bleeding and thrombosis in polycythemia
Chapter 059. Bleeding and Thrombosis (Part 1) pdf
... Chapter 059. Bleeding and Thrombosis (Part 1) Harrison's Internal Medicine > Chapter 59. Bleeding and Thrombosis Bleeding and Thrombosis: Introduction The human hemostatic ... normally inactive GpIIb/IIIa receptor into an active receptor, enabling binding to fibrinogen and vWF. Because the surface of each platelet has about 50,000 GpIIb/IIIa fibrinogen binding sites, ... Fibrin Clot Formation Plasma coagulation proteins (clotting factors) normally circulate in plasma in their inactive forms. The sequence of coagulation protein reactions that culminate in the...
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Chapter 059. Bleeding and Thrombosis (Part 2) potx
... Fibrin formation and dissolution. A. Fibrinogen is a trinodular structure consisting of 2 D domains and 1 E domain. Thrombin activation results in an ordered lateral assembly ... associations. FXIIIa cross-links the D domains on adjacent molecules (C). Fibrin and fibrinogen (not shown) lysis by plasmin occurs at discrete sites and results in intermediary fibrin(ogen) degradation ... Thrombin also activates factor XIII (fibrin-stabilizing factor) to factor XIIIa, which covalently cross-links and thereby stabilizes the fibrin clot. Figure 59-2 Chapter 059. Bleeding and Thrombosis...
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Chapter 059. Bleeding and Thrombosis (Part 3) docx
... PAI1 and PAI2, inhibit the physiologic plasminogen activators; and (2) α2 antiplasmin inhibits plasmin. PAI1 is the primary inhibitor of tPA and uPA in plasma. α2 antiplasmin is the main inhibitor ... of antithrombin. The rate of formation of these inactivating complexes increases by a factor of several thousand in the presence of heparin. Antithrombin inactivation of thrombin and other activated ... fibrin. In response, the endogenous fibrinolytic system is then activated to dispose of intravascular fibrin and thereby maintain or reestablish the patency of the circulation. Just as thrombin...
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Chapter 059. Bleeding and Thrombosis (Part 4) potx
... contributed to the bleeding or thrombotic state. In addition, the history can give clues as to the etiology by determining (1) the bleeding (mucosal and/ or joint) or thrombosis (arterial and/ or venous) ... Chapter 059. Bleeding and Thrombosis (Part 4) Approach to the Patient: Bleeding and Thrombosis Clinical Presentation Disorders of hemostasis may be either inherited or acquired. ... Bleeding A history of bleeding is the most important predictor of bleeding risk. In evaluating a patient for a bleeding disorder, a history of at-risk situations, including the response to past...
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Chapter 059. Bleeding and Thrombosis (Part 5) ppt
... Chapter 059. Bleeding and Thrombosis (Part 5) Epistaxis is a common symptom, particularly in children and in dry climates, and may not reflect an underlying bleeding disorder. However, ... mild bleeding disorder such as vWD. All NSAIDs, however, can precipitate gastrointestinal bleeding, which may be more severe in patients with underlying bleeding disorders. The aspirin effect ... factor XI deficiency and in symptomatic carriers of hemophilia A. Women with underlying bleeding disorders are more likely to have other bleeding symptoms, including bleeding after dental extractions,...
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Chapter 059. Bleeding and Thrombosis (Part 6) doc
... Coexisting coagulopathies, as seen in liver failure or disseminated coagulation; infection; platelet-inhibitory drugs; and underlying medical conditions can all increase the risk of bleeding in ... risk is inherited or acquired. Note: APC, activated protein C; TAFI, thrombin-activatable fibrinolysis inhibitor; TFPI, tissue factor pathway inhibitor. Chapter 059. Bleeding and Thrombosis ... patient with a bleeding tendency must therefore include a thorough assessment for evidence of underlying disease. Bruising or mucosal bleeding may be the presenting complaint in liver disease,...
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Questions to .NET and Programming in C#
... statement’s syntax is incorrect. 51. using System; class Test { static void Main() { int @Main; int[] Static= new int[3]; @Main =100*Static[1]; Console.WriteLine(@Main); } } What ... Prints 100 and 999. c) Compilation error at line 2, variable maxElements was not initialized. b) Prints 999 and 100. d) Compilation error at line 3. 92. What will be printed to standard ... types and reference types c) Pointers and values 32. _________ _in simple terms is nothing but conversion of a value type into a reference type. [1.0] a) Casting c) Unboxing b) Boxing d)...
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Questions to .NET and Programming in C#
... Main(string[] args) { IntIndexer myInd = new IntIndexer(5); myInd[1] = "Some Value"; myInd[4] = "Any Value"; myInd[2] = "Another Value"; Console.WriteLine("\nIndexer ... to an int data type. 203. Which of the following is the correct syntax for declaring an indexer. [1.0] a) protected int this[int var1] c) public int this(int var1) b) public int classname[int ... in the class B d) The function B.F( ) must be declared as “unsafe”. 229. using System; class IntIndexer{ private string[] myData; public IntIndexer(int size) { myData = new string[size];...
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The Duality of Memory and Communication in the Implementation of a Multiprocessor Operating System
... objects are invoked through message passing. Mach runs on the majority of workstations and mainframes within the Department of Computer Science, and supports projects in distributed computing and parallelprocessing ... Programming Languages and Operating Systems. ACM, October,1987. 12address map. Note that the sharing semantics are different than in the inheritance case in that no sharing map isinvolved; ... speech understanding system called Agora [3]. This work is being doneon Mach and currently makes use both of Mach memory sharing and message passing.Both communication and memory sharing are used...
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Friends, Overloaded Operators, and Arrays in Classes
... 2007 Pearson Education, Inc. Publishing as Pearson Addison-Wesleydigit_to_int (optional)digit_to_int is defined as int digit_to_int(char c) { return ( int ( c ) – int ( '0') ... program using function equal is found in Slide 11- 49Copyright â 2007 Pearson Education, Inc. Publishing as Pearson Addison-WesleyOperand 1OperatorOperand 2Overloading << and >>The ... Education, Inc. Publishing as Pearson Addison-WesleyChapter 11Friends, Overloaded Operators, and Arrays in Classes Slide 11- 24Copyright â 2007 Pearson Education, Inc. Publishing as Pearson...
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