basic and translational concepts

ORAL BIOAVAILABILITY Basic Principles, Advanced Concepts, and Applications potx

Ngày tải lên : 05/03/2014, 22:21

... Dedicated to my grandmother Yunzhi Su, my parents Bailing Li and Jie Hu, my wife Xinghang, and my children Richard and Louis for their unconditional love, encouragement, and understanding —Xiaoling ... fundamental concepts and contemporary practice of bioavailability in pharmaceutical research and drug development It is our belief that this book provides both the basic concepts to a novice and the ... of the extent and rate of absorption and the elimination processes, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications, First Edition Edited by Ming Hu and Xiaoling Li...

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Adrenocortical Carcinoma Basic Science and Clinical Concepts ppt

Ngày tải lên : 29/03/2014, 08:20

... glucocorticoids on muscle and bone A high percentage of female patients present with signs and symptoms of androgen excess (hirsutism, acne, androgenetic efﬂuvium) and virilization with or without ... ACC hypersecreting both cortisol and androgens demonstrating a combination of Cushingoid features and signs of hyperandrogenism In a series of patients with pure androgen-secreting tumors, women ... puberty In men, androgen-secreting ACC is usually not associated with clinical changes, as high testicular androgen secretion dominates total androgen activity, and ceiling effects of androgen action...

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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"

Ngày tải lên : 31/10/2012, 15:28

... involved in transcriptional and translational processes As shown in Table 1, the up-regulated genes were COBRA1, ITGB4, STAU2, and HMGN3 with a SLR of 3.30, 2.61, 1.68 and 1.52, respectively ANK3 ... induction of transcription factors (AP1, Elk1, Stat1, SRF and NFκB) and expression of apoptotic genes (Fas receptor, Fas ligand, FADD and caspase 8) [19] In addition, as confirmed by the functional ... to the reported ethanol-induced expression and activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the...

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Tài liệu NEW ADVANCES IN THE BASIC AND CLINICAL GASTROENTEROLOGY docx

Ngày tải lên : 12/02/2014, 16:20

... measures, diet, standards of living and usage of medical drugs Today our diet largely New Advances in the Basic and Clinical Gastroenterology includes industrially produced sterilized food and the use ... susceptibility, 10 New Advances in the Basic and Clinical Gastroenterology environmental factors such as geographic region and diet, and study variables including probiotic strains and doses used (Prescott ... et al., 1983) and increase the digestibility of protein and fat in yoghurt (Fernandes et al., 1987) Enzymatic hydrolysis of protein and fat leads to an increase in free amino acids and short chain...

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Tài liệu ACCELERATING PROGRESS AGAINST CANCER: ASCO’s Blueprint for Transforming Clinical and Translational Cancer Research doc

Ngày tải lên : 14/02/2014, 21:20

... for and trial designs will enable testing of multiple drugs specific trials; and monitor responses to therapy at once, and provide more meaningful insight into what does and doesn’t work, and ... researchers to more quickly and easily identify those that can guide research and patient care A SCO’s Blueprint for Transforming Clinical and Translational Research 11 yy Biomarkers and diagnostic assays ... physical tumor site, in- shops with basic, translational and clinical research- creasing effectiveness and decreasing side effects ers, industry, the Food and Drug Administration (FDA), For example,...

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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx

Ngày tải lên : 19/02/2014, 16:20

... at 50 °C and 10 at 95 °C, followed by a total of 40 twotemperature cycles (15 s at 95 °C and at 60 °C) For the generation of standard curves, serial dilutions of a cDNA sample were used and mRNA ... against iPLA2c and visualization of immunoreactive bands by ECL Expressed recombinant polypeptides are designated according to their expected masses Lanes and 5, 88 kDa iPLA2c; lanes and 6, 74 kDa ... columns and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational...

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Medical Image Processing, Reconstruction and Restoration: Concepts and Methods ppt

Ngày tải lên : 06/03/2014, 12:20

... Parhi and Takao Nishitani Multimedia Systems, Standards, and Networks, edited by Atul Puri and Tsuhan Chen Embedded Multiprocessors: Scheduling and Synchronization, Sundararajan Sriram and Shuvra ... Algorithms, Sensors, and Applications, edited by Kiyoharu Aizawa, Katsuhiko Sakaue and Yasuhito Suenaga Medical Image Processing, Reconstruction and Restoration: Concepts and Methods, Jirí Jan ... persuasion that a good understanding of concepts and principles forms a necessary basis to any valid methodology and solid application It is relatively easy to continue studying and even designing specialized...

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New Advances in the Basic and Clinical Gastroenterology Edited by Tomasz Brzozowski potx

Ngày tải lên : 07/03/2014, 20:20

... interest in basic and clinical medicine, translational medicine and health care as well as it serving to trigger the attention of medical students, and potential patients to understanding the ... measures, diet, standards of living and usage of medical drugs Today our diet largely New Advances in the Basic and Clinical Gastroenterology includes industrially produced sterilized food and the use ... susceptibility, 10 New Advances in the Basic and Clinical Gastroenterology environmental factors such as geographic region and diet, and study variables including probiotic strains and doses used (Prescott...

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Object oriented programming with C++ - Session 1 - Basic Object Oriented Concepts doc

Ngày tải lên : 16/03/2014, 01:20

... properties and actions s OOP techniques help to correspond real-world entities and actions to functions and data at the programming level Object Oriented Introduction to OOP s OOP allows for analysis and ... possible s Code and data are merged into a single indivisible thing an object s Close match between objects in the programming sense and objects in the real world Object Oriented Data and Functions ... functions of a Class • Define Objects • Access Member Functions • Pass and return Objects s Discuss briefly the features of C++ and another OO language (Smalltalk) Object Oriented The Object-Oriented...

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GLAUCOMA - BASIC AND CLINICAL ASPECTS pdf

Ngày tải lên : 17/03/2014, 12:20

... Pinakin Gunvant and “Gaucoma – basic and clinical concepts by Shi‐ mon Rumelt It expands and updates previous topics and adds new ones X Preface I would like to acknowledge each and every one ... general ophthalmologists, glaucoma specialists, and research‐ ers in the field, residents and fellows It covers both basic and clinical concepts of glaucoma and each author incorporated his/ hers on ... won theories, future trends and research Therefore, the book should enable researches and clini‐ cians to adopt new ideas for further basic and clinical research and implementation of the approaches...

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Tourism and Development Concepts and Issues

Ngày tải lên : 19/03/2014, 12:35

... relations and the politics of world heritage, in particular in Spain and the Canary Islands His lecturing specialisms include tourism and economic development and the political economy of leisure and ... in particular island micro-states, tourism has become the dominant economic sector The Caribbean islands, the Indian Ocean islands of the Seychelles and the Maldives and the islands of the South ... needs, famines and widespread hunger, violations of political freedoms and basic liberties, neglect of the interests and agency of women, and increasing threats to the environment and the sustainability...

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Visual Basic and Databases pdf

Ngày tải lên : 30/03/2014, 22:20

... 7-94 Stopping the Application .7-95 © LAP II x Visual Basic and Databases Visual Basic and Databases Introducing Visual Basic and Databases Preview • In this first chapter, we will a quick ... they are used, and how Visual Basic is used with databases And, we’ll review the Visual Basic development environment and the steps followed to build an application in Visual Basic © LAP II Contents ... well as Visual Basic The student should be familiar with the basics of using the Windows operating system • Visual Basic and Databases requires some edition of Visual Basic or Visual Basic There...

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force [electronic resource] animal drawing ; animal locomotion and design concepts for animators

Ngày tải lên : 31/05/2014, 00:37

... vision and allow it to become reality First and foremost there is my family My ever-supportive wife Ellen and inspiring kids, Marin and Makenna They consistently encourage me to follow my dreams and ... We understand how the model's body works, pulls, stretches, and bends We understand that certain poses tell certain stories and represent emotions A slumped-over pose with a person's hands covering ... the next tier is arms, legs, and tail; and then the last is hands, feet, fingers, and toes As you get more sophisticated, the top of the pyramid might be the face and right paw because they best...

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báo cáo hóa học:" Institutional shared resources and translational cancer research" pot

Ngày tải lên : 18/06/2014, 15:20

... chain of translational research and therefore biobanks are actively contributing to advances in translational research by offering opportunities to safely collect and store these samples and link ... collection, management, and analysis In fact, CaBIG consists of interoperable software tools, data standards, and computing infrastructure conceived to advance basic and clinical research As ... pathology laboratory relying on standard optical microscopes The assessment of FISH and CISH performances in cancer research and diagnosis is beyond the scope of this article and is described in several...

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Báo cáo hóa học: "Biomedical informatics and translational medicine Indra Neil Sarkar" pot

Ngày tải lên : 18/06/2014, 16:20

... molecules and cells, tissues and organs, individuals, and populations) The crossing of translational barriers (T1, T2, and T3) can be enabled using translational bioinformatics and clinical research ... informatics approaches to enable the assessment and moving of basic science innovations from the T1 translational barrier and across the T2 and T3 translational barriers (as depicted in Figure ... relevance for translational medicine: (1) Decision Support; (2) Natural Language Processing; (3) Standards; (4) Information Retrieval; and, (5) Electronic Health Records For each topic, progress and activities...

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Insecticides Basic and Other Applications Part 2 potx

Ngày tải lên : 22/06/2014, 03:20

... physiology, 18 Insecticides – Basic and Other Applications biochemistry, genetics and evolution, with focus on disease vector mosquitoes It is expected that the amount and diversity of material available ... published (Payandeh et al., 2011), pointing to a better understanding of the channel function and to its interaction with targeted compounds in a near future Besides pyrethroids and DDT, other ... deriving from relatively recent gene duplications and chromosome rearrangements On the other hand, CaV and KaV have little protein sequence identity and present diverse functions, indicative of more...

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Insecticides Basic and Other Applications Part 3 docx

Ngày tải lên : 22/06/2014, 03:20

... photodegradation (photolysis), photosensitized degradation and photocatalytic degradation (including heterogeneous TiO2 and ZnO processes and photo-Fenton and Fenton-like processes) Carbamates Carbamates ... Fenton reaction and involves electron transfer between H2O2 and Fe(II) with oxidation of Fe(II) to Fe(III) and the resulting production of highly reactive hydroxyl radical ●OH and potentially ... 0027-8424 32 Insecticides – Basic and Other Applications Davies, T.E., O'Reilly, A.O., Field, L.M., Wallace, B., & Williamson, M.S (2008) Knockdown resistance to DDT and pyrethroids: from target-site...

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Insecticides Basic and Other Applications Part 4 potx

Ngày tải lên : 22/06/2014, 03:20

... insects bore into the bark and sapwood and when woodpeckers peck and bore into trees after them People also create wounds in trees for specific purposes 64 Insecticides – Basic and Other Applications ... tree 66 Insecticides – Basic and Other Applications injections effectively, one needs a basic understanding of the (1) method of application, (2) the chemistry applied, and (3) tree condition ... N,N-dimethyl-2-methylcarbamoyoxyimino-2-(methylthio) acetamide) is contact and systemic insecticide, acaricide and nematocide It is used for control of chewing and sucking insects, spider mites and nematodes in ornamentals, frut trees,...

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Insecticides Basic and Other Applications Part 6 pot

Ngày tải lên : 22/06/2014, 03:20

... Somani, SM and Romano, JA, Eds CRC Press, New York, p191-214 96 Insecticides – Basic and Other Applications Ellman, G L., Courtney, K D., Andres, V Jr., & Feather-stone, R M (1961) A new and rapid ... waters and to select products which less likely to cause problems The data are derived from 104 Insecticides – Basic and Other Applications laboratory studies and are given only as a guideline and ... the rate of OP detoxification and its levels in blood (Raveh, 1997; Ashani & Pistinner, 2004) It would be unlikely that Cmax values (20 and 23 U/ml at mg/kg and 17 and 10 U/kg at 2.5 mg/kg) following...

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