoxaparin alone, in patients with an initial ... fibrin formation and fibrin dissolution Anticoagulant therapy with enoxaparin blunted intravascular fibrin formation, leading to a decline in soluble fibrin levels D-dimer and fibrinogen/fibrin ... retroperitoneal bleeding, bleeding requiring surgical intervention, or development of hematomas requiring prolonged hospitalization, and minor bleeding defined as a decrease in hemoglobin of
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PINI and MEK2 regulate BPGAPI induced ERK activation and cell migration
... domain of BPGAP1 harbors a cryptic Pin1-binding site 73 3.1.1 Potential Pin1-bining sites in BPGAP1 3.1.2 Pin1 interacts with BPGAP1 specifically at the GAP domain of BPGAP1 3.1.3 Distinct binding ... differential binding profiles to BPGAP1 under the influence of Mek2-SD 3.5.2 Active Mek2 -induced binding of BPGAP1 and WW domain of Pin1 is independent of phosphorylation 3.5.3 WW domain of Pin1 binds ... „Arginine finger‟ (Gamblin and Smerdon, 1998) During the reaction, RhoGAP domain interacts with 30 Chapter INTRODUCTION both switch I and switch II regions and the P-loop in the GTP-binding core...
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Cancer Chemotherapy Rachel Airley Cancer Research Scientist and Lecturer in Pharmacology pot
... breast (77%) and cervix (61%) cancers; 10–50% survival, including colon (47% in males, 48% in females), renal (45% in males, 48% in females) and brain (12% in males, 15% in females); and cancers where ... p53 -induced cell cycle arrest is linked to its transcriptional activation of p21, a protein that binds and inhibits the cyclin–CDK complex at the G1–S checkpoint, leaving the protein pRb in its ... Cancer Chemotherapy Rachel Airley Cancer Research Scientist and Lecturer in Pharmacology Cancer Chemotherapy Cancer Chemotherapy Rachel Airley Cancer Research Scientist and Lecturer in Pharmacology...
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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx
... staining pattern in mouse knee joint was influenced by disease severity Mild inflammation (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in ... morphogenetic protein-2 (BMP2) during collageninduced arthritis Immunohistochemistry in the initial phase (a, b), with increasing severity (c-f), and in the destructive phase of collageninduced arthritis ... morphogenetic protein signaling in joint homeostasis and disease Cytokine Growth Factor Rev 2005, 16:287-298 Sancho E, Batlle E, Clevers H: Signaling pathways in intestinal development and cancer Annu...
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Báo cáo y học: "DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lpr mice in vivo" potx
... replaced with random nucleotide triplets Similarly, ODNs INH-44, INH-46, and INH-48 are linear derivatives of INH-18 lacking CCT, GGG, or both triplets INH-4 and INH13 are palindromic or linear analogues ... with linear CpG-DNA ligands In addition to autoreactive B cells, class R INH-ODNs are capable of blocking both DNA/antiDNA -induced and RNA/anti-RNA -induced IFN-α secretion from DCs Interestingly, ... GGG-3') [39] INH-1 was created by adding a complementary strand of nucleotides generating a 24-mer ODN forming a complete palindrome INH-18 is a linear 24-mer class B INH-ODN in which the 5' INH-ODN...
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Báo cáo y học: " Carcinomatous meningitis in a patient with Her2/neu expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature" ppt
... Tomlin I, Visseren-Grul CM, Conte PF: Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, ... survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer J Clin Oncol 2005, 23:4602-4608 ... concordance in bladder cancer [9] as well as the fact that Her2/neu expression is more common in bladder cancer than in breast cancer [5], it remains to be seen if the incidence of carcinomatous meningitis...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... participated in the animal instillation and in the histological and immunohistochemical experiments JC initiated the project, participated in the design of the study and in the interpretation of data, and ... embedded in paraffin, and sectioned at μm The tissue sections were stained with hematoxylin and eosin (HE) and van Gieson's stain (vG) for collagen fibers Silicotic nodules were graded as following: ... using a 3, 3'-diaminobenzidine tetrahydrochloride Substrate Kit (Beijing Zhongshan Golden Bridge Biotechnology Ltd., China) The sections were counterstained with hematoxylin for min, rinsed and...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... actin associated proteins, myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin ... genes involved in lipid use and energy balance (AMP-activated protein kinase-gamma3, uncoupling protein (UCP)-3, GLUT4 in the case of silencing NR4A1 and FABP4, CAV3, UCP2 in the case of silencing ... apart from other DNA binding proteins, and a largely conserved C terminal domain which has sufficient variation to allow for ligand selectivity and possesses a ligand induced activation function...
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- bleeding and thrombosis in acute promyelocytic leukemia
- bleeding and thrombosis in the myeloproliferative disorders
- signs of death and dying in cancer patients
- bleeding and thrombosis in polycythemia
- bioactive foods and supplements in cancer prevention
- telomere and telomerase in cancer recent progress
- subsets expansion and role in cancer progression
- oligonucleotide induced modification of alternative splicing in cancer
- cancer metabolic networks metabolic pathways modeling and metabolomics in cancer research
- antithrombotic therapy and suvival in cancer patients
- induction intra arterial chemotherapy iac with epirubicin and mitoxantrone in locally advanced breast cancer
- genomics proteomics and metabolomics in cancer research
- sirna attenuated the poly i c induced growth inhibition and apoptosis in sk n as cells
- nk and nkt cell activation and functions in hiv infection
- polymer induced phase separation and crystallization in model immunoglobulin g solutions
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