... 0.55) of QLQ-C30 The functional well-being ofthe FACT-G was highly correlated withthe role functioning (r = 0.61) and the physical functioning (r = 0.58) ofthe QLQ-C30 The social domains of QLQ-C30 ... especially considering the fact that members ofthe general public not often include aspects of adaptation into their valuations The responsiveness ofthe instruments needs to be evaluated longitudinally; ... ECOG-PS score of 3, these individuals were combined withthe adjacent group to form the ECOG-PS 2-3 group Quality of Life Scores Table displays a summary ofthe QOL scores obtained from the instruments...
... 0.55) of QLQ-C30 The functional well-being ofthe FACT-G was highly correlated withthe role functioning (r = 0.61) and the physical functioning (r = 0.58) ofthe QLQ-C30 The social domains of QLQ-C30 ... especially considering the fact that members ofthe general public not often include aspects of adaptation into their valuations The responsiveness ofthe instruments needs to be evaluated longitudinally; ... ECOG-PS score of 3, these individuals were combined withthe adjacent group to form the ECOG-PS 2-3 group Quality of Life Scores Table displays a summary ofthe QOL scores obtained from the instruments...
... reflect the management of all patients admitted to ICUs under thecareof 26 intensive care specialists, it is possible that patients treated in other types of ICUs or in other health regions or with ... purposes, the value that deviated the furthest from the median ofthe reference range was taken Where there was no difference between the minimum and maximum value from the median, the maximum ... care without cardiopulmonary resuscitation (CPR), comfort care) Severity of illness at inception (within the first day of ICU admission) was assessed using the APACHE II score and intensity of...
... People and the Press, each ofthe top 10 stories of public interest in the United States during 1999 were about bad news Withthe exception ofthe outcome ofthe American election, the birth of septuplets ... and capture the public’s imagination The goal of these campaigns is not to educate people so they can make informed choices for themselves the goal is to regulate or, preferably, toThe Fraser ... or as easy to read as a news story, they are full of valuable information and will provide the interested citizen with a basic understanding ofthe state ofthe science, including the many questions...
... American Adults Prevalence Prevalence, the percentage ofthe population with a history of cancer, is a function of both new cases of cancer and the survivability of cancer Over 5% of American adults 10.6 ... compared with 3%, 2%, 1%, and 2%, respectively, ofolder men The Burden of Cancer in American Adults Two percent of middle-aged and 7% ofolder women have a history of breast cancer, the most ... history of smoking, compared with 44% of cancer-free adultsThe higher prevalence of smoking history among those with a history of cancer is consistent by gender and across all age groups 35 The...
... for the conduct of these studies because of delays in registration The main value ofthe registry is rather to evaluate the completeness and representativeness ofthe case series 394 The role of ... disease) together withthe adoption of western lifestyles suggest that the burden of cancer in these countries is likely to increase in the near future Most often cancer registries provide the only ... established, by the method of data collection used and by the resources available tothe registry However, the emphasis should be on the quality ofthe data collected rather than on the quantity...
... number of states Many credit NCPA studies ofthe Medicare surtax as the main factor leading tothe 1989 repeal ofthe Medicare Catastrophic Coverage Act NCPA forecasts show that repeal ofthe Social ... far too slowly for humans to have evolved specific resistance tothe toxins in many common foods.” c) Humans have not had time to evolve a “toxic harmony” with all of their dietary plants The ... scare The whole aim of practical politics” said H.L Mencken, “is to keep the populace alarmed — and hence clamorous to be led to safety — by menacing it with a series of hobgoblins, all of them...
... cancer cases, and 42% of newly diagnosed stomach cancer cases By comparison, fewer than 4% ofthe world’s new cases of each of these cancers occur in the United States In of these Asian countries, ... 48% ofthe world’s population (6.7 billion) • China and India together account for 37% of world population • The median age ofthe population varies widely among the countries, from a low of 19 ... presented for the United States These fifteen Asian countries comprise 48% ofthe world’s population China and India together account for 37% ofthe worldwide population Distribution ofthe worldwide...
... parameters ofthe mycobacterial dehydrogenase determined for: (A) the L-gulono-1,4-lactone substrate in the presence of 121 lM cytochrome c; and (B) the cytochrome c substrate in the presence of 50 ... membrane-associated, in agreement withthe enzyme behavior in the presence of a detergent In contrast tothe related aldonolactone oxidases [13,16,19], but similar tothe plant l-galactono-1,4-lactone dehydrogenases ... characterized up to now, and the first example of a specific, vitamin C biosynthetic enzyme of bacterial origin Further studies will be necessary to elucidate the role ofthe Rv1771 l-gulono-1,4-lactone dehydrogenase...
... hoá đợt bệnh to n phát tợng xẩy khắp giới Mặc dù chế xác virut herpes gây ung th cha đợc hiểu rõ, số lớn thông tin sở phân tử cho chế đợc tập hợp lại đợc nhanh chóng hiểu rõ hoàn to n Nếu hy vọng ... 1980 có tăng đột ngột khối u KS đàn ông trẻ tuổi kèm theo bắt đầu dịch bệnh AIDS Các nghiên cứu dịch tể cẩn thận chứng minh tăng cao bệnh KS theo bệnh lây truyền đờng tình dục (STD) yếu tố khác ... dạng yếu tố ngời ta sử dụng kỹ thuật phân tử hoàn to n kỹ thuật phân tích khác biệt đại diện (RDArepresentational differrence analysis), hoàn to n khác với phơng pháp chuẩn để phát virut Kỹ thuật...
... population To give an idea of what could be done to ease the adjustment ofthe elderly care sector we study consequences of a hypothetical improvement in the ability ofthe elderly to run their daily ... used to analyse by means of ordered logit models the impacts of age, dependency and other factors on probabilities to use home and community care for the elderly With these models and the age profile ... variable tothe form ofcare is easiest seen by comparing their contributions at the sample means (the last column ofthe parameter table) The size of FSMAGRANT tells that the average grants from the...
... review of these hypotheses and ofthe design and interpretation of such trials is given in the first IARC Handbook of Cancer Prevention10 Review ofthe role of diet in the aetiology ofthe major ... contributions during the drafting ofthe manuscript References Doll R, Peto R The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today Journal ofthe National ... should, therefore, be focussed on these factors (Table 2) If other dietary factors are established to affect cancer risk then these can be added to existing policy frameworks, but at present the other...
... epidermal-growth-factor-like growth factor [4] tothe IL-2 receptor, redirecting its potent cytotoxicity toward a therapeutic purpose [5,6] A comparable strategy to alter the target of an intracellular toxin ... engineered into the framework region ofthe Fv [25–27] A cytotoxic fragment of PE can be inserted at the C-terminus of one ofthe two Fv polypeptide chains (Fig 1) The generation and production of PE-based ... PDIs in PE intoxication comes from the pathways of other protein toxins The protein toxins ricin and cholera toxin (CT) both follow routes through the ER and into the cytosol after receptor-mediated...
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining tothe health ofthe public The Institute acts under the responsibility given tothe ... Health Care, The Quality Chasm’s Ten Rules to Guide the Redesign of Health Care, 2-1 2-2 The Six Aims of High-Quality Health Care, 57 The Quality Chasm’s Ten Rules to Guide the Redesign of Health Care, ... from the councils ofthe National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members ofthe committee responsible for the report were chosen for their...
... dare I say it, the wisdom ofthe experts The elegance ofthe process was one ofthe many attractions to me of assuming the role of chair ofthe Panel I could pretend that it was the major reason, ... version ofthe full Report It highlights the wealth of information and data studied by the Panel and is designed to give readers an overview ofthe key issues contained within the Report, notably the ... present the findings of these reviews The Panel’s judgements are displayed in the form of matrices that introduce five of these chapters, and in the summary matrix on the fold-out page inside the...
... reproduced, stored or transmitted in any form or by any means, only withthe prior permission in writing ofthe publishers, or in the case of reprographics reproduction, in accordance withthe terms of ... advertisements herein are the responsibility ofthe contributor or advertiser concerned Accordingly, Cancer Research UK, the publishers, the editorial committee and their respective employees, officers and ... OPEN logo and details ofthe precise terms ofthe licence that applies to it How does this affect the review of my paper? It doesn’t – BJC will not discuss the BJC OPEN option with authors until...
... carcinogens (94) For 90% ofthe carcinogens, the MTD/740,000 was within a factor of 10 ofthe VSD (Table 5) This is similar tothe finding that in near-replicate experiments ofthe same chemical, potency ... because the estimate of cancer risk would be low regardless ofthe results of a 2-year bioassay Either linear extrapolation to a risk of less than in 100,000 or use of an uncertainty factor of 10,000 ... had time to evolve a “toxic harmony” with all ofthe plants in their diet The human diet has changed markedly in the last few thousand years Indeed, very few ofthe plants that humans eat today...
... status to long-term constraints The reduced-form is obtained by substituting the determinants ofthe chosen health behaviors into equation (1) for the xht To derive the determinants ofthe xht, ... negatively associated withthe probability of stunting 27 Similar tothe previous explorations, Model replaces the prenatal care variable with one measuring the quality of child care, while also including ... Furthermore, these analyses imply different relationships among the two types of care, the methods of measuring quality, and the three aspects of growth Even though the two types ofcare are correlated,...
... marrow) continue to grow indefinitely, without reference tothe needs ofthe body Many cancers have the capacity to spread to other parts ofthe body and to kill the patient With more than million ... eliminating the risk of developing the disease One ofthe most important medical discoveries ofthe twentieth century was the role of tobacco smoking as a cause of cancers ofthe lung and various other ... at the Institute of Public Health ofthe Republic of Slovenia, where he holds the post of Adviser tothe Director He is involved in teaching at the Department of Public Health He trained at the...