cdk as targets for cancer therapy and imaging
Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... CD44v6 is expressed in breast, cervical and colon cancers, and in squamous cell carcinomas Thus CD44v was chosen as a model for therapy A Phase clinical trial was performed with an immunotoxin ... fibrosarcomas, breast cancer, mesotheliomas and prostate cancer, transfected with HAS1, HAS2 and HAS3 genes, triggered intracellular signaling pathways that promoted anchorage-independent growth and ... cancer- associated stromal myofibroblasts [103] As hMSCs can be easily expanded in vitro and possess an extensive multipotent capacity for differentiation, they have been explored as vehicles for...
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recombinant antibodies for cancer therapy, methods and protocols
... periplasmic disulfideisomerase DSbA as well as periplasmic peptidylprolyl cis,trans-isomerases (PPIase) PpiA and SurA did not increase the yield of soluble antibody fragments (82–84) In contrast, ... HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease J Clin Oncol 17, 2639–2648 Application of Recombinant Antibodies 49 156 Baselga, J., Norton, ... antibody against HER2 for metastatic breast cancer that overexpresses HER2 N Engl J Med 344, 783–792 159 Tan, A R and Swain, S M (2001) Adjuvant chemotherapy for breast cancer: an update Semin...
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nanocarriers as an emerging platform for cancer therapy
... ligands (peptides, vitamins, and carbohydrates) Targeting cancer with a mAb was described by Milstein in 198123 Over the past two decades, the feasibility of antibody-based tissue targeting has ... screening for conformational-sensitive targeting agents such as affibodies, avimers and nanobodies, as well as intact antibodies and their fragments process, scFv antibodies have been identified for ... mesothelioma, ovarian and acute lymphoblastic leukaemia Adenocarcinoma of the oesophagus, 5, 91, 100, 101 metastatic breast cancer and acute lymphoblastic leukemia 73, 74 Metastatic or recurrent...
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báo cáo hóa học:" Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer" doc
... luminescencebased cell number assay and the data was analyzed as described in Materials and Methods Two independent HT-RNAi screens were conducted using and 10 nM gem- Figure HT-RNAi kinase screening for ... gene targets such as STK6 [29,30] and ATR [31] have previously been studied as therapeutic targets in pancreatic cancer Another target, CAMK1 has been identified as being antiapoptotic, and a ... DOA, SM, JMT and DDV were responsible for the initial conception and design of this study DOA was responsible for planning of the experiments RNAi screening was performed by IMG and MCH and analyzed...
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Báo cáo y học: "The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer" pptx
... factors such as tumour size, tumour grade and metastasis to local lymph nodes New prognostic markers are most urgently needed for cancers such as breast and prostate cancer In breast cancer, prognostic ... markers for breast cancer are increased in patients with early disease and are thus of little value in identifying women at increased risk of developing this malignancy [55] As well as breast cancer, ... HER2 overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease J Clin Oncol 1999, 17:2639-2648 80 Asakura M, Kitakaze M, Takashima S, et al: Cardiac...
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Improvement of different vaccine delivery systems for cancer therapy pptx
... delivery and expression in vitro These findings support the development of VLPbased strategies for both prophylaxis and therapy of HPVassociated diseases, and for using VLPs in an effort to avoid ... suitable for when high doses and robust immune responses are desired such as cancer vaccines and gene therapy Clinical trials in progress and planned using Derma Vax include 1) Prostate cancer (Phase ... photodynamic therapy, boron neutron capture therapy, and gene therapy for cancer are being examined [63] Recently, the modified fluorescent nanoparticles have been synthesized as a targeting and delivery...
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Quick Reference Dictionary for Massage Therapy and Bodywork pot
... locally by invasion and systemically by metastasis; massage therapy is contraindicated for cancers which might metastasize Apply massage only if you have the approval of a physician candidiasis: Infection ... is a member of American Massage Therapy Association, Associated Bodywork and Massage Professionals, Ohio State Massotherapy Associa- xii About the Author tion, and Massage Focus Group He is a ... involved with massage and bodywork education He was president of the Ohio State Massotherapy Association in 1995 and was a founding member of the Ohio Massage Schools Council in 1999 Ed was selected...
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nanotechnology for cancer therapy, 2007, p.810
... expansion and metastasis This realization and the accompanied potential for development of successful cancer therapeutics, as well as for tumor imaging strategies based on tumor-associated vasculature, ... tumors as well as serve as multifunctional nanovector devices for cancer therapy, imaging, diagnostics, and monitoring of response to anti-tumor therapy Although the development of nanoplatforms for ... received attention for their utility as tunable multicolor nanoparticles that can be used for in vivo tumor imaging in animal models of cancer as well as for multiplex detection of mRNAs and proteins...
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Báo cáo sinh học: " Matrix attachment regions as targets for retroviral integration" ppt
... human breast carcinomas and not in normal and benign breast disease tissues Cancer Res 1996, 56(3):457-462 Leman ES, Getzenberg RH: Nuclear matrix proteins as biomarkers in prostate cancer J ... proteins as proteomic markers of preneoplastic and cancer lesions : commentary re: G Brunagel et al., nuclear matrix protein alterations associated with colon cancer metastasis to the liver Clin Cancer ... genes was identified for MoFe2 and SL3-3 at single insertion sites, although not for SL3-3 integrated at CISs Analysis was then performed to determine if preferred integration into genes was associated...
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báo cáo hóa học:" Matrix attachment regions as targets for retroviral integration" doc
... human breast carcinomas and not in normal and benign breast disease tissues Cancer Res 1996, 56(3):457-462 Leman ES, Getzenberg RH: Nuclear matrix proteins as biomarkers in prostate cancer J ... proteins as proteomic markers of preneoplastic and cancer lesions : commentary re: G Brunagel et al., nuclear matrix protein alterations associated with colon cancer metastasis to the liver Clin Cancer ... genes was identified for MoFe2 and SL3-3 at single insertion sites, although not for SL3-3 integrated at CISs Analysis was then performed to determine if preferred integration into genes was associated...
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Báo cáo sinh học: "Targeting TNF-α for cancer therapy" potx
... 42-kD serine protease inhibitor (serpin); inhibits EC migration and tumor growth and vascularity in mice 110- and 98-kD proteins with metalloprotease and disintegrin-like domains, and carboxy-terminal ... JC: Tumor stroma-associated antigens for anti -cancer immunotherapy Cancer Immunol Immunother 2006, 55:481-494 Pasqualini R, Koivunen E, Ruoslahti E: Alpha v integrins as receptors for tumor targeting ... fragments Thrombin Endothelial and tumor cell mitogen, increases metastasis in vivo uPA (plasminogen activator, urokinase) Only expressed in angiogenic endothelium; has a role in preventing excessive...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
... nephritis was inversely associated with anti-La (SS-B) and associated with anti-dsDNA It has been repeatedly shown that anti-dsDNA, single anti-Ro antibodies as well as Sm antibodies [10] are associated ... significantly increased frequency of CD19+/CD27high plasma cells and had a predictive value for disease activity that was greater than traditional humoral/clinical measurements (for example, anti-dsDNA, ... with lupus disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated by the SLEDAI and the Systemic...
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báo cáo khoa học: "From basic research to clinical development of MEK1/2 inhibitors for cancer therapy" pot
... disease lasting 3-7 months [84] The phase I study was extended and clinical activity was documented by partial responses in melanoma patients and 24 cases of disease stabilization (22 melanoma and ... clinical activity for this class of agents On this basis, a phase II study was initiated in 67 patients with advanced breast, pancreatic, colon and non-small cell lung cancers [80] Unfortunately, ... distinct MAP kinase pathways (Fig 2A) Aside from MEK1/MEK2, the MAPKKs MKK4 and MKK7 phosphorylate and activate the c-Jun N-terminal kinase (JNK) isoforms, MKK3 and MKK6 phosphorylate and activate...
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tóm tắt luận án cu based organic frameworks as catalysts for c c and c n coupling reactions (tiếng anh)
... (BDC)2 (DABCO) and Cu2 (BPDC)2 (BPY) The second objective is to study their use as heterogeneous catalysts for the direct C–C and C–N coupling reactions to form proparylamines and quinoxalines ... Fourier transform infrared (FT-IR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), inductively coupled plasma mass spectrometry (ICP-MS), and gas physisorption measurement, ... (BPY) and Cu(BDC) as catalysts for the synthesis of proparylamines and quinoxalines: i) Synthesis and characterization of the Cu-MOFs including Cu3 (BTC)2 , Cu2 (BDC)2 (DABCO), Cu2 (BPDC)2 (BPY) and...
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Cu based organic frameworks as catalysts for c c and c n coupling reactions
... Cu(NO3)2 3H2O and H2 BDC was dissolved in DMF and then heated at 110 o C in an isothermal oven for 36 hours to form a blue powder The BET surface areas of 625 m2/g and Langmuir surface areas of m2 ... dicarboxylates and DABCO as a pillar ligand in methanol solution [56] In that synthesis, a methanol solution of copper (II) sulfate pentahydrate, terephthalic acid and formic acid was stand for several ... 2-hydroxybenzaldehyde and 1,4-dioxane using Cu2(BPDC)2 (BPY) as a solid catalyst [61] 25 Recently, Cu2(BPDC)2 (BPY) was used as solid catalyst for the oxidative crossdehydrogenative coupling of phenols and formamides...
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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
... spectroscopy and zeta potential measurements, as well as by saturation of magnetization The infrared spectra of Magh-Rh (H cit) (Figure 2C) showed intense absorptions assigned to asymmetrical as (COO) and ... MCF-10A breast normal cell line was noted than in the 4T1 and MCF-7 breast cancer cell lines Nonetheless, the Magh-Rh (H cit) and Lip-Magh-Rh (H cit) treatments were more selective to breast cancer ... effect differed between breast normal (MCF-10A) and breast carcinoma (4T1 and MCF-7) cell lines, being more pronounced in breast normal cells (Table and 2) Our data are, therefore, in agreement with...
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Surface functionalization of superparamagnetic iron oxide nanoparticles for potential cell targeting, imaging, and cancer therapy applications
... molecular imaging modalities, MRI is one of the best imaging modalities in both research and clinical fields for injury and disease diagnosis as it offers high spatial and temporal information ... than 41 oC Therefore, hyperthermia based on the generation of heat at the tumor site is a promising cancer therapy and is a supplementary treatment to chemotherapy, radiotherapy, and surgery (Lu ... drastically reduces the efficiency of SPIONs-based diagnostics and therapeutics In addition, specific accumulation of SPIONs in target organs is also required for cancer therapy via SPIONs-based...
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Use of IPs cell derived neural stem cells as a cellular vehicle for glioma and breast cancer therapy
... cell based cancer gene therapy 28 1.5.5 Future of stem cell based cancer gene therapy 30 Aims and objective 31 Material and methods 33 3.1 Cell culture 33 3.2 Mouse iPSC-derived NSC for glioma therapy ... affect angiogenesis, tumor invasion and metastasis Angiogenesis is a good target for cancer gene therapy as solid tumors are limited in size without sufficient oxygen and nutrition Commonly used ... block the invasion and metastasis of cancer Antisense oligonucleotides against mRNA of Bcl-2, c-myc and ras family of oncogenes has resulted in tumor growth inhibition in solid tumors and leukemia...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
... SH-SY5Y (neuroblastoma) [43] and MCF-7 (breast cancer) cell lines and various cancers such as gliomas [44], cervical cancers [45], colon carcinoma [46], gastric cancers [47] and sarcomas [48] HERG ... endometrial cancer, gastric and glioblastoma [52-55] The first tissue expression of HERG channels in cancer showed that herg mRNA and HERG protein was expressed in 67 and 82% of endometrial cancer ... of shRNAs for HERG1 and the HERG-1b isoform, reduced growth rate, cell viability and inhibited colony formation of neuroblastoma cells restricting them to G0/G1 phase of cell cycle There was also...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
... cInvasive ductal carcinoma, dInvasive Paget’s disease, eDistance metastasis patients had lung metastasis and two had liver metastasis One patient had mediastinal involvement On the other hand, ... factor for OS Distant metastasis rate was higher in no-RT group compared to RT group (42% vs 12%), bone and liver metastasis being higher in number as of distribution among metastatic sites Therefore, ... Early Breast Cancer Trialists’ Collaborative Group (EBCTCG): Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised...
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