8synthetic extracellular matrix for cardiac tissue engineering

... Fib-CL scaffolds IX LIST OF ABBREVIATIONS ECM Extracellular matrix MI Myocardial Infarction LV Left Ventricle TE Tissue Engineering CTE Cardiac Tissue Engineering VEGF Vascular Endothelial Growth ... other therapies are experimented for the treatment of the infarcted myocardium, of which the tissue engineering approach is gaining much attention Cardiac tissue engineering promises to bring about ... fibronectin is crucial for the formation of “primary matrix (in developing the granulation tissue) which functions as a meshwork for the deposition and adhesion of other matrix proteins such as...

Ngày tải lên: 05/10/2015, 19:04

... neointimal hyperplasia [84, 106] 2.3 Vascular Tissue Engineering (VTE) Vascular tissue engineering (VTE) is an interdisciplinary field involving the principles of engineering and life sciences to develop ... TCP Tissue Culture Plate TEBV Tissue Engineered Blood Vessel TGF-β1 Transforming Growth Factor Beta UV Ultraviolet UV-Vis Ultraviolet-Visible vSMC Vascular Smooth Muscle Cell VTE Vascular Tissue ... media into the intima, followed by the formation of fibrocellular tissue with an abundant proteoglycan matrix [82] The failure of secreting inhibitors for vSMC proliferation such as NO and heparin...

Ngày tải lên: 10/09/2015, 09:08

... FUNCTIONAL PERFORMANCE OF EXTRUSION-BASED ADDITIVE MANUFACTURED SCAFFOLDS FOR BONE TISSUE ENGINEERING MUHAMMAD TARIK ARAFAT (B.Sc in Mechanical Engineering, BUET) A THESIS SUBMITTED FOR THE DEGREE ... medicine with the methods of engineering The purpose of TE is to develop a biological substitute that can replace, repair and/or improve tissue function Scaffold-based tissue engineering (TE) aims to ... Scaffold-based tissue engineering (TE) aims to aid in the repair and regeneration of bone defects Using this approach, the scaffold acts as a platform which carries cells or therapeutic agents for regenerative...

Ngày tải lên: 10/09/2015, 15:51

... differentiation………………… 21 2.3.4.1 Cartilage tissue engineering using hydrogels……………………… 21 2.3.4.2 Cartilage tissue engineering using polymeric scaffolds…………… 23 2.4 Cartilage formation and regeneration using ... FUNCTIONALITY………………………………………… 98 4.4.1 Cartilage tissue engineering using hESC-derived chondrogenic cells………………………………………………………………… 98 4.4.1.1 Optimal growth factor induction for cartilage tissue engineering 98 vii 4.4.1.2 ... chondrogenic differentiation of ESCs and for cartilage tissue engineering Some of the biomaterials and their associated outcomes in ESC-based cartilage tissue engineering and regenerative medicine...

Ngày tải lên: 11/09/2015, 09:57

... selection for liver tissue engineering 2-11 Scaffold fabrication for liver tissue engineering 2-16 Scaffold surface modification 2-20 Tissue culture for liver tissue engineering ... failure 2-8 2.2 TISSUE ENGINEERING AND APPLICABILITY IN LIVER FAILURE 2-10 2.2.1 Overview of tissue engineering 2-10 2.2.2 Liver tissue engineering 2-11 ... functions Finally, in the context of this liver tissue engineering study, the principles of tissue engineering and the status of current liver tissue engineering research are reviewed in this chapter...

Ngày tải lên: 12/09/2015, 10:22

... BASED MICROCARRIERS FOR BONE TISSUE ENGINEERING APPLICATIONS FENG YONG YAO, JASON B.Eng.(Hons), National University of Singapore A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT ... biomaterial for bone tissue engineering, intended as a single-step cell expansion and in-situ osteogenic differentiation platform to be implemented as a non-invasive, injectable bone graft substitute for ... microcarriers for bone tissue engineering Key Engineering Materials 529530 2013 Conferences (Oral): 1) Feng J, Chong M, Chan J, Zhang ZY, Teoh SH, Thian ES Cell-loaded ceramic based microbeads for direct...

Ngày tải lên: 22/09/2015, 15:18

... has challenged research on tissue engineering strategy in recent years to reconstitute its function when lost by replacing with a functional neotissue (engineering tissue) with similar mechanical ... scaffold for ligament tissue engineering Hence, the objectives of this study are: (i) To design and develop a bi-axial cyclic loading and low shear stress perfusion bioreactor system for ligament tissue ... the conclusions and recommendations for the future development are provided in Chapter CHAPTER 2: LITERATURE SURVEY 2.1 LIGAMENT TISSUE ENGINEERING Tissue engineering represents a new approach...

Ngày tải lên: 04/10/2015, 10:25

... field of bone tissue engineering for an ideal bone substitute 1.1.3 Strategies in BTE Tissue engineering is the restoration, improvement, maintenance and substitution of damaged tissues and organs ... Instron micro tester for mechanical testing  Ms Irene Kee (Dept of Experimental Surgery, SGH), for her valuable assistance and support during animal surgeries and taking care for them after implantations ... give the reader an overview of the current trends in bone tissue engineering (BTE) Following that, limitations of available treatments for bone defects and various strategies of BTE will be discussed...

Ngày tải lên: 09/10/2015, 11:18

... skeletal tissue, and this treatment strategy was later coined as “bone tissue engineering A key component in tissue engineering for bone regeneration is the scaffold that serves as a 3D template for ... cell interactions and the formation of boneextracellular matrix to provide structural support to the newly formed tissue The porous scaffold provides the necessary support for cells to attach, proliferate, ... 1.1.1 Bone tissue engineering Loss of human tissues or organs is a devastating problem that can affect individuals of all ages Bone, a complex living tissue that provides internal support for all...

Ngày tải lên: 09/10/2015, 11:18

... for cardiac tissue replacement, further confirming its huge promise for cardiovascular tissue engineering application This thesis reports on a novel hybrid nanofibrous PCL membrane scaffold for ... dimensional system for tissue engineering application - 20 - Chapter 2: LITERATURE REVIEW - 21 - 2.1 Cardiovascular Tissue Engineering The limitation of existing therapies necessitates the need for alternative ... to promote in vivo tissue regeneration; and scaffold-based tissue engineering approaches, the formation of functional tissue in vitro, followed by implantation and in vivo tissue regeneration...

Ngày tải lên: 26/11/2015, 22:40

... efforts are required to enhance the beneficial effects of growth factors on tissue engineering 14.3.2 Favorable Environments for Tissue Regeneration There are two modes of tissue engineering for ... of tissue engineering for tissue construction One is in vitro (ex vivo) tissue engineering and the other in vivo (in situ) tissue engineering In the beginning of tissue engineering research, many ... engineering This may be the reason for very limited applications of in vitro tissue engineering mostly to epidermal production Tissue engineering below means the in vivo tissue engineering unless specified...

Ngày tải lên: 25/10/2013, 08:20

... Cells for Tissue Engineering is a new volume in the John Wiley series Culture of Specialized Cells, with focus on procedures for obtaining, manipulating, and using cell sources for tissue engineering ... effort to provide a user-friendly reference for sourcing, characterization, and use of cells for tissue engineering, for researchers with a variety of backgrounds (including basic science, engineering, ... 61 Cell Sources for Cartilage Tissue Engineering Brian Johnstone, Jung Yoo, and Matthew Stewart 83 Lipid-Mediated Gene Transfer for Cartilage Tissue Engineering Henning...

Ngày tải lên: 22/03/2014, 15:20

... surrounded by an astrocytic scar is formed following this tissue loss Where the injury extends to pia mater, collagen will also contribute in the formation of the scar tissue As Approaches to treatment ... and Bunge [31] for review) The core approach of tissue engineering consists of provision of an interactive environment between cells, scaffolds and bioactive molecules to promote tissue repair ... field very slow for many years But, in the last decade, the rapid progress that has been made in the field of tissue engineering as the result of Page 10 of 16 (page number not for citation purposes)...

Ngày tải lên: 19/06/2014, 10:20

... scaffolds, which are used for framework and initial support for the cells to attach, proliferate and differentiate, and form an extracellular matrix, is one area of tissue engineering [2] The goal ... of three-dimensional scaffolds for tissue engineering Chem Eng Res Des 2007, 85:1051-1064 Guarino V, Cause F, Ambrosio L: Bioactive scaffolds for bone and ligament tissue Expert Rev Med Dev 2007, ... phosphate for tissue engineering scaffold Sung-Min Kim1, Soon-Aei Yi1, Seong-Ho Choi2, Kwang-Mahn Kim1, and Yong-Keun Lee*1 Department and Research Institute of Dental Biomaterials and Bioengineering,...

Ngày tải lên: 21/06/2014, 17:20

... formalin They were decalcified for a week in 10% formic acid Knee joints were dehydrated with an automated tissue processing apparatus (Miles Scientific TissueTek VIP tissue processor; Miles Scientific, ... cartilage for the new tissue that will be generated However, for BMP-2 to have a reparative effect, it is crucial that the degradational properties not exceed the production of extracellular matrix ... synthesis overexpression on mRNA levels of extracellular matrix molecules and proteoglycan (PG) synthesis (a,b) Relative expression of mRNA levels of extracellular matrix molecules Cartilage of mice...

Ngày tải lên: 09/08/2014, 10:21

... at inducing dental hard tissue formation than calcium hydroxide, possibly via a physicochemical reaction in which released calcium ions react with tissue phosphates to form hydroxyapatite C Research ... stimulate the differentiation of odontoblasts as well as to promote new dentin formation [42] c Gene-enhanced tissue engineering for growth factor delivery To date, only a few groups have actively investigated ... the initial formation of both dental and periodontal attachment tissues In short, this approach is intended to mimic the normal biological process that occurs as these tissues are formed early...

Ngày tải lên: 11/08/2014, 23:22

... associated with cellular membrane and extracellular space specific themes ('integral to membrane', 'plasma membrane', 'extracellular region', 'extracellular matrix part') The cellular processes ... cytoskeleton lysosome cell projection part cytoplasmic part extracellular matrix part endoplasmic reticulum extracellular region part mitochondrion extracellular region cytoplasm plasma membrane protein ... over-represented biological themes at each information-specific level A similar gene enrichment computation was performed for KEGG categories, except that no information-specific levels were considered...

Ngày tải lên: 14/08/2014, 08:20

... of extracellular matrix proteins and new tissue formation Therefore, the properties of such biomaterials are crucial in determining the success of many tissue engineering applications Tissue engineering ... sheet engineering revolutionised the concept of Tissue Engineering when Teruko Okano et al used thermosensitive materials to create cell sheets for cardiac tissue engineering [43] Cell sheet engineering ... infrastructures for building a highly cellularized tissue construct Cells are traditionally seeded onto fibrous scaffolds and cultured for long periods to allow extracellular matrix production and tissue formation...

Ngày tải lên: 11/09/2015, 09:10

... valuable tool for promoting and directing the growth of functional tissues for tissue engineering applications (102) However, tissue engineering approaches have not been extensively studied for tendon ... any tissue engineering strategy Because of inherent difficulties associated with tissue grafts, several biodegradable polymeric systems have been used as materials for engineering load-bearing tissues ... biological tissues for tendon/ligament repair and regeneration 16 Tissue Engineering: An ideal treatment has yet to be defined as a long-term solution for tendon/ligament repair The current demand for...

Ngày tải lên: 11/09/2015, 09:11