... I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence Andrea Savarino* †1 , Antonello Mai ... buthionine sulfoximine (BSO), alone or in combinationFigure 4 Effects on HIV-1 replication and cell viability of class I-selective HDACIs, MS-275 and buthionine sulfoximine (BSO), alone or in combination. ... HDACIs with increased selectivity and decreased toxicity. Finally, we are currently searching for novel γ-glutamyl-cysteine synthetase inhibitors acting in the nanomolar range and displaying lower
Ngày tải lên: 12/08/2014, 23:21
... Interleukin-1 β protein (x-fold over Sham control) Figure 3 Protein concentration of interleukin-1b. Protein concentration of interleukin (IL)-1b was determined by a swine specific enzyme- linked-immunosorbent ... carbon dioxide (suction rate, 200 mL/min; M-PRESTN; Datex-Ohmeda Inc., Helsinki, Finland). Total intravenous anesthesia (TIVA) was maintained by continuous infusion of 4 to 8 mg/k g/h propofol ... ICAM-1 1.9 ± 0.7-fold compared with sham control). These results were also confirmed for IL-1b on protein level. Experimental settings employing hypothermia in combination with sevoflurane showed that
Ngày tải lên: 13/08/2014, 20:21
tóm tắt luận án tiến sĩ nghiên cứu kết quả điều trị của hai phác đồ peginterferon alfa-2a kết hợp ribavirin và peginterferon alfa-2b kết hơp ribavirin trong điều trị bệnh nhân viêm gan virus c mạn tín
... vững c a Peginterferon alfa - 2a kết hợp Ribavirin là 82% và c a Peginterferon alfa 2b là 84% - Tỉ lệ tái phát c a Peginterferon alfa - 2a kết hợp Ribavirin là 12% ... điều trị Peginterferon alfa kết hợp Ribavirin trong điều trị viêm gan C mạn tính, theo tác giả Đinh Dạ Lý Hương 84,7% . Peginterferon alfa 2b tỏ ra hiệu quả hơn Peginterferon alfa 2a đối ... tính cho kết quả khả quan hiện nay là 2 Peginterferon alfa - 2a kết hợp Ribavirin và Peginterferon alfa - 2b kết hợp Ribavirin. Tuy nhiên hai loại Peginterferon này vẫn có những tính chất dược
Ngày tải lên: 27/08/2014, 11:12
In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... University of Singapore 2009 In vitro and In vivo study of ABT-869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular ... of combination therapy. Thus a clinical trial using sequence-dependent combination therapy with ABT-869 in AML is initiated. Neoangiogenesis plays an important role in leukemogenesis. We investigated ... domain only CDNA clone IMAGE:5261213 interferon, gamma-inducible protein 16 interferon, gamma-inducible protein 16 acyl-Coenzyme A dehydrogenase, short/branched chain S100 calcium binding protein
Ngày tải lên: 11/09/2015, 09:06
Study of sample preparation and pretreatment methods and their applications, in combination with high resolution chromatography
... disadvantages in detail, mainly combined their applications with GC/MS. In the beginning, for the first time, the feasibility of using SFE to extract PCBs from pine needle was fully studied. Compared with ... viii Initial temperature 50 oC held for mins then increased at a rate of oC/min to 220 oC and held for mins, and then temperature increased at a rate of oC/min till to 265 oC. The injector ... APPLICATIONS, IN COMBINATION WITH HIGH-RESOLUTION CHROMATOGRAPHY ZHU XUERONG NATIONAL UNIVERSITY OF SINGAPORE 2005 STUDY OF SAMPLE PREPARATION AND PRETREATMENT METHODS AND THEIR APPLICATIONS, IN COMBINATION
Ngày tải lên: 16/09/2015, 15:54
bevacizumab in combination with paclitaxel and carboplatin for firstline treatment of advanced ovarian cancer pdf 82600672924357 (1)
... Bevacizumab is administered by intravenous infusion Bevacizumab in combination with carboplatin and paclitaxel has a UK marketing authorisation for 'the front-line treatment of advanced (International ... Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer (TA284) Guidance Please note that NICE can only issue guidance on any drug within the ... 42 Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer (TA284) stage and debulking status (optimally debulked stage III [with maximum
Ngày tải lên: 20/05/2018, 15:40
Herbal extracts in combination with nanosilver inhibit Bacterial leaf blight disease caused by Xanthomonas oryzae pv. oryzae in rice
... respectively Finally, the individual extract from C fragrans, E Cochinchinensis, and C sappan were combined with nanosilver particles and used to access BLB inhibition capacity in vivo, using the rice ... detected in Fukuoka, Kyushu, Japan in 1884 (Tagami and Mizukami, 1962) The BLB disease has widely spread in many countries, especially in all Asian rice producing countries, including Vietnam, leading ... imported from China including 70% ethanol, chloroform, nhexane, 100% acetone, 100% acetonitrile, and dimethyl sulfoxide (DMSO) 271 Herbal Extracts in Combination with Nanosilver Inhibit Blight
Ngày tải lên: 09/01/2020, 15:57
The effects and mechanism of YK-4-279 in combination with docetaxel on prostate cancer
... transferred to polyvinylidene fluoride (PVDF) membranes (Millipore) After blocking nonspecific binding sites with blocking buffer, the membranes were incubated overnight at 4˚C with the following primary ... proliferation and induce apoptosis by binding to β-tubulin and causing cell-cycle arrest [17] The addition of docetaxel to ADT has survival benefits compared with ADT alone in patients with metastatic ... stained with µg/ml PI in PBS for 10 Then we identified apoptotic cells using a fluorescence microscope Cells with classical morphological features including nuclear condensation, cell shrinkage,
Ngày tải lên: 14/01/2020, 22:07
Effects of dexmedetomidine in combination with fentanyl-based intravenous patient-controlled analgesia on pain attenuation after open gastrectomy in comparison with conventional thoracic
... Hence, in this prospective, randomized clinical trial, we investigated the effects of dexmedetomidine in combination with fentanyl-based IV-PCA on pain attenuation in patients undergoing open ... dexmedetomidine in combination with fentanyl-based intravenous patient-controlled analgesia (IV-PCA) on pain attenuation in patients undergoing open gastrectomy in comparison with conventional ... Paper Effects of dexmedetomidine in combination with fentanyl-based intravenous patient-controlled analgesia on pain attenuation after open gastrectomy in comparison with conventional thoracic
Ngày tải lên: 15/01/2020, 10:16
Toxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice model
... bilirubin, total protein, albumin, globulin, and albumin/globulin ratio of animal groups treated with O.s (200 or 400 mg/kg/day) and rosmarinic acid (32 mg/kg/day) alone or in combination with ... total bilirubin levels were also within normal range indicating that no toxic event occurred in kidneys treated with O.s, rosmarinic acid, and gemcitabine either alone or in combination treatment ... hand, a gain in body weight was observed in animals treated with rosmarinic acid (0.4%) alone and in combination with gemcitabine (5.3%) (Table 2) There was significant difference (P < 0.05) in average
Ngày tải lên: 15/01/2020, 13:32
Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine in carbon tetrachloride model in wistar rats
... potential of Aegle marmelos in? ?combination with? ?piperine in? ?carbon tetrachloride model in? ?wistar rats Deepti Rathee1, Anjoo Kamboj2 and Shabir Sidhu3* Abstract The current study investigated hepatoprotective ... constituent present in the extract i.e rutin was quantified by using HPLC Further, the study explored hepatoprotective effect of A marmelos (70% ethanol extract) in combination with piperine The normal ... asthmatic complications [2] Increased use of A marmelos as a medicinal agent in different systems of medicine including folk medicine, various research studies undertaken in recent past to explore
Ngày tải lên: 29/05/2020, 13:18
Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients with trastuzumabresistance: A retrospective study of a Chinese population
... Open Access Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients with trastuzumabresistance: a retrospective study of a Chinese population ... party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material If material is not included in the article's ... 12.5% in the TBP group (P = 0.018) Conclusion: The combination of lapatinib and capecitabine showed a prolonged PFS relative to TBP in patients who had progressed on trastuzumab Keywords: Lapatinib,
Ngày tải lên: 17/06/2020, 03:16
Final results from IMPROVE: A randomized, controlled, open-label, two-arm, cross-over phase IV study to determine patients’ preference for everolimus in combination with exemestane or
... Capecitabine (Cap) + bevacizumab (Avastin®, Bev) combination therapy is indicated for first-line treatment of adult patients with MBC for whom treatment with taxanes and/or anthracyclines is inappropriate ... treatment line Unrelated TEAEs starting within 30 days of end of first-line therapy and after start of second-line therapy were considered treatment-emergent in both treatment lines in case second-line ... Chiabudini: No conflict of interest Julia Falkenstein: No conflict of interest Martin Indorf: No conflict of interest Eva Runkel: No conflict of interest Karin Potthoff: No conflict of interest
Ngày tải lên: 17/06/2020, 11:30
Efficacy and safety of HER2 inhibitors in combination with or without pertuzumab for HER2-positive breast cancer: A systematic review and meta-analysis
... patients in clinical settings Pertuzumab in combination with trastuzumab and docetaxel for the treatment of patients with HER2+ breast cancer has been approved by the Food and Drug Administration ... significant in HR- than in HR+, with absolute increases of 17.0 and 9.0%, respectively Our result was consistent with those obtained in other studies investigating the effects of combined therapy on ... efficacy of vinorelbine in combination with pertuzumab and trastuzumab for first-line treatment of patients with HER2-positive locally advanced or metastatic breast cancer: VELVET cohort final results
Ngày tải lên: 17/06/2020, 18:10
Summary of Doctoral thesis in Medicine: Anticancer effects of vaccine strain measles virus in combination with nimotuzumab in treatment of laryngeal cancer in vitro and in vivo
... To evaluate the anticancer effect of measles vaccine virus? ?in combination? ?with? ?Nimotuzumab? ?in? ?vitro To evaluate the anticancer effect of measles vaccine virus? ?in combination? ?with? ?Nimotuzumab on nude mouse model? ?with head and neck cancer (in? ?vivo) ... glycoproteins are the hemagglutinin (H) and fusion (F) proteins that mediate viral binding and integration? ?with? ?the host cells. In? ?current OLV therapy, the use of Edmonston vaccine strains includes a ... We conducted the project “Anticancer effects of vaccine strain measles virus? ?in? ?combination? ?with? ?nimotuzumab? ?in? ?the treatment of laryngeal cancer? ?in? ?vitro and? ?in? ?vivo”? ?with? ?two objectives To evaluate the anticancer effect of measles vaccine virus in
Ngày tải lên: 23/07/2020, 00:58
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
... We examined the effects with a colorimetric assay and cell cycle analyses, and investigated molecular events in cells treated with metformin and/or nutlin-3a with Western blot analyses An involvement ... are growing particularly in emerging countries [1] A combination of cisplatin and pemetrexed, the current first-line chemotherapy, demonstrated its effectiveness compared with cisplatin alone ... Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways Kengo Shimazu1,2,3†, Yuji Tada1†, Takao Morinaga2,
Ngày tải lên: 06/08/2020, 07:55
A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors
... potential benefit of combining MEK inhibitors with chemotherapy has been demonstrated in preclinical studies of tumor xenograft models, in which selumetinib in combination with cytotoxic agents, ... combination with erlotinib or temsirolimus are presented in the companion paper (Infante et al., in preparation) Selumetinib was tolerable in combination with docetaxel or dacarbazine As with the ... concentrations over time of (A) selumetinib 75 mg BID alone and in combination with dacarbazine 1000 mg/m2 or (B) dacarbazine 1000 mg/m2 alone and in combination with selumetinib 75 mg BID (EPS 1925 kb)
Ngày tải lên: 20/09/2020, 01:33
Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool
... specimens with phosphate buffered saline (PBS Buffer), fixation using paraformaldehyde, embedding in paraffin and cutting the sample in 10 μm slices which were stained with hematoxylin and eosin (HE ... an intraoperative cryosection analysis As both optical imaging methods are non-invasive, a subsequent staining with conventional HE stain remains feasible, allowing for a direct comparison with ... following clinical decision making Methods: In this contribution we will show that the combination of the three label-free non-linear imaging modalities CARS (coherent anti-Stokes Raman-scattering),
Ngày tải lên: 20/09/2020, 14:12
Cost-effectiveness analysis of bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (VR-CAP) in patients with previously untreated mantle cell
... compared with rituximab in combination with fludarabine and cyclophosphamide (R-FC) Alternative rituximabbased chemotherapy induction regimens are also administered in the first-line setting, but ... in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (VR-CAP) The National Institute of Health and Care Excellence recently recommended the use of VR-CAP in ... Cost-effectiveness analysis of bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (VR-CAP) in patients with previously untreated mantle cell lymphoma
Ngày tải lên: 20/09/2020, 15:15
Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms
... by combining PIT with chemotherapy, as compared with PIT alone, in human gastric cancer cells Our findings suggest that PIT in combination with 5-FU showed enhanced antitumor effects in HER2-expressing ... hematoxylin and eosin staining) Bleeding and massive granulation with inflammatory changes were observed, and only scant viable cells were present in the tumor nodules treated with PIT in combination ... HER2 targeting photoimmunochemotherapy with Tra-IR700 and 5-FU in vivo To determine the antitumor effects of PIT in combination with 5-FU compared to PIT alone in vivo, the following experiments
Ngày tải lên: 21/09/2020, 11:17