... identifying patients at risk for complicated diverticular
disease. Dis Colon Rectum. 1991;34:339-42.
4. Kourtesis GJ, Williams RA, Wilson SE. Surgical options in acute
diverticulitis: value of sigmoid ...
Schumpelick V. Increased distribution of collagen type III and
reduced expression of matrix metalloproteinase 1 in patients
with diverticular disease. Int J Colorectal Dis. 2001;16:271-5.
3. ... (arrow).
Discussion
The prevalence of diverticulum in patients aged
65 years or more is as high as 65%, but merely 5% in
those below 40 years of age [6].
Sigmoid colon diverticulum is closely...
... even easier.
HOW TO GET THE MOST OUT OF PATCH BY EXCEPTION
Many organisations have successfully implemented the Patch by Exception solution by establishing a
maintenance contract with an installer ...
manage, but that will accommodate the developing technologies of tomorrow.
WHAT IS PATCH BY EXCEPTION?
Patch by Exception is a product feature of KRONE's HIGHBAND 8 and 10 modules that allows ... changes without the need for assistance from an
installer.
To date this has been achieved by assigning a hub port and an extension port to each individual within an
organisation. If an individual...
... the tissues
producing it. In response to tissue injury, such as
hepatic and renal injury, the inactive single-chain HGF
is converted to a two-chain form exclusively in
the injured tissue. This ... exclusively in
the injured tissue. This conversion is mediated by ser-
ine protease activity, which is induced in the injured
tissue [28]. The two-chain form is required for the bio-
logical activity ... TMPRSS13.
Proteolytic activation of pro-HGF by TMPRSS13
Pro-HGF is proteolytically activated by matriptase
and hepsin, and the protease activity is inhibited by
HAI-1 [9,10,18]. Therefore, we examined...
... investigations that include
analysis of pancreatic islet cells.
The H-PGDS TG mouse is a novel obesity model
with which to investigate the mechanism of adipogene-
sis. As is the case for obese people ... et al. (2001) The mechanisms by which both
heterozygous peroxisome proliferator-activated receptor
gamma (PPARgamma) deficiency and PPARgamma
agonist improve insulin resistance. J Biol Chem 276,
41245–41254.
38 ... molecular mecha-
nisms underlying adipogenesis may lead to the devel-
opment of strategies for reducing the prevalence of
obesity.
Adipogenesis is a complex process accompanied by
various changes...
... followed by Strep-tag II
was isolated by BamHI digestion and inserted into the
BamHI site of pmGFP–calpain 7.
To construct pCMV3xFLAG–IST1 and pGEX–IST1, an
IST1 cDNA fragment was amplified by PCR, ... autolysis. Therefore, it is premature
to draw conclusions regarding the mechanism of the
enhancing effects of IST1 on mGFP–calpain 7–Strep
autolysis in vitro.
Both mGFP–calpain 7 and IST1 have ... FLAG–IST1 did not
enhance the autolysis of mGFP–calpain 7 in cultured
cells. On the other hand, overexpression of FLAG–
IST1
DMIM1,2
suppressed the autolysis. This observation
might be explained by...
... K
m
values is exclu-
sively displayed by the tetramer forms, and low-
efficiency kinetics with high K
m
values is displayed by
the dimer forms. These observations strengthen the
previous hypothesis that ... K
m
is the Michaelis
constant and K
0.5
is the substrate concentration where
v = 0.5 V
max
. When n = 1, there is no co-operativity, and
K
0.5
= K
m
.
Acknowledgements
This work was supported by ... behaviour after dilution to 6 lgÆmL
)1
indicate that
dissociation of the tetramer to the dimer is a slowly
progressing process. This is supported by the kinetic
behaviour of the recombinant enzyme...
... was
detected using MUPP1 antibodies.
Immunohistochemistry
Mice were raised and maintained according to governmen-
tal and institutional care instructions. Immunohistochemis-
try was carried out on 14 lm ... different odorant molecules is governed by the diverse array of
olfactory receptors expressed by olfactory sensory neurons in the nasal
epithelium. Olfactory receptors consist of seven transmembrane ... between
MUPP1 and OR2AG1 is inhibited by over-expressing
the interacting PDZ domains, the resulting response of
OR2AG1 to odorant is modified in that the rapid
decay of signal is impaired.
We finally...
... cancer. The activity of cyclin dependent
kinase 4 is controlled by multiple mechanisms, including phosphorylation
of tyrosine 17. This site is equivalent to tyrosine 15 of cyclin dependent
kinase ... in HeLa lysates. C-YES
is a 62 kDa nonreceptor tyrosine kinase of the Src
family that is expressed in a wide range of tissues [24].
The N-terminus of C-YES is dually myristoylated and
palmitoylated ... thyroid epithelial cells: activation by TSH, inhi-
bition by TGFbeta, and phosphorylations of its
subunits demonstrated by two-dimensional gel electro-
phoresis. Exp Cell Res 291, 135–149.
35 Sexl...
... aureus is a major food- borne pathogen
which produces a number of toxins and virulence fac-
tors [1]. The staphylococcal enterotoxins produced by
S. aureus are known to cause staphylococcal food
poisoning, ... cytokine synthesis
and febrile response induced by SEC1 is dependent on
NADPH oxidase and not on PI3K ⁄ Akt or 5-LOX ⁄
FLAP because these phenomena are attenuated by
apocynin and not by ETYA, MK ... and
IL-6 that is blocked by the NF-jB inhibitor (PDTC or
SN-50). Moreover, the NF-jB binding ability is abro-
gated by binding site competition and antibody super-
shift analysis. These findings...
... precipitated DNA was analyzed by 1% agarose gel electro-
phoresis. DNA was visualized by staining with ethidium bromide. Results are represented by negative images. Asterisks indicate nucleic
acids ... and were isolated as a single peak fraction by
a 0.1–1.0 m NaCl linear gradient in R buffer. Histone H1,
which exists in the DNA affinity fraction, was separated as
a major component stepwise elution ... nuclear foci
linked to phosphorylated histone H2AX (c-H2AX) [3],
which is responsible for the redistribution of repair
factors to DSB sites [4], although it is dispensable
for initial damage recognition...