11 considering systemic antibiotics as monotherapy in the treatment of periodontal disease

... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into ... detected in BACE1, which is involved in the rate-limiting step of β-secretase cleavage of APP in Aβ formation (Vassar et al., 1999) Overall, the findings on familial AD support amyloid cascade theory,...

Ngày tải lên: 09/09/2015, 08:17

... used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the necrotic ... intravenous antibiotics in the treatment of patients with severe pancreatitis, even in the setting of pancreatic necrosis The few prospective studies that exist investigating antibiotic use in ... selective decontamination of the digestive tract Selective decontamination is attractive as it may allow the use of prophylaxis without the risk of inducing superinfections through the use of long-term...

Ngày tải lên: 12/08/2014, 19:22

... affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution in patients with ascites [52] Hepatitis C virus (HCV) infection is a leading cause of cirrhosis ... is recommended as well as monitoring of levels during treatment Discontinuation of valproate when aminotransferase levels are "clearly increased above the normal pretreatment baseline" is recommended ... aberrations Of note, lithium in combination with angiotensin converting enzyme (ACE) inhibitors may produce an increased risk of arrhythmia [42,51] Valproate has an increased risk of liver injury in conjunction...

Ngày tải lên: 25/10/2012, 10:51

... the angles of the dural opening The most significant step involves constructing small supporting pillars on the bilateral sides of the vessels as they pass the edge of the dural window (the pillars ... craniectomy, which was introduced by Cushing,11 involves removing the part of the skull beneath the temporal muscle by opening the dura This was an important surgical method for the treatment of severe ... each incision in one row was adjacent to an intact dural bridge in the rows on either side The same course was then performed, but in a direction vertical to the initial incision This method was...

Ngày tải lên: 25/10/2012, 11:40

... types of movement The same activity can increase or decrease the volume of the limb depending on several factors such as, for example, the weight and the fitness of the patient and the duration of ... efficacious in the reduction of the edema The hypothesis of the mechanism of action is that cervical stimulation causes the contraction of the lymphangions Passive mechanical lymph drainage Passive ... as brushing the floor, that involve the mobility of the limb and can be transformed into a form of treatment Several studies, both ongoing and in press, show that the association of these activities...

Ngày tải lên: 26/10/2012, 09:39

... Randomization Clinical assessments as indicated; first dose in clinic Clinical assessments as indicated Clinical assessments as indicated Clinical assessments as indicated 30 60 Treatment Period ... withdrawn from the study (without penalty) if, in the opinion of the treating physician, it was not in the patient’s best interest to continue For instance, if during the course of the study a patient ... including glucosamine and chondroitin, one month prior to study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients...

Ngày tải lên: 26/10/2012, 09:48

... inhibitors inducing thereby the wound healing [16] As a result of the increased angiogenesis, the local antibiotic concentrations are increased, too [3, 11] Last but not least, the transport of cellular ... and the possibility of costs minimization [8, 14] The disadvantage of lacking inspections of the sponges can be compensated by daily controlling of the canister fluid and monitoring of the inflammation ... However, there was no negative influence on the remaining therapy progress with regard to the infection sanitation In cases no 10 and 16, the infection persisted so that the endoprosthesis had...

Ngày tải lên: 26/10/2012, 09:53

... by the ratio in which the antibiotics are mixed into the cement and therefore, the total dose of antibiotics should not exceed 10% of the weight of the cement in order to avoid fracture of the ... accumulating in the potential joint space and decreasing the risk of soft-tissue contractures [18] Recent studies [19] suggest that the ALC may remove the need for systemic antibiotics in the interval ... cement (ALC) in the form of spacers during the interval period to deliver antibiotics locally has become popular as it has increased rates of infection control achieving up to 95% in several studies...

Ngày tải lên: 26/10/2012, 09:53

... implanted In 70 cases a “normal” spacer has been implanted, whereas in the remaining 18 cases a spacer head has been placed onto the in situ remained femoral stem In the latter cases, there was either ... remove the femoral stem For loading of the bone cement, the combination of gentamicin and vancomycin was most frequently used followed by the combination of gentamicin and teicoplanin Data about the ... pruritus) against the intravenous antibiotics administered (in both cases combination of clindamycin and flucloxacillin) The symptoms were resolved after adjustment of the antibiotic therapy An...

Ngày tải lên: 26/10/2012, 09:53

Ngày tải lên: 03/11/2012, 11:01

... time-consuming phase-encoding steps, thereby allowing both the acquisition time and the ETL to be reduced In particular, DWI with parallel imaging reduces the number of phase-encoding steps, the effective ... hyperintensity mass d ADC map demonstrates the tumor as hypointensity and the normal myometrium as hyperintensity (arrow) The ADC value within the mass is 0.87×10–3 mm2/s potential usefulness in the ... within the solid component c DWI with b = 1,000 s/mm2 shows hyperintensity within the solid component d The ADC map demonstrates the tumor as intermediate intensity and urine in the bladder as...

Ngày tải lên: 13/02/2014, 06:20

... food intake, these findings lend further support to the mechanism by which malonyl-CoA participates in the regulation of feeding behavior Role of carnitine acyltransferases The brain and neurons in ... sequences as a highly homologous member of the CPT1 class of enzymes and was shown to bind malonyl-CoA [47] Interestingly, its tissue distribution was restricted to the brain Being a malonyl-CoA binding ... levels of the orexigenic and anorectic Signaling mediators in the treatment of obesity neuropeptide expression in the hypothalamus [22] Thus an increase in malonyl-CoA promotes a decrease in neuropeptide...

Ngày tải lên: 14/02/2014, 22:20

... number The S-phase kinase-associated protein (Skp)1–CullinF-box protein (SCF) ubiquitin ligase (E3) complex targets cyclin-dependent kinase inhibitors for degradation by the 26S proteasome and thereby ... adipocyte hyperplasia as a result of increased proliferation or recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important in the regulation of adipocyte ... by cyclin ⁄ cyclin-dependent kinase holoenzymes, releasing the E2F complex and thereby resulting in activation of the E2F target genes [9] Fajas et al [10] demonstrated that the E2F protein 566...

Ngày tải lên: 06/03/2014, 01:20

... imaging of the brain was also performed in a subset of patients in this study.36 It was found that use of corticosteroids possibly reduced the risk of developing hydrocephalus and vasculitic infarcts; ... treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases ... risk of recurrent TB CORTICOSTEROIDS IN OTHER FORMS OF EXTRAPULMONARY TB Credible evidence from clinical trials for the use of corticosteroids in other infrequent forms of TB, such as genitourinary...

Ngày tải lên: 06/03/2014, 04:20

... rifampin induces the activity of the CYP2C19 and CYPD6 isozymes The rifamycins vary in their potential as CYP450 inducers, with rifampin being most potent, rifapentine intermediate, and rifabutin ... outcomes of proteaseinhibitor-based antiretroviral therapy in the setting of rifabutin-based tuberculosis treatment 1, 41 Though no comparative studies have been done, the combination of rifabutin ... rifampin-based TB treatment Zidovudine / lamivudine / abacavir / tenofovir with rifampin-based TB treatment1 0 Zidovudine / lamivudine / tenofovir with rifampin-based TB treatment Zidovudine /...

Ngày tải lên: 06/03/2014, 04:20

... RNA-binding domain proteins (CS-RBD) The “cold-inducible RNA-binding protein” (CIRP) is one of these proteins, and has been involved in protection as the result of hypothermia treatment in in vitro ... metabolic insult Combination therapy is based in the extension of the therapeutic window of hypothermia using pharmacotherapy and establishes an interesting approach in hypothermia research 4.1 Hypothermia, ... injury by hypothermia Depth of hypothermia The efficacy of hypothermia increases as the depth of hypothermia increases, though the response is not linear In a large meta-analysis of animal studies,...

Ngày tải lên: 23/03/2014, 17:20

... overexpressed in certain esophagus squamous cell carcinomas as well as other head, neck, bladder, and breast cancers Other functions for the cyclins exist as well The cyclin A gene is the site of integration ... expression of proteins involved in the cell cycle (G1/S phase) p53 functions as the “guardian of the genome” by inhibiting the cell cycle via interactions with specific cyclin/CDK complexes or inducing ... for carcinogenesis in inherited neoplasms or cancers appearing in ontogeny GENE THERAPY APPROACHES TO THE TREATMENT OF CANCER One strategy in the gene therapy of cancer is the compensation of a...

Ngày tải lên: 10/04/2014, 22:11

... criticism of the use of the RCT as a necessary measure of the success of an intervention has been that in the real world the treatment setting is never as controlled as in RCT conditions This has led ... the intervention and its effectiveness is calculated by comparing measures taken at baseline (the beginning of treatment) and comparing them to measures taken at the end of treatment Increasingly ... psychodynamic psychotherapy therapy, or a combination of both The main elements of the brief Adlerian treatment were encouraging relationships, identifying the focus, and determining areas of possible...

Ngày tải lên: 02/06/2014, 09:39

... medial pain and swelling in the left knee A bone scan showed increased activity in the medial femoral condyle indicating possible localised osteolysis, and there was some low-grade uptake in the proximal ... image of the left knee showing the introducing cannula and simultaneous venting of the medial tibial condylar cyst Discussion When dealing with massive periprosthetic osteolysis the aims of surgery ... by creeping substitution [21] We were unable to find any data in the literature pertaining to the use of bone cements in the context of osteolytic cysts in knee arthroplasty, however these analogues...

Ngày tải lên: 20/06/2014, 04:20

... RNA-binding domain proteins (CS-RBD) The “cold-inducible RNA-binding protein” (CIRP) is one of these proteins, and has been involved in protection as the result of hypothermia treatment in in vitro ... metabolic insult Combination therapy is based in the extension of the therapeutic window of hypothermia using pharmacotherapy and establishes an interesting approach in hypothermia research 4.1 Hypothermia, ... injury by hypothermia Depth of hypothermia The efficacy of hypothermia increases as the depth of hypothermia increases, though the response is not linear In a large meta-analysis of animal studies,...

Ngày tải lên: 27/06/2014, 10:20