7mucosal delivery of dry powder vaccines

... delivery of vaccines, genes, drugs and other biomolecules in the body They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of ... likelihood of active targeting of nanoparticles Nanoparticles for Oral delivery: In recent years, significant research has been done using nanoparticles as oral drug delivery vehicles Oral delivery of ... a number of biomolecules, drugs, genes and vaccines to the site of interest in-vivo During the 1980’s and 1990’s several drug delivery systems were developed to improve the efficiency of drugs...

Ngày tải lên: 11/08/2014, 08:20

... the lipoplex delivery of p-omp25 altered the profile of responsive T cells from a mainly CD8+ T cell response to a CD4+ dominated response, suggesting a possible effect of lipoplex delivery was ... efficacy of the candidates was evaluated after either, (a) the known protective regimen of four doses of naked DNA vaccine, (b) a single dose of naked DNA vaccine or (c) a single dose of lipoplexed ... lipoplex delivery of this vaccine prompted a modest increase in the number of SFC The difference Table IFNg ELISPOT data for the ialB and omp25 based vaccines showing the contribution of CD4+...

Ngày tải lên: 14/08/2014, 19:22

... lx) First of all, consumers were briefed on the concept of the methodology and the procedure The aim of this was to allow for development of the vocabulary to describe the four types of dry- cured ... 55.58% of the Table Demographic, socio-economic characteristics and frequency of dry- cured ham consumption of the participants (% of respondents, n = 109) Socio-demographic characteristic % of respondents ... characteristics and frequency of dry- cured ham consumption of the consumers involved in the present study are shown in Table About 44.0% of the consumers were men and 56.0% women and most of them were aged...

Ngày tải lên: 03/04/2013, 21:07

... widow with a pack of children that gave the husbandman frequent anxious misgivings In the woman there was a strain of the Spanish She had wedded one of the name of O'Brien Dry Valley was a connoisseur ... sudden end Of course Mrs O'Brien favoured the match as soon as Dry Valley's intentions were disclosed Being the mother of a woman child, and therefore a charter member of the Ancient Order of the ... strawberry patch To the outraged vision of Dry Valley there seemed to be a sheep corral full of them; perhaps they numbered five or six Between the rows of green plants they were stooped, hopping...

Ngày tải lên: 29/10/2013, 01:15

... development of a GPwSI service The activities of a GPwSI service will depend on a number of factors, including the location of the service and its overall aims In principle ,the main activities of the ... Good understanding of roles, responsibility and structure of PCOs and how to influence them to bring about improvement in delivery of sexual health services Understanding of primary care structures ... and how these may affect delivery of services within the PCO Understanding of service redesign and care pathways Knowledge of local educational providers Indicators of sexual health risk Skills...

Ngày tải lên: 14/02/2014, 21:20

... professionals involved in the planning, delivery and funding of services need to acknowledge the range of problems and issues experienced by those living in exile By taking a wide perspective of ... perception of the situation Clients have said “I'm not mad, I don't need counselling’ (NHS worker) 'A lot of people don't want to engage because of shame or because of their perception of the situation' ... said that individuals are wary of accessing services and often want to access them out of the borough’ The problem of gaps in service provision Asked why the provision of mental health services for...

Ngày tải lên: 24/02/2014, 18:20

... muscle via local delivery, whereas systemic siRNA delivery is the only way to reach metastatic and hematological cancer cells Local delivery offers several advantages over systemic delivery, such ... showed robust protection of the animals from lethal infection Intracellular siRNA delivery In many aspects, siRNA delivery is similar to that of delivering other types of nucleic acids such as ... delivery Cell-penetrating peptides (CPPs), short cationic polypeptides with a maximum of 30 amino acids, have been extensively used to obtain enhanced intracellular delivery of a wide range of...

Ngày tải lên: 06/03/2014, 01:23

... because of the cohesion of the cells of its more superficial layers; a firm and supple skin because of the existence of a dense supportive tissue and of the presence of numerous elastic fibers of ... [41] ROUTES OF PENETRATION OF DRUGS The determination of penetration pathways of topically applied substances into the skin is the subject of several investigations The permeation of drugs through ... enhancer of hydrophilic permeants, but is less effective at promoting the transdermal delivery of lipophilic agents [6] Urea Urea is one of the components of the natural moisturising factor (NMF) of...

Ngày tải lên: 14/03/2014, 10:20

... Conditioned medium of nontransfected Cos7 cell (a), ng of BNC from the conditioned medium (b), 100 ng of EGFP (c) and a mixture of ng of BNC with 100 ng of EGFP (d), and ng of L(n45)-FLAG-EGFP ... potential to form a particle Topology analysis of the C-terminus of L fusion protein Consisting of 56 amino acids, the primary structure of the C-terminus of the S region is rich in hydrophobic residues ... the results of previous studies of the topology of the HBsAg protein It is suggested that the C-terminus of the envelope protein protrudes from the particle in 1987 [12] Localization of HBV epitope...

Ngày tải lên: 23/03/2014, 15:20

... in grams of rubber present in 100 g of latex" The Dry Rubber Content (ORC) of Hevea latex is a very familiar term to all in the rubber industry It is probably one of the few properties of latex ... average error of the measurement is about 4% of the value estimated by the standard procedure, which compares with the oven dry weight of a sample of rubber coagulated from 10g sample of latex The ... weight of representative sample of the latex with dilute acetic acid, sheet the coagulum and dry it at about 750C in an oven The DRC of the latex is therefore the percentage by weight of the dry...

Ngày tải lên: 23/03/2014, 21:21

... preclinical proof of concept; (2) evidence of safety; and (3) early indications of benefit and efficacy (Phase I/IIA or B human clinical trials) A high level of predictability of a continuing chain of funding ... now an emeritus professor from the Faculty of Medicine and resides in an office in the Department of Chemical Engineering She is also a member of the Scientific Advisory Board of the Imperial College ... understanding and ­ nvesting in the delivery of i regenerative medicines to the benefit of patients Professor Lord Ara Darzi, KBE, HonFrEng FmedSci Professor of Surgery, Oncology, Reproductive...

Ngày tải lên: 03/05/2014, 19:37

... peace "II The settlement of every question, whether of territory, of sovereignty, of economic arrangement, or of political relationship, upon the basis of the free acceptance of that settlement by ... and shooting of priests, and the most inhuman treatment of Ukrainian prison- war (684 prisoners of war died during a period 30 days in a single camp out of a total of six or ers of of eight thousand) ... ruins of old Russia Galicia, part of Northern Against the exercise of this right of self-determination has arisen Poland, attempting to conquer Eastern Galicia by force of arms During the course of...

Ngày tải lên: 04/06/2014, 17:32

... Proceedings of the National Academy of Sciences of the United States of America 1982, 79:5292-5296 Gear ARL: Rhodamine 6G A potent inhibitor of mitochondrial oxidative phosphorylation Journal of Biological ... dendrimers are larger than the upper limit of the physiologic pore size of the BBTB of RG-2 gliomas Using ADF STEM, we measured the diameters of a population of our Gd-G8 dendrimers to be 13.3 ± 1.4 ... concentrations over a minimum of hours because particle sizes of these generations of Gd-dendrimers are clearly above the threshold of effective renal filtration [17] As a result of the long blood half-lives,...

Ngày tải lên: 18/06/2014, 15:20

... The mode of introduction of siRNA affects the ability to establish RNAi Based on the timing experiments, the establishment of resistance to RNAi correlated with the onset of WNV RNA Page of 13 (page ... resistance Nonetheless, it is possible that the method of delivery independently affects the ability of the siRNA to prime the RNAi response The route of delivery differs between TKO transfection and ... an average of three independent experiments and error bars indicate standard error of the mean B Induction of RNAi resistance by an attenuated lineage II WNV Inset Genomic structure of the attenuated...

Ngày tải lên: 19/06/2014, 08:20

... The mode of introduction of siRNA affects the ability to establish RNAi Based on the timing experiments, the establishment of resistance to RNAi correlated with the onset of WNV RNA Page of 13 (page ... resistance Nonetheless, it is possible that the method of delivery independently affects the ability of the siRNA to prime the RNAi response The route of delivery differs between TKO transfection and ... an average of three independent experiments and error bars indicate standard error of the mean B Induction of RNAi resistance by an attenuated lineage II WNV Inset Genomic structure of the attenuated...

Ngày tải lên: 20/06/2014, 04:20

... impact of dry eye on vision-related functioning and dry eye symptoms in terms of severity, it covers only some of these aspects and is therefore unlikely to describe the full impact and burden of dry ... specific to dry eye patients, and meets current FDA patient-reported outcomes guidelines The use of this questionnaire will provide assessment of the impact of dry eye on patient dry eye-related ... Development and validation of the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients Linda...

Ngày tải lên: 20/06/2014, 15:20

... on the best-effort delivery service in the form of UDP (the size of the UDP datagram is limited to 1,500 bytes), which does not guarantee reliability or the delivery order of network packets ... undirected graph comprising a set of participating peers and a set of overlay links at time t Then, Q is a finite set of peers and E is a set of unordered pair {u, v} of distinct peers in the P2P ... reliance of overhead on the centralized on-demand VoD server limits the scalability of the system in the presence of large and dynamic peers Figure Percentage of requested file received Page 13 of...

Ngày tải lên: 20/06/2014, 22:20

... the protocols as follows [24]: briefly, mL of APTES was dissolved in 25 mL of dry toluene Approximately 0.6 g of clay powder was added, and the suspension was dispersed ultrasonically for 30 The ... PBS, dehydrated through a series Page of of alcohol concentrations (30%, 50%, 70%, 90%, 100%), embedded in Epon, and sliced to a thickness of 70 nm Images of the sliced images were recorded at ... the percentage of fluorescent cells out of the total number of cells Fluorescence was detected from the FAM labeled on ASODNs at 488-nm excitation In vitro cell toxicity assay of the f-HNT-ASODN...

Ngày tải lên: 20/06/2014, 23:20

... Braga, Portugal 2Centre of Chemistry (CQ/UM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal 3Laboratory of Microbiology, Faculty of Pharmacy and Centre of Medicinal Chemistry ... concentrations that were able to cause 50% of cell growth inhibition (GI50) are summarized in Table Page of Table Values of compound concentration needed for 50% of cell growth inhibition (GI50) GI50 ... compound Further developments of the present study will involve assays of liposome cell internalization and mechanism of action, keeping in mind the application of this compound as an antitumoral...

Ngày tải lên: 21/06/2014, 01:20