ar—c oh bond formation by ar se reactions and associated secondary reactions
Báo cáo Y học: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin potx
Ngày tải lên :
24/03/2014, 04:21
... method is based on direct linear least-squares boundary modeling by a superposition of sedimentation profiles of ideal nondiffusing particles [30] A regularization parameter of p ¼ 0.95, and a buffer ... to G J H and S B E., and the Australian Research Council to S B E., and a Melbourne Research Scholarship to D.M.H We thank Lynne Lawrence at C.S.I.R.O., Health Sciences and Nutrition, Parkvillle, ... As nuclei and fibril ends both recruit monomers, it seems likely that their interfaces are structurally similar and consequently they expose a similar binding site to clusterin Because fibril extension...
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Báo cáo khoa học: On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes ppt
Ngày tải lên :
23/03/2014, 17:22
... short or loosely placed analogs are positioned with orientations requiring conformational rearrangements in order to participate in peptide bond formation [3,5,6] These rearrangements are bound ... ASM and of the rotated RM (shown as atoms) The cross-section and the parallel views of the two-fold symmetry axis are shown in red shell (called here the Ôouter strandsÕ) and the parts of H75 and ... case of the archaeon H marismortui [4], requires significantly higher concentrations than those used clinically Hence, in this critical aspect, H marismortui resembles eukaryotes more than prokaryotes...
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Biofilm formation by sulfate reducing bacteria and biocorrosion of metals in seawater
Ngày tải lên :
16/10/2015, 15:38
... å 2OHThe overall reaction is: 2Meo + ½ nO2 + nH2O å 2Men+ + 2nOHThe anodic and cathodic reactions can occur separately at distant locations on the metal surface When anodic sites are sparse and ... spectrometry (ICP) and TimeOf-Flight Secondary Ionization Mass Spectrometry (TOF-SIMS) are also applied in this field Over the years, research has intensified with detailed examination with regard to corrosion ... proposed several models of SRB-mediated corrosion and described current hypothesis based primarily on important corrosion reactions In these models, the depolarizing effect of hydrogenase enzyme,...
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Báo cáo khoa học: "Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan" pptx
Ngày tải lên :
09/08/2014, 09:20
... Wong FS, Vicario D, Seagren S, Kumar P, Weisman R, Pellitteri P, Thomas JR, Flick P, et al: A novel organ preservation protocol for advanced carcinoma of the larynx and pharynx Arch Otolaryngol Head ... survival with a preserved larynx compared with patients who received induction chemotherapy Secondary cancer was a major cause of death The median time to the development of a second primary malignancy ... first and patients in the organ preservation group However, patients who survived longer than three years had a 33.2% larynx preservation rate in the latter group Two large phase III randomized...
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Liên kết arc(=o)H hình thành thông qua phản ứng ar SE
Ngày tải lên :
15/04/2015, 09:22
... corresponding nonmetallated aromatic compounds through an Ar SE reaction (Sections 5.3.1 and 5.3.2) In addition, there are methods for preparing substituted aryl metal compounds that are isomerically pure ... especially elegant possibility for carrying out orthoselective Ar SE reactions (Section 5.3.), which otherwise is practically impossible Finally, aryl boron compounds are the best substrates for the ... place in such a way that the Csec−butyl−Li bond exhibits considerable partial charges: a positive charge on the Li atom and a negative charge in the sec−butyl moiety The sec−butyl moiety thus becomes...
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Báo cáo khoa học: Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain pptx
Ngày tải lên :
14/03/2014, 23:20
... peptides, which can be separated by RP-HPLC and characterized by MS [17] The basic structure of bacitracin consists of a cyclic peptide of seven amino acids with a linear peptide side chain of ... that were used to discriminate different bacitracin analogs by MALDI-TOF ⁄ TOF MS are shown (D) The purity of each fraction was assessed by analytical RP-HPLC, with similar conditions as used for ... prior to the disulfide bond formation with Cys314 or Cys345, bacitracin H and F, which are more hydrophobic than bacitracin A and B, might be more potent binding partners Karala and Ruddock [16] tested...
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Báo cáo khoa học: Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy technique docx
Ngày tải lên :
16/03/2014, 05:20
... fluorophores are separated by more than 10 nm We expressed elongin B together with pVHL30-cerulean and citrine-elongin C, and the interaction between pVHL30 and elongin C was investigated by FRET–FLIM ... cerulean-linked pVHL30 and citrine-linked elongin C Data are derived from whole cell regions of interest and are expressed as mean ± SD a1 and a2 are the exponential coefficients (%) for the s1 and s2 decay ... cerulean-linked elongin B and citrine-linked elongin C expressed in living CHO-K1 cells Data are derived from whole cell regions of interest and are expressed as mean ± SD a1 and a2 are the exponential...
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Báo cáo khoa học: Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation pdf
Ngày tải lên :
16/03/2014, 13:20
... higher than that estimated by this method (assuming a secondary isotope effect > 1) With d2 7-OMe coumarin, the secondary effects would be multiplicative [26], and if a secondary isotope effect as ... before use The deuterated substrates were prepared and characterized as described elsewhere [19] The syntheses and characterization of 3-hydroxy, 7-OMe coumarin and 3-hydroxy, 7-OEt coumarin are ... 7-OEt coumarin and d2 7-OMe coumarin some perturbation can occur because of a geminal secondary kinetic isotope effect These values are traditionally £ 1.2 for each deuterium atom [26], and only...
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Degradation of bacteria escherichia coli by treatment with ar ion beam and neutral oxygen atoms
Ngày tải lên :
18/05/2014, 20:33
... previous observations on selective etching of organic materials by oxygen radicals21 DISCUSSION Figures 3, and represent SEM images of bacteria E coli Bacteria presented in Figure are live what ... composed predominantly of chemically bonded water as well as some sugars, proteins and lipids – material that are a bad scatterer for electrons That’s why the SEM image looks rather dim A SEM ... confirmed by cultivation using the standard plate count technique Bacteria are covered with a thin film of jelly of lipopolysaccharides and is called capsule The majority of lipopolysaccharide cover...
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Heterogeneous catalysis in protodecarboxylation and c c bond formation 1
Ngày tải lên :
10/09/2015, 09:07
... closed system in the presence of (□) air and (♦) N2 80 Figure 3.5 Total conversion and selectivities towards benzene, biphenyl and terphenyl obtained in each of the consecutive Pd-PEG-EG catalysed ... Continuous flow reactor set-up for decarboxylative cross-coupling 175 Figure 6.2 Proposed mechanism for Pd-catalysed decarboxylative cross-coupling of heteroaromatic carboxylic acids and aryl halide 176 ... ABSTRACT Ullmann reaction and decarboxylative cross-coupling reactions are green alternatives for the formation of C-C bonds between aromatic compounds These methods not require preformed...
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Heterogeneous catalysis in protodecarboxylation and c c bond formation 2
Ngày tải lên :
10/09/2015, 09:08
... for comparison Identification of the phases can be achieved by comparing the diffraction pattern to a known standard or to a database Each peak within the pattern represents a particular lattice ... described by Marck et al in 1994 [49] They used a Pd/C heterogeneous hydrogenation catalyst, and observed that the reaction proceeded in the presence [49], [50] and in the absence of phosphine ligands ... Br, I, OTf R -Ar H-Het R -Ar R-Het Scheme 1.6: Catalytic transformations of carboxylic acids Protodecarboxylation is the most basic transformation of aryl carboxylic acids [77] The carboxylate group...
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Tài liệu Chapter 6: Carbon-carbon bond formation pptx
Ngày tải lên :
23/12/2013, 07:19
... a catalyst prepared from and or could be used as base with similar results Carbon-carbon bond formation 213 The palladium complex of the dibenzofuran-based water-soluble tertiary phosphine 49 ... the presence of a base both Ar groups take part in the coupling [35] Carbon-carbon bond formation 217 Due to its stability and water-solubility sodium tetraphenylborate is a particularly convenient ... palladium-based catalyst and a base scavenger for the hydrogen halide Copper(I) iodide is a particularly effective co-catalyst allowing the reaction to proceed under mild conditions Carbon-carbon bond formation...
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf
Ngày tải lên :
14/02/2014, 22:20
... translocators) and one hydrophilic partner (also called the V antigen in Pseudomonas aeruginosa and Yersinia spp.; Figs and 2) comprise the translocon, and are essential for its formation in all ... 131–137 Membrane targeting and pore formation by the T3SS 38 Imada K, Minamino T, Tahara A & Namba K (2007) Structural similarity between the flagellar type III ATPase FliI and F1-ATPase subunits Proc ... Membrane targeting and pore formation by the T3SS (YopB) and pathogenic Escherichia spp (EspD) all carry two predicted TM regions, and are predicted to have a N-terminal coiled-coil region and, occasionally,...
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Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
Ngày tải lên :
16/02/2014, 09:20
... assessed using the MTT assay Caspase activity was assessed by measuring degradation of the Ac-DEVD-pNA peptide Open bars: control cells; filled bars: TRAIL-treated cells; shaded bars: TRAIL- and ... cell survival and apoptosis is undeniable, and Itch could be an important signalling gateway Several apoptotic molecules are the target of ubiquitin ligases and are downregulated by proteasomal ... with TRAIL or TRAIL and EGF as above in the presence of 20 lM SP600125 or vehicle (dimethylsulfoxide) Cell survival was assessed using the MTT assay Caspase activity was assessed by measuring degradation...
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Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf
Ngày tải lên :
18/02/2014, 08:20
... intriguing similarity between STAT3 and STAT1 Both factors share activating stimuli and a high homology of sequence, and they have common gene targets and recognize very similar consensus sequences; ... STAT3 and STAT1 recognize very similar sequences on the gene promoters and share common targets; they can also form heterodimers, whose function has not been clearly elucidated In the present ... Because STAT3 and STAT1 share a high degree of homology and bind to similar promoter sequences, they are likely to interact with the same ODN Although hpST3dODN induced the death of SW480 cells, and...
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Tài liệu Báo cáo khoa học: Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity pdf
Ngày tải lên :
18/02/2014, 18:20
... full-length jararhagin and 0.5% of jararhagin C [42] Thus, from this example, we can estimate that approximately only one-quarter of the jararhagin synthesized is processed to jararhagin C The ... complexity regard to secondary structure and folding [17–25] Thus, at least superficially, it seems that similar folding motifs and structures can give rise to different disulfide bonding patterns ... In the case of catrocollastatin and jararhagin, where a certain population of the proteins has been seen to be processed, there are folding isomers, perhaps promoted by the presence and relative...
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Tài liệu Báo cáo khóa học: Non-specific depolymerization of chitosan by pronase and characterization of the resultant products pptx
Ngày tải lên :
19/02/2014, 12:20
... indicated the absence of free -OH groups and the involvement of both -OH 3 and -CH 2OH 6 in intra- and intermolecular hydrogen bonding (Fig 2) [31] Line width and frequency position of the band above ... Homogeneity and specific activity of pronase Capillary zone electrophoresis and SDS/PAGE of pronase showed the presence of a single homogeneous protein (Fig and the inset) of molecular mass 20 ... molecular mass and DA on chitosanolysis by pronase Preliminary studies indicated that chitosan could be degraded nonspecifically by proteases such as pepsin, papain, protease, etc It was observed...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... of carbon-centred radicals derived from a diverse set of substrates are on the order of about 10)10 s [98] Moreover, the randomness of the apparent intramolecular KIEs for unrearranged and rearranged ... Akhtar, M.E & Akhtar, M (1995) Mechanistic kinship between hydroxylation and desaturation reactions: acylcarbon bond cleavage promoted by pig and human CYP17 (P-45017a; 17a-hydroxylase-17,20lyase) ... 1,2dioxygenase is a heterohexamer composed of an equimolar combination of a- and b-subunits, each a-subunit bearing an Fe2S2 cluster and a mononuclear iron site [208] Two histidines and one bidentate...
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Tài liệu Báo cáo Y học: Use of site-specific recombination as a probe of nucleoprotein complex formation in chromatin Micha Schwikardi and Peter Droge ¨ potx
Ngày tải lên :
22/02/2014, 07:20
... sites (arrows with open head) are present as direct repeats on a circular substrate Synapsis occurs by collision of two loxP-bound dimers (filled circles) The two sites are aligned in an antiparallel ... integrase mutant Int-h (pPGKInthss) served as controls It is important to emphasize here that recombinases are expressed from the same eukaryotic promoter (PGK) in the same vector background, and ... genomic targets Genomic DNA was prepared from TRE2/3 cells 72 h after electroporation with recombinase expression vectors DNA was digested with Bam HI, separated on a 0.8% (w/v) agarose gel, transferred...
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THE ANTHROPOLOGY OF ONLINE COMMUNITIES BY Samuel M.Wilson and Leighton C. Peterson doc
Ngày tải lên :
06/03/2014, 21:20
... continuous across several media, and how people use those several media to develop their identities in ways that carry over to other settings” (Agre 1999, p 4) Several researchers are exploring the ... strategy for research is to explore how and if local users are employing and defining terms such as Internet, cyberspace, and the Web, and to explore “how diversely people experience similar technologies” ... deconstructing dichotomies of offline and online, real and virtual, and individual and collective An important part of the research going on, particularly in communications and sociology, involves the...
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