beyond guinea pigs anatomy of an ethical clinical trial

... associated with more organ dysfunction, greater need of mechanical ventilation, and greater use of vasopressors • Moreover, early treatment (within 24 hours of appearance of first organ dysfunction) ... JO'B, XW, and AW have all participated in clinical trials sponsored by Eli Lilly and Co J-LV and AW have served as paid consultants for Eli Lilly and Co RG, BLT, and DPS are employees and stockholders ... infusion of study drug was 17.5 hours Only 11% of PROWESS patients began DrotAA infusion more than 24 hours after OD, which limits the power of an analysis with only the subjects from this trial...

Ngày tải lên: 12/08/2014, 23:23

... Australian, Hungarian and UK English versions, and item of the South African, item of the "somnolence" dimension of the German and South African and item of the "sleep disturbance" dimension of the ... items and 12 of the "sleep adequacy" dimension for the Australian and Hungarian versions, item 11 of the "somnolence" dimension for the German, Hungarian and South African versions, and item of ... Australian, Hungarian and South African versions of the MOS-Sleep showed limited psychometric properties when taken individually in the specific conditions of the clinical trial, German, Polish and...

Ngày tải lên: 18/06/2014, 19:20

... Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan 2Department of Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 5378511, Japan 3Department of Pathology and ... writing of the manuscript and in the orthopedic workup of the patient; KH: assisted in the drafting of the manuscript and in the orthopedic workup of the patient; TK: assisted in the writing of the ... Classification of Tumors Pathology and genetics of tumours of soft tissue and bone Lyon: IARC Press; 2002, 247-251 Rastogi R, Garg R, Thulkar S, Bakhshi S, Gupta A: Unusual thoracic CT manifestations of...

Ngày tải lên: 09/08/2014, 01:24

... powered double-blind randomised trial of the clinical effectiveness of AAT augmentation therapy has been lacking The individual and combined analysis of the Danish-Dutch and EXACTLE trials confirms ... least one valid CT scan assessment at the Month 12 visit or after For the Danish-Dutch and EXACTLE studies, PD15 was analysed using an analysis of covariance (ANCOVA) model with change from baseline ... conflicts of interest to disclose Jan Stolk has served on company advisory board meetings of various companies and served as consultant to some of them Fees were directly donated to the bank account of...

Ngày tải lên: 12/08/2014, 11:22

... clubs, employees of industrial plants and commercial houses, improvement clubs, social settlements, and representatives of all important lines of trade and industry across San Francisco Four hundred ... perceptions of Indians, medical and scientific rivalries and the interaction between plague Ian Catanach, ―Plague and the Indian Village, 1896-1914‖, in Rural India: Land, power and society under ... but it 39 Assistant US Surgeon-General J M Eager, Eradicating Plague from San Francisco: Report of the Citizens‘ Health Committee and an account of its work, (San Francisco: Press of C.A Murdock...

Ngày tải lên: 09/09/2015, 18:48

... abduction and opposition of the thumb, whereas severe CTS can cause permanent loss of sensation and paralysis in abduction and opposition of the thumb Page of The Problem CTS can be treated with surgery ... loss and hand weakness and clumsiness causing difficulties in daily activities The prevalence of median nerve symptoms and electrophysiological median neuropathy in the general population of Maastricht ... http://www.jbppni.com/content/5/1/11 trial with a detailed description of the aim of the study and of the implications of participation Only subjects able to read, understand and sign the informed consent...

Ngày tải lên: 10/08/2014, 10:20

... parameters: (1) maximum ranges of motion in the sagittal, coronal, and axial planes and (2) average velocities in the sagittal, coronal, and axial planes from neutral to end ranges Standing Postural Sway ... the trial GB is the principal investigator of the HRSA grant award, and MH is the site principal investigator CS prepared the first draft of the manuscript and organized revisions MG, EO, DW and ... method of minimization for allocation to clinical trials a review Control Clin Trials 2002, 23:662-674 53 Bronfort G, Evans R, Nelson B, Aker P, Goldsmith C, Vernon H: A randomized clinical trial of...

Ngày tải lên: 13/08/2014, 15:21

... actively and passively sensitized guinea pigs Methods Animals Male, albino, Hartley-strain guinea pigs were obtained from Sankyou Laboratory Service (Toyama, Japan) They were quarantined in the Animal ... passively sensitized guinea pigs Guinea pigs were anesthetized by an intraperitoneal injection of 75 mg/kg of sodium pentobarbital and placed in a supine position After the trachea was cannulated with ... pooled, and kept frozen until use The antibody titre of this serum was 1:12,800, 1:6,400 and 1:512, as estimated by passive cutaneous anaphylaxis at h, 24, and days, respectively Normal guinea pigs...

Ngày tải lên: 13/08/2014, 08:20

... positions of men and women and of different age groups However, most people not live alone and, for many purposes, what will be most important for their standard of living is the total income of the ... our work by a very wide range of organisations and individuals, to all of whom we are most grateful However, the views and opinions in the Report are those of the Panel and are not necessarily ... strands’ and to close a gap in existing equalities legislation, by addressing the needs of those who are not currently protected An anatomy of economic inequality in the UK Ways of working and...

Ngày tải lên: 08/03/2014, 06:20

... for an F, up to 52 for an A and 56 for an A* 10 An anatomy of economic inequality in the UK The position of different groups Tables S4 and S5 at the end of this summary bring together measures of ... this), and how they develop across the life cycle Of course, people can be described in terms of many of their characteristics (age group, gender, ethnicity, and so on), and so are members of many ... want to warmly thank Professor Hills and his panel for their comprehensive report This is important work done to the highest standard of professionalism It is the responsibility of we in Government...

Ngày tải lên: 08/03/2014, 06:20

... lives of people in business Current perspective and legal only enhance the importance of moral codes, making them an important part of the landscape of the company The increasing relevance of the ... you, is ethical elements of a professional accountant important or not? As an accountant of a business, you have to comply with ethical principles of an accountant or not? For example: Transparency ... readers with an understanding of the necessity of the role of ethics in the modern organization It mentions the importance of leadership in the establishment and maintenance of ethical principles...

Ngày tải lên: 13/03/2014, 14:20

... different angles and disclosing the process of the making of “Hello”, thus making the project as transparent as possible H ­ opefully you will follow us in our work, and don’t hesitate if you want ... rganization’ as a m o phenomenon and the way the office has ­ eveloped as an ­ rganism d o in a world of ever-­ aster technology evolution, new ­ orking f w s ­ tructures and ­ rganizational forms We simply ... of elements: playful, paradoxical, often overglossy, inviting, troubling, messy, and yet strangely clear Radiating meaning, bending what’s real and ­ istilling what’s unreal he combines ­ rganic...

Ngày tải lên: 29/03/2014, 22:20

... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited...

Ngày tải lên: 03/06/2014, 02:07

... as: Mariani and Venuti: HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future Journal of Translational Medicine 2010 8:105 Submit your next manuscript ... 90% of cases, thus indicating the central role of immunity in the resolution of cervical and anogenital HPV-associated diseases Conversely, clearance of papillomavirus infection is significantly ... cross-neutralizing antibodies against several clinically relevant HPV types[61-63] In particular, the concatenation of L2 of diverse types results in the repetitive display of B-cell epitopes that enhances antibody...

Ngày tải lên: 18/06/2014, 16:20

... femur and shank - right and left ankle dorsiflexion: the angle between shank and foot Statistical analysis Continuous data were summarised in terms of means and standard deviation of the mean The ... extensors and flexors of the hip, flexors and extensors of the knee, and dorsiflexors and plantarflexors of the ankle We used four previously reported tests [1] to evaluate lengthening capacity of pectoralis ... substantial contributions to conception and design of the study, analysis and interpretation of data and she was involved in drafting the manuscript and revising it critically for relevant intellectual...

Ngày tải lên: 19/06/2014, 08:20

... RAHC-DA NANG Tran Van Quan,DVM 15 Le Thanh Quang, DVM 20 Huynh Thi Manh, Ms 20 RAHC-CAN THO Nguyen Ba Thanh, Ms 15 Truong Kim Dung, Ms 20 Tran Quoc Phong, DVM 20 NAVETCO Dr.Tran Xuan Hanh 15 Nguyen ... primary animal handlers and managers, they will be major beneficiaries of the final outcome of better diagnosis and control of animal diseases 7 Implementation & Sustainability Issues 7.1 Issues and ... round of surveillance, 120 cattle sera and 120 pig sera from each province - RAHC-Da Nang: provinces (Kontum and Quang Nam), total 480 sera - RAHC-Can Tho: provinces (An Giang, Kien Giang ),...

Ngày tải lên: 22/06/2014, 12:20

... Protocol manuals for submission and handling of samples and provision of feedback of results Laboratory Quality Control procedures documented and tested Internal Quality control results documented and ... control of FMD As a result of these outputs of the project, Vietnam has been used as an example for others in the region to show the type of information that can be collected on serosurveillance and ... was twofold - to develop capacity for FMD (and other disease) surveillance and diagnosis at both a laboratory and field level, and to investigate the serotypes of FMDV circulating in Vietnam and...

Ngày tải lên: 22/06/2014, 12:20

... molecular and sequencing techniques Training and education of field veterinarians in sample and data collection showed an impact with an increase in quality and numbers of samples collected and submitted ... a result of an outbreak of FMD in pigs in the province in that year, which would increase willingness of farmers to present piglets for vaccination and sampling and enhanced awareness and enthusiasm ... collected from 10 provinces – An Giang, Binh Phuoc, Dong Thap, Kien Giang, Kom Tum, Lang Son, Long An, Quang Nam, Quang Ninh and Tay Ninh No samples were ever collected from Lang Son Samples were also...

Ngày tải lên: 22/06/2014, 12:20

... Hoa CAN THO: Dr Nguyen Ba Thanh, Dr Truong Thi Kim Dung DA NANG: Dr Tran Van Quan, Dr Nguyen Thi My Phuong NAVETCO Dr.Tran Xuan Hanh, Nguyen Van Hung, Nguyen Lam Huong, Van Phuc DAH: Dr Bui Quang ... Thanh Dr Nguyen Thu Ha Nguyen Tung, Ms 90 120 120 Tran Van Quan,DVM 90 Le Thanh Quang, DVM Huynh Thi Manh, Ms Nguyen Ba Thanh, Ms 120 120 90 Truong Kim Dung, Ms 120 Tran Quoc Phong, DVM Dr.Tran ... establishment of an effective laboratory network for the diagnosis and control of FMD will provide a greater understanding of FMD epidemiology and will facilitate the coordination and implementation of...

Ngày tải lên: 22/06/2014, 12:20

... primary animal handlers and managers, they will be major beneficiaries of the final outcome of better diagnosis and control of animal diseases Implementation & Sustainability Issues 7.1 Issues and ... Objectives of the project: To establish an effective laboratory network for the diagnosis and control of FMD by the provision of resources and training of staff in required methods and quality assurance ... shown an impact with an increase in quality of sample collection and number of samples collected and submitted to the laboratory The project has provided training and technology transfer of FMD...

Ngày tải lên: 22/06/2014, 12:20