blood supply of the jaws and teeth
Sensory evaluation techniques
Ngày tải lên :
23/05/2014, 13:39
... reference standards should make use not only of the senses and imagination of the panelists, but also of the accumulated experience of the sensory profession as recorded in the literature; and (3) ... in the mouth which affect taste perception are the temperature, viscosity, rate, duration, and area of application of the stimulus, the chemical state of the saliva, and the presence of other ... until they fully understand the task at hand The annals of sensory testing are replete with results that are unreliable because many of the panelists did not understand the questions and/ or the...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
Ngày tải lên :
25/10/2012, 11:10
... efficiency and cell recovery) [25] Loaded amount The total amount of pravastatin entrapped in 0.1 ml of the final packed erythrocytes Efficiency of entrapment The percentage of the loaded amount of pravastatin ... pravastatin to the total amount of that added during the entire loading process Cell recovery The percentage ratio of the hematocrite value of the final loaded cells to that of the initial packed ... tube The samples were rotated vertically while incubated at 37◦C At the beginning of the test and also at 0.25, 0.5, 1, 2, 8, 20, and 23 h intervals, one of the samples was harvested and then...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
Ngày tải lên :
08/03/2014, 10:20
... comparison of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth and rough ... measure of the rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease of the concentration of oxyHb increased as the pH was ... effects of the LPSs of rough and smooth E coli on the oxidation of Hb A0, both in the presence and absence of EDTA, is provided in Fig The rate of oxidation was increased in the presence of the LPSs...
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Financial Relationships and Interests in Research Involving Human Subjects: Guidance for Human Subject Protection pdf
Ngày tải lên :
15/03/2014, 20:20
... investigators, IRB members and staffs, institutions engaged in human subjects research and their officials, and other interested members of the research community C Underlying Principles The regulations ... industry and others, and recognizes that these relationships often legitimately include financial relationships However, to the extent financial interests may affect the rights and welfare of human ... be managed? Would the rights and welfare of human subjects be better protected by any or a combination of the following: • reduction of the financial interest? • disclosure of the financial interest...
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BELMONT REPORT: ETHICAL PRINCIPLES AND GUIDELINES FOR THE PROTECTION OF HUMAN SUBJECTS OF RESEARCH ppt
Ngày tải lên :
22/03/2014, 15:21
... judgments, including the nature and degree of risk, the condition of the particular population involved, and the nature and level of the anticipated benefits (v) Relevant risks and benefits must ... the subjects should understand clearly the range of risk, and the voluntary nature of participation A special problem of consent arises, where informing subjects of some pertinent aspect of the ... investigators and members of their institutions are obliged to give forethought to the maximization of benefits and the reduction of risk that might occur from the research investigation In the case of...
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Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
Ngày tải lên :
22/03/2014, 17:20
... Studies on the origin of blood vessels and of red blood corpuscles as seen in the living blastoderm of chicks during the second day of incubation Contrib Embryol 9, 214 Murray PDF (1932) The development ... possible rejection by the host immune system, the quantity administered, the developmental stage of the cells derived from hESC differentiation, and the quality and ⁄ or viability of the transplanted ... hypothesized to be the in vitro human equivalent of the hemangioblast, characterized by expression of the endothelial markers PECAM-1 (CD31), Flk-1 (KDR) and VE-cadherin (CD144), but not the...
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ETHICAL AND LEGAL ASPECTS OF HUMAN SUBJECTS RESEARCH ON THE INTERNET docx
Ngày tải lên :
29/03/2014, 20:20
... into the group The faceless nature of online interactions may not always allow for this course of action Finally, there is the nature of the consent form and the validity of the process In the ... understanding of the issue and then expands this understanding to include the psychological perspective of the participants In a paper on proposed ethical guidelines for the reporting of results ... between the public and private domains based not on the accessibility of the data, but on the psychological perception of the subjects with regard to the information The technological point of view...
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Báo cáo hóa học: " Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects" potx
Ngày tải lên :
18/06/2014, 16:20
... conclusion, the current study suggests feasibility of significant mobilization of cells expressing hematopoietic stem cell and EPC markers and properties The area of nutritional modulation of the stem ... existence of various subsets of cells with EPC potential residing outside of the CD34+ KDR+ fraction Further studies are required to elucidate functional importance of the variable kinetics of mobilization, ... localized in the bone-marrow At a basal rate low levels of stem/progenitor cells are released from their niche and circulate in the peripheral blood [42] Initially, upregulation of peripheral blood...
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Báo cáo hóa học: " Are quantum dots ready for in vivo imaging in human subjects?" docx
Ngày tải lên :
22/06/2014, 18:20
... depended on the molecular size of the PEG and on the density of substitution Most importantly, the injected dose of all types of QDs tested in these studies was excreted in the feces within 1–2 days ... biopsies and resections, the enormous amount of QDs needed to generate detectable signal in the tumor is a major concern in terms of both toxicity and cost Surface coating and the in vivo behavior of ... unclear whether the ‘‘stop and go’’ pattern is typical for the majority of injected QD conjugates or if it is only limited to a small subset of QDs It is likely that the majority of the QD conjugates...
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báo cáo khoa học: " Human subjects protection issues in QUERI implementation research: QUERI Series" pptx
Ngày tải lên :
11/08/2014, 05:22
... and Site Memorandum of Agreement) It is critical that the involvement of the site PI is supported by their organizational supervisors and relevant to their own career goals b Varying levels of ... implementation research are often elusive, and the regulatory definition of "minimal risk" is imprecise There often are no physiological risks in implementation research and, in the case of our studies, ... with clinical systems and practices, and the known risks of poor quality care, the ethical issues of adding burden to the process of improving care should be considered in these determinations...
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Báo cáo y học: "valuation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccine." pps
Ngày tải lên :
11/08/2014, 10:23
... runs The standard error of the loss estimate was simply the standard deviation of the observed differences divided by the square root of the number of runs in which a difference was calculated The ... analysis The potency losses associated with lyophilization were calculated as the average of the differences observed between the liquid samples and the -70°C (lyophilized) samples tested in the same ... Journal of Immune Based Therapies and Vaccines 2007, 5:4 Background Varicella virus vaccine live is a lyophilized preparation of live, attenuated VZV (Oka/Merck) [1] The inherent lability of the...
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Báo cáo khoa học: "Bench-to-bedside review: Human subjects research – are more standards needed" ppsx
Ngày tải lên :
13/08/2014, 03:20
... However, in the 10 years since the release of the Final Rule, investigators in the USA have reported variability in IRB interpretation, and have called for standardization and refinement of the rule ... more standards but rather refinement and uniformity of current standards, and their interpretation both to protect human subjects and to advance medicine through research Competing interests The ... standards at different institutions may be inherently unethical [6] The duplication of approvals and renewals also costs a great deal of time and resources, for both investigators and IRBs The...
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Tài liệu Báo cáo khoa học: Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins pdf
Ngày tải lên :
20/02/2014, 23:20
... steroid biosynthesis The process of binding and uptake of maternal lipoproteins is carried out by placental trophoblast [17], which lines the chorionic villi and represents the epithelial layer ... primarily on the plasma membrane of JAr and Jeg3 cells and to a much lesser degree in the cytoplasma of both cell lines (Fig 4B,C) Omission of the primary antibody (data not shown) or replacement of primary ... separating the maternal and fetal circulation [18] In the human placenta chorionic villi, a layer of syncytiotrophoblasts lies over the cytotrophoblasts, and surrounds the internal mesoderm and fetal...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
Ngày tải lên :
06/03/2014, 09:22
... representative of the totality of the single-stranded overhang, and which may be important for these ligands being able to differentiate telomeric quadruplexes from others in the genome It has ... treated, and little evidence of concomitant telomere shortening [11,18,32] This has subsequently been shown to be characteristic of the G-quadruplex ligand class as a whole, and the observations of ... drug discovery does have these few structures as starting points [42–47], although these also indicate that the flexibility of the TTA loops is ligand dependent, and therefore structural information...
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Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
Ngày tải lên :
06/03/2014, 22:21
... developed in China in the 1980s It is a member of the bleomycin family, and is also known as bleomycin A5 It has been found to reduce the DNA synthesis of cancer cells and cut off the DNA chain [8] ... times, and bars and standard errors in the data were obtained from three independent experiments (A) The pH change of Tca8113 and Tca8113 ⁄ PYM cells with or without Atz treatment The pH of the ... ELISA XL (BIOHIT, BP800, Helsinki, Finland) The growth rate was calculated as the ratio of the absorbance of the experimental well to that of a blank well, and the IC50 was also calculated Hoechst...
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Báo cáo khoa học: Novel repressor of the human FMR1 gene ) identification ¨ of p56 human (GCC)n-binding protein as a Kruppel-like transcription factor ZF5 ppt
Ngày tải lên :
07/03/2014, 05:20
... affinities to the protein of interest In the case of the rpL32 fragment or the (GCC)9 sequence, there are several repeated ZF5-binding sites within a single oligonucleotide Therefore, the affinity of those ... the first cDNA strand Two pairs of primers, which amplify overlapping 5¢- and 3¢-parts of ZF5 cDNA, were designed using Primer software developed by V Prutkovsky and O Sokur of the Institute of ... Identification of a GC element in the promotor of the murine L32 ribosomal protein L32 gene and the 3¢-terminal region of the human apolipoprotein A-I gene, capable of binding with murine and human...
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Báo cáo khoa học: Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene pptx
Ngày tải lên :
07/03/2014, 15:20
... eliminates repression of the HSVtk promoter in transfected HeLa cells [14] To study the roles of Site-2 and Site-3 individually, they were mutated and placed in front of the HSVtk promoter These constructs ... transfection efficiency The values of the activities are set relative to the activity of the clone carrying wt Site-2 and Site-3 elements The results represent the mean value ± S.E of five independent ... 0.25 mL of sample The column was eluted at 0.1 mLÆmin)1 Fractions of 0.5 mL were collected after the void volume of the column SDS/PAGE and protein identification by MALDI-TOF MS Samples from the...
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Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
Ngày tải lên :
15/03/2014, 13:09
... photophobia and hyperlacrimation) - hearing loss - unilateral orchitis( inflammation of one or both of the testes) ** These conditions are usually relieved with the treatment of 1% atropine and steroids ... liver and spleen Fruit bats not show any symptoms Best candidate to be the reservoir More research needs to be done Geography The link between human infection by the Ebola virus and their proximity ... as the Democratic Republic of Congo In these two instances the mortality rate was between 50 –90% Following those epidemics, Ebola hit Africa in many other instances the worst yet being in the...
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Báo cáo khoa học: Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation pptx
Ngày tải lên :
16/03/2014, 10:20
... produced either as a soluble protein in the presence of detergents or as a precipitate in the absence of detergents We analyzed the yield and sample quality of ETB synthesized in the presence of FEBS ... T7-tag at the N-terminus and a poly(His)10-tag at the C-terminus (Fig 1) To obtain the highest yields of the individual constructs, optimization of the Mg2+ and K+ concentrations in the ranges ... expression and stabilization The functional folding of membrane proteins overproduced by the new cell-free (CF) approach is of primary interest, and we therefore further analyzed the quality of ETB...
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