3 molecular analysis of invasive breast cancer

... and some were Zoppino et al BMC Cancer (2018) 18:700 Page of 17 Fig Differential expression of total genes in breast cancer Volcano plots of genes expression analysis accomplished by Edge R method ... deregulated in all molecular subtypes of breast cancer while others appeared deregulated in specific molecular subtypes We also found that the overall survival of breast cancer patients appeared associated ... Supervised risk predictor of breast cancer based on intrinsic subtypes J Clin Oncol 2009;27(8):1160–7 Cancer Genome Atlas N Comprehensive molecular portraits of human breast tumours Nature 2012;490(7418):61–70

Ngày tải lên: 24/07/2020, 01:51

... influence the function of NY-BR-1 in healthy tissue as well as in breast cancer Keywords: NY-BR-1, Breast cancer, Antigen, SNPs, In silico Background Breast cancer is one of the most common malignancies ... Abstract Background: Breast cancer is one of the most common malignancies with increasing incidences every year and a leading cause of death among women Although early stage breast cancer can be effectively ... Kosaloglu et al BMC Cancer (2016) 16:901 expressed in over 70% of primary breast tumors and metastases [1] and additional details on the involvement of NY-BR-1 in breast cancer will lead to a

Ngày tải lên: 20/09/2020, 18:43

... described breast CSC markers in archival primary breast cancer tissues [36] In concordance to our findings in breast cancer cell lines, primary cancer tissues of triple negative breast cancer had ... suitability of current approaches for breast cancer stem cell analyses to evaluate heterogeneity of breast cancer cells through their extensive genetic and epigenetic characterization Methods: Breast cancer ... resistance of breast cancer stem cells isolated from HER2-negative breast cancer cells Clin Cancer Res 2012, 18(24):6634–6647 Vincent A, Van Seuningen I: On the epigenetic origin of cancer stem

Ngày tải lên: 05/11/2020, 05:52

... of women with no history of breast pathology, which included systematic histological examination of at least one breast, and which allowed calculation of the prevalence of incidental breast cancer ... review of autopsy studies in 1997, which reported a median rate of 1·3% of undiagnosed invasive breast cancer and 8·9% of undiagnosed ductal carcinoma in-situ (DCIS) [16] Potential breast cancer ... an indication of the potential for overdiagnosis of specific cancers if efforts to detect preclinical cancers and pre-cancers are made The prevalence pool of incidental breast cancer was investigated

Ngày tải lên: 06/08/2020, 03:26

... comparable efficacy to that of tamoxifen (TAM) in breast cancer patients Herein, we compared the safety of TOR to that of TAM in the adjuvant treatment of premenopausal breast cancer Methods: This was ... AG, Winer EP Breast cancer treatment: a review JAMA 2019;321(3): 288–300 Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Davies C, Godwin J, et al Relevance of breast cancer hormone ... Toremifene for breast cancer: a review of 20 years of data Clin Breast Cancer 2014;14(1):1–9 Hong et al BMC Cancer (2020) 20:663 12 International Breast Cancer Study G, Pagani O, Gelber S, Price

Ngày tải lên: 06/08/2020, 05:44

... (defined as 30 days) of treatment prior to being defined as switching to a greater line of therapy Any switching or addition of agents within 30 days of the start of each line of therapy was considered ... paclitaxel approved for the treatment of metastatic breast cancer (MBC) This analysis was designed to characterize the treatment patterns, efficacy, and safety of nab-paclitaxel for MBC treatment ... unless otherwise stated Liang et al BMC Cancer (2015) 15:1019 Background Taxanes are some of the most active chemotherapeutic agents in the treatment of breast cancer [1–3] However, sensory neuropathy,

Ngày tải lên: 21/09/2020, 10:20

... pegfilgrastim in chemotherapy-naïve breast cancer patients receiving doxorubicin/docetaxel chemotherapy Methods: Patients with high-risk stage II, III, or IV breast cancer and an absolute neutrophil ... approved by the Ministry of Health of Ukraine Central Ethics Committee and local independent ethics committees (IECs) Keywords: Neutropenia, Febrile neutropenia, Breast cancer, Recombinant granulocyte-colony ... subcutaneous injection of lipegfilgrastim (n = 101) or pegfilgrastim (n = 101) on day of each 21-day chemotherapy cycle (4 cycles maximum) The primary efficacy endpoint was the duration of severe neutropenia

Ngày tải lên: 05/11/2020, 05:59

... 20-30% of cases [17,18] TN breast tumors, which account for 10-25% of all invasive breast cancers [19,20], have poorer prognosis than luminal A, the most common subtype [8,9,13] While ER+ breast cancers ... with luminal A invasive breast cancer We considered a two-sided P value less than 0.05 as statistically significant when testing for homogeneity of HRs across subtypes of breast cancer All statistical ... Black women have higher risk of death after breast cancer diagnosis than white women [1,2] and are more likely than white women to have an aggressive subtype of breast cancer that is associated

Ngày tải lên: 05/11/2020, 06:24

... characteristics in primary invasive breast cancer patients Methods: The protein levels of GGH, FAAH, PIR and TAF5L were assessed by immunohistochemistry (IHC) on a panel of 80 primary invasive breast tumors ... progression of invasive breast cancer, warranting further investigations Our findings suggest that GGH serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast ... short-term follow-up in breast cancer The GGH may be a very attractive targeted therapy for selected patients Keywords: GGH, Breast cancer, Primary invasive breast cancer tumors, Prognostic factor,

Ngày tải lên: 05/11/2020, 07:05

... carcinoma in situ HR Hazard ratio IBC Invasive breast cancer iIBC Ipsilateral invasive breast cancer NCR Netherlands cancer registry PALGA Nationwide network and registry of histology and cytopathology, ... situ
Invasive breast cancer
Surgery
Radiotherapy
Population-based cohort study Abbreviations BCS Breast- conserving surgery CI Confidence interval cIBC Contralateral invasive breast cancer ... assessment of the effect of treatment strategies on IBC, using existing observational data [12] We assessed the effect of DCIS treatment strategies on risk of subsequent ipsilateral invasive breast cancer

Ngày tải lên: 19/03/2023, 15:44

... often in the form of secondary metabo- lites, are selected for in invasive plants in the introduced ranges. Members of the aster family are capable of synthe- sis of a broad spectrum of secondary ... the first published set of ESTs derived from an invasive weed that will be targeted to study invasive behavior. Understanding the genetic basis of evolution for increased invasiveness in exotic ... Page 1 of 10 (page number not for citation purposes) BMC Plant Biology Open Access Research article A first step in understanding an invasive weed through its genes: an EST analysis of invasive

Ngày tải lên: 12/08/2014, 05:20

... previous studies of miRNA expression in human breast cancer have focused on comparing normal tissues to tumor samples Here we focused on miRNA expression analysis of a large set of primary human ... Trust /Cancer Research UK Gurdon Institute, University of Cambridge, The Henry Wellcome Building of Cancer and Developmental Biology, Tennis Court Rd, Cambridge CB2 1QN, UK §Department of Biochemistry, ... expression of miRNA biogenesis enzymes This study forms the basis for developing miRNA expression signatures as diagnostic tools for breast cancer and also furthers our understanding of the role of miRNAs

Ngày tải lên: 14/08/2014, 08:20

... important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium Proceedings of the National Academy of Sciences of the United States of America 102: 832-837 ... Molecular analysis of the roles of yeast microtubule-associated genes in Agrobacterium-mediated transformation Chen Zikai (B Sc.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... VIII LIST OF MANUSCRIPTS X LIST OF TABLES XI LIST OF FIGURES XII LIST OF ABBREVIATIONS XV CHAPTER LITERATURE REVIEW 1.1 Overview of the structure

Ngày tải lên: 09/09/2015, 10:08

... important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium." Proceedings of the National Academy of Sciences of the United States of America 102(3): ... cells." Proceedings of the National Academy of Sciences of the United States of America 102(3): 856-861. Seki, M., M. Narusaka, et al. (2002). "Monitoring the expression profiles of 7000 Arabidopsis ... Joining of Single-Stranded-DNA by Vird2 Protein of Agrobacterium-Tumefaciens Ti Plasmids - Analogy to Bacterial Conjugation." Proceedings of the National Academy of Sciences of the United States of

Ngày tải lên: 09/09/2015, 11:19

... Molecular Analysis of the Breeding Biology of the Asian Arowana (Scleropages formosus) by Chang Kuok Weai Alex Thesis submitted in partial fulfillment of the requirements for the degree of Doctor of ... batch of offsprings were collected from brooder A7 but the genotyped results of 12 microsatellite marker showed that A7 was not one of the genetic parent. The table below showed the results of additional ... results\WH001\WH001_parents.txt Offspring file:D:\New Folder\PAPA results\WH001\WH001_offspring_p1.txt Global level of transmission error:0 Distribution of transmission error:0 Names of loci file: D:\New

Ngày tải lên: 14/09/2015, 08:49

... women with breast cancer Oncology Nursing Forum 30: 834-840 Singapore Cancer Society (2002) Breast Cancer (www.singaporecancersociety.org.sg/c_breastcancer.htm ) Singapore Department of Statistics ... (2000) Measuring quality of life of Chinese cancer patients: a validation of the Chinese version of the Functional Assessment of Cancer Therapy-General (FACT-G) scale Cancer 88: 1715-1727 Yuan ... 63 Figure BR-23 scores of breast cancer patients at baseline and after 11-13 weeks of TCM treatment……………………………………………… 65 Figure Single item score distribution of breast cancer patients at baseline

Ngày tải lên: 15/09/2015, 17:10

... CO-ENCAPSULATION OF ANTI -BREAST CANCER DRUGS IN NANOPARTICLES REDUCES ANTAGONISM TAN GUANG RONG NATIONAL UNIVERSITY OF SINGAPORE 2014 CO-ENCAPSULATION OF ANTI -BREAST CANCER DRUGS IN NANOPARTICLES ... 35 iv SUMMARY In the fight against breast cancer, the totality of tumour treatment dictated therapy outcome and the probability of cancer remission. Differential metabolism of docetaxel (DCL) and tamoxifen ... of treatment effect of the individual agent [85] For example, the combination of DCL and TAM were shown to be synergistic in triple negative breast cancer. .. adaptive responses of

Ngày tải lên: 01/10/2015, 17:28

... CO-ENCAPSULATION OF ANTI -BREAST CANCER DRUGS IN NANOPARTICLES REDUCES ANTAGONISM TAN GUANG RONG NATIONAL UNIVERSITY OF SINGAPORE 2014 CO-ENCAPSULATION OF ANTI -BREAST CANCER DRUGS IN NANOPARTICLES ... 35 iv SUMMARY In the fight against breast cancer, the totality of tumour treatment dictated therapy outcome and the probability of cancer remission. Differential metabolism of docetaxel (DCL) and tamoxifen ... of treatment effect of the individual agent [85] For example, the combination of DCL and TAM were shown to be synergistic in triple negative breast cancer. .. adaptive responses of

Ngày tải lên: 03/10/2015, 20:58

... MOLECULAR ANALYSIS OF THE GENE LAS17 MEDIATING T-DNA TRAFFICKING IN YEAST CELLS HARIPRIYA BATHULA DEPARTMENT OF BIOLOGICAL SCIENCES NATIONAL UNIVERSITY OF SINGAPORE 2010 MOLECULAR ANALYSIS OF THE ... course of my research programme at the National University of Singapore. i TABLE OF CONTENT Pages Acknowledgements i Table of contents ii Summary v List of Tables vi List of Figures vii List ... SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF BIOLOGICAL SCIENCES NATIONAL UNIVERSITY OF SINGAPORE 2010 ACKNOWLEDGEMENTS I would like to thank my mentor Associate Professor Pan Shen

Ngày tải lên: 13/10/2015, 16:50

... and telomerase levels, an area of extensive study in the field of cancer research We wish to thank the authors of the various chapters of Molecular Analysis of Cancer for their excellent contributions ... Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark PER GULDBERG Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer ... Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark JESPER ZEUTHEN Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer...

Ngày tải lên: 08/04/2014, 12:51